Clinical trials: Case-control Study
COPD
Chronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study
Chronic obstructive pulmonary disease (COPD) is a common inflammatory disease of the airway affecting approximately 10% of individuals aged 40 years or more with a smoking history.
- Trial name
- NCT01780298
- Where
- United Kingdom
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Breast Cancer
Metabolic Syndrome and Female Breast Cancer
The role among metabolic syndrome and breast cancer risk is not well understood and must be further explored. The objective of this study is to evaluate the association between metabolic syndrome and breast cancer in Southern…
- Trial name
- NCT02282592
- Testing
- Observation about the presence of metabolic syndrome
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Catholic University of Pelotas
Atrial Fibrillation (AF)
Understanding the Increased Risk of Atrial Fibrillation in Athletes: a Case-control Study
Exercise is beneficial to heart health, however, there appears to be a 'U' shaped relationship where too much exercise may increase the risk of an irregular heart rhythm, called atrial fibrillation.
- Trial name
- AFLETES-ECG (NCT06844656)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Puerperal Sepsis, Postpartum Hemorrhage
Assessing Childbirth-related Complications at the Community Level in Kenya
Kenya is one of the countries in sub-Saharan Africa that still experience high maternal mortality. For instance, in 2008/09 maternal mortality ratio was estimated to be 488/100,000 live births.
- Conditions
- Puerperal Sepsis, Postpartum Hemorrhage, Preeclampsia and Eclampsia, Retained Placenta, Without Hemorrhage
- Trial name
- NCT01665456
- Where
- Kenya
- Volunteers
- 585 people, healthy volunteers welcome
- Sponsor
- Wilson Liambila
Atrial Fibrillation, Endothelial Function
A Case Control Study to Investigate the Possible Association Between Atrial Fibrillation and Endothelium Dysfunction by Using Flow-Mediated Vasodilation Method
Endothelial function is closely related to the hemostasis , vascular tone, and organ perfusion in cardiovascular system, and its dysfunction would cause overactivation of the coagulative system to induce thrombus formation.
- Trial name
- NCT00173966
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Orthodontic Appliance, Debonding
Comparison of Two Orthodontic Clean-Up Protocols
Orthodontic clean-up following debonding remains a technically demanding procedure, with documented risks of enamel roughening, microdefects, discoloration, and increased plaque retention.
- Conditions
- Orthodontic Appliance, Debonding, Case-control Study
- Trial name
- NCT07304310
- Testing
- Two-step ultrasonic protocol, One-step clean-up protocol
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- IRCCS San Raffaele
Childhood Asthma With Acute Exacerbation
Antibiotic Treatment of Recurrent Episodes of Asthma in Children
Copsac has discovered that asthmatic exacerbations are as closely linked to bacterial as to viral infection. The current study will examine whether treatment of asthmatic exacerbations with macrolide antibiotics - in the abscence…
- Trial name
- AB-studie (NCT01233297)
- Testing
- Azithromycin
- Where
- 2 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Copenhagen Studies on Asthma in Childhood
Generalized Chronic Periodontitis
Activated MMP-8 as Diagnostic Test for Periodontitis
Background: Untreated periodontal disease may influence general health. However, how may a physician who is not trained in periodontal probing detect untreated periodontitis? Activated matrix metalloproteinase-8 (aMMP-8) in…
- Trial name
- MMP-8 (NCT02280122)
- Testing
- no intervention provided
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Goethe University
Abdominal Aortic Aneurysm
Acute Technical Outcomes of the Talent Abdominal Aortic Aneurysm (AAA) Stent-Graft Versus Cook Zenith Stent-Graft
The purpose of this study is to compare acute technical outcomes of the Talent AAA Stent Graft system versus Cook Zenith Endograft at two high volume institutions, Albany Medical Center and St. Peter's Hospital in Albany, NY.
- Trial name
- NCT00922454
- Testing
- Endovascular Repair of the abdominal aorta, Cook Zenith Stent-Graft, Talent Stent-Graft
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Center for Vascular Awareness, Albany, New York
MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)
Prevalence and Clinical Significance of Hematological Abnormalities in Patients With Clinically Diagnosed Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Case-Control Study
this study aims to investigate the prevalence of hematological abnormalities among patients with clinically diagnosed MASLD, evaluate their clinical correlates, and examine their association with non-invasive fibrosis scores.
- Trial name
- MASLD (NCT07872059)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cancer, Immune Checkpoint Inhibitor
Troponin to Detect Major Cardiovasculaire Advserse Events on Immune Checkpoint Inhibitors
Recent guidelines suggest the use of troponin to detect immnune related cardiovascular advserse events in patients treated by immune checkpoint inhibitors for cancer.
- Conditions
- Cancer, Immune Checkpoint Inhibitor, Cardiovascular Biomarkers
- Trial name
- TILT (NCT06007274)
- Testing
- No intervention
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Institut Mutualiste Montsouris
Pelvic Floor Disorders
Prevalence of Pelvic Floor Dysfunctions in Female Badminton Athletes and Sedentary
The objective of the study is to know the prevalence of pelvic floor dysfunctions in female badminton athletes compared to sedentary women, and the hypothesis is that the prevalence of pelvic floor dysfunctions is going to be…
- Trial name
- NCT06455150
- Testing
- Assessment of pelvic floor dysfunctions' symptoms and sings, pelvic floor muscle strength and quality of life
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Pulmonary Sarcoidosis, Chronic Beryllium Disease
Study Comparing Chronic Beryllium Disease to Pulmonary Sarcoidosis
Inhalation of beryllium can induce specific sensitization and diffuse pulmonary granulomatosis called chronic beryllium disease (CBD).
- Trial name
- BERYSARC (NCT06113991)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colo-rectal Cancer
Colorectal Analysis for Signature Cancer Assessment Using Delta-HLD
CASCADE (Colorectal Analysis for Signature Cancer Assessment Using delta-HLD Technology) is a proof-of-concept case-control study designed to evaluate the performance of delta-HLD, Epiliquid's proprietary liquid biopsy…
- Trial name
- CASCADE (NCT07148297)
- Where
- Argentina
- Volunteers
- 600 people
- Sponsor
- Epiliquid Holding, Inc
Breast Cancer
Fujifilm DBT Plus S-View Versus FFDM Alone in the Detection of Breast Cancer
The purpose of this pilot is to provide credible performance estimate information in order to conduct a subsequent pivotal reader study.
- Trial name
- NCT03491917
- Testing
- DBT plus S-View, FFDM alone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fujifilm Medical Systems USA, Inc.
Gastric Cancer, Atrophic Gastritis
AG & IM in CA Stomach Protocol
This is a multi-center prospective case control study aiming to compare different methods of risk stratification models in predicting the risk of gastric cancer development.
- Conditions
- Gastric Cancer, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT04184960
- Testing
- Gastroscopy and gastric biopsies
- Where
- 4 sites in Hong Kong, Japan and 2 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Hip Arthropathy
Gluteus Maximus Transfer Following THA Does Not Improve Abductor Strength
Gluteus maximus transfer following THA does not improve abductor strength - a case-control gait analysis study of 15 patients with gluteus medius disruption The investigators have compared 15 gluteus maximus transferred patients…
- Trial name
- NCT04798742
- Testing
- Gluteus maximus transfer
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Sjögren's Syndrome
HRR as a Novel Biomarker in Sjögren's Syndrome
Sjögren's syndrome (SS) is an autoimmune disorder characterized by chronic salivary and lacrimal gland dysfunction leading to dry mouth (xerostomia) and dry eye (xerophthalmia) sensation (1).
- Trial name
- NCT05633524
- Testing
- blood sample analysis
- Where
- China
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Asthma
Circulating Innate Lymphoid Cell Type 2 (ILC2) Levels and Asthma: a Case-control Study
The primary objective of this study is to demonstrate differences in ILC2 blood levels between asthma patients and control patients.
- Trial name
- ILC2-Asthma (NCT03128762)
- Testing
- ILC2 levels in blood
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Gastric Cancer
The Effect of Prucalopride Succinate on Gastrointestinal Motility After Laparoscopic Gastrectomy : Prospective Double Blind Case-control Study
In order to improve postoperative ileus in patients undergoing gastrointestinal surgery, digestive medications and prokinetics have been routinely used.
- Trial name
- NCT05966246
- Testing
- Arm I : Experimental (Prucalopride succinate group), Arm II : Control (Mosapride citrate group)
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Gangnam Severance Hospital
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