Clinical trials: Cell Invasion
Malignant Neoplasm of Skin Head and Neck
Photon/Proton Radiation Therapy for Carcinoma of the Skin of the Head and Neck
The purpose of this study is to collect information from the questionnaire and your medical records to see what effects the proton radiation has on you and your cancer and collect and analyze morbidity outcomes: Incidence of…
- Trial name
- SK01 (NCT00797043)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Florida
Lymphoma, Non-Hodgkin, Diffuse Large B-cell Lymphoma
Phase II Study to Evaluate the Combination of Rituximab and DepoCyte® in the C5R Chemotherapy Protocol in Patients Between the Ages of 18 and 60 Years With Primary Cerebral Non-Hodgkin Lymphoma and Systemic Diffuse Large B-cell Lymphoma With Neuromeningeal Invasion at Diagnosis
The purpose of this study is to measure the rate of complete response (CR and UCR) at the end of a course of immuno-chemotherapy: before cerebral radiotherapy for PCL after the course of immuno-chemotherapy for aggressive…
- Trial name
- NCT00553943
- Testing
- Rituximab, Cytarabine
- Where
- 46 sites in Belgium, France
- Volunteers
- 60 people
- Sponsor
- Lymphoma Study Association
Squamous Cell Carcinoma Mouth
Primary Tumor Depth of Invasion and Lymph Node Management in Oral Squamous Cell Carcinoma
To evaluate the diagnostic accuracy of preoperative MRI in the determination of the primary tumor depth of invasion (DOI) as a predictor factor in neck lymph nodes management in T1T2N0 oral cavity squamous cell carcinomas as…
- Trial name
- NCT07127614
- Testing
- MRI, Histo-Pathological examination of the resected tumor tissues
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Al-Azhar University
Carcinoma, Hepatocellular, Hepatocellular Cancer
Vascular Invasion Prediction Via a Multimodal Model Supports Re-staging of Early-stage Hepatocellular Carcinoma
Effective strategies for personalized treatment decisions for early-stage hepatocellular carcinoma (HCC) remain critically limited. Microvascular invasion (MVI) is a distinctive pathological hallmark of HCC invasiveness.
- Conditions
- Carcinoma, Hepatocellular, Hepatocellular Cancer, Liver Cancer
- Trial name
- NCT05540925
- Testing
- Curative-intent liver resection
- Where
- China
- Volunteers
- 3,650 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Placenta Accreta
Comparison Between the Role of Transabdominal Ultrasound Versus Transvaginal Ultrasound in Evaluation of Placental Invasion in Cases of Placenta Previa Anterior Wall With Previous Uterine Scar
Objective: To compare between the role of Transabdominal ultrasound versus Transvaginal ultrasound in evaluation of placental invasion in cases of placenta previa anterior wall with previous uterine scar applying the unified…
- Trial name
- NCT03437291
- Testing
- Cesarean section, Transabdominal ultrasound, Transvaginal ultrasound
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Hepatocellular Carcinoma
Sorafenib VS TACE in HCC Patients With Portal Vein Invasion
The investigators are going to compare the therapeutic effect of sorafenib and transarterial chemoembolization in advanced hepatocellular carcinoma with major branch of portal vein invasion.
- Trial name
- NCT01480817
- Testing
- Sorafenib, TACE for HCC with portal vein invasion
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Seoul National University Hospital
Pancreatic Cancer
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence
The primary objective is to develop a rapid in vitro screening assay for detection of pancreatic cancer biomarkers in blood of patients with pancreatic cancer.
- Trial name
- NCT01707758
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kansas
Healthy
Inflammation, Intracellular Invasion and Colonization of the Nasal Mucosa by Staphylococcus Aureus
An inflammatory state of the nasal cells (very close to keratinocytes) could favour the internalization of Staphylococcus aureus and thus constitute a persistent reservoir for the carriage of this bacterium.
- Trial name
- I3COSa (NCT04469348)
- Testing
- nasal swab
- Where
- France
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hepatocellular Carcinoma, Lenvatinib
Study of TACE Combined With Lenvatinib to Prevent Postoperative Recurrence in Patients With MVI Positive HCC
single-center clinical trial studies have verified the safety and effectiveness of transcatheter arterial chemoembolization (TACE) combined with lenvatinib in preventing postoperative recurrence of microvascular invasion (MVI)…
- Trial name
- NCT04911959
- Testing
- Lenvatinib, TACE
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cholangiocarcinoma Non-resectable
Preoperative Right Hepatic Artery Embolization for Locally Advanced Bismuth IIIb and IV Perihilar Cholangiocarcinoma
This is a prospective, multicenter, single-arm study investigating the efficacy and safety of preoperative right hepatic artery embolization (PHAE) followed by surgical resection in patients with locally advanced Bismuth IIIb or…
- Trial name
- PHAE-PHCC (NCT07326189)
- Testing
- Preoperative Right Hepatic Artery Embolization
- Volunteers
- 33 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Endometrial Endometroid Carcinoma
Assessing Uterine Ultrasound Done as a Diagnostic Tool for the Depth of Carcinoma Invasion
In this study the investigators aim to assess the diagnostic performance of intraoperative, ultrasonographic assessment of the surgical extracted uterus for determining myometrial invasion's depth in comparison to preoperative…
- Trial name
- NCT02407535
- Testing
- Intraoperative ultrasound
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Carmel Medical Center
Carcinoma, Hepatocellular
Adjuvant Therapy With Apatinib for HCC Patients With PVTT Who Underwent Radical Resection
In this phase 2 study, we aim to evaluate the effects and safety of adjuvant apatinib therapy for the patients who underwent R0 resection for hepatocellular carcinoma with portal vein tumor thrombus.
- Trial name
- NCT03261791
- Testing
- Apatinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Cancer of the Uterine Cervix
Magnetic Resonance Imaging (MRI) Staging of Cervix Cancer
The researchers propose that it may be corpus invasion, rather than tumour volume per se, which is one of the important determinants of ultimate outcome in cervix cancer.
- Trial name
- NCT00193934
- Where
- 16 sites in United States, Australia and 3 more
- Volunteers
- 109 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Rectal Neoplasms, Prognosis
Application of Multimodal MRI in Histological Grading and Prognostic Assessment of Rectal Cancer
Rectal cancer (RC) is among the most prevalent gastrointestinal cancers [1], characterized by significant tumor heterogeneity [2].
- Trial name
- NCT07269912
- Testing
- intravoxel incoherent motion magnetic resonance imaging
- Volunteers
- 400 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Glioblastoma, Glioma, Malignant
Grafts of GSCs Into Brain Organoids for Testing Anti-invasion Drugs
In patients operated for glioblastoma, glioma stem-like cell lines will be obtained from tumor tissue, and IPSCs from skin fibroblasts or PBMCs.
- Trial name
- 2253 (NCT05772741)
- Testing
- Biological sample collection
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer, HER2-negative Breast Cancer
Clinical Study of Breast Conserving Surgery Combined With Intraoperative Radiotherapy for Early Breast Cancer
A Single-center, open, prospective study，for analyzing the local recurrence rate, the incidence of incision complications and the aesthetic effect of intraoperative radiotherapy in early breast cancer patients after…
- Trial name
- NCT06375798
- Testing
- radiotherapy
- Where
- China
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- Hebei Medical University Fourth Hospital
Advanced Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8
Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial
This phase III trial compares the effect of immunotherapy (IO) with stereotactic body radiation therapy (SBRT) to IO alone in treating patients with liver cancer (hepatocellular cancer) that may have spread from where it first…
- Conditions
- Advanced Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8, Stage IV Hepatocellular Carcinoma AJCC v8
- Trial name
- NCT07166406
- Testing
- Atezolizumab, Bevacizumab, Biospecimen Collection
- Where
- 139 sites in United States, Canada
- Volunteers
- 226 people
- Sponsor
- NRG Oncology
Recurrence of HCC After LDLT
Single Center Experience Over a Decade in Living Donor Liver Transplantation for Egyptian Patients With Hepatocellular Carcinoma: Stretching the Limits
Within community with high incidence of HCC, stretching the limits could be justified based on tumor characters and its biological behavior
- Trial name
- NCT01937286
- Where
- Egypt
- Volunteers
- 590 people
- Sponsor
- Ain Shams University
Hepatocellular Carcinoma
Comparison of TACE Versus TACE/TACI Combination in Advanced Hepatocellular Carcinoma With Portal Vein Invasion
The aim of this study is to compare the efficacy of transarterial chemoembolization with adriamycin to transarterial chemoembolization with adriamycin/transarterial chemoinfusion with cisplatin combination in advanced…
- Trial name
- NCT01857726
- Testing
- Doxorubicin, Cisplatin
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Preeclampsia
Maternal Serum Stathmin-1 Levels in Preeclampsia
The goal of this observational study is to investigate maternal serum Stathmin-1 levels in pregnancies affected by preeclampsia compared to healthy gestations. The main questions it aims to answer are: 1.
- Trial name
- MSSLP (NCT06481683)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Burak Yücel Special Clinic