Clinical trials: Case-control Study
Rectal Cancer
Laparoscopic Intersphincteric Resection in Elderly Patients
The aim of the present study is to assess if it is possible to offer intersphincteric rectal resection (IRR) to selected patients older than 70 years affected by ultra-low rectal cancer.
- Trial name
- NCT04673526
- Testing
- Laparoscopic intersphincteric resection, Laparoscopic abdomino-perineal procedures
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- ASL Verbano Cusio Ossola
Postpartum Pain
Biomechanical Changes in Women With Post-partum Pelvic Girdle Pain: An Observational Case-control Study
Research suggests that changes in pelvic alignment during the perinatal period are the primary cause of pelvic girdle pain (PGP), both perinatally and postnatally.
- Trial name
- NCT04077801
- Testing
- diagnostic test, Postpartum pain, Visual analogue scale
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Alopecia Areata, TLRs
Association of TLR7 Gene rs3853839 Polymorphism With Disease Severity in Alopecia Areata: A Case-Control Study
Alopecia areata is an autoimmune, non-scarring hair loss disorder characterized by variable clinical severity. Toll-like receptor 7 (TLR7) plays a key role in innate immune activation and autoimmune responses.
- Trial name
- TLR7-AA (NCT07454876)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Benha University
Diabetes Mellitus, Biomarker
Study of Biomarkers in Diabetic Chronic Wounds
This study aims to discover, verify and evaluate the potential biomarkers with regard to the diagnosis, prognostic and/or prediction of diabetic chronic wounds.
- Conditions
- Diabetes Mellitus, Biomarker, Chronic Wound
- Trial name
- NCT05342740
- Testing
- collect whole blood, urine and stool samples
- Where
- China
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Yibing Wang
Pelvic Floor Disorders
Prevalence of Pelvic Floor Dysfunctions in Female Badminton Athletes and Sedentary
The objective of the study is to know the prevalence of pelvic floor dysfunctions in female badminton athletes compared to sedentary women, and the hypothesis is that the prevalence of pelvic floor dysfunctions is going to be…
- Trial name
- NCT06455150
- Testing
- Assessment of pelvic floor dysfunctions' symptoms and sings, pelvic floor muscle strength and quality of life
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Vitiligo, Melanoma (Skin)
Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo
This study examines melanoma and nonmelanoma skin cancer in people diagnosed with vitiligo compared to matched controls.
- Conditions
- Vitiligo, Melanoma (Skin), Nonmelanoma Skin Cancer, Squamous Cell Carcinoma
- Trial name
- NCT04969419
- Testing
- Exposure of skin cancer of interest
- Where
- United Kingdom
- Volunteers
- 75,771 people
- Sponsor
- Momentum Data
Sensitivity, Peri-implant Mucositis
Sensitivity and Specificity of Peri-Implantitis-Related Parameters
Bleeding on probing demonstrated to have high specificity with certain level of sensitivity to detect periodontal disease. Again, understanding the weak hemidesmosome attachment to the implant surface is imperative to discern on…
- Conditions
- Sensitivity, Peri-implant Mucositis, Peri-Implantational Loss, Peri-Implantitis
- Trial name
- NCT03031392
- Testing
- Sensitivity test
- Where
- Spain
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain
Kidney Failure, Chronic
Case-Control Study on Analgesics and Nephropathy (SAN)
The objective of the international, multicenter case-control study was to evaluate the association between end-stage renal disease (ESRD) and use of non-phenacetin-containing analgesics with particular emphasis on combined…
- Trial name
- NCT00302835
- Testing
- non-phenacetin containing analgesics
- Where
- Germany
- Volunteers
- 4,200 people
- Sponsor
- Center for Epidemiology and Health Research, Germany
Restless Legs Syndrome
Autonomic Function and Cardiovascular Risk in Restless Legs Syndrome
The purpose of this study is to explore whether patients with restless legs syndrome (RLS) differ from healthy subjects in daytime and night time autonomic function and cardiovascular risk markers and whether 4 week treatment…
- Trial name
- AUTOREST (NCT02025608)
- Testing
- Pramipexole
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mauro Manconi
Chronic Intestinal Pseudo-Obstruction
Pseudo-obstruction Assessment With MRI
This study will explore the potential for a standardized MRI scan after a liquid meal to be used in diagnosis of the rare but debilitating chronic intestinal pseudo-obstruction (CIPO).
- Trial name
- POM (NCT04193735)
- Testing
- MRI scans after a liquid meal
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Nottingham
Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI)
Development and Validation of a Risk Prediction Model for De Novo Stress Urinary Incontinence After Pelvic Floor Reconstruction Surgery
This observational study aims to develop a predictive model for the occurrence of new-onset stress urinary incontinence (SUI) after pelvic organ prolapse (POP) repair surgery in women.
- Trial name
- NCT07601282
- Testing
- Telephone follow-up
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Labor, Induced
Induction of Labour With a Double Balloon Catheter
The objective of this study is to provide a comprehensive analysis of various time intervals (1:1). In addition to evaluating the time interval until delivery after completion of induction, the study also aims to investigate the…
- Trial name
- NCT05874024
- Testing
- induction of labour with double balloon catheter placement for 6 hours, induction of labour with double balloon catheter placement for 12 hours
- Where
- Germany
- Volunteers
- 248 people
- Sponsor
- Jena University Hospital
REM Sleep Behavior Disorder
Familial Aggregation and Biomarkers in REM Sleep Behaviour Disorder.
In this cohort study, the investigators aim to study the familial aggregation of REM sleep behavior disorder (RBD) and compare the differences in major biomarkers of neurodegeneration, including percentage of EMG activity during…
- Trial name
- NCT03660982
- Where
- Hong Kong
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Hepatocellular Carcinoma
Laparoscope Anatomical and Aon-anatomical Hepatectomy
The purpose of this study is to compare short-term and long-term efficacy of two surgical methods by laparoscopic hepatectomy, and provide the evidence for the choice of surgical method from the pathology and cytology.
- Trial name
- NCT02009176
- Testing
- Laparoscopic Anatomical Hepatectomy, Laparoscopic Aon-anatomical Hepatectomy
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Shuguo Zheng, MD
Ovarian Neoplasms
Cancer Loyalty Card Study
Approximately 7,400 new cases of ovarian cancer are diagnosed each year in the United Kingdom (UK), and with over 4,000 women dying from the disease each year it is a particularly lethal form of cancer.
- Trial name
- CLOCS (NCT03994653)
- Testing
- Risk Factor Questionnaire, Clinical Questionnaire
- Where
- United Kingdom
- Volunteers
- 963 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Epilepsy
Risk Factors and Etiologies of Epilepsy in Urban and Rural Rwanda
Epilepsy is one of the most common chronic brain disorders. Up to 85% of persons living with epilepsy (PwE) live in the developing world. In sub-Saharan Africa (SSA), Rwanda has one of the highest prevalence rates (±5%).
- Trial name
- REpiCa (NCT05698537)
- Testing
- EEG, Neuroimaging, Blood sample
- Where
- Rwanda
- Volunteers
- 1,745 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Disorder Related to Lung Transplantation, Bronchiolitis Obliterans
Aerosol Liposomal Cyclosporine for Chronic Rejection in Lung Transplant Recipients
This is a single-center pilot study to investigate the efficacy and safety of aerosolized liposomal cyclosporine A in the treatment of chronic rejection in lung transplant recipients with bronchiolitis obliterans syndrome (BOS).
- Conditions
- Disorder Related to Lung Transplantation, Bronchiolitis Obliterans, Decreased Immunologic Activity, Chronic Rejection of Lung Transplant
- Trial name
- NCT01650545
- Testing
- Liposomal aerosol cyclosporine, standard immune suppression, oral
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Maryland, Baltimore
Severe Haemophilia A With Inhibitors
Case-control Pilot Study of the Immune Modulating Effect of FEIBA on Patients With Haemophilia A and Inhibitors
This study aims to evaluate the immunomodulatory effect of FEIBA® in patients with severe haemophilia A and inhibitors.
- Trial name
- NCT02018393
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario La Paz
Cystic Fibrosis (CF), Mucoviscidosis
Environmental Reservoirs of Non-tuberculous Mycobacteria in Cystic Fibrosis Households
This multicenter, non-interventional case-control study investigates whether household environmental reservoirs, particularly water systems, are associated with non-tuberculous mycobacterial (NTM) infections in people with cystic…
- Conditions
- Cystic Fibrosis (CF), Mucoviscidosis, Non-Tuberculous Mycobacteria, Mycobacterium Abscessus Infection
- Trial name
- NTMecoCF (NCT07369414)
- Testing
- Multi-modal NTM diagnostic including PCR, WGS, culture
- Where
- 2 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Research Center Borstel
Ulcerative Colitis
Ulcerative Colitis - Vedolizumab- With/Without Prior Exposure to Anti-TNF（Tumor Necrosis Factor）Therapy
A case-control study to evaluate the immunoinflammatory effect of prior exposure to anti-TNF therapy in patients with ulcerative colitis starting vedolizumab therapy
- Trial name
- NCT03802214
- Testing
- Vedolizumab
- Where
- 2 sites in United States, Canada
- Volunteers
- 1 people
- Sponsor
- Stanford University
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