Clinical trials: Carotid Disease
Carotid Atherosclerosis, Coronary Atheroscleroses
Carotid Atherosclerosis in Predicting Coronary Artery Disease
Carotid plaque burden and composition features, particularly lipid necrotic core, are significantly associated with severity of CAD stenosis.
- Trial name
- CACA (NCT06253962)
- Testing
- coronary agiongraphy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Stenosis, Carotid Stenosis
Detection of Coronary Stenosis With Intravenous Microbubbles
To detect coronary artery disease by both coronary and carotid artery imaging and myocardial perfusion imaging using a new low mechanical index real time system.
- Conditions
- Coronary Stenosis, Carotid Stenosis, Myocardial Reperfusion
- Trial name
- NCT00580580
- Testing
- Optison, Definity, PESDA
- Sponsor
- University of Nebraska
Neurocognitive Disorders, Alzheimer's Disease
Evaluation of the Link Between Carotid Arterial Wall Viscosity and Major Neurocognitive Disorders
The mechanical behavior of conductance arteries is viscoelastic. While the elastic component has been extensively studied, the viscous component has often been neglected for methodological reasons and also because it was…
- Trial name
- VISCOG (NCT07205003)
- Testing
- Assessment of carotid wall viscosity in patients with vascular dementia, Assessment of carotid wall viscosity in patients with Alzheimer's disease, Assessment of carotid wall viscosity in patients not presenting dementia.
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Rouen
Atherosclerosis
The Influence of Dietary Plant Sterols and Plant Stanols on Cholesterol and Plant Sterol Levels in Atheromatous Plaques
This study aims to explore whether the increased supply of dietary plant sterols and plant stanols have any influence on serum levels of phytosterols and on consistency of carotid atheromatous plaques.
- Trial name
- NCT00737919
- Testing
- Plant Stanol, Plant Sterol
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- University of Helsinki
Aortic Valve Stenosis, Ventricular Outflow Obstruction, Left
Polish Registry of Common Carotid Artery Access for TAVI
Transcatheter aortic valve implantation (TAVI) is valuable treatment option for patients, who are at the high risk of surgical aortic valve replacement (AVR).
- Trial name
- POL-CAROTID (NCT03361007)
- Testing
- Transcatheter Aortic Valve Implantation (TAVI)
- Where
- 6 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Atherosclerosis, Hypercholesterolemia
Investigating the Effects of Lipid-therapy Intensification With Alirocumab on Endothelial Function, Carotid Arteries, Lipoprotein Particle Subfractions, Inflammation and Post-prandial Lipemia
A prospective, open-label, pilot study with 24 cardiovascular high risk patients (N=24) having insufficient Low density lipoprotein cholesterin (LDL-C) reduction despite standard of care lipid-modifying therapies (LMTs), to…
- Conditions
- Atherosclerosis, Hypercholesterolemia, Post Prandial Lipemia, Cardiovascular Diseases
- Trial name
- ALIROCKS (NCT03559309)
- Testing
- Magnet Resonance Tomography, Carotid Arteries Sonography, Flow-mediated Dilation, Fat-tolerance Test, Laboratory Testing
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
PsA (Psoriatic Arthritis)
Effect of Metformin on Carotid Atherosclerosis for Non-diabetic Patients With PsA (CAMPA Study)
Background: Psoriatic arthritis (PsA) is a common chronic inflammatory disease with a prevalence up to 670 every 100,000 subjects.
- Trial name
- NCT05988684
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 24 people
- Sponsor
- Chinese University of Hong Kong
Plummer Disease, Multinodular Goiter
Prospective, Observational Study on the Carotid Intima-media Thickness in Patients Undergoing Thyroid Surgery
The evaluation of carotid intima-media thickness (cIMT) has become a possible predictor of the future risk of cardiovascular diseases (CVD).
- Conditions
- Plummer Disease, Multinodular Goiter, Graves Disease, Hyperthyroidism
- Trial name
- TIROVASC (NCT05774535)
- Testing
- Experimental
- Where
- Italy
- Sponsor
- Istituto Auxologico Italiano
Moyamoya Disease, Intracranial Hemorrhages
5T MRI and Metabolomics-Based Hemorrhage Risk Prediction in Moyamoya Disease
Intracranial hemorrhage is a leading cause of death and disability in patients with moyamoya disease (MMD), yet clinically available tools for predicting long-term hemorrhage risk are lacking.
- Conditions
- Moyamoya Disease, Intracranial Hemorrhages, Stroke
- Trial name
- NCT07781579
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beijing Hospital
Carotid Artery Stenosis
A Randomized Trial of Carotid Artery Stenting With and Without Cerebral Protection
The primary objective of this study is to evaluate carotid artery stenting (CAS) with and without cerebral protection (CP) to determine if CP improves safety and effectiveness of CAS.
- Trial name
- NCT00177346
- Testing
- CAS with cerebral protection, CAS without cerebral protection
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Pittsburgh
Fibromuscular Dysplasia
Cross-sectional Study of Patients With Renal or Craniocervical Fibromuscular Dysplasia
ARCADIA is a national registry designed to document phenotypic and genetic traits in patients with renal and/or cervical artery fibromuscular dysplasia (FMD).
- Trial name
- ARCADIA (NCT02884141)
- Where
- 17 sites in Belgium, France
- Volunteers
- 499 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cognitive Manifestations
Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates
Carotid artery plaques are known to cause stroke. Cognitive impairment is an insidious but poorly understood problem in patients with carotid plaques.
- Trial name
- ACCOF (NCT01353196)
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Carotid Stenosis
Risk Prediction Model for Cerebrovascular Events in Carotid Artery Stenosis
Atherosclerotic carotid artery stenosis is a major cause of stroke, and early identification of high-risk patients combined with surgical intervention can significantly reduce stroke risk.
- Trial name
- NCT06452173
- Testing
- Plasma, carotid high-resolution magnetic resonance imaging
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Ischemic Attack, Transient
Carotid Occlusion Surgery Study
The purpose of this study is to determine if extracranial-intracranial bypass surgery when added to best medical therapy can reduce the subsequent risk of ipsilateral stroke in high-risk patients with recently symptomatic carotid…
- Conditions
- Stroke, Ischemic Attack, Transient, Cerebral Infarction
- Trial name
- COSS (NCT00029146)
- Testing
- extracranial-intracranial bypass surgery, best medical therapy
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis, Obesity
Ultrasound Assessment of the Carotid Intimal Medial Thickness in Obese Subjects; Weight Loss
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- CIMT-LOSEIT-I (NCT02954627)
- Testing
- Dietary Supplement: Intensive dietary intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Henrik Gudbergsen
Metabolic Syndrome
Carnitine for the Treatment of Atherosclerosis.
Obesity is one of the main causes of the metabolic syndrome, a condition which is becoming more common in Canada and worldwide. Metabolic syndrome is a name for a group of heart disease risk factors that occur together: obesity…
- Trial name
- ECoM (NCT02117661)
- Testing
- L-carnitine capsules, Cellulose capsules
- Where
- 2 sites in Canada
- Volunteers
- 177 people
- Sponsor
- Dr. Amer Johri
Unruptured Intracranial Aneurysm, Arteriovenous Cerebral Malformations
ACtive Catheterization for EndovaScular TreatmentS
The objective of this clinical investigation is to evaluate the safety and technical success of the Basecamp Vascular controllable directional GECKO guidewire when used to facilitate endovascular access to the targeted vessel in…
- Conditions
- Unruptured Intracranial Aneurysm, Arteriovenous Cerebral Malformations, Carotid Stenosis
- Trial name
- ACCESS (NCT05355259)
- Testing
- GECKO Active Guidewire
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Basecamp Vascular
Carotid Stenosis
Perioperative GFAP and Neurological Complications After Carotid Endarterectomy
This prospective, single-center observational study will evaluate whether blood levels of glial fibrillary acidic protein (GFAP), a protein associated with injury to supporting cells in the brain, are related to neurological…
- Trial name
- NCT07843979
- Testing
- Serum GFAP Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Filiz Ata
Type 2 Diabetes, Hypertension
Step Monitoring to Improve ARTERial Health
Many people with diabetes and/or high blood pressure (hypertension) are not very active. When people are more active, they can reduce the chances of having a heart attack or stroke.
- Trial name
- SMARTER (NCT01475201)
- Testing
- Step count prescription, Usual care
- Where
- 6 sites in Canada
- Volunteers
- 347 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Atherosclerosis, Carotid Artery Plaque
New Technologies to Determine Carotid Plaque Vulnerability
Hypothesis: Identification of vulnerable atherosclerotic plaques (with or without neovascularization) using carotid CEUS is an independent predictor of MACE (over clinical risk factors, stress echo wall motion results, and…
- Trial name
- CEUS (NCT02224339)
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Mayo Clinic
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