Clinical trials: Cell Function
Chronic Rhinosinusitis
Effect of Prednisone onTregs and TH17
The primary objective of this study is to see whether systemic corticosteroids (such as Prednisone) have an effect on the peripheral blood Treg and Th17 function in patients with CRS.
- Trial name
- NCT01002313
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Healthy Humans
Cranberry Enhances Human Immune Function and Reduces Illness
The purpose of this study is to determine whether consuming a beverage made with cranberry polyphenols and proanthocyanidins is effective in modifying immune function by enhancing immune cell proliferation, cytokine production…
- Trial name
- NCT01398150
- Testing
- Beverage made to look like the cranberry beverage, Beverage made from cranberry compounds
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obesity, Fasting
Investigating the Effect of Short-term Fasting on T Cell Metabolism, Function, and Phenotype in Obesity
The immune system is made up of many types of immune cells, each of which play a specialized role in protecting against pathogens.
- Conditions
- Obesity, Fasting, T-Cell Dysfunction
- Trial name
- NCT05886738
- Testing
- Fasting
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Longevity, Healthy Aging
Collagen Peptides and Cellular Aging
The goal of this clinical trial is to learn if daily collagen peptide supplementation can stabilize or lengthen telomeres and improve related markers of cellular aging in adults aged 50-70 years with overweight and…
- Conditions
- Longevity, Healthy Aging, Biological Ageing
- Trial name
- NCT07456449
- Testing
- Collagen peptides
- Where
- Austria
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Healthy
Acute Effects of Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
This study aims to investigate the effect of spices on gene expression of pathways associated with glucose homeostasis, oxidative stress and inflammation, in the postprandial phase in healthy human subjects.
- Trial name
- NCT02479334
- Testing
- Fat challenge breakfast, Fat challenge breakfast+spices, Carbohydrate challenge breakfast
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lund University
Improvement in Immune Cell Function in Elderly Humans
Oral Glutathione Supplementation in Older Healthy Adults and Its Effect on the Number of Healthy Days Experienced During Four Months of Supplementation Compared to Placebo
A randomized, double blind placebo-controlled parallel intervention in adults over the age of 50 will be performed. Participants will receive a supplement capsule containing placebo (Crystalline Cellulose) or 500mg of Setria®…
- Trial name
- GSH (NCT02438956)
- Testing
- Setria glutathione supplement, Crystalline Cellulose
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Florida
Peri-Implantitis, Peri-implant Mucositis
Proteomic Analysis of Newly Restored Single Implants
In 10 systemically healthy non-smokers, free of periodontitis, one newly restored implant (baseline-T0) and one corresponding tooth were followed over 12 months (T1). All implants were screw-retained, and platform-switched.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Periodontal Diseases
- Trial name
- NCT06379022
- Testing
- Plaque control
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Melanoma
MicroRNA Expression and Function in Cutaneous Malignant Melanoma
Spectrophotometric intracutaneous analysis (SIAscopy) is a new technique for imaging pigmented skin lesions and for diagnosing melanoma and non-melanoma skin cancer.
- Trial name
- NCT00536029
- Where
- Denmark
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 2 Diabetes Mellitus
Effects of SGLT2 Inhibitors on Islet Cell Function and Insulin Sensitivity in Patients of Type 2 Diabetes Mellitus
The main pathogenesis of type 2 diabetes mellitus is insulin resistance and insufficient secretion of insulin by pancreatic beta cells.
- Trial name
- NCT04014192
- Testing
- Dapagliflozin, Empagliflozin, Canagliflozin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Fertility
Secretory Azoospermia and FDG (Fluoro Deoxyglucose) PET-CT
Compare FDG PET-CT parameters between azoospermia patients having an extraction of sperm cells by positive testicular extraction and those with a negative extraction.
- Trial name
- AzoPredHisto (NCT02043444)
- Testing
- FDG PET-CT
- Where
- 5 sites in France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Stage 1 Diabetes Mellitus, Type 1
GLP-1 RA for Stage 1 Type 1 Diabetes
This study seeks to evaluate the hormone responses of insulin, c-peptide, glucagon, and incretins to semaglutide, a GLP-1 receptor agonist therapy, in individuals with stage 1 type 1 diabetes.
- Trial name
- NCT07430332
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Lymphocytic Leukemia (CLL)
The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL
Patients with chronic lymphocytic leukemia (CLL)have had very poor humoral responses to pneumococcal polysaccharide vaccine (PPV).
- Trial name
- KLL2 (NCT00919321)
- Testing
- Pneumococcal polysaccharide vaccine (PPV)
- Where
- Finland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Frailty
Mesenchymal Stem Cells for Age-Related Frailty
Frailty is a health state related to the aging process in which multiple body systems gradually lose their built-in reserves. It is a medical condition of reduced function in older adults which is associated with increased risks…
- Trial name
- MESCAFY (NCT05284604)
- Testing
- Mesenchymal Stem Cells (MSCs)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Obesity, Type 2 Diabetes
Role of Pancreatic Triglyceride Content in Beta-cell Function
The study evaluates if fat accumulates in the pancreas in individuals at risk of developing obesity-related diabetes. It also evaluates if the amount of fat in the pancreas can predict the residual functional capacity of the…
- Trial name
- NCT00602953
- Testing
- No intervention planned.
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Type 1 Diabetes
Beta Cell Function in (Pre)Type 1 Diabetes
Increased glycemic variability has been proposed as an independent predictor of hypoglycemia in diabetic patients. Likewise, episodes of dysglycemia have been found to be predictive of diabetes in antibodypositive nondiabetic…
- Trial name
- NCT01402037
- Testing
- Glucose, Continuous glucose monitoring
- Where
- 3 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Sickle Cell Anemia
Establishment of Functional MRI Imaging Parameters for Use in the Evaluation of Sickle Cell Disease
Patients with sickle cell anemia (SCA) are at an increased risk for damage to brain tissue due to their disease. The investigators are interested in how blood flow and cerebral inflammation are different in SCA patients and how…
- Trial name
- NCT02445144
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Idiopathic Pulmonary Fibrosis, Healthy
Determining in Vitro Properties of Epithelial Cells From Individuals With Genetic Variants Associated With Idiopathic Pulmonary Fibrosis
The investigators are trying to understand the role of specific genes in the function of airway surface cells. The investigators know that there are some common genetic markers that are associated with various lung diseases.
- Trial name
- NCT02187393
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes, Type 2 Diabetes
Glucotoxicity and Acute Exercise
Experimental hyperglycemia (5 hours) will be induced via a constant- or fluctuating-rate glucose infusion to establish different patterns of glycemia in healthy individuals.
- Trial name
- NCT01771614
- Testing
- Exercise, Hyperglycemia
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy Volunteer
Food (Poly)Phenol Metabotypes and Beta-cell Mass and Function.
Cross-sectional, single-centre, 'low intervention' clinical study, without drug or medical device testing, with low-risk diagnostic technique.
- Trial name
- META-BETA (NCT06888167)
- Testing
- Study setting
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Aging
Dehydration, Rehydration, and Impact on Physiology
Our goal is to determine whether hydration status influences inflammation, and overall physiological performance in adults aged 45-65.
- Trial name
- DRIP (NCT07084675)
- Testing
- Hydration-Dehydration-Rehydration Protocol (HDR)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Texas Tech University