Clinical trials: Cell Function
Sickle Cell Anemia, Muscle Dysfunction
Physical Rehabilitation in Sickle Cell Anemia
Sickle cell anemia (SCA) is one of the most neglected diseases worldwide, according to the World Health Organization. In the adult population with SCA, the systemic effects of the disease, such as respiratory and peripheral…
- Conditions
- Sickle Cell Anemia, Muscle Dysfunction, Quality of Life, Physical Activity
- Trial name
- NCT04705792
- Testing
- Physical activity
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Centro Universitário Augusto Motta
Cognitive Side Effects of Cancer Therapy, Malignant Ovarian Epithelial Tumor
Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy
This clinical trial is studying changes in brain function in patients with stage I, stage II, stage III, or stage IV ovarian, primary peritoneal, or fallopian tube cancer who are receiving chemotherapy.
- Conditions
- Cognitive Side Effects of Cancer Therapy, Malignant Ovarian Epithelial Tumor, Ovarian Brenner Tumor, Ovarian Carcinosarcoma
- Trial name
- NCT01080521
- Testing
- Cognitive Assessment, Quality-of-Life Assessment
- Where
- 182 sites in United States
- Volunteers
- 247 people
- Sponsor
- Gynecologic Oncology Group
Melanoma
Prospective Measurement of Post-Treatment Lymphedema
The goal of this study is to measure the amount of limb swelling (lymphedema) that sometimes occurs after melanoma treatment, and to find out how people feel and react to the diagnosis and treatment of melanoma.
- Trial name
- NCT00495950
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- M.D. Anderson Cancer Center
Graft Failure, Poor Graft Function
CD34+ Selected Stem Cell for Poor Graft Function or Graft Failure
The proposed trial is a single arm, non-randomized, single center pilot study utilizing CliniMACS CD34 Reagent System for patients following allogeneic hematopoietic stem cell transplant (HSCT) requiring treatment of graft…
- Trial name
- NCT06569082
- Testing
- CD34+ Selected Donor Cell Boost, Blood Stem Cell Infusion
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- NYU Langone Health
Acute Lymphoblastic Leukemia
Endothelial Function, Arterial Stiffness and Components
Specific Aim: Compare the endothelial function, arterial stiffness and components of metabolic syndrome of childhood Acute Lymphoblastic Leukemia (ALL) survivors to healthy sibling controls.
- Trial name
- NCT01439217
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Age-Related Lung Function Decline
Ongoing Lung Decline With Age Intensified Response
This Phase II, randomized, double-blind, placebo-controlled pilot study will evaluate the effects of fisetin, a senolytic flavonoid compound, on lung function and biomarkers of cellular senescence in older adults aged 60 years…
- Trial name
- OLD AIR (NCT07676435)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Low Grade Glioma, Glioblastoma Multiforme
(11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas
Background: The blood-brain barrier helps to protect the central nervous system (brain and spinal cord) from harmful toxins, but also prevents potentially useful chemotherapy from reaching brain tumors.
- Conditions
- Low Grade Glioma, Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma
- Trial name
- NCT01281982
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
ICU Anemia, Functional Iron Deficiency
Randomized Study Comparing Ferric Carboxymaltose to Iron Sucrose to Treat Fe Deficiency in the Surgically Critically Ill
Critically ill surgical patients are observed to have a functional iron deficiency which contributes to anemia, iron-deficient erythropoiesis, and an increased red blood cell transfusion requirement.
- Trial name
- NCT02009943
- Testing
- Ferric carboxymaltose, Iron sucrose
- Where
- United States
- Sponsor
- Denver Health and Hospital Authority
Renal Cell Carcinoma (Kidney Cancer)
Patient Reported Outcomes and Different Renal Artery Clamping Techniques During Robot Assisted Kidney Resection
The target population for this study consists of all patients undergoing kidney surgery at Haukeland University Hospital, Norway, with the primary focus being patients undergoing robot-assisted partial nephrectomy.
- Trial name
- RAPTOR (NCT07853001)
- Testing
- Standard clamping strategy, Early declamping strategy
- Where
- Norway
- Volunteers
- 130 people
- Sponsor
- Bjarte Almas
Metastatic Melanoma
Local Modulation of Immune Receptors to Enhance the Response to Dendritic Cell Vaccination in Metastatic Melanoma
Our proposed study is designed to test the safety of a new vaccine against melanoma. The induction of immune activity against cancers such as melanoma is a promising approach to cancer treatment, but to date, only a few…
- Trial name
- NCT01216436
- Testing
- Vaccination with RNA-transfected mature autologous DC
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Duke University
Recurrent Glioblastoma
Individualized Systems Medicine Functional Profiling for Recurrent Glioblastoma
A study to determine the feasibility and safety of individualized cancer stem cell targeted therapy based on high-throughput functional profiling of FDA/EMA-approved drugs in patients with GBM that has recurred or progressed…
- Trial name
- ISM-GBM (NCT05043701)
- Testing
- Personalized drug combination
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Thyroid Neoplasms, Carcinoma, Papillary
Hybrid Endoscopic Hemithyroidectomy and Targeted Ablation for Bilateral Papillary Thyroid Carcinoma
This study evaluates a thyroid-function-preserving alternative to routine total thyroidectomy for bilateral papillary thyroid carcinoma (PTC).
- Trial name
- NCT07033572
- Testing
- Endoscopic Hemithyroidectomy with Central-Neck Dissection, Ultrasound-Guided Radiofrequency Ablation of Contralateral Nodule
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fujian Medical University
Astrocytoma, Glioma
Qualitative, Qualitative, and Functional Studies Over the First Year in Measuring Immune System Response During the First Year of Therapy in Patients With Brain Tumors
This research trial studies qualitative, qualitative, and functional studies over the first year in measuring immune system response in patients with brain tumors.
- Conditions
- Astrocytoma, Glioma, Oligodendroglioma
- Trial name
- NCT02747407
- Testing
- Hepatitis A Vaccine, Laboratory Biomarker Analysis, Tetanus Toxoid Vaccine
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes
Characterization of the Variability Of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Prediabetes
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT01663207
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Foundation for the National Institutes of Health
Liver Cancer
Bone Marrow Derived Adult Liver Stem Cell Recruitment After Major Liver Resections: Correlation With Liver Regeneration and Hepatic Function
The results of this study may or may not establish useful baseline data, which will help us understand how bone marrow derived adult liver stem cells behave in normal healthy adults/volunteers (the control group), and in patients…
- Trial name
- NCT00605800
- Testing
- blood drawn
- Volunteers
- healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Insulin Resistance Syndrome X, Pancreatic Beta Cell Function
Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion
A prolonged elevation of plasma free fatty acids (FFA) impairs glucose stimulated insulin secretion. The concept of fatty acid impairment of glucose stimulated insulin secretion (lipotoxicity) has now been well accepted.
- Trial name
- NCT00188773
- Testing
- N-acetylcysteine, intralipid, heparin
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Peripheral Arterial Diseases
Effect of Cilostazol Endothelial Progenitor Cells and Collateral Formation in Peripheral Occlusive Artery Disease (PAOD)
1. The number and function of circulating endothelial progenitor cells (EPCs) are inversely associated with coronary risk factors and atherosclerotic diseases such as PAOD. 2.
- Trial name
- NCT01952756
- Testing
- Cilostazol
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- National Cheng-Kung University Hospital
Sjogren's Syndrome
Functional Analysis of Salivary Glands and Correlation With Sialoscintigraphy in Sjogren's Syndrome
Sjögren's syndrome is a complex autoimmune disorder. The investigators hypothesize that striated ductal cells may function as non-professional antigen-presenting cells in Sjögren's syndrome.
- Trial name
- NCT06536075
- Testing
- Sialoscintigraphy
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma
To Decrease Fatigue With Light Therapy
Cancer related fatigue (CRF) is one of the most prevalent and distressing long-term complaints reported by (non-) Hodgkin survivors.
- Trial name
- SPARKLE (NCT03242902)
- Testing
- Light therapy intensity 1, Light therapy intensity 2
- Where
- 9 sites in Netherlands
- Volunteers
- 166 people
- Sponsor
- The Netherlands Cancer Institute
Relapse Remitting Multiple Sclerosis
Deficient T Regulatory Cell (Treg) Function in Patients With Relapsing Remitting Multiple Sclerosis
The purpose of this research is to find out how the T regulatory (Treg) cells control autoimmune response in multiple sclerosis.
- Trial name
- NCT04857489
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
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