Clinical trials: Carotid Occlusion
Acute Coronary Syndrome, Coronary Artery Disease
Salts of Clopidogrel: Investigation to ENsure Clinical Equivalence
Clopidogrel besylate (CB) is not differentiated relative to the orignal clopidogrel hydrogen sulfate (CHS) in the pharmacokinetics and in antiplatelet potency in healthy volunteers.
- Conditions
- Acute Coronary Syndrome, Coronary Artery Disease, Ischemic Stroke, Peripheral Artery Disease
- Trial name
- SCIENCE (NCT02126982)
- Where
- Greece
- Volunteers
- 1,500 people
- Sponsor
- University of Ioannina
Carotid Artery Stenosis
Evaluation of the Ton-bridge Carotid Stent for Carotid Artery Stenosis
The purpose of this trial is to evaluate effectiveness and safety of the Ton-bridge carotid stent for the treatment of carotid artery stenosis.
- Trial name
- NCT06365697
- Testing
- Ton-bridge carotid stent, WALLSTENT carotid stent
- Where
- 7 sites in China
- Volunteers
- 188 people
- Sponsor
- Ton-Bridge Medical Tech. Co., Ltd
Atherosclerosis, Aortic Coarctation
Carotid Atherosclerosis in Patients With Aortic Coarctation
Despite aortic coarctation (CoA) repair these patients have cardiovascular complications and coronary artery disease is the most common cause of death.
- Trial name
- CoA (NCT03999073)
- Testing
- Ultrasound measurement
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Cognitive Function, Stenosis
Clinical Registration Study of Patients With Intracranial / Carotid Stenosis
Through prospective registration and follow-up, this study will collect data of patients with intracranial/carotid stenosis, including clinical information, neuropsychological scales, multimodal magnetic resonance images.
- Trial name
- NCT05322824
- Testing
- standard medical treatment, Interventional stenting
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Solid Malignancy Located in the Head and Neck, Cancer
Study of 68GaNOTA-Anti-MMR-VHH2 in Oncological Lesions, Cardiovascular Atherosclerosis, Syndrome With Abnormal Immune Activation and sarcoïdosis
Phase II study to evaluate the clinical potential of 68GaNOTA-anti-MMR-VHH2 for in vivo imaging of Macrophage Mannose Receptor (MMR)-expressing Macrophages by means of Positron Emission Tomography (PET) in patients with…
- Conditions
- Solid Malignancy Located in the Head and Neck, Cancer, Carotid Stenosis, Atherosclerosis of Artery
- Trial name
- MITRAS (NCT04758650)
- Testing
- 68GaNOTA-Anti-MMR-VHH2
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitair Ziekenhuis Brussel
Coronary Artery Disease
Fluid Responsiveness Through the Corrected Carotid Flow Time, Before and After Sternotomy
Perioperative fluid management is used to maintain the perfusion of vital organs, prevent hypovolemia, inadequate tissue perfusion, and tissue edema, and cardiovascular complications caused by the infusion of large amounts of…
- Trial name
- NCT06967142
- Testing
- Correcte Carotid flow measurement by USG Doppler
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Hypopituitarism, Pituitary Tumors
Effect of 5 Years of GH Replacement on Atherosclerosis
Adult patients with hypopituitarism under adequate conventional hormone replacement therapy have reduced life expectancy due to excess vascular events (1-4).
- Conditions
- Hypopituitarism, Pituitary Tumors, Growth Hormone Deficiency
- Trial name
- 5yrGH (NCT00462475)
- Testing
- Recombinant Growth Hormone, Genotropin (Pfizer)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Intracranial Embolism, Cerebral Thromboembolism
Effect of ARC1779 on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy
The purpose of this study is to determine, in patients undergoing carotid endarterectomy, the effect of ARC1779 Injection on the number of microembolic signals detected by transcranial Doppler immediately after surgery.
- Conditions
- Intracranial Embolism, Cerebral Thromboembolism, Carotid Stenosis
- Trial name
- NCT00742612
- Testing
- ARC1779 Injection
- Where
- 7 sites in United States, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Archemix Corp.
Carotid Stenosis, Mild Cognitive Impairment
Dental Carotid Cognitive Study
Periodontal Disease (PD) is present in 60+% of adults >65 years and is associated with tobacco smoking, diabetes, and atherosclerosis that worsen inflammation, comorbidities common in older people with mild to moderate cognitive…
- Conditions
- Carotid Stenosis, Mild Cognitive Impairment, Periodontitis
- Trial name
- NCT03755362
- Testing
- Standard Treatment, Intensive Treatment
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Maryland, Baltimore
Moyamoya Disease
Functional Magnetic Resonance-Based Observations of Brain Networks in Moyamoya Disease Patients Under Anesthesia
Moyamoya disease is characterized by progressive stenosis of the genesis of the distal internal carotid arteries bilaterally and progressive generation of compensatory pathological vascular networks at the basis cranii, and these…
- Trial name
- NCT06041659
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Tiantan Hospital
Atherosclerosis, Cardiovascular Diseases
Progression of Sub-Clinical Atherosclerosis
To determine the rate of progression of sub-clinical cardiovascular disease as measured in carotid intimal medial thickness over a period of 8 to 10 years.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Carotid Artery Diseases
- Trial name
- NCT00241787
- Volunteers
- 2,900 people
- Sponsor
- Tufts Medical Center
Atheroscleroses, Rheumatoid Arthritis (RA
Atherosclerosis in Early Rheumatoid Arthritis Patients Using Atherogenic Index of the Plasma and Carotid Intima Media Thickness
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily affecting the peripheral joints, yet its extra-articular burden particularly on the cardiovascular (CV) system has emerged as its most consequential…
- Trial name
- NCT07772466
- Volunteers
- 70 people
- Sponsor
- Assiut University
Stroke
Ultrasound Evaluation of Carotid Artery Atherosclerotic Plaques and Recanalization
The purpose of this multiple-center study are: 1) To establish the ultrasound criteria for evaluating vulnerable plaques by comparing the plaque echo characteristics before CEA (carotid artery endarterectomy) and plaque specimen…
- Trial name
- NCT03786666
- Testing
- Carotid artery recanalization CEA or carotid artery stenting
- Where
- China
- Volunteers
- 1,213 people
- Sponsor
- Xuanwu Hospital, Beijing
Atherosclerosis
Pilot Study of Ultrasonic Determined Carotid Plaque Composition
Pilot prospective two group observational study to create a model of the carotid plaque composition based on ultrasonic backscattered signals and select clinical data.
- Trial name
- UMP (NCT01879397)
- Testing
- Research Ultrasound Exam
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- D. Geoffrey Vince
Cognition Disorder, Stroke
NeuroCognition After Carotid Recanalization
Complete occlusion of the Internal carotid artery (ICA) by atherosclerotic disease (COICA) causes approximately 15%-25% of ischemic strokes in the carotid artery distribution.
- Conditions
- Cognition Disorder, Stroke, Occlusion Carotid
- Trial name
- NIA-SCORE (NCT04219774)
- Testing
- Endovascular intervention, Aspirin and Clopidogrel (maximal medical Therapy)
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Carotid Artery Stenosis
Evaluation of a Novel Technique to Diagnose Carotid Artery Stenosis
The purpose of this study is to determine the accuracy of a new non-invasive device, the Carotid Stenotic Scan (CSS), to check for stenosis of the internal carotid artery (ICA) as compared to a carotid ultrasound study.
- Trial name
- NCT03464851
- Testing
- Carotid Stenotic Scan (CSS)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The Cleveland Clinic
Moya Moya Disease
Managing Transient Neurologic Episodes in Surgery for Moyamoya Disease
The goal of this study is to study the incidence of post-operative Transient Neurologic Events (TNEs) within 30 days postoperatively, as assessed by clinical neurological scales, binned by week.
- Trial name
- MagNETs (NCT06880341)
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Stanford University
Carotid Stenosis
Cognitive Outcome After Carotid Surgery
The purpose of this study is to understand how carotid endarterectomy (CEA) or percutaneous carotid angioplasty and stenting (CAS) affect memory and thinking resulting in improving or worsening of thinking or memory.
- Trial name
- NCT02118233
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Lahey Clinic
Psoriatic Arthritis, Atherosclerosis
PsA T2T Statin Trial on Carotid and Coronary Atherosclerosis
Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with an increased risk of myocardial infarction (MI). Using coronary computer tomography angiogram (CCTA), it is found that a significantly higher prevalence…
- Trial name
- NCT04176978
- Testing
- Rosuvastatin, Treat-to-target strategy
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Coronary Arteriosclerosis
Association Between Carotid Plaque Length and Cardiovascular Events
This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No.
- Trial name
- NCT05159804
- Where
- 5 sites in China
- Volunteers
- 3,637 people
- Sponsor
- Changhai Hospital