Clinical trials: Carotid Intima-media Thickness
Cardiovascular Disease, Diabetes
The FLAVO Trial: Dietary Flavonoids and Cardiovascular Disease Risk Reduction in Postmenopausal Women With Type 2 Diabetes
The purpose of this placebo controlled trial is to determine whether a year long intervention with flavonoids (found in cocoa and soy) is more effective in reducing the risk of cardiovascular disease in postmenopausal women with…
- Trial name
- FLAVO (NCT00677599)
- Testing
- Flavonoid enrichment (cocoa / soy compounds)
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- University of East Anglia
Atherosclerosis
ELITE: Early Versus Late Intervention Trial With Estradiol
The purpose of this study is to examine the effects of oral 17B-estradiol (estrogen) on the progression of early (subclinical) atherosclerosis and cognitive decline in healthy postmenopausal women.
- Trial name
- NCT00114517
- Testing
- 17B-estradiol
- Where
- United States
- Volunteers
- 643 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Kidney Transplantation, Vitamin D Deficiency
Vitamin D Replacement After Kidney Transplant
Vitamin D deficiency accelerates vascular risk progression after kidney transplant.
- Trial name
- NCT00748618
- Testing
- Standard vitamin D3 treatment, High dose vitamin D3 treatment
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- University of Nebraska
Coronary Artery Disease, Cerebrovascular Disease
RESTORE-IT-Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients With a History of Atherosclerotic Disease
The objective of this study is to evaluate an antibiotic therapy called Rifalazil to determine its effect on hardening of the carotid arteries.
- Conditions
- Coronary Artery Disease, Cerebrovascular Disease, Peripheral Vascular Disease
- Trial name
- NCT00385385
- Testing
- Rifalazil
- Where
- 6 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- ActivBiotics
Ischemic Stroke
Carotid Intima-media Thickness in Japan Statin Treatment Against Recurrent Stroke(J-STARS Echo)
Carotid ultrasound can reveal the intima-media complex thickness(IMT), that has been reported to be a marker of atherosclerosis as well as a risk of cardiovascular events, and to be attenuated by…
- Trial name
- NCT00361530
- Testing
- Statin
- Where
- 2 sites in Japan
- Volunteers
- 854 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Oxidative Stress, Endothelial Dysfunction
Genes, Fibrinolysis and Endothelial Dysfunction- Dialysis Aim 3
The purpose of the study is to see how two classes of blood pressure medications,angiotensin-converting enzyme inhibitors (Ace inhibitors) and angiotensin receptor blockers (ARBs), differ in their long term effects on certain…
- Trial name
- NCT00878969
- Testing
- valsartan (ARB), ramipril (ACE inhibitor)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Cardiovascular Risk Stratification, Carotid Intima-media Thickness (CIMT)
CIMT and Plaque Assessment Findings in Subjects Undergoing Stress Echocardiography For Risk Stratification
The purpose of this research study is to determine if carotid artery ultrasound scanning can provide additional information for determining cardiovascular risk in patients.
- Conditions
- Cardiovascular Risk Stratification, Carotid Intima-media Thickness (CIMT), Stress Echocardiography (SE)
- Trial name
- NCT02245048
- Testing
- Carotid Intima-Media Thickness (CIMT)
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Mayo Clinic
Primary Prevention
Genetical, Anthropometrical and Biochemical Factors Influencing High Risk Subclinical Atherosclerosis
Subclinical atherosclerosis is the atherosclerotic process identified before clinical symptoms and thus it can be a useful marker of future cardiovascular events. It can be evaluated by many methods.
- Trial name
- NCT02487615
- Where
- 2 sites in Brazil
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Atherosclerosis, Menopause
Estrogen Exposure and Atherosclerosis in Postmenopausal Women
One hundred Spanish postmenopausal women accepted to be investigated for cardiovascular risk actors including clinical features, serum biochemical parameters, single nucleotide polymorphisms for estrogen receptor, and imaging…
- Conditions
- Atherosclerosis, Menopause, Estrogens, Carotid Intima-media Thickness
- Trial name
- NCT02951949
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Abdominal Obesity, Growth Hormone Deficiency
Effectiveness of Growth Hormone Releasing Hormone in Reducing Abdominal Fat in People Who Are Obese
Obesity, a condition that occurs when a person has too much body fat, affects about 31% of people in the United States. It is associated with increased risk of diabetes, high blood pressure, high cholesterol, and cardiovascular…
- Trial name
- NCT00675506
- Testing
- Growth hormone releasing hormone (GHRH) 1-44
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Atherosclerosis of Arteries of the Extremities, Unspecified
Beneficial Effects of Grape Seed Proanthocyanidin Extrat on Progression of Atherosclerotic Plaques in Clinical Use
The purpose of this study is to investigate the antiatherogenic effect of GSPE in clinical use
- Trial name
- GSPE (NCT01707615)
- Testing
- GSPE, lifestyle intervention
- Volunteers
- 287 people
- Sponsor
- Jie Qiu
Atherosclerotic Cardiovascular Disease, Subclinical Disease and/or Syndrome
Gastric Bypass Versus Best Medical Treatment on Progression of Carotid-intima Media Thickness in Type 2 Diabetes Mellitus (T2DM)
Background: Type 2 Diabetes Mellitus (T2DM) is associated with an increased burden for cardiovascular disease (CVD). Multifactorial interventions are necessary to reduce the CV risk in T2DM.
- Trial name
- EURDSS (NCT01353066)
- Testing
- Intensive Medical Treatment, IMM+Roux-en-Y Gastric Bypass (RYGBP)
- Where
- Spain
- Volunteers
- 240 people
- Sponsor
- Hospital Clinic of Barcelona
Cardiovascular Imaging, Echocardiography
Assessment of Cardiac and Carotid Ultrasound Measurements in a Cohort of Healthy Children in Italy
This observational ambispective cohort study aims to establish reference values for cardiac structure and function, coronary artery dimensions, and carotid intima-media thickness (cIMT) in a healthy pediatric population living in…
- Conditions
- Cardiovascular Imaging, Echocardiography, Carotid Intima-Media Thickness
- Trial name
- NORMECO (NCT07666451)
- Where
- Italy
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Atherosclerosis, Coronary
Air Pollution (PM2.5) on Accelerated Atherosclerosis: A Montelukast Interventional Study in Modernizing China
Background: Longterm exposure to air pollution has been associated with cardiovascular events and mortality on top of traditional risk factors. Pulmonary inflammation and oxidative stress have been implicated.
- Trial name
- NCT04762472
- Testing
- Montelukast Oral Tablet
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cardiovascular Disease, Cigarette Smoking
Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers
This cross-sectional study was primarily a cardiovascular disease (CVD) study designed a) to compare selected CVD biomarker data between subjects who were long-term consumers of cigarettes or moist snuff and non-consumers of…
- Trial name
- NCT01692353
- Testing
- Subject's usual brand (UB) tobacco product
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Tobacco Company
Diabetic Peripheral Angiopathy
A Study to Compare the Effects of Improving the Carotid Artery Intima Media Thickness and Changing Lipid Levels by Cilostazol/Ginkgo Leaf Extract and Aspirin in Diabetic Peripheral Angiopathy.
This study is to compare and evaluate the effect of improving the carotid IMT and lipid level of the Cilostazol/Ginkgo leaf extract group with the aspirin administrated group in patients with diabetic peripheral angiopathy.
- Trial name
- NCT05906199
- Testing
- Renexin CR 200/160mg, Aspirin 100mg
- Where
- 2 sites in South Korea
- Volunteers
- 105 people
- Sponsor
- SK Chemicals Co., Ltd.
Chronic Kidney Disease
Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study
The ATIC study is a randomised, double- blind, placebo-controlled trial in which the effects of oxidative stress-lowering treatment on vascular function and structure are studied in patients with chronic non-diabetic renal…
- Trial name
- NCT00384618
- Testing
- pravastatin, vitamin E
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Amsterdam UMC, location VUmc
Type 2 Diabetes Mellitus
Dapagliflozin, Cardio-Metabolic Risk Factors and Type-2 Diabetes
Dapagliflozin is a member of the sodium-glucose cotransporter-2 (SGLT2) inhibitor class antidiabetes agents which produces significant and sustained reductions in glycemic parameters in patients with type 2 diabetes (T2DM).
- Trial name
- NCT03377335
- Testing
- Dapagliflozin 10mg, Metformin
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- University of Palermo
Atherosclerosis, Cardiovascular Diseases
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
The INTENSITY-LOW study aims to answer if there are any limits to LDL reduction in relation to benefitting vascular health from a mechanistic viewpoint, and therefore potentially limitations to primary prevention in healthy…
- Trial name
- NCT03273972
- Testing
- Written Informed Consent, Inclusion/Exclusion check, Full Clinical Chemistry and Haematology Bloods
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Type 2 Diabetes, A1C Variability
Is Carotid Intima-media Thickness Affected by A1C Variability?
This study was conducted to evaluate the effect of A1C variability on the progression of carotid artery intima-media thickness in type 2 diabetic patients.
- Trial name
- NCT00842972
- Sponsor
- Yonsei University