Clinical trials: Cell Function
Maxillary Sinus Squamous Cell Carcinoma
Functional Evaluation After Maxillectomy and Scapular Free Flap Reconstruction
The goal of the study is to analyse the functional and aesthetic outcomes after removal of the maxillar bone and reconstruction with part of the scapular bone for people having maxillary tumor
- Trial name
- NCT06865313
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Hôpital de la Croix-Rousse
Executive Functioning, Pediatric ALL
Effectiveness of EEG Neurofeedback in Pediatric Occupational Therapy to Improve Executive Functioning
EEG Neurofeedback is a noninvasive way that allows the central nervous system to self regulate and the frontal cortex to be accessed through quieting of the limbic system at the subcortical level.
- Trial name
- NCT04221620
- Testing
- Zengar Electroencephalogram (EEG) Neurofeedback device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northern Arizona University
Multiple Myeloma
A Study of Belantamab Mafodotin in Multiple Myeloma Participants With Normal and Impaired Hepatic Function
The purpose of this study is to assess the pharmacokinetics (PK), safety, and tolerability of belantamab mafodotin monotherapy in Relapsed/Refractory Multiple Myeloma (RRMM) participants with impaired hepatic function and in…
- Trial name
- DREAMM 13 (NCT04398680)
- Testing
- Belantamab mafodotin
- Where
- 18 sites in United States, Greece and 1 more
- Sponsor
- GlaxoSmithKline
Pancreatic Steatosis, Metabolic Syndrome X
Identification of a Score for the Assessment of Intrapancreatic Fat
The SPES clinical study aims to evaluate the relationship between pancreatic fat accumulation (pancreatic steatosis) and metabolic health.
- Conditions
- Pancreatic Steatosis, Metabolic Syndrome X, Diabetes
- Trial name
- SPES (NCT07155473)
- Testing
- C-peptide dosage
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Knee Osteoarthritis, Osteo Arthritis Knee
Effectiveness of Physical Therapy in Stem Cell Transplant Recipients for Knee Osteoarthritis
Knee osteoarthritis has been considered as 11th highest contributor factor to nonfatal burdens in the world. It is considered one of the most common degenerative diseases of synovial joint and major cause of muscle impairment…
- Conditions
- Knee Osteoarthritis, Osteo Arthritis Knee, OA Knee
- Trial name
- NCT05959902
- Testing
- Forward Walking, Physiotherapy Exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 48 people
- Sponsor
- Dow University of Health Sciences
Vestibular Schwannoma
Remote Ischemic Preconditioning in Vestibular Schwannoma Surgery
Vestibular schwannomas are primarily benign (WHO grade I) tumors originating from the Schwann cells of the vestibular nerve and are among the most common tumors of the skull base.
- Trial name
- RIC-VS (NCT05567341)
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
Islets of Langerhans Transplantation, Pancreatitis, Chronic
Clinical Outcome After Total Pancreatectomy With Islet Autotransplantation
A total pancreatectomy with islet autotransplantation (TPIAT) can be performed for a number of benign indications, such as chronic pancreatitis.
- Conditions
- Islets of Langerhans Transplantation, Pancreatitis, Chronic, Diabetes Mellitus
- Trial name
- TOPPER (NCT05287737)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Leiden University Medical Center
Diabetes Mellitus, Type 2
Association Between Insulin Resistance and Beta Cell Function With HbA1C in Diabetics
Progression of T2DM is widely accepted to be contributed by two main components: beta cell function deterioration where insulin secretion is impaired and insulin resistance where insulin physiological response is reduced.
- Trial name
- InsuReB (NCT03196154)
- Testing
- Fasting insulin level, Plasma drug level
- Where
- Malaysia
- Volunteers
- 255 people
- Sponsor
- Clinical Research Centre, Malaysia
Type 2 Diabetes Mellitus
The Effect of Vildagliptin Based Treatment Versus Sulfonylurea on Glycemic Variability, Oxidative Stress, GLP-1, and Endothelial Function in Patients With Type 2 Diabetes
The effect of vildagliptin based treatment versus sulfonylurea based treatment on glycemic variability, oxidative stress, and endothelial function in patients with type 2 diabetes.
- Trial name
- NCT01404676
- Testing
- Add Vildagliptin, Add Glimepiride
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Samsung Medical Center
Advanced Glycation Endproducts, AGEs
Restriction of Dietary AGEs to Prevent Diabetes in Overweight Individuals
Current efforts to arrest the epidemic of type 2 diabetes mellitus (T2DM) have had limited success. Thus there is an urgent need for effective approaches to prevent the development of T2DM.
- Conditions
- Advanced Glycation Endproducts, AGEs, Diet, Insulin Sensitivity/Resistance
- Trial name
- NCT03866343
- Testing
- Diet low or high in advanced glycation endproducts
- Where
- Netherlands
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type 1 Diabetes
DIATOR-Diabetes Intervention With Atorvastatin
Clinical studies have shown that immunomodulators (like Anti-CD3 antibodies) have effects on beta-cell-preservation. The lipid-lowering agent atorvastatin is also a potent immunomodulator.
- Trial name
- NCT00974740
- Testing
- Atorvastatin
- Where
- 12 sites in Germany
- Volunteers
- 63 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Type 2 Diabetes Mellitus
The Verona Newly Diagnosed Type 2 Diabetes Study
Type 2 diabetes mellitus is a complex disease whose clinical phenotype results from the variable combination of genetic and nongenetic factors.
- Trial name
- VNDS (NCT01526720)
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Type 2 Diabetes
Exercise and GLP-1 RA on Insulin Secretion
The purpose of this study is to determine the effect of endurance exercise on insulin secretory capacity, alone or in addition to treatment with the glucagon-like-peptide receptor agonist semaglutide, in patients with type 2…
- Trial name
- EXISECRET (NCT04383197)
- Testing
- Endurance exercise training, Semaglutide
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Copenhagen
Normal Physiology
Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids
Background: The immune system defends the body against bacteria and other harmful invaders. But it can overact and attack healthy cells by mistake.
- Trial name
- NCT02798523
- Testing
- Methylprednisolone sodium succinate(Solu-Medrol), Topical methylprednisolone (Advantan emulsion 0 /1%)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Coronary Artery Disease, Diabetes Mellitus, Type 2
The Effect of Liraglutide on the Treatment of Coronary Artery Disease and Type 2 Diabetes
The purpose of this study is to investigate the effect of combined glucagon-like-peptide-1 (GLP-1) analogue and metformin therapy on glucose metabolic and cardiovascular endpoints compared to metformin monotherapy in patients…
- Trial name
- AddHope2 (NCT01595789)
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Haugaard, Steen Bendix, M.D., DMSc
Lung Cancer (Diagnosis)
The Effects of Low Intensity Endurance Exercise on Improving Mitochondrial Function, Cell Bioelectrical Impedance Phase Angle, Fatigue and Quality of Life in Lung Cancer Patients With Cancer-related Fatigue
To conduct a randomized controlled trial (RCT) targeting lung cancer patients with cancer-related fatigue to achieve the following objectives: Objective 1: To investigate whether a low-intensity endurance exercise intervention…
- Trial name
- NCT07806682
- Testing
- Low-Intensity Endurance Continuous Exercise, Low-Intensity Endurance Interval Exercise
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Taipei Medical University
Diabetes Mellitus, Healthy
Genetic Influence on Susceptibility to Type 1 Diabetes Mellitus
Type 1 diabetes mellitus is an autoimmune disease in which the body's immune cells attack the insulin-producing cells of the pancreas.
- Trial name
- NCT00001985
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes
Clinical Trial to Assess the Effects of Dairy on Insulin Sensitivity and β-Cell Function
The aim of this trial is to evaluate the effects of dairy product consumption on insulin sensitivity and pancreatic β-cell function in men and women at risk for the development of type 2 diabetes mellitus (T2DM) who habitually…
- Trial name
- NCT01936935
- Testing
- Low-fat dairy, Sugar-sweetened beverages
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Provident Clinical Research
Obesity, Healthy
Effect of Bile Acids on Satiety, Cell Function and Body Weight in Patients With Obesity and Abnormal Satiety Phenotype
The purpose of this research is to study the effect of the study drug (a conjugated bile acid dietary supplement) or placebo on cell function, hormones and body weight.
- Trial name
- NCT05314374
- Testing
- Ileocolonic-release conjugated bile acid
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson's Disease
Leukine (Sargramostim) for Parkinson's Disease
The purpose of this study is to determine if Leukine (sargramostim) can be safely administered to Parkinson's disease patients for an extended period of time (56 days) and restore immune deficits seen in Parkinson's patients…
- Trial name
- NCT01882010
- Testing
- sargramostim
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Nebraska
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