Clinical trials: Cataracts
Fuchs Dystrophy, Cataract
The Evaluation of Balanced Salt Solution During Cataract Surgery
This study aims to identify if the use of BSS PLUS® Sterile Intraocular Irrigating Solution as an irrigation solution leads to improved corneal outcomes vs BSS® Sterile Irrigating Solution in more compromised corneas.
- Trial name
- NCT05853978
- Testing
- BSS Plus, BSS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Adam Fedyk, MD, FACS
Cataract
Evaluating Patient Satisfaction After Cataract Surgery With Multifocal Intraocular Lens
Multifocal lens allow most patients to be spectacle-free after cataract surgery. Most studies published up-to-date have focused on visual acuity, but not on patient-reported outcomes.
- Trial name
- NCT03787576
- Testing
- Cataract surgery
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Clínica Rementería
Dry Eye Disease, Cataract
Systane Hydration in Subjects Undergoing Cataract Surgery
The primary objective of this study is to demonstrate reduced corneal staining with use of Systane Hydration among subjects with dry eye disease (DED) undergoing routine cataract removal and monofocal intraocular lens (IOL)…
- Trial name
- NCT05056233
- Testing
- Systane Hydration lubricant eye drops
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Alcon Research
Cataract, Keratoconic Subjects
Visual Outcomes and Quality of Life After Vivity EDOF IOL Implantation in Early-Stage Keratoconus
The goal of this clinical trial is to learn if the Vivity Extended Depth of Focus intraocular lens works to improve vision in adults with cataracts and early-stage keratoconus.
- Trial name
- VIVITY-KCONUS (NCT07338708)
- Testing
- Extended Depth of Focus Intraocular Lens Implantation
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Ocular Inflammation
Comparison Study of ISV-303 to Durasite Vehicle in Cataract Surgery Subjects
The purpose of this study is to evaluate the ocular safety, tolerability and efficacy of topical administration of ISV-303 compared with Durasite Vehicle.
- Trial name
- NCT01808547
- Testing
- ISV-303, DuraSite Vehicle
- Volunteers
- 268 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Surgical Education
Global Learning: an Orbis Virtual-platform Evaluation Study
Currently, surgical training is often conducted using the traditional "apprentice model", where a trainee observes a qualified surgeon and learns from him/her, and then the surgeon supervises the trainee performing surgery on a…
- Trial name
- GLOVES (NCT04908072)
- Testing
- Orbis-FundamentalVR MSICS Simulator
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Orbis
Cataract, Glaucoma
IOP Changes Associated With SICS and Phako
Prospective randomized trial in patients requiring cataract surgery in which IOP, angle anatomy and other demographic and clinical data are compared. Subjects randomized to both MSICS and phakoemulsification
- Trial name
- NCT02642211
- Testing
- cataract surgery
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Robin, Alan L., M.D.
Dry Eye Disease, Cataract Surgery
Pre-Surgical Ocular Surface Treatment With Intracanalicular Dexamethasone Insert And Effect On Intraocular Lens Measurement Accuracy
This prospective study will use a self controlled design for 35 eyes. Patients scheduled to undergo routine cataract surgery in at least one of their eyes will have their pre-surgical measurements performed, IOL calculated and…
- Conditions
- Dry Eye Disease, Cataract Surgery, Ocular Surface Disease
- Trial name
- NCT04530864
- Testing
- Dextenza 0.4Mg Ophthalmic Insert
- Volunteers
- 35 people
- Sponsor
- Prism Vision Group
Sedation
Patient-controlled Sedation With Propofol During Cataract Surgery Under Topical Anesthesia
Controversies exist about the use of propofol in sedation of patients for cataract surgery. This prospective randomised double-blind study evaluates the efficacy of patient-controlled sedation compared with placebo using the same…
- Trial name
- CATARSIS (NCT02771912)
- Testing
- Propofol
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cataract, Ocular Inflammation
Safety and Effectiveness of Drop-free Small Incision Cataract Surgery
This is a randomized control trial comparing the effects of subconjunctival triamcinolone administration during surgery to topical prednisolone drops on the development of post-operative inflammation and macular edema in manual…
- Conditions
- Cataract, Ocular Inflammation, Ocular Hypertension, Post-Op Complication
- Trial name
- NCT05248139
- Testing
- Intraoperative delivery of medication, Kenalog (Triamcinolone), Topical post-operative eyedrops, Prednisolone acetate
- Volunteers
- 100 people
- Sponsor
- Visualiza
Cataracts
AcrySof® IQ ReSTOR® +2.5 D Multifocal Intraocular Lens (IOL) Model SN6AD2 [SV25T0] in Japan
The purpose of this study is to evaluate safety and effectiveness of AcrySof® IQ ReSTOR® +2.5 D Multifocal IOL Model SN6AD2 [SV25T0] in Japanese cataract patients.
- Trial name
- NCT01605877
- Testing
- AcrySof® IQ ReSTOR® +2.5 D Multifocal IOL Model SN6AD2 [SV25T0]
- Where
- 2 sites in Japan
- Volunteers
- 70 people
- Sponsor
- Alcon Research
Cataract Senile, Endophthalmitis
Postoperative Safety Outcomes of Intraoperative Intracameral Preservative-Free Moxifloxacin Versus Levofloxacin
Comparative safety study of intracameral levofloxacin versus moxifloxacin for postoperative infection prophylaxis
- Conditions
- Cataract Senile, Endophthalmitis, Antibiotic Side Effect, Safety Issues
- Trial name
- NCT04403334
- Testing
- Levofloxacin Ophthalmic, Moxifloxacin Ophthalmic
- Where
- Philippines
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Peregrine Eye and Laser Institute
Cataract
Assessment of Low Energy Lens Fragmentation Cataract Extraction in Patients Undergoing Cataract Surgery
The purpose of this research study is to evaluate the clinical outcomes of the use of low-energy segment removal with a micro-interventional irrigation/aspiration port (MICOR-304) to evacuate the lens prior to intraocular lens…
- Trial name
- NCT04747834
- Testing
- MICOR-304
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
GLAUCOMA 1, OPEN ANGLE, D (Disorder), Cataract
Comparison of Visual Outcomes and Patient Satisfaction in Mild to Moderate Glaucoma Patients Undergoing Cataract Surgery With EDOF Versus Monofocal IOLs
Cataract is the leading cause of reversible vision loss, while glaucoma remains the primary cause of irreversible blindness, often impairing contrast sensitivity (CS), glare tolerance, and dark adaptation.
- Trial name
- NCT07436871
- Testing
- Cataract surgery (Monofocal intraocular lens implantation), cataract surgery (Extended depht of focus intraocular lens implantation)
- Volunteers
- 74 people
- Sponsor
- OMIQ Research
Cataracts, Cataract Surgery
Endothelial Cell Loss and Induced Astigmatism After Wound-directed and Wound-assisted IOL Injection
The purpose of this study is to determine if there is any difference in astigmatism (eye surface curvature) or corneal endothelial cell density (the inner cell lining of the eye surface) after two different methods for inserting…
- Trial name
- NCT01250964
- Testing
- Lens insertion during cataract surgery
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of North Carolina, Chapel Hill
Senile Cataract
Clinical Study on Second-eye Pain in Cataract Surgery
The degree of perceived pain in the second-eye surgery of cataract patients is significantly higher than that in the first-eye surgery, which can lead to nervous tension during surgery and affect the surgical outcome and…
- Trial name
- NCT03766230
- Volunteers
- 600 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Cataract
Clinical Evaluation of a New Aspheric Intraocular Lens.
This study evaluates the visual performance and occurrence of posterior capsular opacification after implantation of a new aspherical intraocular lens compared with a control spherical lens of otherwise identical design.
- Trial name
- NCT00786565
- Testing
- Advanced Akreos Adapt in one operated eye., Akreos Adapt in fellow operated eye.
- Volunteers
- 75 people
- Sponsor
- Bausch & Lomb Incorporated
Cataracts, Meibomian Gland Dysfunction (MGD)
A Post-Market Evaluation of LipiFlow Treatment in Cataract Surgery Practice
This is a post-market, prospective, randomized, multi-center, bilateral, open-label, cross-over, comparative clinical study. Study group will undergo preoperative LipiFlow treatment and Control group will not receive preoperative…
- Trial name
- NCT03708367
- Testing
- LipiFlow Thermal Pulsation System
- Where
- 5 sites in United States
- Volunteers
- 117 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Epiretinal Membrane, Cataract Senile
Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery
This study evaluates the safety and efficacy simultaneous, trans-conjunctival, 25-Gauge vitrectomy and phacoemulsification with intraocular lens implant in patients with metamorphopsia and visual impairment due to idiopathic…
- Trial name
- NCT03045367
- Testing
- Phacoemulsification, intraocular lens implant, vitrectomy.
- Volunteers
- 30 people
- Sponsor
- Clinica Oculistica dell'Università di Torino
Macular Disease, Rhegmatogenous Retinal Detachment
Combined Vitrectomy and Femtosecond Laser-assisted Cataract Surgery
Based on the progress of cataract surgery, intraocular lens development, vitreoretinal surgery and anesthesia technology in recent years, the purpose of this study is to develop a new type of more accurate and minimally invasive…
- Conditions
- Macular Disease, Rhegmatogenous Retinal Detachment, Epiretinal Membrane, Cataract
- Trial name
- NCT05588037
- Testing
- FLACS +PPV+IOL + air, FLACS +PPV+IOL + epiretinal membrane peeling + Ozurdex, FLACS + PPV+IOL + internal limiting membrane peeling + air
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Aier School of Ophthalmology, Central South University