Clinical trials: Cataract
Cataract, Age Related Macular Degeneration
Cataract and AMD in a Trial of a Multivitamin and Cocoa Extract
COSMOS-Eye is an ancillary study of the COcoa-Supplement and Multivitamins Outcomes Study (COSMOS; NCT02422745). COSMOS is a randomized clinical trial of cocoa extract supplement (containing a total of 500 mg/d flavanols…
- Trial name
- COSMOS-Eye (NCT03205202)
- Testing
- Cocoa extract, Multivitamin
- Volunteers
- 21,442 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cataract
Safety Profile Comparison of Undiluted Intracameral Moxifloxacin vs. Levofloxacin in Cataract Surgery
The goal of this randomized clinical trial study is to compare safety profile undiluted intracameral moxifloxacin vs levofloxacin during cataract surgery.
- Trial name
- NCT05741632
- Testing
- Moxifloxacin Ophthalmic Solution, Levofloxacin Ophthalmic
- Where
- Indonesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Presbyopia, Low Vision
Ocular Biomarkers for Successful Premium Trifocal Intra-ocular Lenses Implantation
The purpose of this study is to identify ocular biomarkers that can predict the success of phacoemulsification with bilateral AT LISA try 839MP (Carl Zeiss Meditec AG) implantation to achieve satisfactory post-post-operativly…
- Trial name
- NCT05863247
- Testing
- Patient Reported Outcomes / Biometric data revision
- Where
- Portugal
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Hospital dos Lusíadas
Cataract
Satisfaction With Multifocal vs Accommodating Lens Implants 2 Years After Surgery
This study will examine patient satisfaction and spectacle independence using a survey in patients who have undergone uncomplicated cataract surgery with a presbyopia-correcting lens at least 2 years prior to administration of…
- Trial name
- NCT02578524
- Testing
- Survey
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- MDbackline, LLC
Cataract
Femtosecond Laser-assisted Arcuate Incisions Versus Manual Arcuate Incisions Outcomes
This study is designed to compare the effectiveness of LenSx laser arcuate relaxing incisions vs. manual (blade) arcuate relaxing incisions in patients with low, but significant, levels of astigmatism.
- Trial name
- NCT04126174
- Testing
- femtosecond laser system arcuate corneal incision, Manual LRI
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Gainesville Eye Associates
Dry Eye Syndromes
Effect of Cequa Treatment on Accuracy of Pre-operative Biometry & Higher Order Aberrations in Dry Eye Patients Undergoing Cataract Surgery
The purpose of this study is to examine the effect of Cequa treatment on the accuracy of pre-operative biometry and on corneal higher-order aberrations (HOAs) in cataract patients who have signs of dry eye disease.
- Trial name
- NCT04342988
- Testing
- Cequa
- Where
- 3 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Research Insight LLC
Hyperalgesia
Effect of Gabapentin on Pain of the Second Cataract Surgery
Gabapentin pretreatment may reduce hyperalgesia occurring at the second surgery in serial, bilateral cataract surgery.
- Trial name
- NCT02127853
- Testing
- gabapentin
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cataract, Vitreous Hemorrhage
Study on Eye-Brain Cross-Organ Mapping and Systemic Disease Association Based on Multimodal Big Data
This project integrates multimodal eye data (CFP, OCT, OCTA) from 50,000 cases, brain MR data from 150,000 cases, and ICD diagnoses, medical orders, and test results from an eye-brain paired cohort of 8,000 cases to construct an…
- Conditions
- Cataract, Vitreous Hemorrhage, Diabetic Eye Diseases, Cerebral Small Vessel Disease
- Trial name
- NCT07541651
- Testing
- No interventions were involved in this study.
- Volunteers
- 208,000 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Cataract
Clinical Investigation of OMEGA Gemini Capsule, Model Gemini IV With an Approved Monofocal or Toric IOL
This study is a prospective, randomized, controlled, paired eye, subject-masked design.
- Trial name
- NCT04058314
- Testing
- Gemini IV, Control Eye
- Where
- Costa Rica
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Omega Ophthalmics
Ophthalmology, Lens Opacities
LensAge to Reveal Biological Age
Assessment of aging is central to health management. Compared to chronological age, biological age can better reflect the aging process and health status; however, an effective indicator of biological age in clinical practice is…
- Conditions
- Ophthalmology, Lens Opacities, Biological Age
- Trial name
- NCT05588921
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cataract
Clinical Evaluation of the One-Piece Tecnis Multifocal Intraocular Lens (IOL)
The purpose of this study is to evaluate near vision of the One-Piece Tecnis Multifocal lens (ZMB00) vs. the One-piece Tecnis monofocal lens (ZCB00)and additionally evaluate general postoperative outcomes of the One-Piece Tecnis…
- Trial name
- NCT01210807
- Testing
- One-Piece Tecnis Multifocal IOL, One-Piece Tecnis monofocal IOL, Model ZCB00
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Glaucoma, Suspect, Diabetic Retinopathy
Eye Health Intervention Study in Upper Manhattan
Individuals living in Upper Manhattan have limited access to eye care, high vision impairment rates, and poor ocular health outcomes.
- Conditions
- Glaucoma, Suspect, Diabetic Retinopathy, Cataract, Refractive Errors
- Trial name
- EYES-UM (NCT06112431)
- Testing
- Intervention, Usual Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Cataract, Signs and Symptoms
Spherical Aberration and Contrast Sensitivity in IOLs
Purpose: To determine whether implantation of an intraocular lens (IOL) with a modified anterior aspheric surface results in reduced spherical aberration and improved contrast sensitivity after cataract surgery.
- Conditions
- Cataract, Signs and Symptoms, Pseudophakia, Lens Diseases
- Trial name
- IOLs (NCT00576485)
- Testing
- Cataract surgery and intraocular lens implantation
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Cataract
The Use of an Anterior Chamber Maintainer as a Sole Fluid Source in Micro Incision Cataract Surgery as Compared to a Standard Phacoemulsification Procedure
The purpose of this study is to compare the use of an Anterior Chamber Maintainer (ACM) as the sole fluid source in phacoemulsification micro incision cataract surgery (using 1.1mm corneal incision) as opposed to conventional…
- Trial name
- NCT01553760
- Testing
- Phacoemulsification using an ACM as the sole fluid source, Conventional Phaco
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Presbyopia, Pseudophakia
Visual Outcomes After Extended Depth of Focus Intraocular Lens Implantation With and Without Digital Assistance
The primary objective of this study is to compare the postoperative visual acuity curves of patients that underwent one of the following surgical procedures: Insertion of an extended depth of focus intraocular lens with digital…
- Conditions
- Presbyopia, Pseudophakia, Cataract, Refractive Errors
- Trial name
- NCT06460389
- Testing
- Visual Acuity Assessment
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Cataract, Macular Degeneration
S0000B: Vitamin E and/or Selenium in Preventing Cataract and Age-Related Macular Degeneration in Men on SELECT SWOG-S0000
RATIONALE: Aging may affect a person's vision. Vitamin E and/or selenium may help prevent cataracts or age-related macular degeneration in men receiving these drugs as part of a clinical trial for the prevention of prostate…
- Trial name
- SEE (NCT00784225)
- Testing
- selenium, vitamin E
- Where
- United States
- Volunteers
- 13,475 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Cataract
Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts
Cataract, in which the lens of the eye is opacified, is the major cause of blindness. This study will examine protein material of the lens called crystallins to try to determine what causes nuclear cataracts, a type of cataract…
- Trial name
- NCT00001613
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Cataract, Myopia
Measurement of Antioxidant Activity on Postoperative Inflammation in Patients Undergoing Ophthalmic Surgery
This trial hypothesized that novel laser refractive surgery techniques (PRK, LASIK, SMILE) or laser-assisted cataract surgery (FLACAS) could suppress postoperative inflammation and improve recovery in patients by reducing…
- Trial name
- NCT05905237
- Testing
- Cataract surgery, Femtosecond-LASIK, SMILE
- Where
- 2 sites in Taiwan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cataract, Macular Edema
The Role of Radial Peripapillary Vessel Density in Irvine-gass Syndrome
Pseudophakic cystoid macular edema (PCME), also known as Irvine-Gass syndrome (IGS), is an accumulation of fluid in the macula that occurs after cataract surgery, with an early or late presentation (cut-off 3 months) .
- Trial name
- OCTA and PMCE (NCT06436170)
- Testing
- OCTA
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federico II University
Cataract, Presbyopia Correction
Photopic and Mesopic Multifocal IOL Performance
Modern cataract surgery has become a refractive procedure. Both, multifocal lens implantation and pseudophakic monovision with monofocal IOLs are effective means to address presbyopia correction after cataract surgery.
- Trial name
- MIOLRead (NCT06978556)
- Testing
- No intervention is subject of the study. Only standard pre- and postoperative data will be evaluated.
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IROC AG