Clinical trials: Cartilage Diseases
Osteoarthritis, Knee
Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN
A previous multicenter trial led by Bioiberica S.A. has confirmed the efficacy and safety of DROGLICAN for the treatment of osteoarthritis (OA) in patients with severe pain.
- Trial name
- DRIP (NCT02821468)
- Testing
- Droglican, Paracetamol or oral NSAIDs excluding COX2 inhibitors
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Bioiberica
Sleep Apnea, Obstructive, Respiration Disorders
Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty
This is a research study of the effect of treating laryngomalacia (floppiness of tissue on top of the voice box that can possibly block breathing) found in association with obstructive sleep apnea (blockage of breathing while…
- Trial name
- NCT00394550
- Testing
- supraglottoplasty with laser
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Tracheomalacia, Tracheobronchomalacia
Tracheal Mechanics During Bronchoscopy
The main purpose of this study is use a new type of measurement to help decide what kind of therapy would help people with a collapsing windpipe or tracheomalacia.
- Trial name
- NCT00536315
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Knee Osteoarthritis
A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)
The study was established to show safety and efficacy of canakinumab and LNA043 in patients with knee osteoarthritis (OA).
- Trial name
- NCT04814368
- Testing
- canakinumab, LNA043
- Where
- 11 sites in United States, Czechia and 4 more
- Volunteers
- 23 people
- Sponsor
- Novartis Pharmaceuticals
Knee Osteoarthritis
Safety and Efficacy of AMT-RegeneraActiva in the Management of Knee Osteoarthritis (OA)
The goal of this clinical trial is to compare in 60 patients suffering for Knee OA to demonstrate that AMT-RegeneraActiva is able to speed up the improvement process of knee osteoarthritis (OA) compared to Sodium Hyaluronate…
- Trial name
- NCT06123689
- Testing
- AMT-Regenera activa, Hyalubrix
- Sponsor
- Human Brain Wave S.r.l.
Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis
Gait Rehabilitation to Treat FastOA
The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament…
- Conditions
- Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Osteo Arthritis Knee
- Trial name
- NCT05848622
- Testing
- Real-time gait biofeedback
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of North Carolina, Chapel Hill
Tympanic Membrane Perforation, Conductive Hearing Loss
Outcomes of Cartilage Tympanoplasty in Children
This study evaluates the anatomical and hearing outcomes of cartilage tympanoplasty in pediatric patients with chronic tympanic membrane perforations.
- Conditions
- Tympanic Membrane Perforation, Conductive Hearing Loss, Chronic Otitis Media
- Trial name
- NCT07866222
- Testing
- Cartilage Tympanoplasty
- Volunteers
- 35 people
- Sponsor
- Assiut University
Degenerative Osteoarthritis, Defect of Articular Cartilage
Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect
This is a long term follow-up study to investigate the safety and efficacy of CARTISTEM®, human umbilical cord blood-derived mesenchymal stem cells, in repair of cartilage injury or defects, compared with microfracture.
- Trial name
- NCT01626677
- Testing
- CARTISTEM, Microfracture
- Where
- 10 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Medipost Co Ltd.
Feeding Disorders, Swallowing Disorder
Feeding and Swallowing Problems in Infants With Laryngomalacia
Observational cross-sectional study Infants with laryngomalacia Feeding and swallowing assessment
- Conditions
- Feeding Disorders, Swallowing Disorder, Laryngomalacia
- Trial name
- NCT05337475
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Osteoarthritis, Exercise
Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading
In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise.
- Trial name
- NCT01090375
- Testing
- Exercise, Non Exercise
- Sponsor
- Bispebjerg Hospital
Osteoarthritis, Knee
Effects of Intra-articular Stromal Vascular Fraction Injection on Clinical Symptoms and Cartilage Health in Osteoarthritic Knees
Background: Osteoarthritis (OA) is a prevalent form of arthritis worldwide. Intra-articular stromal vascular fraction (SVF) injections are a potential therapeutic option for patients with OA.
- Trial name
- NCT06562101
- Testing
- Intra-articular Stromal Vascular Fraction Injection
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Shu-Hao Chang, MD
Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradiation (TBI) in those diagnosed with Common Variable Immunodeficiency…
- Conditions
- Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder, Immune Dysregulation, DiGeorge Syndrome
- Trial name
- CVID/PIRD (NCT07284641)
- Testing
- Hematopoietic stem cell transplant (HSCT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Paul Szabolcs
Airway Disease
Airway Pressure and Lumen Changes During NIV With Flexible Bronchoscopy
Introduction: The non-invasive ventilation (NIV) of continuous nasopharyngeal O2 with intermittent close/open nose and abdomen compression (PO2-NC-AC) can provide effective oxygenation, ventilation and circulation.
- Trial name
- NCT03666403
- Testing
- NIV rate: 0/min, NIV rate: 10-20/min, NIV rate: 5-10/min
- Where
- 2 sites in Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Defect of Articular Cartilage, Knee Osteoarthritis
Clinical Trial to Compare ReJoinTM to Sodium Hyaluronate Injection for Knee Osteoarthritis Cartilage Defects
The purpose of this study is to evaluate the effectiveness of ReJoinTM for the Knee Osteoarthritis patients with Cartilage Defects comparing to Sodium Hyaluronate Injection.
- Trial name
- NCT02855073
- Testing
- ReJoinTM, Sodium Hyaluronate
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai AbelZeta Ltd.
Hallux Valgus, Cartilage Damage
Prospective Study: The Effect on Clinical Outcome After Treatment of MTP Cartilage Lesions in Hallux Valgus Surgery
The aim of this study is to investigate the point or nonsense of treating cartilage lesions at the level of the first metatarsophalane joint.
- Trial name
- NCT04716140
- Testing
- Debridement of the MTP1 cartillage lesion and microfracture
- Where
- Belgium
- Volunteers
- 99 people
- Sponsor
- Tom Lootens
Tracheobronchomalacia, Excessive Dynamic Airway Collapse
Airway Stents for Excessive Dynamic Airway Collapse
Airway stents are used as standard of care to identify which patients with excessive dynamic airway collapse will benefit from a definitive surgical treatment.
- Trial name
- NCT02982876
- Testing
- Dynamic Flexible Bronchoscopy, Rigid Bronchoscopy, Stent placement
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Knee Osteoarthritis, Cartilage Damage
Clinical Study of Pain Reduction by Peri-arthroscopic PRP Application in Knee Degeneration
The purpose of this study is to investigate reduction of pain, gain of function and improvement of life quality by intraoperative applied platelet- rich- plasma ( PRP ) during knee arthroscopy for degeneration and osteoarthritis…
- Conditions
- Knee Osteoarthritis, Cartilage Damage, Meniscal Tear
- Trial name
- PRP-Bochum (NCT02189408)
- Testing
- Platelet rich plasma
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Ruhr University of Bochum
Tendonitis, Bursitis
Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis
The purpose of this study is to evaluate the effect of a ketoprofen topical patch on the pain associated with tendonitis or bursitis of the shoulder, elbow or knee
- Trial name
- NCT00426985
- Testing
- Ketoprofen Topical Patch 20%
- Where
- United States
- Volunteers
- 381 people
- Sponsor
- Alkemira SA
Multiple System Atrophy, Parkinson Disease
Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases
This is a non-interventional observational study designed to systematically record the results of routine laryngeal examinations and specific characteristics of dysphagia in patients with neurodegenerative disorders.
- Conditions
- Multiple System Atrophy, Parkinson Disease, Progressive Supranuclear Palsy, Motor Neuron Disease
- Trial name
- FEEMSA (NCT04706234)
- Where
- 16 sites in Austria, Germany and 6 more
- Volunteers
- 350 people
- Sponsor
- Kliniken Beelitz GmbH
Pectus Carinatum
Dynamic Compression Brace for Pectus Carinatum
Pectus carinatum (PC) is a deformity of the anterior chest wall which is a common pediatric condition, characterized by an idiopathic overgrowth of the costal cartilages resulting in protrusion of the sternum.
- Trial name
- NCT03559244
- Testing
- Dynamic compression brace, Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Marmara University