Clinical trials: Cell Function
Renal Cell Carcinoma, Renal Function Abnormal
The Cold Ischemia Robot-assisted Partial Nephrectomy
To establish evidence that cold ischemia, achieved through the use of ice slush, can improve the recovery from ischemia on the operated kidney in patients undergoing robot-assisted partial nephrectomy.
- Trial name
- NCT07326280
- Testing
- Cold ischemia robot-assisted partial nephrectomy, Warm ischemia robot-assisted partial nephrectomy
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Sun Yat-sen University
Advanced Cancer, Ovarian Cancer
COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies
Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary antitumor activity of COM902 as monotherapy and in combination with COM701 in subjects with advanced…
- Conditions
- Advanced Cancer, Ovarian Cancer, Lung Cancer, Colon Cancer
- Trial name
- NCT04354246
- Testing
- Dose escalation: COM902 monotherapy., Evaluation of safety/tolerability: COM902 in combination with COM701 (both at the RDFE), Cohort expansion: COM902 (RDFE) monotherapy.
- Where
- 9 sites in United States
- Volunteers
- 94 people
- Sponsor
- Compugen Ltd
Breast Cancer, Cognitive/Functional Effects
Psychosocial Adjustment After Radiation Therapy in Patients With Cancer
RATIONALE: Gathering information about psychological and social adjustment after radiation therapy in patients with cancer may help doctors plan the best treatment.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Colorectal Cancer, Lung Cancer
- Trial name
- NCT00905086
- Testing
- questionnaire administration, cognitive assessment, psychosocial assessment and care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Case Comprehensive Cancer Center
Aging, Physical Activity
NEUROmuscular Training for Enhanced AGE Longevity
In recent years the research group on Prevention and Health in Exercise and Sport (PHES) has carried out numerous studies that have provided current and convincing evidence of the benefits of physical activity and exercise for…
- Conditions
- Aging, Physical Activity, Training
- Trial name
- NEUROAGE (NCT06620666)
- Testing
- Water-based power resistance training + Dietary supplement I (WPowDSI), Elastic band-based power resistance training + Dietary supplement I (EBPowDSI), Elastic band-based eccentric resistance training + Dietary supplement II (EBEccDSII)
- Where
- Spain
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Type 2 Diabetes Mellitus
Study of Subcutaneous Doses of HIP2B in Subjects With Type 2 Diabetes Mellitus Treated With Metformin
HIP2B is being developed for the treatment of type 1 and type 2 diabetes mellitus. The purpose of this study is to investigate the safety and tolerability of repeat doses of HIP2B in subjects with type 2 diabetes mellitus.
- Trial name
- NCT01933256
- Testing
- HIP2B
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- CureDM
Primary Immunodeficiencies, ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
Long-term Psychological and Cognitive Evaluation of Children Treated With Allogeneic Hematopoietic Stem Cell Transplantation for Immunodeficiency
Primary immunodeficiencies (PIDs) are a large group of genetic diseases of the immune system with highly variable clinical presentations.
- Trial name
- PSY-DIP (NCT07766304)
- Testing
- Neurocognitive, psychological, and psychosocial assessement
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Tumor, Pediatric, Medulloblastoma, Pediatric
Components of Social Functioning in Survivors of Pediatric Brain Tumors
Children with brain tumors are at risk for a number of psychological late effects, including neurocognitive and social deficits.
- Trial name
- NCT03361033
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- St. Jude Children's Research Hospital
Type 2 Diabetic Patients, Insufficient Metabolic Control
Beta-Cell Function of Insulin Glargine Compared to Neutral Protamine Hagedorn (NPH) Insuline and to Insulin Detemir in Combination With Metformin
The aim of the study is to show that treatment with Glargine will lead to an improvement in beta cell function especially within times of maximal beta cell stress occurring after a meal.
- Conditions
- Type 2 Diabetic Patients, Insufficient Metabolic Control, OAD Treatment
- Trial name
- NCT00941148
- Testing
- Insulin Glargin, NPH insulin, Insulin detemir
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- ikfe-CRO GmbH
Type 2 Diabetes Mellitus
Rosiglitazone-Metformin Combination Versus Metformin-Sulfonylurea Combination On Beta-Cell Function In Type 2 Diabetes
It has been shown in previous study that progressive glycemic deterioration was associated with progressive loss of b-cell function, measured by the decrease in plasma insulin levels, irrespective of the therapy used (diet…
- Trial name
- NCT00367055
- Testing
- rosiglitazone-metformin, Metformin, metformin+ gliclazide
- Volunteers
- 84 people
- Sponsor
- GlaxoSmithKline
Acute Lymphatic Leukemia, Lymphoma
More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls.
- Trial name
- MaximALL (NCT07705178)
- Testing
- QOL assessment, Neuropsychological, Spirometry, DLCO measurement
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hyperlipidemia
Differential Effects of a Diet Supplementation With Plant Sterol Esters on Human Monocytes
The purpose of this study is to evaluate the effects of a diet supplementation with plant sterol esters on serum lipids, plant sterol concentrations and monocyte subpopulations.
- Trial name
- PSE-MO (NCT00928616)
- Testing
- margarine + plant sterol esters
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Saarland
Chronic Pancreatitis
Analysis of Graft Function Following Autologous Islet Transplantation
Analyze inflammatory markers and islet graft function through blood samples collected from subjects with chronic pancreatitis who undergo total pancreatectomy with auto islet transplantation.
- Trial name
- NCT03097185
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Type 1 Diabetes
Early High-Dose Vitamin D and Residual β-Cell Function in Pediatric Type 1 Diabetes
The project aims to study the effect of early high-dose vitamin D supplementation on type 1 diabetes in children and adolescents receiving intensive insulin therapy.
- Trial name
- NCT05270343
- Testing
- Cholecalciferol (Vit D3) 400Unit Cap
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Sickle Cell Disease
Voxelotor Neurocognitive Function Study
This is a Phase 3b, randomized, double-blind, placebo-controlled, multicenter study to assess the treatment effect of voxelotor on neurocognitive function as assessed by the National Institute of Health (NIH) Toolbox Cognition…
- Trial name
- NCT05228834
- Testing
- Voxelotor Only Product in Oral Dose Form
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Pfizer
Long-Functioning Pancreas Allografts, Pancreas Transplant
Assessment of Insulin Production From Native Pancreas in Patients With Pancreas Transplants
This study will examine whether insulin-producing cells in the pancreas (beta cells) can recover in patients with type 1 diabetes who have had a pancreas transplant.
- Trial name
- NCT00246844
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Stage IA NSCLC
Study of Robotic Assisted/Image Guided Electromagnetic Navigation Bronchoscopic Therapies and Surgery in Stage IA NSCLC
This study aims to address the core deficiencies in the field by situating bronchoscopic ablation within the same evidentiary frame as segmentectomy and lobectomy.
- Trial name
- NCT07741344
- Testing
- Bronchoscopic Microwave Ablation, Surgical Resection
- Where
- Hong Kong
- Volunteers
- 292 people
- Sponsor
- Chinese University of Hong Kong
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission
Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Reducing CMV Related Complications in Patients With Blood Cancer Undergoing Donor Stem Cell Transplant
This randomized phase II trial studies how well multi-antigen cytomegalovirus (CMV)-modified vaccinia Ankara vaccine works in reducing CMV related complications in patients with blood cancer who are undergoing donor stem cell…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission, Bone Marrow Transplantation Recipient
- Trial name
- NCT03438344
- Testing
- Multi-antigen CMV-Modified Vaccinia Ankara Vaccine, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Sponsor
- City of Hope Medical Center
Acute Lymphoblastic Leukemia, Acute Myeloblastic Leukemia
Natural Killer Index From Hematopoietic Stem Cell Graft
Numerous studies about the potential role of NK alloreactive during a n hematopoietic stem cells graft are based on genotypical analyses of the KIR receptors and on genotypic incompatibilities between KIR and HLA for couple…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloblastic Leukemia, Chronic Myeloid Leukemia
- Trial name
- NCT00435864
- Testing
- Blood test
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
HIV Infections
Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional Cure
This study will be done in people living with HIV to see if an investigational vaccine made from a person's own white blood cells is safe and tolerated.
- Trial name
- DC-HIV04 (NCT03758625)
- Testing
- a1DC + inactivated whole autologous HIV, a1DC + conserved HIV peptides, a1DC + no antigen
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Sharon Riddler
Type 1 Diabetes
Encapsulated Faecal Microbiota Transplantation to Preserve Residual Beta Cell Function in Type 1 Diabetes Mellitus
In this single arm pilot study it will be investigated whether encapsulated autologous fecal microbiota transplantation may be used to halt the decline in residual beta cell function in individuals with recent onset Type 1…
- Trial name
- ENCAPSULATE (NCT05323162)
- Testing
- encapsulated autologous fecal microbiota transplantation
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Nordin Hanssen
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