Clinical trials: Cell Invasion
Locally Advanced Rectal Cancer
Neoadjuvant mFOLFOXIRI Chemotherapy Alone for Extramural Vascular Invasion Positive Locally Advanced Rectal Cancer
Extramural Vascular Invasion Positive(EMVI+) is a high risk of distant metastasis for locally advanced rectal cancer(LARC) after resection.
- Trial name
- NCT04170530
- Testing
- mFOLFOXIRI
- Where
- China
- Volunteers
- 51 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Pancreas Cancer
Preoperative/Neoadjuvant Therapy and Vascular Debranching Followed by Resection for Locally Advanced Pancreatic Cancer
Pancreatic cancer continues to have a poor prognosis. Many patients are diagnosed with advanced disease. In a considerable proportion of these patients, the tumor has contact with or invades into arterial blood vessels supplying…
- Trial name
- PREVADER (NCT04136769)
- Testing
- Visceral Debranching
- Where
- 3 sites in Germany
- Volunteers
- 3 people
- Sponsor
- Ulrich Ronellenfitsch, MD
Central Nervous System Embryonal Neoplasm
Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Genetic study to learn more about genes involved in the development of central nervous…
- Trial name
- NCT00010114
- Where
- 9 sites in United States
- Volunteers
- 83 people
- Sponsor
- Pediatric Brain Tumor Consortium
Early Gastric Cancer
A Clinical Trial to Evaluate the Sensitivity and Specificity of "WAYMED Endo" Compared to the Endoscopists in Classifying Early Gastric Cancer (EGC) Based on the Depth of Invasion in Endoscopic Images
The purpose of this clinical trial is to prove that the prediction capability of 'WAYMED endo' is superior to that of the endoscopists in classifying EGC based on the depth of invasion categories in gastro-endoscopic images.
- Trial name
- NCT06317103
- Testing
- WADYMED endo, Control group (the endoscopists)
- Where
- South Korea
- Volunteers
- 653 people
- Sponsor
- WAYCEN Inc
Hepatocellular Carcinoma (HCC), Solitary Mass
Ten-Year Outcomes of Operable Solitary Hepatocellular Carcinoma Patients: Impact of Tumor Size Over 6.5 cm and Microvascular Invasion
The goal of this study is to evaualte the impact of tumor size and microvascular invasion among patients with solitary hepatocellualr carcinoma and post operation.
- Trial name
- NCT06628661
- Testing
- Surgery for HCC larger than 6.5 cm, Surgery for HCC larger than 2 cm
- Where
- Taiwan
- Volunteers
- 3,000 people
- Sponsor
- Chang Gung Memorial Hospital
Pancreas Cancer
A New Scoring System for Perineural and Vascular Invasion in Pancreatic Cancer
The aim of this study is to validate both retrospectively and prospectively a newly proposed scoring system for perineural and vascular invasion in pancreatic ductal cancer and correlate it with disease free survival, early…
- Trial name
- VANISSh (NCT04024358)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Massimo Falconi
Cervical Cancer
Detection of Loco-regional Invasion of Cervical Cancer With 7 Tesla MRI
Background of the study: The accurate assessment of local cervical cancer spread (i.e. invasion) is of clinical importance for staging and treatment considerations.
- Trial name
- DETECT (NCT02083848)
- Testing
- 7T MRI
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- UMC Utrecht
Upper Tract Urothelial Carcinoma
OptiCross HD IVUS for Assessing Invasion Depth in Upper Tract Urothelial Carcinoma
Upper tract urothelial carcinoma (UTUC) is difficult to stage accurately because cross-sectional imaging and ureteroscopic biopsy may not reliably demonstrate muscular or periureteral invasion.
- Trial name
- NCT07751796
- Testing
- OptiCross HD Coronary Imaging Catheter
- Volunteers
- 15 people
- Sponsor
- Yonsei University
Lymph Node Metastasis, Neurovascular Invasion
Adjuvant Immunotherapy Combined With ChemoRadiation for Patients With High-risk Resectable Extrahepatic Cholangiocarcinoma（AICRC）
The purpose of this prospective, observational study is to investigate whether adjuvant chemoradiotherapy combined with immunotherapy for high-risk recurrence populations after extrahepatic cholangiocarcinoma resection can…
- Conditions
- Lymph Node Metastasis, Neurovascular Invasion, Pathology Showed R1 Resection
- Trial name
- AICRC (NCT06997913)
- Testing
- Adjuvant Immunotherapy Combined With ChemoRadiation for Patients With High-risk resectable Extrahepatic Cholangiocarcinoma（AICRC）
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Hengchao Yu
Hepatocellular Carcinoma
Sorafenib and TACE as Adjuvant Therapy for MVI in HCC Patients After Radical Resection
This study is a prospective non-randomized controlled study. The purpose of this study is to evaluate the validity and safety of sorafenib and transcatheter arterial chemoembolization (TACE) for microvascular invasion (MVI) in…
- Trial name
- NCT02537158
- Testing
- Sorafenib, TACE
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese Academy of Medical Sciences
Oral Squamous Cell Carcinoma
"Ultra-High Frequency intraOral UltraSonography of the TONgue" (HOUSTON)
Oral diseases are currently diagnosed by means of clinical examination and supported by surgical biopsy procedures. In particular, daily oral medicine practice is lacking the use of a routine diagnostic support to the…
- Trial name
- HOUSTON (NCT06336941)
- Testing
- Ultrasound
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University of Pisa
Hepatocellular Carcinoma
The Impact on Recurrence Risk of Adjuvant Lenvatinib for Patients With Hepatocellular Carcinoma And Microvascular Invasion (MVI) After Hepatectomy : A Random, Controlled, Stage III Clinical Trial.
To compare The Impact on Recurrence Risk of Adjuvant Lenvatinib for Patients With Hepatocellular Carcinoma And Microvascular Invasion (MVI) After Hepatectomy.
- Trial name
- NCT04053972
- Testing
- Lenvatinib
- Where
- China
- Volunteers
- 377 people
- Sponsor
- Sun Yat-sen University
Hepatocellular Carcinoma, Obstructive Jaundice
Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma
The prognosis of patients with obstructive jaundice caused by hepatocellular carcinoma (HCC) is dismal even after biliary drainage; due to malfunction of the biliary drainage tube caused by hemobilia and/or tumor emboli.
- Trial name
- NCT01506115
- Testing
- Photofrin
- Where
- South Korea
- Volunteers
- 11 people
- Sponsor
- Samsung Medical Center
Breast Cancer
Comparison of Diagnostic Performance of an Algorithm and a High Definition Classical Iterative Algorithm Positron Emission Tomography (PET) to 18Fluoro-deoxy-glucose (18FDG) in the Evaluation of Axillary Lymph Node Invasion of Breast Tumors
The primary endpoint of this study is to show that this algorithm in high definition is superior to the classical algorithm in the diagnosis of lymph node metastases.
- Trial name
- TEP-Sein (NCT01436591)
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Centre Francois Baclesse
Bladder Cancer
Preoperative Detection of Muscle Invasion in Bladder Cancer with Contrast-enhanced Ultrasonography
To evaluate the diagnostic accuracy of CEUS for the preoperative staging of bladder cancer, which would benefit the implementation of efficient therapeutic strategies.
- Trial name
- NCT05204108
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
GI Cancer
Improving Diagnosis and Treatment for Patients With Rectal Cancer
The cancer stage information from scans guides pre-operative treatment and the type of surgery offered. The investigators are studying whether a new Magnetic Resonance Imaging (MRI) staging method can improve the accuracy of…
- Trial name
- MERCURY 3 (NCT07054047)
- Testing
- mrTDV
- Where
- 3 sites in United Kingdom
- Volunteers
- 438 people
- Sponsor
- Imperial College London
Placental Insufficiency
Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation
To establish wether a prophylactic intervention from first trimester with low-dose of aspirin improves trophoblastic invasion evaluated at third trimester in women defined as high-risk by abnormal uterine artery Doppler at first…
- Trial name
- ASAP (NCT01616615)
- Testing
- Aspirin
- Where
- 3 sites in Spain
- Volunteers
- 190 people
- Sponsor
- Sara Varea
Hepatocellular Carcinoma, Recurrence
Sorafenib Treatment in Patients With Hepatocellular Carcinoma With Microvascular Invasion After Radical Resection
This prospective multicenter non-randomized controlled study evaluates the efficacy and safety of treatment with Sorafenib (Nevaxar) in patients with hepatocellular carcinoma with microvascular invasion after radical resection…
- Trial name
- NCT02867280
- Testing
- Sorafenib
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Sun Yat-sen University
Rectal Adenocarcinoma
Reporting of Tumour Deposits in Colorectal Cancer by Radiology and Pathology
Recent research shows that tumour deposits-small spots of cancer found near the main bowel tumour-may give doctors important information about how aggressive the cancer is and how likely it is to come back.
- Trial name
- RADAR (NCT07345273)
- Testing
- No Intervention: Observational Cohort
- Where
- 4 sites in United Kingdom
- Volunteers
- 225 people
- Sponsor
- Imperial College London
Prostate Cancer (Diagnosis), Prostate-specific Membrane Antigen
Intratumoral Heterogeneity on [18F]PSMA and [18F]FDG PET/CT in Predicting Invasion and Prognosis of Prostate Cancer
The purpose of this study is to analyze heterogeneity of prostate cancer（PCa）based on the head-to-head imaging of prostate-specific membrane antigen (PSMA) and fluorodeoxyglucose (FDG) positron emission tomography computed…
- Conditions
- Prostate Cancer (Diagnosis), Prostate-specific Membrane Antigen, Positron Emission Tomography (PET)
- Trial name
- NCT06919159
- Testing
- PSMA PET/CT scan, FDG-PET
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Jiequn Yu