Clinical trials: Cell Invasion
Carcinoma, Hepatocellular
Adjuvant TACE to Reduce the HCC Recurrence After Resection
Hepatocellular carcinoma (HCC) is the sixth most common malignancies worldwide and the second leading cause of cancer-related death.
- Trial name
- NCT02788526
- Testing
- Adjuvant TACE, Follow-up
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Sun Yat-sen University
Placenta Accreta, Placenta Previa
Placenta Accreta New Detection Procedure by Rapid Assessment of Serum BNP
The placenta accreta is defined as a placenta that is abnormally adherent to the myometrium. It can thus invade the entire thickness of the myometrium (placenta increta) or even exceed the serosa and invade neighboring organs…
- Conditions
- Placenta Accreta, Placenta Previa, Normal Pregnancy
- Trial name
- PANDORA (NCT04215484)
- Testing
- serum BNP assessment
- Where
- Tunisia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ben marzouk Sofiene
Hepatocellular Carcinoma
Non-invasive Prediction of Microvascular Invasion in Hepatocellular Carcinoma by Blood-Oxygen-Level Dependent Magnetic Resonance Imaging (BOLD MRI)
Liver resection and liver transplantation are the acceptable treatment of Hepatocellular Carcinoma (HCC). But the long-term survival is unsatisfactory as a result of high rate of intra and extra hepatic recurrences.
- Trial name
- NCT00963612
- Testing
- BOLD MRI test
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University Health Network, Toronto
Hepatocellular Carcinoma
Preoperative Estimation of Microvascular Invasion in Hepatocellular Carcinoma
Presence of microvascular invasion can be estimated preoperatively, by some clinical imaging features such as patient characteristics, serum biomarkers and radiological features.
- Trial name
- NCT03110068
- Testing
- contrast-enhanced ultrasound, contrast-enhanced computed tomography
- Volunteers
- 370 people
- Sponsor
- Ming Kuang
Head and Neck Cancer, Multiparametric MRI
Use of Multiparametric MRI in the Management of Head and Neck Cancer: a Prospective Analysis
The investigators aim to validate specific MRI parameters that could improve diagnostic accuracy of metastatic cervical lymph nodes in patients with a squamous cell carcinoma in the head and neck region.
- Conditions
- Head and Neck Cancer, Multiparametric MRI, Cervical Lymph Node, Bone Invasion
- Trial name
- NCT03993665
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- AZ Sint-Jan AV
Endometrial Cancer
Unusual Infiltrative Patterns of Malignant Cells in Endometrial Carcinoma and Immunohistochemical Expression of P53
The goal of this observational study is to clarify the significance of TB, PDC, DR, MELF, and immunohistochemical expression of those infiltrative patterns in patients with endometrial carcinomas (EC).
- Trial name
- NCT05755893
- Volunteers
- 100 people
- Sponsor
- Assiut University
Placenta Accreta Spectrum, Placenta Accreta
Evaluation of Cervical Invasion and Length in Placenta Accreta Patients
Placenta accreta spectrum (PAS), also called morbidly adherent placenta, is a serious pregnancy problem where the placenta attaches too deeply to the uterus wall and does not come out normally after birth.
- Conditions
- Placenta Accreta Spectrum, Placenta Accreta, Placenta Previa
- Trial name
- NCT07452185
- Volunteers
- 200 people
- Sponsor
- Sohag University
Prostate Cancer
Cystoprostatectomy Versus Radiotherapy Combined With ADT for the Treatment of cT4 Prostate Cancer With Bladder Invasion
Prostate cancer is the most common male cancer in global, which accounts for 19% of the total and poses great hazards to male health.
- Trial name
- CRADT (NCT03482089)
- Testing
- Cystoprostatectomy, external beam radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Tongji Hospital
Hepatocellular Cancer
A Randomized Phase II Trial of Surgery Plus Sorafenib vs. Sorafenib Alone for Hepatocellular Cancer (HCC) With Portal Vein Invasion
Patients with HCC with portal vein involvement not involving the bifurcation (vP1-vP3) and no evidence of extra-hepatic spread will be enrolled.
- Trial name
- NCT03971201
- Testing
- hepatic resection, Sorafenib
- Where
- China
- Volunteers
- 200 people
- Sponsor
- White Plains Hospital
Non-Small Cell Lung Cancer
SERPIN D1 and Its Role in Lung Cancer Invasion and Metastasis
To evaluate the correlation between SERPIN D1 expression in clinical specimen (including surgical specimen and blood sample) and lung cancer metastasis.
- Trial name
- NCT00155116
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Surgically Staged Endometrial and Cervical Carcinoma, Cervical Cancer: Invasive Disease, FIGO Stage 1B1 or Higher
Diagnostic Accuracy of MRI, DWI MRI, FDG-PET/CT and FEC PET/CT in the Detection of Lymph Node Metastases in Surgically Staged Endometrial and Cervical Carcinoma
This is a prospective diagnostic performance study which compares three new imaging methods with the current standard imaging method for the diagnosis of metastatic lymph nodes.
- Conditions
- Surgically Staged Endometrial and Cervical Carcinoma, Cervical Cancer: Invasive Disease, FIGO Stage 1B1 or Higher, Endometrial Cancer, Stage 1A With Myometrial Invasion or Any Higher Stage and Grade 3
- Trial name
- MAPPING (NCT01836484)
- Testing
- Diffusion-weighted MRI, Fluorodeoxyglucose-18-PET/CT, Fluoro-ethyl-coline-PET/CT
- Where
- 7 sites in United Kingdom
- Volunteers
- 162 people
- Sponsor
- Barts & The London NHS Trust
Chemotherapy Effect
A Study of Postoperative Adjuvant Chemotherapy for Upper Urinary Urothelial Carcinoma With Lymphovascular Invasion
This project is to explore the effect of adjuvant chemotherapy on total tumor survival time, progression-free survival time, and recurrence-free survival time in patients with pTanyN0M0 upper urinary urothelial carcinoma with…
- Trial name
- NCT04255771
- Testing
- Gemcitabine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Qinghua Xia,Prof
Predictive Cancer Model, Pancreas Cancer
A Preoperative Model to Predict the Lymphovascular Invasion in Pancreatic Ductal Adenocarcinoma
Importance: Lymphovascular invasion (LVI) is a poor prognosis pathologic feature in pancreatic ductal adenocarcinoma (PDAC) patients. Neoadjuvant therapy may bring survival benefits to these patients.
- Trial name
- NCT05997147
- Where
- China
- Volunteers
- 1,009 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Cell Migration, Cell Invasion
This Repeated Measures Parallel-group Investigation Will Examine the Influence of Short-term Melatonin Supplementation (5mg, 3 x Day for 72 Hours) on Cellular Responses, Functional Performance and Recovery Following an Acute Bout of Dynamic Resistance Exercise in Resistance Trained Men and Women
Oral Melatonin is a commercially available product available alone and as a constituent in a number of supplements. Previous research suggests that short-term supplementation with oral melatonin may amplify the recovery response…
- Conditions
- Cell Migration, Cell Invasion, Exercise Recovery
- Trial name
- NCT06617351
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Placenta Accreta With Bladder Invasion
Bladder Conservative Surgery in r Abnormally Invasive Placenta With Bladder Invasion
Placental borders and mapping by ultrasonography and Doppler ultrasonography (placental mapping) preop. And verified intraoperatively .
- Trial name
- NCT04263753
- Testing
- Bladder conservative surgery in placenta accretta
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Cavernous Sinus Invasion by Pituitary Adenoma
Evaluation of Cavernous Sinus Invasion by Pituitary Adenoma Using Deep Learning Based Denoising MR
Preoperative evaluation of cavernous sinus invasion by pituitary adenoma is critical for performing safe operation and deciding on surgical extent as well as for treatment success.
- Trial name
- NCT04268251
- Testing
- MRI with deep learning based denoising
- Where
- South Korea
- Volunteers
- 67 people
- Sponsor
- Asan Medical Center
Hepatocellular Carcinoma, Unresectable Hepatocellular Carcinoma
Chemoembolization With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery
This randomized phase III trial studies chemoembolization and sorafenib tosylate to see how well they work compared with chemoembolization alone in treating patients with liver cancer that cannot be removed by surgery.
- Trial name
- NCT01004978
- Testing
- Cisplatin, Computed Tomography, Doxorubicin Hydrochloride
- Where
- 281 sites in United States
- Volunteers
- 235 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer
Incidence of Unresectable Cases of Cervical Cancer
Objective : to calculate the incidence of unresectable cases of cervical cancer in gyne-oncology unit of Alexandria university hospital and to indentify its relation to pathological types, grading and lymph vascular space…
- Trial name
- NCT05537012
- Testing
- clinical and radiological staging, pathological types, grading and lymphovascular space invasion
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- HOSSAM ALSUKARI
Liver Cancer
A Prospective, Single-Arm, Open-Label Clinical Study of the Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Combined With Targeted Therapy and a PD-1 Inhibitor in Patients With Postoperative Hepatocellular Carcinoma and Microvascular Invasion
A Prospective, Single-Arm, Open-Label Clinical Study of the Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Combined with Targeted Therapy and a PD-1 Inhibitor in Patients with Postoperative Hepatocellular Carcinoma…
- Trial name
- NCT07790419
- Testing
- HAIC, Donafenib + lenvatinib+apatinib, Sintilimab+camrelizumab+tislelizumab
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhai Wenlong
Visual Impairment, Ocular Illness
Pupillometry and Locus Coeruleus Activation (PuLCA)
This project will apply non-invasive, trans-cutaneous vagal nerve stimulation using various stimulation parameters to young, healthy adults to find the optimal set of parameters to elicit pupil response.
- Trial name
- PuLCA (NCT04579653)
- Testing
- transcutaneous electrical nerve stimulation devices
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida