Clinical trials: Cartilage Disease
Degenerative Osteoarthritis, Defect of Articular Cartilage
Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect
This is a long term follow-up study to investigate the safety and efficacy of CARTISTEM®, human umbilical cord blood-derived mesenchymal stem cells, in repair of cartilage injury or defects, compared with microfracture.
- Trial name
- NCT01626677
- Testing
- CARTISTEM, Microfracture
- Where
- 10 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Medipost Co Ltd.
Degenerative Joint Disease of the Hip
A Prospective, Multicenter, Single Arm Feasibility Study of the Safety and Performance of GRADION™ Hip Total Cartilage Replacement (TCR)™ in the Treatment of Degenerative Joint Disease of the Hip
This is a prospective, multicenter, single arm feasibility study of the safety and performance of the GRADION™ Hip Total Cartilage Replacement (TCR)™ in patients who require cartilage replacement.
- Trial name
- NCT01982266
- Testing
- GRADION™ Hip Total Cartilage Replacement (TCR)™
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Biomimedica, Inc
Articular Cartilage Disorder of Knee
The Clinical Outcome of BiCRI in the Treatment of Chondral and Osteochondral Lesions
Based on the previous successful experiences, the investigators like to extend our patient population. In this study, the investigators aim to determine the safety and effectiveness of the Biphasic Cartilage Repair Implant…
- Trial name
- NCT05924763
- Testing
- Biphasic Cartilage Repair Implant (BiCRI)
- Where
- 2 sites in Taiwan
- Volunteers
- 11 people
- Sponsor
- BioGend Therapeutics Co.Ltd
Sprain, Strain
Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain
The purpose of this study is to evaluate the effect of a ketoprofen topical patch on the pain associated with ankle sprain or strain.
- Trial name
- NCT00351104
- Testing
- Ketoprofen Topical Patch 20%
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Alkemira SA
Osteoarthritis, Traumatic Arthritis
The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte)
A clinical trial to evaluate the long-term efficacy and safety of a CHONDRON (Autologous cultured Chondrocyte) for 48weeks, and additional 96weeks in patients with cartilage defects in their knees.
- Trial name
- NCT02539056
- Testing
- Chondron Implantation
- Where
- 2 sites in South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Rheumatoid Arthritis
The SPECTRA Study
The purpose of this study is to compare IL-1ra and the combination of IL-1ra and PEGsTNF-RI with respect to their ability to reduce inflammation and bone and cartilage destruction in the synovium of subjects with rheumatoid…
- Trial name
- NCT00537667
- Testing
- anakinra, anakinra and PEG sTNF-R1
- Volunteers
- 22 people
- Sponsor
- Amgen
Osteoarthritis, Knee
Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects
The MegaCarti® is the decellularized allogeneic cartilage and acts as a cover after bone marrow stimulation to prevent the loss of blood clots and induces cartilage regeneration by assisting in the location of stem cells derived…
- Trial name
- NCT05440370
- Testing
- MegaCarti®, Microfracture
- Where
- 4 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- L&C Bio
Meniscus Tears, Loose Bodies
Clinical Efficacy Study Comparing VisionScope Imaging (VSI) to Magnetic Resonance Imaging (MRI) in Injuries of the Knee
The purpose of the study is to accumulate efficacy data on VisionScope Imaging (VSI) for pre-operative diagnosis of certain knee injuries (meniscal and articular cartilage injuries).
- Conditions
- Meniscus Tears, Loose Bodies, Articular Osteoarthritis, Articular or Capsular Trauma
- Trial name
- VSI-001 (NCT01695720)
- Testing
- VisionScope Imaging (VSI) Exam
- Where
- 7 sites in United States
- Volunteers
- 105 people
- Sponsor
- VisionScope Technologies
Osteoarthritis of First Metatarsalphalangeal Joint
A Study to Evaluate the Effectiveness and Safety of an Implant in the Treatment of Osteoarthritis of the Great Toe
This study will evaluate whether Cartiva is an effective treatment for individuals with osteoarthritis of the great toe.
- Trial name
- NCT00969969
- Testing
- Arthrodesis, Cartiva
- Where
- 12 sites in Canada, United Kingdom
- Volunteers
- 236 people
- Sponsor
- Cartiva, Inc.
Nasal Septal Deviation, Nasal Airway Obstruction
Open-Label Study to Evaluate the Safety and Effectiveness of the Spirair Implant
Pilot study of bioabsorbable implant and delivery device for correction of septal deviation.
- Trial name
- NCT06163404
- Testing
- Implantation of Spirair Nasal Device using the Spirair delivery system.
- Where
- 8 sites in United States
- Volunteers
- 102 people
- Sponsor
- Spirair, Inc
Knee Injuries, Cartilage Injury
Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee
Multi-center, prospective, concurrently controlled, non-randomized, double-blind (patient and assessor). Treatment of large chondral lesions in the knee with microfracture plus the Chondro-Gide® ACC is non-inferior to treatment…
- Conditions
- Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
- Trial name
- SECURE (NCT04537013)
- Testing
- Microfracture, Microfracture plus placement of Chondro-Gide® ACC
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 82 people
- Sponsor
- Geistlich Pharma AG
Articular Cartilage Disorder of Knee, Cartilage Damage
Human ECM Implanted Within Microfracture Interstices & the Cartilage Defect in the Knee to Regenerate Hyaline Cartilage
HST003 is a human extracellular matrix designed for injection into the subchondral bone following microfracture surgery by an injection into the interstices created by the surgical awl and filling the full defect to help…
- Conditions
- Articular Cartilage Disorder of Knee, Cartilage Damage, Microfractures
- Trial name
- hECM;HST003 (NCT05082831)
- Testing
- microfracture surgery + HST003
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- Histogen
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Neocartilage Implant to Treat Cartilage Lesions of the Knee
ISTO Technologies, Inc. is proposing a clinical study with 225 subjects, to establish the safety and efficacy of the Neocartilage Implant for the treatment of ICRS Grade 3 and 4 articular cartilage lesions of the knee compared to…
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01400607
- Testing
- Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
- Where
- 9 sites in United States
- Volunteers
- 14 people
- Sponsor
- ISTO Technologies, Inc.
Osteoarthritis, Knee
Efficacy of Allogeneic UCMSCs for Treating Large Defects Knee Injury
In terms of the surgical treatment of the cartilage injury, various techniques and ways are created to repair or regenerate articular surface of synovial joint following traumatic damage or degeneration of the cartilage.
- Trial name
- NCT05016011
- Testing
- Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), Marrow cellution
- Where
- Malaysia
- Volunteers
- 28 people
- Sponsor
- Cytopeutics Sdn. Bhd.
Knee Cartilage Defects
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
This study will test whether CARTISTEM is safe and works better than debridement (a surgery that cleans out damaged tissue) for people with knee cartilage damage and osteoarthritis.
- Trial name
- CARTISTEM23-01 (NCT07339111)
- Testing
- CARTISTEM® + Debridement, Debridement
- Where
- 35 sites in United States
- Volunteers
- 300 people
- Sponsor
- Medipost, Inc.
Degenerative Disc Disease
A Study Comparing the Safety and Effectiveness of Cartilage Cell Injected Into the Lumbar Disc as Compared to a Placebo
This is a clinical study to collect safety and preliminary efficiency information on the use of NuQu chondrocytes (cartilage cells) delivered to the center of a lumbar spinal disc to treat low back pain.
- Trial name
- NCT01771471
- Testing
- NuQu
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- ISTO Technologies, Inc.
Chondral Defect, Osteochondritis Dissecans (OCD)
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of participants aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the…
- Conditions
- Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
- Trial name
- PEAK (NCT03588975)
- Testing
- MACI, microfracture
- Where
- 14 sites in United States
- Volunteers
- 45 people
- Sponsor
- Vericel Corporation
Articular Cartilage, Cartilage Diseases
The Objectives of the Cartilage Repair Registry is to Report Long Term Efficacy and Safety of Cartilage Repair Procedures in Registry Patients
The objectives of the Cartilage Repair Registry is to report the long term efficacy and safety of cartilage repair procedures in Registry patients.
- Trial name
- NCT00140634
- Testing
- Carticel (autologous cultured chondrocyte) implantation
- Where
- United States
- Volunteers
- 2,233 people
- Sponsor
- Vericel Corporation
Knee Osteoarthritis
Assessment of Protective Effect of JOINS on Cartilage in Knee Osteoarthritis
A Pilot study Randomized and Double-blinded Placebo controlled In 2 parallel group (JOINS 200mg:Placebo = 1:1) Overall 24 months treatment (JOINS:Placebo comparison up to 12 months, Additional follow-up assessment up to 24…
- Trial name
- Joins_Carp_Ⅳ (NCT01293955)
- Testing
- JOINS 200mg
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- SK Chemicals Co., Ltd.