Clinical trials: Cell Function
Cardiovascular Function, Gene Expression
Effect of a Polyphenol-rich Cocoa Extract on Peripheral Blood Mononuclear Cells Gene Expression
It has been evidenced that chocolate and cocoa consumption increase vasodilation and reduce blood pressure. However, the mechanisms implicated in these effects have not been elucidated yet.
- Trial name
- NCT01681394
- Testing
- Polyphenol-rich cocoa extract, Chocolate cream
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Sepsis, Antigen-presenting Function
Study on Antigen-presenting Function of Gamma Delta T Cells in Sepsis and Its Molecular Mechanisms
Study on antigen-presenting function of gamma delta T cells in sepsis and its molecular mechanisms
- Conditions
- Sepsis, Antigen-presenting Function, γδ T Cells
- Trial name
- NCT03379896
- Testing
- Collect peripheral blood sample
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Healthy
Impact of Propionic Acid on Regulatory T Cell Function in Healthy Adults ( Pro-Health)
Pro-Health is a single-center, double-blind, randomized and placebo-controlled intervention study in healthy adults. The investigators address the effect of a dietary food supplementation of propionic acid on the immune system…
- Trial name
- Pro-Health (NCT06198374)
- Testing
- Sodium propionate
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Healthy Humans
Cranberry Enhances Human Immune Function and Reduces Illness
The purpose of this study is to determine whether consuming a beverage made with cranberry polyphenols and proanthocyanidins is effective in modifying immune function by enhancing immune cell proliferation, cytokine production…
- Trial name
- NCT01398150
- Testing
- Beverage made to look like the cranberry beverage, Beverage made from cranberry compounds
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cardiovascular Diseases
Red Blood Cell ATP Release and Vascular Function in Humans
Previous work demonstrates that the red blood cells of older adults do not release a potent vasodilator (ATP) as well as the red blood cells of younger adults.
- Trial name
- NCT03404843
- Testing
- Fasudil Hydrochloride, Saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Normal Physiology
Collection of Peripheral Blood Stem Cells Using G-CSF and Plerixafor in Normal Volunteers
Background: Many treatments for immune system disorders involve the use of stem cells that have been collected from blood marrow.
- Trial name
- NCT01123499
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 2 Diabetes Mellitus
Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes
The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have…
- Trial name
- EPC-DM (NCT01176578)
- Testing
- Aerobic Exercise Training
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
COVID-19
Endothelial Function and COVID-19
The present study aims to investigate the endothelial vasodilator function in patients with COVID-19
- Trial name
- NCT04525443
- Where
- 2 sites in United States, Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Hospital San Carlos, Madrid
Hyperlipidemia
Differential Effects of a Diet Supplementation With Plant Sterol Esters on Human Monocytes
The purpose of this study is to evaluate the effects of a diet supplementation with plant sterol esters on serum lipids, plant sterol concentrations and monocyte subpopulations.
- Trial name
- PSE-MO (NCT00928616)
- Testing
- margarine + plant sterol esters
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Saarland
Cardiac Toxicity, Chemotherapeutic Agent Toxicity
Cardiac Magnetic Resonance Imaging in Patients With Non-Hodgkin Lymphoma or Hodgkin Lymphoma Receiving Doxorubicin
RATIONALE: Diagnostic procedures, such as cardiac magnetic resonance imaging, may help doctors detect early changes in the heart caused by chemotherapy.
- Conditions
- Cardiac Toxicity, Chemotherapeutic Agent Toxicity, Lymphoma
- Trial name
- NCT00577798
- Testing
- contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Preeclampsia, Hypertension
Cardiac and Immune Cell Function in Preeclampsia
Preeclampsia is a multi-system vascular disease which affects 2-5% of pregnancies. It is also a risk factor for the development of cardiovascular disease later in life and a number of functional and structural cardiac changes…
- Conditions
- Preeclampsia, Hypertension, Pregnancy Induced Hypertension, Pregnancy Related
- Trial name
- NCT04508582
- Testing
- Cardiovascular magnetic resonance, Echocardiography, Blood test
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Multiple Myeloma
Protocol to Obtain Blood and Bone Marrow Samples for Myeloma Research
The purpose of this study is to collect a blood or bone marrow sample from patients with multiple myeloma and from volunteers without myeloma.
- Trial name
- NCT01382615
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Healthy, Helminthiasis
Comparison of Immune Response in Normal Volunteers and Patients With Helminth Infections
This study will compare the structure, chemical composition and other characteristics of skin and blood in people with and without parasitic infections. Cell samples will be taken from blisters produced by suction blistering.
- Trial name
- NCT00004996
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Gut Microbiota
Correlation Between Gut Microbiota and Pancreatic Β-Cell Function in Diabetic Patients
The gut microbiota plays a crucial role in digestion, metabolism, nutrition, and immune regulation in the human body. In recent years, numerous studies have indicated that the gut microbiota and its metabolites are closely…
- Trial name
- NCT06645223
- Testing
- No Interventions
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Healthy
T Cell Responses to Various Levels of Exercise Stress
The objective of this project is to quantify the immunoendocrine response to acute stress events combining both physical and psychological challenges.
- Trial name
- NCT06638684
- Testing
- Exercise
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Skeletal Muscle Hypertrophy
Effects of a Multi-ingredient Supplement Study: a Randomized Controlled Trial in Men and Women
Resistance exercise training is a known stimulant for muscle protein synthesis (MPS) to occur, however the consumption of protein is also necessary to induce a shift towards a positive net protein balance.
- Trial name
- SRCT (NCT03525197)
- Testing
- Whey protein-based supplement, Collagen protein-based supplement
- Where
- 2 sites in Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- McMaster University
Type 2 Diabetes
Study of Vitamin D and Omega-3 Supplementation for Preventing Diabetes
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids…
- Trial name
- NCT01633177
- Testing
- Vitamin D3, Omega-3 fatty acid (fish oil)
- Where
- United States
- Volunteers
- 22,220 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Influenza, Human
Functional Consequences of T-bet Expression in Flu-specific Memory B Cells After Live Attenuated Influenza Vaccine (LAIV)
As yet the investigators do not understand if there are biomarkers of immune protection after the Flumist or Live Attenuated Flu Vaccine (LAIV).
- Trial name
- LAIV (NCT04080245)
- Testing
- Treatment Group Live Attenuated Flu Vaccine (LAIV)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Bladder Cancer, Cystectomy
Supporting Sexual Recovery in Women With Bladder Cancer
This study looks at how bladder cancer and removing the bladder can affect women's sexual well-being. Bladder cancer can be more serious in women, and treatment like bladder removal can impact how they feel about themselves and…
- Conditions
- Bladder Cancer, Cystectomy, Female Sexual Dysfunction
- Trial name
- SPARC (NCT07091565)
- Testing
- Qualitative interview/Focus group
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King's College London
Diabetes Mellitus, Sport Injury
Cryopreserved Hair Follicles for Disease and Cell Replacement
To explore the application of cells expanded from plucked hair follicles after collection, transport, and cryopreservation, in disease modeling and cell-based therapies.
- Conditions
- Diabetes Mellitus, Sport Injury, Injury Traumatic
- Trial name
- NCT06764719
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Acorn Biolabs Inc.