Clinical trials: Cell Invasion
Metastatic Cancer, Local Tumor Invasion
A Study to Examine the Value of Broad Agnostic Next Generation Sequencing (NGS) Panel Testing Versus Reimbursed Organ-directed NGS: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Center
Title of the study A study to examine the value of broad agnostic NGS panel testing versus reimbursed organ-directed NGS: a Belgian Precision study of the BSMO in collaboration with the Cancer Centre Study Number BSMO 2020-1…
- Trial name
- NCT04641676
- Testing
- NGS testing
- Where
- 12 sites in Belgium
- Volunteers
- 1,000 people
- Sponsor
- The Belgian Society of Medical Oncology
Non-small Cell Lung Cancer, Spread Through Air Space
Deep Learning Signature for Predicting Aggressive Histological Pattern in Resected Non-small Cell Lung Cancer
The purpose of this study is to evaluate the performance of a PET/ CT-based deep learning signature for predicting aggressive histological pattern in resected non-small cell lung cancer based on a multicenter prospective cohort.
- Conditions
- Non-small Cell Lung Cancer, Spread Through Air Space, Visceral Pleural Invasion, Lymphovascular Invasion
- Trial name
- NCT05925738
- Testing
- PET/CT-based Deep Learning Signature
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Cutaneous Squamous Cell Cancer
Correlation of Dermoscopic Findings With Histopathological Features and Invasion Depth in Cutaneous Squamous Cell Carcinoma
This is a retrospective study including patients diagnosed with cutaneous squamous cell carcinoma between 2016 and 2025. Demographic, clinical, histopathological, and dermoscopic data were obtained from hospital records.
- Trial name
- SCC-DERM (NCT07384949)
- Where
- Turkey (Türkiye)
- Volunteers
- 238 people
- Sponsor
- Istanbul Training and Research Hospital
Gastric Cancer, Chemoradiation
Feasibility Trial of Neoadjuvant Chemoradiotherapy for Locally Advanced Gastric Cancer
Because locally far-advanced gastric cancer combined with adjacent tissue invasion has a poor prognosis, some phase 2 and 3 clinical trials of neoadjuvant chemotherapy (NAC) are performed in Japan.
- Trial name
- NCT01381913
- Where
- Japan
- Volunteers
- 12 people
- Sponsor
- Kagawa University
Laryngeal Cancer, Hypopharyngeal Cancer
The Role of MMPs in the CXCL12-Induced Invasion of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma
Investigate the role of MMPs in the CXCL12-induced invasion of laryngeal and hypopharyngeal squamous cell carcinoma
- Trial name
- NCT00302562
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Liver Cirrhosis, Liver Cancer
Development of a Set of Auxiliary Decision-making System for the Perioperative Period of Hepatectomy Based on Static CT and Artificial Intelligence.
The study will prospectively recruit patients with chronic liver disease and liver cancer for static CT scans to establish a high-definition CT database.
- Trial name
- NCT07056270
- Testing
- static CT scans
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Bladder Cancer
Validation of VI-RADS for the Detection of Detrusor Muscle Invasion
To evaluate the accuracy of Multiparametric MRI in differentiation between invasive and non-invasive bladder cancer using vesical imaging reporting and data system (VI-RADS) score.
- Trial name
- NCT05123404
- Testing
- multi parametric MRI, transurethral resection of bladder tumor
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Egyptian Biomedical Research Network
Breast Cancer
PiA: Prognosis Used Every Day for Patients With Operable Breast Cancer - Comparison of Invasion Factors uPA/PAI-1 With Other Prognostic Factors
The improvement of the healing rates for breast cancer is based to an important part on the consistent use of so-called adjuvant ("supporting ") medicamentous therapies, including chemotherapy.
- Trial name
- PiA (NCT01592825)
- Volunteers
- 1,000 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Pregnancy, Polycystic Ovary Syndrome
Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women
A more recent prospective nonrandomized placebo-controlled double-blind clinical study demonstrated that metformin exerts a slight but significant deleterious effect on serum homocysteine (Hcy) levels in patients with PCOS, and…
- Trial name
- NCT01115140
- Testing
- Metformin plus folic acid
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Oral Squamous, Cell Carcinoma
Radio/Pathological Evaluation of Tongue Cancer Infiltration
The aim of the study is to assess the good correlation and prediction of the DOI for the post-operative pathological results and prognosis.
- Trial name
- RaP E ToC (NCT04821128)
- Testing
- Radiologic and pathological review.
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Adenocarcinoma of Lung
Differentiating the Invasiveness of Lung Adenocarcinoma by Dual Energy CT Parameter
The core purpose of this study is to investigate whether the extracellular volume (ECV) fraction measured in delay phase by dual energy computed tomography (DECT) can distinguish precancerous lesions from early-stage lung…
- Trial name
- NCT06441357
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Tang-Du Hospital
Advanced Hepatocellular Carcinoma
Concurrent Nivolumab and External Beam Radiation Therapy for Patients With Advanced HCC
To investigate the efficacy and safety of nivolumab for patients with advanced HCC undergoing EBRT
- Trial name
- Nextrah (NCT04611165)
- Testing
- Nivolumab
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Gastric Tumor, Early Gastric Cancer
Endoscopic Ultrasonographic Staging and Conventional Endoscopic Staging for Depth of Invasion for Early Gastric Cancer
The accurate prediction of depth of tumor invasion in early gastric cancer is essential for the proper selection of candidates for endoscopic resection.
- Trial name
- NCT01832246
- Where
- South Korea
- Volunteers
- 560 people
- Sponsor
- Seoul National University Hospital
Colonic Lesions
Prospective Image Collection of Colorectal Polyps.
It concerns a study in which we wish to collect images and corresponding histological information (microscopic characteristics) in a prospective manner in various European and non-European centers (multicentric).
- Trial name
- NCT07401264
- Where
- Belgium
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cancer of Mouth, Cancer of the Tongue
Adjuvant Radiotherapy in Early Stage Oral Cancers
This study will assess the benefit of postoperative adjuvant radiotherapy in patients with an early oral squamous cell carcinoma (OSCC) having tumor thickness more than or equal to 5mm.
- Conditions
- Cancer of Mouth, Cancer of the Tongue, Cancer of the Head and Neck, Buccal Mucosa Cancer
- Trial name
- AREST (NCT03853655)
- Testing
- Post-operative adjuvant radiotherapy
- Where
- 8 sites in India
- Volunteers
- 392 people
- Sponsor
- Tata Memorial Hospital
Hypoxia, Autophagy
Hypoxia-induced Autophagy in the Pathogenesis of MAP
To investigate the role of HIF 1α and LC3B in the pathogenesis of MAP, to evaluate the role of MMP-9 in the antenatal prediction of MAP, and to compare the expression of HIF1α, LC3B, and level MMP-9 between patients of placenta…
- Conditions
- Hypoxia, Autophagy, Placenta, Morbidly Adherent Placenta
- Trial name
- NCT05817448
- Testing
- HIF 1α and LC3B expression and MMP-9 level
- Volunteers
- 80 people
- Sponsor
- Assiut University
Obstetric Labor Complications, Staging of Placental Invasion
Ultrasound Staging in the Placenta Accreta
The investigators evaluated the efficacy of a staging system introduced by the American Institute of ultrasound in medicine 2015 including sonographic parameters associated with morbidly adherent placenta for antenatal prediction…
- Trial name
- NCT04253197
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Beni-Suef University
Hepatocellular Carcinoma Resectable, Surgery
Compare the Accuracy of ctDNA-MRD and MVI Result in Predicting Postoperative Recurrence of Hepatocellular Carcinoma
The aim of this study was to compare the accuracy of ctDNA-MRD longitudinal surveillance model and internationally accepted pathological MVI results in predicting recurrence after radical hepatectomy.
- Conditions
- Hepatocellular Carcinoma Resectable, Surgery, Recurrence
- Trial name
- NCT06449846
- Testing
- circulating tumor cell DNA detection
- Where
- 4 sites in China
- Volunteers
- 152 people
- Sponsor
- Zhujiang Hospital
Hepatocellular Carcinoma
Postoperative Adjuvant Sintilimab in Hepatocellular Carcinoma With Microvascular Invasion
To compare the impact on recurrence risk of adjuvant Sintilimab (a recombinant fully human anti-PD-1 monoclonal antibody) for patients with hepatocellular carcinoma and microvascular invasion (MVI) after hepatectomy.
- Trial name
- NCT06089369
- Testing
- Sintilimab (9 cycles), Sintilimab (18 cycles), Active surveillance
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Tongji Hospital
Placenta Percreta, Bladder Injury
Bladder Suture in Uterus-Sparing Surgery and Hysterectomy for Placenta Percreta
This study aimed to evaluate the short-term and long-term complications of placenta percreta with bladder invasion. This evaluation focuses on cases where bladder dissection and ACAR-style bladder sutures were applied in cases of…
- Conditions
- Placenta Percreta, Bladder Injury, Sutures
- Trial name
- NCT06267599
- Testing
- ACAR-Style Bladder Suture
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Necmettin Erbakan University