Clinical trials: Carotid Occlusion
Anesthesia
Ultrasound-Guided Intermediate Versus Deep Cervical Plexus Block for Carotid Endarterectomy
Cervical plexus blocks are regional methods used in carotid endarterectomy. Cervical plexus blocks consist of three blocks: superficial, intermediate and deep. These three blocks can be used alone or combined.
- Trial name
- NCT05353218
- Testing
- Intermediate cervical plexus block, Deep cervical plexus block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Ischemic Stroke, Carotid Stenosis
STAND: iSchemic sTroke evAluated at Bed Side With ultrasouND
Ischemic strokes account for more than 80% of strokes. Ischemic strokes are caused by the occlusion of an intracranial artery by a thrombus, responsible for tissue ischemia related to a decrease in local cerebral blood flow…
- Trial name
- STAND (NCT04180826)
- Testing
- Observational
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Moyamoya Disease
Prognostic Prediction Model in Patients With Moyamoya Disease Undergoing Revascularization Surgery
Moyamoya Disease (MMD) is a rare chronic cerebrovascular disease characterized by progressive occlusion of the internal carotid artery or its major branches, with blood flow compensated by the formation of an abnormal vascular…
- Trial name
- NCT06051552
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Beijing Tiantan Hospital
Atherosclerosis, Healthy
PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Carotid Atherosclerosis
Inflammation in the vascular wall is important in atherosclerosis and the blockage of the artery. The peripheral benzodiazepine receptor is involved in inflammation and in this protocol we will attempt to take pictures, using PET…
- Trial name
- NCT00547976
- Testing
- [C-11]PBR28
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Mental Health (NIMH)
Carotid Artery Diseases, Morbid Obesity
The Relationship Between Morbid Obesity and Carotid Artery Stenosis
The correlation between metabolic syndrome and carotid artery stenosis is well established. The purpose of this study is to evaluate the relationship between morbid obesity and carotid artery stenosis.
- Conditions
- Carotid Artery Diseases, Morbid Obesity, Metabolic Syndrome
- Trial name
- NCT03306771
- Testing
- Ultrasound Duplex
- Volunteers
- 30 people
- Sponsor
- HaEmek Medical Center, Israel
Metabolic Syndrome
Effect of Aged Garlic Extract on Atherosclerosis
The investigators will be assessing the effect of Aged Garlic Extract on the coronary arteries. The investigators will enroll patients in a double blind study, where half the patients will receive placebo, and have the patients…
- Trial name
- Garlic4 (NCT01534910)
- Testing
- aged garlic extract
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Moyamoya Disease, TIA
The Effect of RIC on TIA/Stroke in Children With Moyamoya Disease
Moyamoya disease is a common reason of transient ischemic attack (TIA) and stroke in children. Remote ischemic conditioning (RIC) has been shown to prevent recurrent stroke in intracranial arterial stenosis, but it is unclear…
- Conditions
- Moyamoya Disease, TIA, Children, Stroke
- Trial name
- RIC-PMD-1 (NCT03821181)
- Testing
- RIC group
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Capital Medical University
Carotid Stenosis
Carotid Endarterectomy Versus Carotid Artery Stenting? A Prospective Comparison of Neuropsychological Outcome in Patients With Carotid Stenosis.
In this prospective study, patients with carotid stenosis will be randomly assigned to one of the two surgical procedures (carotid endarterectomy (CEA) and carotid stenting (CAS)).
- Trial name
- NCT01337128
- Testing
- Carotid endarterectomy (CEA), Carotid stenting (CAS), Neurocognitive functions
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Ghent
Moyamoya Disease
Remimazolam Consumption: TCI vs. Manual Infusion
The purpose of this prospective randomized controlled trial is to compare the total consumption of remimazolam between two different administration methods-Target-Controlled Infusion (TCI) and manual infusion-in patients…
- Trial name
- NCT07377695
- Testing
- Target-Controlled Infusion (TCI) of Remimazolam, Manual Infusion of Remimazolam
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Carotid Artery Plaque
Ultrasound Elastography for Individual Carotid Plaque Stratification
Ischemic strokes are a leading cause of death and disability worldwide. In 20% of cases they are caused by the rupture of atherosclerotic plaques in carotid arteries. Risk estimation of plaque rupture is currently suboptimal.
- Trial name
- Ultra-COMPASS (NCT05029661)
- Testing
- Carotid ultrasound
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Carotid Artery Stenosis
Neuropsychological Functioning and Cerebral Perfusion Post Carotid Endarterectomy
The study aims to investigate the relationship between neuropsychological functioning and brain perfusion in patients undergoing carotid endarterectomy and control patients undergoing other peripheral vascular procedures.
- Trial name
- NCT04759859
- Where
- United States
- Sponsor
- CAMC Health System
Carotid Artery Stenosis
Improved Image Quality for Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound FLOW Imaging
Objective: To evaluate the technical performance of a novel cascaded wave imaging technique compared to plane wave imaging for blood flow imaging in patients with and without carotid artery stenosis.
- Trial name
- CAS-iFLOW (NCT06170580)
- Testing
- Conventional duplex, Ultrasound-based flow imaging using plane wave imaging, Ultrasound-based flow imaging using cascaded wave imaging
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Carotid Stenosis, Carotid Artery Diseases
Modified Method of Eversion Carotid Endarterectomy in Patients With Extensive Atherosclerotic Disease of Carotid Bifurcation
A prospective comparative randomized single-centre non-inferiority trial. The purpose of this study is to compares of modified method of eversion carotid endarterectomy with standard eversion carotid endarterectomy for 3,6 and 12…
- Trial name
- NCT04255316
- Testing
- Modified method of eversion carotid endarterectomy, Standard method of eversion carotid endarterectomy
- Where
- Russia
- Volunteers
- 126 people
- Sponsor
- Pirogov Russian National Research Medical University
Visceral Obesity, Atherosclerosis
Abdominal Fat and Imaging Measurements of Heart Disease
Although it is frequently mentioned in the media that overweight and obesity have reached epidemic proportions worldwide and in this country, some Canadians are perplexed and sometimes confused about the role of obesity in…
- Conditions
- Visceral Obesity, Atherosclerosis, Metabolic Syndrome
- Trial name
- NCT01447745
- Where
- Canada
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Laval University
Moyamoya Disease
Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing Surgery
Adult patients with moyamoya disease (MMD) are reported to suffer from considerable impairment of executive function/attention. Although reduced cerebrovascular reserve (CVR) in frontal areas has been detected by perfusion MRI…
- Trial name
- NRAAMUS (NCT02305407)
- Testing
- Surgical Revascularization, Conservative treatment
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Moya Moya Disease, Moyamoya Syndrome
Efficacy and Safety of Ischemic Preconditioning Therapy Versus Optimal Medical Therapy in Reducing the Recurrence of Ischemic Events in Symptomatic Moyamoya Disease
This clinical trial aims to investigate whether remote ischemic conditioning (RIC) can reduce the risk of cerebral ischemic events, delay clinical progression, and improve long-term outcomes in patients with symptomatic Moyamoya…
- Trial name
- NCT07889531
- Testing
- Standard Remote Ischemic Preconditioning
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tiantan Hospital
Atherosclerosis
Study to Determine the Effect of 14 Days Dosing With Darapladib (SB-480848) on Carotid Plague Composition in Patients With Planned Carotid Endarterectomy
The primary objective is to determine Lp-PLA2 activity in atherosclerotic carotid plaques after 14 (+/-4) days treatment with darapladib, compared to placebo.
- Trial name
- NCT01916720
- Testing
- SB-480848 40 mg, SB-480848 80 mg
- Volunteers
- 103 people
- Sponsor
- GlaxoSmithKline
Internal Carotid Artery Stenosis
MICHI™ Neuroprotection System (NPS+f) Filter Debris Analysis Study (The F-1 Study)
This study will be conducted in up to 10 hospitals in Europe, up to 75 patients will be enrolled. The purpose of the study is to evaluate any debris that may be captured in the inline filter of the MICHI(TM) Neuroprotection…
- Trial name
- NCT01877174
- Testing
- MICHI(TM) NPS+f, transcarotid stenting
- Where
- 6 sites in Belgium, Germany and 1 more
- Volunteers
- 24 people
- Sponsor
- Silk Road Medical
Carotid Artery Stenosis, Aortic Calcification
Aortic Calcification - is it a Marker for Carotid Artery Stenosis?
Atherosclerosis is the major contributor for the morbidity and mortality for the variety of cardiovascular diseases. Aortic calcification on x-ray is a marker for arterial atherosclerosis and an independent prognostic factor for…
- Trial name
- NCT01458860
- Volunteers
- 200 people
- Sponsor
- Ziv Hospital
Moyamoya Disease
Clinical Safety and Efficacy Evaluation of the Blood-cooling and Stasis-removing Formula as an Adjunct to Atorvastatin in the Treatment of Hemorrhagic Moyamoya Disease.
Moyamoya disease is a relatively rare chronic cerebrovascular disease, and its exact cause is currently unknown. This disease is characterized by the gradual narrowing or even blockage of important blood vessels in the brain (the…
- Trial name
- NCT07894640
- Testing
- Atorvastatin, Blood-cooling and Stasis-clearing Formula
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University