Clinical trials: Cartilage Damage
Osteoarthritis, Knee, Chondral Defect
Evaluation of Treatment of Osteoarthritis of the Knee in the Form of Chondromalacia of the Articular Cartilage Treated in the Arthroscopic Technique With the Use of:Autogenous Transplantation of Fragmented Adipose Tissue,PRP GF,Mesenchymal Cells,Hyaluronic Acid-low Molecular Weight and Cross-linked
The main objective of the research project is to evaluate the results of the treatment of chondromalacia of the cartilage in the knee joint with the use of: autogenous transplantation of fragmented adipose tissue taken from the…
- Conditions
- Osteoarthritis, Knee, Chondral Defect, Chondromalacia, Left Knee, Chondromalacia, Right Knee
- Trial name
- NCT07110402
- Testing
- Autogenous transplant of fragmented adipose tissue taken from abdominal integuments, PRP GF (platelet-rich plasma with growth factors), Mesenchymal cells centrifuged from bone marrow cells taken from the iliac crest
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- eMKa MED Medical Center
Femoroacetabular Impingement
Hip Impingement - Understanding Cartilage Damage
Femoro-acetabular impingement (FAI) is a known cause of hip pain and possibly a major cause of adult hip osteoarthritis. The relationship between cam-type FAI deformity characteristics and joint degradation to better identify…
- Trial name
- NCT01546493
- Testing
- MRI, qCT, Motion Analysis
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Ottawa Hospital Research Institute
Articular Cartilage Defects in the Knee Joint
Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects
Multicenter, open-label, controlled, non-randomized, double arm trial with a prospective treatment arm (GelrinC). This study compares the efficacy and safety of GelrinC to a historical control arm (microfracture) in the treatment…
- Trial name
- SAGE (NCT03262909)
- Testing
- GelrinC, Microfracture historical control arm
- Where
- 13 sites in United States
- Volunteers
- 181 people
- Sponsor
- Regentis Biomaterials
Hip Osteoarthritis, Hip Impingement Syndrome
Losartan to Improve Hip Microfracture
Phase I/IIA randomized, double-blind, placebo-controlled clinical trial to assess safety and efficacy of oral losartan for improving cartilage repair following microfracture to treat focal cartilage defects during hip arthroscopy.
- Conditions
- Hip Osteoarthritis, Hip Impingement Syndrome, Cartilage Damage, Fibrosis
- Trial name
- NCT04212650
- Testing
- Losartan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Steadman Philippon Research Institute
Knee Pain Chronic, Knee Osteoarthritis
BioPoly® Partial Resurfacing Knee Implant IDE
The goal of this randomized controlled clinical trial is to demonstrate the safety and effectiveness of the BioPoly® Partial Resurfacing Knee Implant for the treatment of cartilage defects of the distal femur in adult patients…
- Conditions
- Knee Pain Chronic, Knee Osteoarthritis, Cartilage Damage, Cartilage Defects of the Knee
- Trial name
- NCT06915363
- Testing
- BioPoly, surgical standard of care (SSOC)
- Where
- 4 sites in United States
- Volunteers
- 152 people
- Sponsor
- BioPoly LLC
Cartilage Injury, Defect of Articular Cartilage
BioPoly RS Knee Registry Study for Cartilage Defect Replacement
Information will be collected on the pre-op and post-op clinical status of patients with focal cartilage defects of the femoral condyles treated with the BioPoly RS Partial Resurfacing Knee Implant, a permanent orthopaedic…
- Conditions
- Cartilage Injury, Defect of Articular Cartilage, Cartilage Damage
- Trial name
- NCT01473199
- Testing
- BioPoly RS Partial Resurfacing Knee Implant
- Where
- 5 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- BioPoly LLC
Cartilage Injury, Cartilage Damage
ProChondrix® CR Articular Cartilage Restoration Evaluation (PACE) Registry
The primary objective of this registry is to obtain long-term outcomes on ProChondrix CR in cartilage repair procedures of the knee, ankle, foot and hip.
- Trial name
- NCT04301258
- Testing
- Articular cartilage repair
- Where
- 5 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AlloSource
Articular Cartilage Disorder of Knee, Cartilage Damage
Human ECM Implanted Within Microfracture Interstices & the Cartilage Defect in the Knee to Regenerate Hyaline Cartilage
HST003 is a human extracellular matrix designed for injection into the subchondral bone following microfracture surgery by an injection into the interstices created by the surgical awl and filling the full defect to help…
- Conditions
- Articular Cartilage Disorder of Knee, Cartilage Damage, Microfractures
- Trial name
- hECM;HST003 (NCT05082831)
- Testing
- microfracture surgery + HST003
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- Histogen
Femoroacetabular Impingement, Cartilage Damage
Cartilage Repair Using a Hyaluronic Acid-Based Scaffold With Bone Marrow Aspirate Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
Femoroacetabular impingement (FAI) is a hip disorder resulting from a mismatch of the hip joint, resulting in hip pain and can potentially cause osteoarthritis.
- Trial name
- CHASE (NCT04875767)
- Testing
- HA-based scaffold with BMA (Hyalofast®; Anika Therapeutics, Bedford, MA, USA)
- Sponsor
- McMaster University
Knee Osteoarthritis
Autologous Stromal Vascular Fraction of Cells for Treatment of Knee Articular Cartilage Dystrophy
Stromal vascular fraction of cells (SVF) will be extracted from lipoaspirate by enzymatic digestion. SVF will be administered in a single dose intraarticularly 4 weeks after arthroscopic debridement.
- Trial name
- NCT02827851
- Testing
- Liposuction, SVF isolation, Intraarticular administration of autologous SVF
- Where
- 4 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Knee Injury
Study to Prevent Cartilage Damage Following Acute Knee Injury.
Individuals who have had a severe knee injury have an increased risk of developing arthritis of the knee and at a much earlier age than would otherwise be expected.
- Trial name
- NCT00332254
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Hip Arthroscopy, Articular Cartilage Defect
AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
This is a pilot multi-centre RCT of 40 patients (ages 18-55 years, inclusive) undergoing primary hip arthroscopy with a focal articular cartilage defect of the acetabulum to compare the effect of using autologous matrix-induced…
- Conditions
- Hip Arthroscopy, Articular Cartilage Defect, Microfractures
- Trial name
- REPAIR (NCT05402072)
- Testing
- Autologous matrix-induced chondrogenesis (AMIC)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Cartilage Damage, Osteochondral Lesion
Investigation of the Effectiveness of Physiotherapy and Rehabilitation After Osteochondral Allograft Transplantation Operation
The aim of our study is to add to the literature the effect of the effectiveness of the physiotherapy and rehabilitation in the clinic, which will be applied to the patients after the osteochondral allograft transplantation…
- Conditions
- Cartilage Damage, Osteochondral Lesion, Allograft, Osteoarthritis of Knee
- Trial name
- NCT06644092
- Testing
- Investigation of the Effectiveness of Physiotherapy and Rehabilitation After Osteochondral Allograft Transplantation Operation
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Yeditepe University
Osteoarthritis, Knee Pain Arthritis
Long-Term Study of CartiPRO for Knee Pain Due to Osteoarthritis or Cartilage Damage
This clinical trial aims to evaluate and compare the efficacy and safety of CartiPRO, an approved intra-articular atelocollagen injection, versus Synovian injection for the relief of knee pain in patients with knee…
- Conditions
- Osteoarthritis, Knee Pain Arthritis, Cartilage Defects of the Knee, Knee Osteoarthritis
- Trial name
- NCT07267793
- Testing
- CartiPRO, Synovian®
- Where
- 5 sites in South Korea
- Volunteers
- 194 people
- Sponsor
- DALIM TISSEN Co., Ltd.
Knee Osteoarthristis, Cartilage Damage
Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created by Two Different Systems
The investigators would like to study the differences in the quality of Platelet Rich Plasma (PRP) between two different machines in those with knee osteoarthritis.
- Conditions
- Knee Osteoarthristis, Cartilage Damage, Platelet Rich Plasma, Platelet Rich Plasma Injection
- Trial name
- PRP-PEPC (NCT07491367)
- Testing
- Platelet Rich Plasma, Emcyte PurePRP Supraphysiologic Concentrating System, APEX Biologix XCELL PRP System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Cartilage Damage, Degenerative Osteoarthritis
UCMSC Transplantation in the Treatment of Cartilage Damage
The purpose of this study is to investigate the efficacy and safety of transplantation of umbilical cord mesenchymal stem cells（UCMSCs） in patient with Knee cartilage damage.
- Trial name
- NCT02776943
- Testing
- umbilical cord mesenchymal stem cells, Hyaluronic acid
- Volunteers
- 20 people
- Sponsor
- South China Research Center for Stem Cell and Regenerative Medicine
Anterior Cruciate Ligament Rupture, Knee Instability
Single and Double Bundle ACL Reconstructions, in Term of Cartilage Damage Due to Remaining Instability After Surgery.
The prevalence of ACL (Anterior Cruciate Ligament) ruptures is relatively high, primarily due to sports and military training injuries.
- Conditions
- Anterior Cruciate Ligament Rupture, Knee Instability, Cartilage Damage
- Trial name
- ACL (NCT04626999)
- Testing
- Single Bundle ACL Reconstruction, Double Bundle ACL Reconstruction
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Indonesia
Cartilage Damage
Advanced Cartilage Treatment With Injectable-hydrogel Validation of the Effect
Multicentre, pivotal, non-randomized, prospective, open-label clinical investigation involving a new hydrogel, Hy2Care Injectable hydrogel, developed by Hy2Care B.V., Enschede, The Netherlands (hereafter referred to as "Hy2Care")…
- Trial name
- ACTIVE (NCT05186935)
- Testing
- Injectable Hydrogel treatment
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Hy2Care BV
Knee Joint Osteoarthritis
Effectiveness and Safety of Autologous ADRC for Treatment of Degenerative Damage of Knee Articular Cartilage
Autologous adipose-derived regenerative cells (ADRC) extracted using Celution 800/CRS System (Cytori Therapeutics Inc) from a portion of the fat harvested from the patient's front abdominal wall.
- Trial name
- NCT02219113
- Testing
- Arthroscopic surgery, Liposuction, ADRC isolation
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Cartilage Damage, Osteoarthritis, Hip
Histological Validation of dGEMRIC Indices as a Quantitative Biomarker for Cartilage Damage in the Hip Joint
In this study, the investigators seek to validate 3D model-based dGEMRIC (delayed gadolinium enhanced MRI of cartilage) values against histologic grading of cartilage quality, using osteochondral samples of the femoral head…
- Trial name
- NCT06185036
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern