Clinical trials: Carotid Occlusion
Carotid Stenosis
Ultrasonographic Morphology Assessment of Low-grade Carotid Stenosis
Internal carotid artery (ICA) is intended to supply blood to brain. The carotid bulb located upstream of ICA origin is prone to atherosclerosis.
- Trial name
- QUAMUS (NCT05437991)
- Testing
- Independent morphological quantifications by echo-doppler using ECST method
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Carotid Artery Stenosis
Troponin In Carotid Revascularization
Patients undergoing carotid revascularization procedures are at increased risk for the development of short- and long-term cardiac complications.
- Trial name
- TROPICAR (NCT05293067)
- Testing
- high-sensitive troponin
- Where
- Serbia
- Volunteers
- 527 people
- Sponsor
- University of Belgrade
Arterial Occlusive Diseases, Cardiovascular Diseases
Cholesterol-Lowering Atherosclerosis Study (CLAS)
To determine whether combined therapy with the lipid lowering agents colestipol hydrochloride plus niacin would produce significant change in coronary, carotid, and femoral artery atherosclerosis and coronary bypass graft lesions…
- Conditions
- Arterial Occlusive Diseases, Cardiovascular Diseases, Carotid Artery Diseases, Cerebral Arteriosclerosis
- Trial name
- NCT00000599
- Testing
- colestipol, niacin, diet, fat-restricted
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atherosclerosis, Carotid Artery Disease
Morphological and Serological Criteria of Plaque Vulnerability: Risk Assessment for Symptomatic and Asymptomatic Carotid Artery Stenosis
The aim of this study is to investigate the association of sonographic and histological features of the plaque among each other and with biomarkers of cardiovascular risk.
- Trial name
- VUCAP (NCT02124928)
- Testing
- Carotid endarterectomy
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Prim PD Dr Afshin Assadian
Pain
Erector Spinae Plane Block for Carotid Endarterectomy
The purpose of this study is to test the hypothesis that erector spinae plane block will decrease intraoperative local anesthetic and postoperative analgesic consumption in patients undergoing carotid endarterectomy.
- Trial name
- NCT04224844
- Testing
- Erector spinae plane block, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Antalya Training and Research Hospital
Internal Carotid Artery Stenosis
EEG, Cerebral Oximetry, and Arterial to Jugular Venous Lactate to Assess Cerebral Ischemia During Carotid Endarterectomy
A highly desired result during carotid endarterectomy (CEA) is the ability to predict and warn the surgeon if the brain is at risk of damage during the period of time that the carotid artery is cross-clamped for surgical repair…
- Trial name
- NCT00737334
- Testing
- EEGo, BIS, FORE-SIGHT cerebral oximeter
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Carotid Stenosis
Gadobutrol Enhanced MRA of the Supra-aortic Vessels
Subjects referred for a routine CTA (computed tomography angiography) or MRA (magnetic resonance angiography) will be invited to participate in the study and subjects will be involved in the study for between 2 and 12 days.
- Trial name
- GEMSAV (NCT01344447)
- Testing
- Gadobutrol (Gadovist, BAY86-4875)
- Where
- 56 sites in United States, Argentina and 12 more
- Volunteers
- 479 people
- Sponsor
- Bayer
Coronary Artery Disease
The Effect of Fish Oil Supplementation on Endothelial Function, Heart Rate Variability and Intimal Media Thickness of Patients With Coronary Artery Disease
The purpose of this study is to investigate whether there is a difference in endothelial function, heart rate variability and carotid intimal media thickness in patients with coronary artery disease who are receiving fish oil…
- Trial name
- NCT00454493
- Testing
- Omacor (omega-3-acid ethyl esters)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Non-acute Carotid Artery Occlusion
Revascularization for Symptomatic Non-acute Carotid Artery Occlusion
The short-term and long-term efficacy of recanalization therapy needs to be further confirmed by large-sample prospective studies.
- Trial name
- RESCO (NCT06303414)
- Testing
- Carotid Endarterectomy (CEA), Carotid Artery Stenting (CAS), Hybrid Surgery
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Arterial Disease, Venous Thormboembolism
VTE Incidence After Rivaroxaban + Aspirin or SAPT After Lower-limb Revascularization
Venous thromboembolism (VTE) has a high prevalence in patients with multiple comorbidities undergoing complex surgical procedures.
- Conditions
- Peripheral Arterial Disease, Venous Thormboembolism, Cardiovascular Diseases, Vascular Surgery Patient with PAD / Carotid Stenosis
- Trial name
- RESOLUTION (NCT06873321)
- Testing
- rivaroxaban 2.5 mg bid + aspirin 100 mg, clopidogrel 75 mg od for 3 months followed by aspirin 100 mg od for endovascular procedures or aspirin for open procedures
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Science Valley Research Institute
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in Inflammatory Rheumatic Disease (PREVENER)
PREVENER is a randomized, open-label, multicenter, phase IV clinical trial designed to evaluate the efficacy and safety of a carotid ultrasound-based strategy for the primary prevention of cardiovascular events in patients with…
- Conditions
- Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Axial Spondy, Systemic Lupus Erythematosus (SLE)
- Trial name
- PREVENER (NCT07611747)
- Testing
- Carotid Ultrasound, High-intensity lipid-lowering therapy, Standard care according to ESC 2021 guidelines
- Where
- 17 sites in Spain
- Volunteers
- 1,944 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Coronary Artery Disease
The Effects of Consumption of Pomegranate Juice on Carotid Intima-Media Thickness
Increases in carotid artery intima-media thickness (IMT) are correlated with increased risk of stroke and myocardial infarction.
- Trial name
- NCT00728299
- Testing
- PomWonderful Juice
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Radiant Research
Carotid Artery Plaque, Ultrasonic Diagnosis
Identification of Carotid Plague Vulnerability by Contrast Enhanced Ultrasound: Correlation With Plague Histopathology
OBJECTIVE/BACKGROUND: Intraplaque neovascularization is one of the most important risk factors for unstable carotid plaque. This study was designed to evaluate whether carotid intraplaque neovascularization (IPN) can be…
- Trial name
- NCT02820207
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Atherosclerosis, Inflammation
Silencing Inflammatory Activity by Injecting Nanocort in Patients at Risk for Atherosclerotic Disease
Cardiovascular disease(CVD) is the leading cause of morbidity and mortality in developed nations. CVD is primarily caused by atherosclerosis, a systemic disease characterized by lipid deposition in the subendothelial space with a…
- Trial name
- SILENCE (NCT01601106)
- Testing
- liposomal prednisolone
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atherosclerosis, Heterozygous Familial Hypercholesterolemia
Efficacy and Safety of the ACAT Inhibitor CS-505 (Pactimibe) for Reducing the Progression of Carotid Artery Disease. This Study is Also Known as CAPTIVATE.
The effects of pactimibe versus placebo on the progression of atherosclerosis in the carotid arteries will be assessed using standard ultrasound techniques.
- Trial name
- NCT00151788
- Testing
- Pactimibe sulfate
- Where
- 37 sites in United States, Canada and 7 more
- Volunteers
- 796 people
- Sponsor
- Daiichi Sankyo
Carotid Atherosclerosis, Regional Anesthesia Morbidity
Anterior Ultrasound-guided Cervical Plexus Block for Carotid Endarterectomy
The aim of this study is to describe technique, efficiency, safety and satisfaction of ultrasound guided intermediate cervical plexus block for carotid endarterectomy.
- Trial name
- NCT01640613
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Hôpital Edouard Herriot
Carotid Artery Stenosis
CGUARDIANS III IDE Pivotal Trial
This is a prospective, multi-center, single-arm, pivotal study. The objective of this study is to evaluate the safety and efficacy of the SwitchGuard NPS in providing cerebral embolic protection during Transcarotid Artery…
- Trial name
- NCT07277296
- Testing
- SwitchGuardTM NPS
- Volunteers
- 103 people
- Sponsor
- InspireMD
Carotid Endarterectomy
Predictors of Post-clamping Neurologic Deficits During Carotid Endarterectomy With Regional Anesthesia
Patients undergoing carotid endarterectomy may suffer from neurologic deficits (ND) during the carotid cross-clamping due to cerebral hypoperfusion. An associated risk of postoperative stroke incidence is also well established.
- Trial name
- NCT04347785
- Testing
- carotid endarterectomy
- Where
- Portugal
- Volunteers
- 206 people
- Sponsor
- Universidade do Porto
HIV Infections, HIV Seronegativity
Carotid Artery Thickness in HIV Infected and Uninfected Adults
The intima-media thickness (IMT) test is a low cost, non-invasive way to measure the thickness of the carotid artery (the large artery in the neck).
- Conditions
- HIV Infections, HIV Seronegativity, Atherosclerosis
- Trial name
- NCT00007319
- Where
- 10 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 2 Diabetes Mellitus (T2DM), Atherosclerosis
Colchicine for Primary Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes
This study will test whether a low-cost anti-inflammatory medicine called colchicine can help protect the blood vessels of people with type 2 diabetes.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Atherosclerosis, Cardiovascular Diseases
- Trial name
- Col-DM (NCT07837934)
- Testing
- Colchicine 0.5 MG Oral Tablet Once Daily
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- Tan Tock Seng Hospital