Clinical trials: Cartilage Disease
Knee Osteoarthritis
Knee Osteoarthritis: Platelet Rich Plasma or Hyaluronic Acid
PURPOSE: To compare the effect of hyaluronic acid (HA) or platelet-rich plasma (PRP) on pain, physical function, quality of life and knee joint morphology in patients with knee osteoarthritis severity II-III.
- Trial name
- OA (NCT03801564)
- Testing
- Platelet Rich Plasma Treatment Group (PRP), Hyaluronic Acid Treatment Group (HA)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Antalya Training and Research Hospital
Knee Osteoarthritis, Cartilage Degeneration
Platelet Rich Plasma Injection for Knee Osteoarthritis
The research questions of this study are; 1. Is platelet rich plasma (PRP) treatment effective in knee osteoarthritis (OA)? 2. What are the indications for PRP treatment? 3.
- Trial name
- NCT04454164
- Testing
- PRP, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 324 people
- Sponsor
- Ferhat Say
Hip Dysplasia
Periacetabular Osteotomy With Versus Without Adjunctive Hip Arthroscopy
Although evidence is amassing regarding the role of intra-articular pathology in the surgical management of adolescents and adults with hip dysplasia, the optimal method of detection and especially management of this pathology…
- Trial name
- PRSPAO (NCT02790749)
- Testing
- Adjunctive hip arthroscopy to accompany PAO, PAO without adjunctive hip arthroscopy
- Volunteers
- 44 people
- Sponsor
- Sharp HealthCare
Knee Chondropathy, Osteoarthritis, Knee
Platelet-rich Plasma vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology
The investigators hypothesized that intra-articular injections of Platelet-rich Plasma (PRP) to treat knee degenerative articular cartilage pathology could determine pain relief and recovery of knee function with overall clinical…
- Trial name
- PRP2009 (NCT01670578)
- Testing
- PRP, Hyaluronic acid
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- Istituto Ortopedico Rizzoli
Cleft Lip, Unilateral
Correction of the Unilateral Cleft Lip Nasal Deformity With Sliding Chondrocutaneous Flap and Autologous Cartilage Graft
Cleft lip and cleft palate are the most common birth defects of craniofacial development. The surgical repair of this deformity requires comprehensive management plans and well cooperating interdisciplinary cleft teams.
- Trial name
- NCT03891719
- Testing
- Unilateral cleft lip rhinoplasty
- Where
- Vietnam
- Volunteers
- 35 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Degenerative Arthritis, Knee Arthritis
Follow-up Study for Participants of Jointstem Investigator Initiated Trial by Arthroscopy
This clinical trial is conducted to assess the long-term safety of "jointstem" in patients with degenerative knee arthritis who participated in the previous BS-JS-IIT1 investigator initiated trial.
- Trial name
- NCT04825730
- Testing
- JOINTSTEM
- Volunteers
- 14 people
- Sponsor
- R-Bio
Chondromalacia
Additional Effects of Kinesio Taping on Knee Joint Proprioception and Spatiotemporal Gait Parameters in Patient With Chrondromalacia Patellae
Chondromalacia patellae (CMP), also known as runner's knee, is characterized by anterior knee pain (AKP) and typically occurs in youngsters.
- Trial name
- NCT06561568
- Testing
- Conventional physical therapy, Kinesiotaping
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Foundation University Islamabad
Musculoskeletal Pain, Knee Osteoarthritis
Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
Many patients with osteoarthritis of the knee fail non-operative measures and elect to have knee arthroplasty to improve their quality of life.
- Conditions
- Musculoskeletal Pain, Knee Osteoarthritis, Cartilage Injury, Cartilage Degeneration
- Trial name
- NCT03477942
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Osteochondritis Dissecans, Osteoarthritis
ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee
ACI-C versus AMIC: A controlled randomized trial comparing Autologous Chondrocyte Implantation ( ACI) and Autologous Matrix Induced Chondrogenesis (AMIC) for repair of cartilage defects in the knee.
- Conditions
- Osteochondritis Dissecans, Osteoarthritis, Cartilage Injury, Osteonecrosis
- Trial name
- NCT01458782
- Testing
- Treatment of cartilage defects in the knee
- Where
- Norway
- Volunteers
- 41 people
- Sponsor
- University Hospital of North Norway
Osteoarthritis, Knee
Study of Safety, Tolerability and Pharmacokinetics of LNA043 in Japanese Osteoarthritis Participants
The objective of this study was to determine the safety, tolerability and pharmacokinetics after single ascending dose of LNA043 in Japanese participants with osteoarthritis of the knee.
- Trial name
- NCT04564053
- Testing
- LNA043
- Where
- 2 sites in Japan
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Knee Osteoarthritis
Effect of Knee Bracing on Improving Pain & Disability
The overall purpose of the proposed pilot study is to establish the feasibility of conducting a clinical trial by evaluating the preliminary effects of 8 weeks of knee bracing on physiological measures of self-reported pain and…
- Trial name
- NCT04044612
- Testing
- Medial Unloader Brace
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of North Carolina, Chapel Hill
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Chondromalacia Patellae
Effect of Core Stability Exercise on Isolated Patellofemoral Osteoarthritis.
Purpose: to investigate the effect of core stability on PF OA. Methods: Thirty-one females with PF OA will be recruited. Patients will be randomly assigned into two groups, group A and group B .
- Trial name
- NCT04669834
- Testing
- a traditional therapeutic knee rehabilitation program, core stability exercise
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Cairo University
Cartilage Damage, Degenerative Osteoarthritis
UCMSC Transplantation in the Treatment of Cartilage Damage
The purpose of this study is to investigate the efficacy and safety of transplantation of umbilical cord mesenchymal stem cells（UCMSCs） in patient with Knee cartilage damage.
- Trial name
- NCT02776943
- Testing
- umbilical cord mesenchymal stem cells, Hyaluronic acid
- Volunteers
- 20 people
- Sponsor
- South China Research Center for Stem Cell and Regenerative Medicine
Slipping Rib Syndrome
Slipping Rib Syndrome: A Clinical Entity to Consider in Chest Pain
Slipping rib syndrome consists on false or floating ribs hypermobility, whose can force the ribs to come in contact with each other. The authors reported a fourteen case series presenting a slipping rib syndrome.
- Trial name
- NCT04226638
- Testing
- Dynamic ultrasound
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- AMS Centro Medico del Ejercicio
Knee Osteoarthritis
Magnetic Resonance Imaging Diffusion Tensor Tractography for Early Osteoarthritis Assessment
The aim of this study is the evaluation of new MRI tractography maps for early knee osteoarthritis assessment.
- Trial name
- TRACTILAGE (NCT03181425)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
Osteoarthritis, Knee
Vitamin D to Slow Progression of Knee Osteoarthritis
Knee osteoarthritis (OA) is a common and disabling health problem in older adults and for which there is no cure. The purpose of this study is to determine the effects of vitamin D on knee OA symptoms and physical function in…
- Trial name
- NCT00306774
- Testing
- Vitamin D (cholecalciferol)
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Tufts Medical Center
Lipedema, Knee Osteoarthritis
The Effect of Lipedema on Knee Osteoarthritis
This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context.
- Conditions
- Lipedema, Knee Osteoarthritis, Knee Acute and Chronic Pain, Knee
- Trial name
- NCT07575555
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Izmir Democracy University
Exercise-induced Joint Pain, Exercise-induced Joint Stiffness
NEM® + KD PUR® Fish Oil Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women
This study is intended to evaluate the effect of the dietary supplement combination of NEM® brand eggshell membrane + KD PUR® brand fish oil versus placebo in reducing exercise-induced joint pain, stiffness \& cartilage turnover…
- Conditions
- Exercise-induced Joint Pain, Exercise-induced Joint Stiffness, Exercise-induced Joint Cartilage Turnover
- Trial name
- Move3 (NCT04215198)
- Testing
- Move3™ (NEM® brand eggshell membrane + KD PUR® brand fish oil)
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- ESM Technologies, LLC
Tracheomalacia, Tracheobronchomalacia
Tracheobronchomalacia: Treatment Outcomes
The purpose of this study is to evaluate respiratory symptoms and their impact in the quality of life and after treatment of the respiratory condition (tracheobronchomalacia - TBM).
- Trial name
- NCT00550602
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Beth Israel Deaconess Medical Center