Clinical trials: Cell Function
Sickle Cell Disease
Niacin to Improve Blood Flow in People With Sickle Cell Disease
This study will determine whether niacin can improve blood flow in people with sickle cell disease, in which abnormal red blood cells interfere with blood flow to cause the disease symptoms.
- Trial name
- NCT00508989
- Testing
- Niacin-ER, L-NMMA, Acetylcholine
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cat Allergy, Cat Hypersensitivity
A Randomized Prospective Clinical Trial of Fel d 1 Peptide Immunotherapy
The goal of this study is to identify changes in cells that are related to the treatment with Cat-PAD (ToleroMune Cat).
- Trial name
- NCT02311413
- Testing
- Cat-PAD
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 2 Diabetes, Healthy
Effect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function
Pioglitazone, a drug used in treatment of type 2 diabetes has been shown to improve insulin sensitivity in skeletal muscle, liver, and fat cells.
- Conditions
- Type 2 Diabetes, Healthy, Impaired Glucose Tolerance
- Trial name
- PIO-EX (NCT00845182)
- Testing
- Pioglitazone, Exenatide, Pioglitazone and Exenatide
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
End Stage Renal Disease, Reperfusion Injury
Intra-graft Coagulation Events in Clinical Renal Transplantation and Delayed Graft Function
The purpose of this study is to investigate local activation of the coagulation system in the kidney graft during organ preservation and during early reperfusion in adult kidney transplantation.
- Conditions
- End Stage Renal Disease, Reperfusion Injury, Delayed Graft Function, Kidney Transplantation
- Trial name
- KTX (NCT02568696)
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
Langerhans Cell Histiocytosis of Lung
Evaluation of Efficacy and Tolerance of Cladribine in Symptomatic Pulmonary Langerhans Cell Histiocytosis
ECLA is a phase II, multicenter study testing sub cutaneous cladribine 0.1mg/kg/j during 5 days, administrated every month for 4 courses, in symptomatic adult patients with pulmonary Langerhans cell histiocytosis and impairment…
- Trial name
- ECLA (NCT01473797)
- Testing
- Cladribine
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mitochondrial Function, Physical Function
Resveratrol to Enhance Vitality and Vigor in Elders
Resveratrol, a compound found in red wine and dark-skinned grapes, will improve the function of mitochondria (energy producing components) within the leg muscles of moderate functioning older adults.
- Trial name
- REVIVE (NCT02123121)
- Testing
- Resveratrol 1000 mg/day, Resveratrol 1500 mg/day, Vegetable cellulose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Anal Cancer
Functional Outcomes Following Anal Cancer Treatment
Anal cancer is treated with chemoradiotherapy- combined chemotherapy and radiotherapy. This is very successful (75% long term survival). During the course of the radiotherapy, other organs in the pelvis may be damaged.
- Trial name
- FOFACT (NCT01853059)
- Where
- 2 sites in United Kingdom
- Volunteers
- 176 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Skeletal Muscle Damage, Aseptic Inflammation
Redox Status and Immune Function
In this investigation the investigators utilized N-acetylcysteine (NAC) supplementation to enhance reduced glutathione (GSH) stores during an 8-day recovery period from a strenuous eccentric exercise protocol in order to test the…
- Conditions
- Skeletal Muscle Damage, Aseptic Inflammation, Skeletal Muscle Function
- Trial name
- NCT02930031
- Testing
- n-acetylcysteine
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Asthma
Effect of in Vitro Blocking the Common Beta Chain on Cell Viability in Asthma
This study examines in vitro blockade of signaling through the β-chain, on viability, activation and differentiation of eosinophils and their progenitors collected in sputum, blood and bone marrow samples pre and post-allergen…
- Trial name
- NCT01759849
- Testing
- Allergen
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Obesity
Effect on Energy Metabolism at Cellular Level of Diet Plus Treatment With Ephedrine and Caffeine in Obesity
Brief Summary This trial was part of a sub-project targeted to diet, thermogenesis and obesity of a larger multicentre study named "Interaction between nutritional, social-behavioral and metabolic factors for prevention of…
- Trial name
- NCT02048215
- Testing
- Caffeine, Ephedrine, Hypocaloric diet
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Istituto Auxologico Italiano
Bullous Pemphigoid
Deciphering IL-17-dependant Inflammatory Response in Bullous Pemphigoid
Bullous pemphigoid (BP) is the most frequent autoimmune skin disease and mainly affects elderly individuals. BP classically manifests with tense blisters over urticarial plaques on the trunk and extremities accompanied by intense…
- Trial name
- BP-IL17RB (NCT06479018)
- Testing
- Blood sampling, Liquid bubble sampling, Cutaneous biopsy
- Where
- France
- Volunteers
- 140 people
- Sponsor
- CHU de Reims
Vestibular Schwannoma
Evolution of Balance and Vestibular Function in Patients Treated With Gammaknife Radiosurgery for Vestibular Schwannoma
Vestibular schwannomas are benign lesions of the ponto-cerebellar angle that are potentially dangerous because of their growth in a cramped space and the compressive phenomena they can cause.
- Trial name
- EQUI-GAMMA (NCT04859335)
- Testing
- gammaknife radiosurgery
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Head and Neck Cancer
MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer
RATIONALE: Diagnostic procedures, such as specialized types of magnetic resonance imaging (MRI), may help in planning radiation therapy that does less damage to normal tissues.
- Trial name
- NCT00984074
- Testing
- blood-oxygen-level-dependent functional magnetic resonance imaging, diffusion tensor imaging, dynamic contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Type 2 Diabetes Mellitus
Effect of Intensive Therapy Associated With CSII on β-cell Function With Newly Diagnosed Type 2 Diabetes
The purpose of this study is to investigate and evaluate the effects of different interventions (1.continuous subcutaneous insulin infusion,2.continuous subcutaneous insulin infusion combined with rosiglitazone 3.continuous…
- Trial name
- NCT00948324
- Testing
- CSII,ALA,MET,RSG
- Volunteers
- 400 people
- Sponsor
- Sun Yat-sen University
Neuroendocrine Tumors
Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) - COMPOSE
The purpose of the study is to evaluate the efficacy, safety \& patient-reported outcomes of peptide receptor radionuclide therapy (PRRT) with 177Lu-Edotreotide as 1st or 2nd line of treatment compared to best standard of care in…
- Trial name
- COMPOSE (NCT04919226)
- Testing
- 177Lu-Edotreotide (Peptide Receptor Radionuclide Therapy) PRRT, CAPTEM (Capecitabine and Temozolomide), Amino-Acid Solution
- Where
- 42 sites in United States, Australia and 8 more
- Volunteers
- 259 people
- Sponsor
- ITM Solucin GmbH
Sickle Cell Disease
Functional Neuroimaging of Pain Using EEG and fMRI
The purpose of this research is to use non-invasive imaging technologies to study how the human brain processes pain. The investigators will use contact heat to induce pain and record data scalp EEG and functional magnetic…
- Trial name
- NCT02212691
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Chronic Lymphocytic Leukemia, Frailty
Investigating the Role of Energy Balance Modification on Health Responses in Chronic Lymphocytic Leukaemia
This randomised control clinical trial aims to investigate the effects of exercise training and diet on physical and functional fitness and immunological and metabolic changes in adults with chronic lymphocytic leukaemia.
- Conditions
- Chronic Lymphocytic Leukemia, Frailty, Muscle Function, Immune Function
- Trial name
- HIT-CLL (NCT06379282)
- Testing
- HIT, EXE+ Nutritional Guidance
- Where
- United Kingdom
- Volunteers
- 132 people
- Sponsor
- University of Surrey
Bladder Cancer, Urothelial Carcinoma
A Home-Based Prehabilitation Exercise Intervention for Improving Physical Function in Patients With Bladder Cancer and Upper Tract Urothelial Cancer, Get Moving Trial
Prehabilitation refers to the process of improving a patient's functional capabilities prior to a surgical procedure with the goal of decreasing post-surgical inactivity and physical decline.
- Conditions
- Bladder Cancer, Urothelial Carcinoma, Upper Tract Urothelial Carcinoma, Renal Pelvis and Ureter Urothelial Carcinoma
- Trial name
- NCT06040762
- Testing
- Best Practice, Exercise Intervention, App-Based Intervention
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Washington
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Cervical Cancer
Preservation of Ovarian Function Via LOT in Squamous Cell Carcinoma of the Cervix
The purpose of this study is to evaluate the feasibility, safety and efficacy of laparoscopic ovarian transposition in women less than 40 years of age with locally advanced cervical squamous cell carcinoma
- Trial name
- NCT00204997
- Testing
- Laparoscopic ovarian transposition
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Wisconsin, Madison
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