Clinical trials: Carotid Atherosclerotic Plaques
Carotid Atherosclerosis
Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With Carotid Atherosclerotic Plaques
Sonodynamic therapy (SDT) is a new treatment for carotid atherosclerotic plaque. The aim of this study is to assess the safety and efficacy of this technique.
- Trial name
- SMART-C (NCT03382249)
- Testing
- Sonodynamic therapy (SDT), pseudo-SDT
- Where
- China
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Atherosclerosis of Artery, Coronary Artery Disease
Effects of aSPIrin Versus Aspirin Plus Low-dose RIvaroxaban on Carotid aTherosclerotic Plaque Inflammation
Primary Study Objective : To compare the effects of low-dose rivaroxaban plus aspirin versus aspirin on atherosclerotic plaque inflammation using serial FDG Positron Emission Tomography/Computed Tomography(PET-CT) imaging of…
- Conditions
- Atherosclerosis of Artery, Coronary Artery Disease, Peripheral Arterial Disease, Carotid Stenosis
- Trial name
- SPIRIT (NCT05797376)
- Testing
- Rivaroxaban 2.5mg
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Asan Medical Center
Stenoses, Carotid, Stroke
Anatomical Relationship Between Carotid Artery and Hyoid Bone in Stenotic and Non-stenotic Carotids
Ischaemic stroke is attributable to thromboembolism caused by carotid atherosclerotic disease in 18-25% of patients. Guidelines for prevention of stroke (especially carotid endarterectomy) in patients with carotid atherosclerotic…
- Trial name
- CAROTHYD (NCT05349526)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Atherosclerosis, Atherosclerotic Plaque
Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
This will be a pilot study of 9 patients undergoing standard-of-care clinically indicated carotid endarterectomy. The nine patients will receive an injection of Indocyanine green (ICG) at a dose of 0.25 mg/kg (maximum 25 mg) as…
- Conditions
- Atherosclerosis, Atherosclerotic Plaque, Carotid Stenosis
- Trial name
- BRIGHT-CEA (NCT01873716)
- Testing
- Indocyanine green
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Atherosclerosis
Carotid Atherosclerotic Plaque Study
First, to establish a comparison of the pathophysiology of carotid atherosclerosis and the genetic and environmental variables that cause those plaques to become symptomatic.
- Trial name
- NCT00214006
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Wisconsin, Madison
Atherosclerosis
Pollutants in the Atherosclerotic Plaque and Cardiovascular Events
Air pollution, microplastics and climate change pose serious public health risks. In recent years, air pollution has been associated with an increased risk of morbidity, all-cause mortality, cardio-respiratory-related mortality…
- Trial name
- APAChE (NCT05900947)
- Testing
- analysis of carotid atherosclerotic plaque
- Where
- Italy
- Volunteers
- 312 people
- Sponsor
- University of Campania Luigi Vanvitelli
Carotid Artery Plaque
99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis
This was a single-center, single-dose, study comprising a Proof of Concept (PoC) part and a subsequent Phase II part. The study was being done to assess the ability of the radiotracer 99mTc-rhAnnexin V-128 to image…
- Trial name
- NCT02667457
- Testing
- 99mTc-rhAnnexin V-128
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Advanced Accelerator Applications
Atherosclerosis, Coronary Disease
Specific Lp(a) Apheresis for Regression of Coronary and Carotid Atherosclerosis
To evaluate whether specific lipoprotein(a) apheresis on the top of optimal medical therapy could affect atherosclerotic disease burden in coronary and carotid arteries of coronary heart disease patients with elevated Lp(a)…
- Conditions
- Atherosclerosis, Coronary Disease, Carotid Artery Diseases
- Trial name
- LaRCA (NCT02133807)
- Testing
- Specific Lp(a) apheresis
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Russian Cardiology Research and Production Center
Atherosclerosis
Influenza A VIRus and Destabilization of Atherosclerotic Carotid Plaques
Atherosclerosis is the main cause of cardiovascular diseases and is characterized by the accumulation of lipids and inflammatory cells such as macrophages and lymphocytes within the vessel wall of large and medium-sized arteries…
- Trial name
- VIRAL (NCT06217471)
- Testing
- Carotid Endoarterectomy
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- IRCCS Policlinico S. Donato
Inflammation Plaque, Atherosclerotic, Coronary Disease
Comparison of Fimasartan Versus Amlodipine Therapy on Carotid PlaquE Inflammation
The purpose of this study is to evaluate the effects of angiotensin receptor 1 blocker versus calcium channel blocker on atherosclerotic plaque inflammation using serial FDG PET/CT imaging of carotid artery.
- Conditions
- Inflammation Plaque, Atherosclerotic, Coronary Disease, Renin-Angiotensin System
- Trial name
- FACE (NCT02378064)
- Testing
- 6-month treatment
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Plaque, Atherosclerotic, Immune Checkpoint Inhibitors
A Perspective, Self-control Study on the Progression of Carotid Plaques in Anti-PD-1 mAb Treated Tumor Patients by Artery Ultrasound Follow-up
A Perspective, Self-control Study on the Progression of Carotid Plaques in Anti-PD-1 mAb Treated Tumor Patients by Artery Ultrasound Follow-up
- Conditions
- Plaque, Atherosclerotic, Immune Checkpoint Inhibitors, Programmed Cell Death Protein 1 Inhibitor, Carotid Artery Plaque
- Trial name
- NCT05123287
- Testing
- PD-1 immune checkpoint blockades
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Plaque, Atherosclerotic
Comparison of Clopidogrel Versus Ticagrelor Therapy for Atherosclerotic Plaque Inflammation
Objectives: To compare the effects of clopidogrel versus ticagrelor on atherosclerotic plaque inflammation using serial FDG PET/CT imaging of carotid artery and ascending aorta.
- Trial name
- NCT01905566
- Testing
- Clopidogrel, Ticagrelor
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Atherosclerosis
The Influence of Dietary Plant Sterols and Plant Stanols on Cholesterol and Plant Sterol Levels in Atheromatous Plaques
This study aims to explore whether the increased supply of dietary plant sterols and plant stanols have any influence on serum levels of phytosterols and on consistency of carotid atheromatous plaques.
- Trial name
- NCT00737919
- Testing
- Plant Stanol, Plant Sterol
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- University of Helsinki
Atherosclerosis, Atheroma of Cerebral Arteries
Normal Parameters of Cranial Vessels Using Cranial Vascular Duplex Among Egyptian Population
the study will be carried out to standardize normal parameters of vascular duplex ultrasound of the cranial vessels in the Egyptian population.
- Conditions
- Atherosclerosis, Atheroma of Cerebral Arteries, Atheroma; Carotid Artery, Atheroma; Cerebral
- Trial name
- NCT03252652
- Testing
- vascular duplex ultrasound imaging
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Dyslipidemia, Carotid Atherosclerotic Plaques
Yangxin Dawayimixike Honey Paste for Carotid Atherosclerotic Plaque With Dyslipidemia: A Randomized Controlled Clinical Study
This clinical trial aims to evaluate the efficacy and safety of Yangxin Dawayimixike Honey Paste in intervening carotid atherosclerotic plaque combined with dyslipidemia.
- Trial name
- NCT07314775
- Testing
- Yangxin Dawayimixike Honey Paste
- Volunteers
- 422 people
- Sponsor
- Xinjiang Uygur Pharmaceutical Co., Ltd.
Carotid Stenosis, Carotid Artery Plaque
CARotid Mri of Atherosclerosis
In the entire world most people die from cardiovascular disease. Death is primarily from myocardial infarction (MI) and stroke which are most often caused by rupture of atherosclerotic plaques. Patients with high-grade, i.e.
- Conditions
- Carotid Stenosis, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- CARMA (NCT04835571)
- Testing
- Optimization of cardiovascular risk management
- Volunteers
- 52 people
- Sponsor
- Linkoeping University
Carotid Artery Stenosis Asymptomatic, Carotid Atherosclerosis
Carotid Plaque RADS vs CPVH: Diagnostic Accuracy Comparison
This study compares two methods for assessing carotid artery plaques - deposits of cholesterol and other substances that can build up in the neck arteries and potentially lead to stroke.
- Trial name
- CPVH-P-RADS (NCT07870512)
- Testing
- Carotid Ultrasound with CPVH and Carotid Plaque RADS Assessment
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Limited Liability Company "European Institute of Family Health"
Atherosclerosis
Identification of Genes Expressed in Atherosclerotic Plaque
This study will identify genes and proteins in the blood of patients with atherosclerosis and in that of normal volunteers. The findings will be compared to determine the influence of these substances on the development of…
- Trial name
- NCT00353730
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Carotid Atherosclerosis
Shear Wave Elastography for Carotid Atherosclerotic Plaques
The goal of this prospective diagnostic accuracy cohort study is to compare the accuracy of carotid atherosclerotic plaques stiffness assessed by shear wave elastography (SWE) with greyscale median values (GSM), magnetic…
- Trial name
- NCT06214429
- Testing
- Vascular Ultrasound, Shear Wave Elastography, Greyscale Median
- Where
- Brazil
- Volunteers
- 43 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Carotid Artery Plaques, Atherosclerosis
Effects of Rosa Roxburghii Tratt Freeze-Dried Powder on Carotid Atherosclerotic Plaques: A Real-World Study
This study aims to evaluate the effectiveness and safety of Rosa roxburghii freeze-dried powder in reducing carotid atherosclerotic plaques.
- Conditions
- Carotid Artery Plaques, Atherosclerosis, Ischemic Stroke
- Trial name
- RRC-AS (NCT07840950)
- Testing
- Rosa Roxburghii Freeze-Dried Powder, Conventional Anti-Atherosclerosis Therapy
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University