Clinical trials: Cavities
Oral Cavity Disease
Pain and Safety of Microneedles in Oral Cavity
A randomized, crossover, double-blind, placebo-controlled, one-session clinical trial with 30 male volunteers was performed to access pain and safety of microneedle topical application in different regions of the oral cavity.
- Trial name
- NCT03855397
- Testing
- Microneedle, Hypodermic needle, Flat patch
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Caregiver, Malignant Head and Neck Neoplasm
Prepare to Care, A Supported Self-Management Intervention for Head and Neck Cancer CaregiversHead and Neck Cancer
This pilot clinical trial studies how well Prepare to Care kit works in improving caregiver support in patients with stage I-IV head and neck cancer that is new or has come back.
- Conditions
- Caregiver, Malignant Head and Neck Neoplasm, Paranasal Sinus Squamous Cell Carcinoma, Salivary Gland Squamous Cell Carcinoma
- Trial name
- NCT03032250
- Testing
- Communication Intervention, Watch video, Module completion of the Prepare to Care kit
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Caries, Unsatisfactory or Defective Restoration of Tooth
Clinical Evaluation of "Cention Forte" Restorative Material
Resin composites, the first choice of material for the restoration of posterior teeth, still have several drawbacks including their polymerization shrinkage and potential failure of the resin-dentin interface leading to secondary…
- Trial name
- NCT04796974
- Testing
- Cention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Oropharyngeal Cancers, Biomarker in Early Diagnosis
Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer
The goal of this observational study is to evaluate whether the active-matrix metalloproteinase-8 (aMMP-8) mouth-rinse test can help detect oral and oropharyngeal cancers.
- Conditions
- Oropharyngeal Cancers, Biomarker in Early Diagnosis, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Periodontal Diseases
- Trial name
- NCT06701058
- Where
- Finland
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Alcohol-Related Carcinoma, Fanconi Anemia
Role of Acetaldehyde in the Development of Oral Cancer
This is a minimal risk intervention study where healthy volunteers and individuals with Fanconi anemia will consume a single dose of alcohol and provide primarily non-invasive biological samples at various time points.
- Conditions
- Alcohol-Related Carcinoma, Fanconi Anemia, Oral Cavity Carcinoma
- Trial name
- NCT05973656
- Testing
- Alcohol, Biospecimen Collection, Breath Test
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Dental Caries Class II
Clinical Performance of Two Different Restorative Materials in Restoring Class II Cavities of Primary Molars
The aim of the present study is to assess Flowable Giomer Beautifil Flow Plus X (Shofu Dental Corporation, Japan) and Glass-hybrid-added HVGIC, Equia Forte (GC Corporation, Tokyo, Japan) in class II cavities of primary molars…
- Trial name
- NCT06000085
- Testing
- restoration of proximal cavities of primary molars with flowable giomer, restoration of proximal cavities of primary molars with highly viscous glass ionomer cement
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Plaque, Dental Plaque
Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems
Qualified subjects will be enrolled and randomized to either one of the three study groups described above based on their initial modified gingivitis and plaque scores.
- Conditions
- Plaque, Dental Plaque, Gingivitis
- Trial name
- NCT07842991
- Testing
- 0.45% SnF HW with NaF (1450 F), 67% Bicarbonate with NaF (1400 F), Colgate Cavity Protection Toothpaste
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Oral Cavity Cancer
Risk Factors Contributing to Oral Cancer in Patients at Dr. Hasan Sadikin General Hospital Bandung
Analytical research with a cross-sectional approach was carried out on patients diagnosed with oral cavity cancer who visited our outpatient clinic in Bandung between 2023 and 2024.
- Trial name
- NCT06690918
- Where
- Indonesia
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
White Spot Lesion, Orthodontic Treatment
Comparison of Three Toothpastes for the Prevention and Reduction of White Spot Lesions
The purpose of the study is to determine if Clinpro™ 5000, Clinpro™ Tooth Crème, or MI-Paste Plus has an effect on the formation and resolution of white spot lesions for patients undergoing orthodontic treatment.
- Conditions
- White Spot Lesion, Orthodontic Treatment, Decalcification; Teeth
- Trial name
- NCT03440996
- Testing
- Clinpro™ 5000, Clinpro™ Tooth Crème, MI-Paste Plus
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Oral Cavity Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma
Saliva-based Detection of CD44
The purpose of this study is to test the ability of OncAlert™ to screen for cancer and the reappearance of cancer. OncAlert™ was developed by Vigilant Biosciences, a collaborator in this research study.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Oropharynx, Squamous Cell Carcinoma of the Head and Neck
- Trial name
- Detect 44 (NCT03148665)
- Testing
- OncAlert
- Where
- 4 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Joseph Califano
Ovarian Epithelial Cancer
Lavage of the Uterine Cavity for the Diagnosis of Ovarian and Tubal Carcinoma and Their Premalignant Changes.
Epithelial Ovarian cancer (EOC) is the leading cause of death among gynaecologic malignancies in western civilized countries, with an estimated prevalence in Europe and the US of 752,600 in 2007 and 59,828 deaths annually.
- Trial name
- LUDOC (NCT02062697)
- Testing
- Lavage of the Cavum uteri and proximal fallopian tubes, Liquid-PAP smear
- Where
- 6 sites in Austria, Belgium and 2 more
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity
Fat Perception in Humans (09-0873)
There are many substances naturally present in the mouth that may help us taste fat in food. Two of these substances (lipases and CD36) will be examined in this study.
- Trial name
- OT (NCT01128400)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Fallopian Tube Cancer, Peritoneal Cavity Cancer
A Study of Carboplatin, PLD and Everolimus in Certain Gynecologic Cancer
RATIONALE: Drugs used in chemotherapy, such as carboplatin and pegylated liposomal doxorubicin hydrochloride (PLD) work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from…
- Conditions
- Fallopian Tube Cancer, Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer
- Trial name
- NCT01281514
- Testing
- everolimus, carboplatin, pegylated liposomal doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Head and Neck Cancer
A Trial Evaluating Omission of Radiotherapy to Regional Lymphatic's
The present study is a phase II/III prospective randomized trial designed to determine whether eliminating of post operative radiotherapy to regional lymphatics in pN0-N1oral cavity is associated with similar treatment outcomes.
- Trial name
- Eliminate (NCT07528495)
- Testing
- IMRT - adjuvant concurrent CRT/ RT, ommission of IMRT - adjuvant concurrent CRT/ RT for regional lymphatics, Cisplatin
- Where
- India
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Dental Caries in Children, Dental Caries Class II
Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective…
- Conditions
- Dental Caries in Children, Dental Caries Class II, Dental Caries
- Trial name
- NCT03770286
- Testing
- 5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Shoulder Pain, Abdominal Pain (AP)
Outcome of Active Aspiration Versus Simple Compression to Remove Residual Gas From Abdominal Cavity in Reducing Pain After Laparoscopic Cholecystectomy
The aim of this study is to compare outcome of active aspiration versus simple compression to remove residual gas from abdominal cavity in reducing pain after laparoscopic cholecystectomy.
- Trial name
- Lap Chole (NCT07299656)
- Testing
- Group A (Active Aspiration), simple compression
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Microbial Colonization
The Influence of Endurance Sports Activity on the Oral Microbiota of Young Adults.
The oral cavity is an easily accessible anatomical site that accurately reflects the health of the individual. The mouth is considered an early indicator of biological aging, leading to the identification of oral biomarkers…
- Trial name
- ORAMICAP (NCT05765422)
- Testing
- salivar and gum sampling
- Where
- France
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Nasal Synechiae, Adhesions of Nasal Cavity
Study of Mitomycin C and Nasal Splint to Treat Nasal Synechiae
This study evaluates whether Mitomycin C is an effective alternative to septal splints in the treatment of nasal synechiae.
- Conditions
- Nasal Synechiae, Adhesions of Nasal Cavity, Nasal Adhesions, Tissue Adhesions
- Trial name
- NCT00966056
- Testing
- Mitomycin C, Teflon nasal septal splint
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karnataka Institute of Medical Sciences
Oral Lichen Planus, Oral Squamous Cell Carcinoma
Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity
The aim of this study was to examine molecular alterations on the protein level in lesions of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa.
- Trial name
- NCT03026361
- Testing
- global proteomic profiling
- Where
- Croatia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Tooth Decay, Tooth Restoration
Clinical and Radiographic Evaluation of Two Matrix Systems for Restoration of Class II Cavities in Primary Molars
this study aims to evaluate and compare the clinical and radiographical efficacy, operator ease, satisfaction and patient comfort in restoring class II cavities in primary molars using Fender Mate system with T-band system.
- Trial name
- NCT06447324
- Testing
- Fender Mate matrix system, T-band matrix
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aswan University