Clinical trials: Cell Invasion
Glioblastoma (GBM)
Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced Spread
The goal of this clinical trial is to learn if a combined treatment approach can treat glioblastoma (GBM) with ventricular invasion or meningeal metastasis in adults.
- Trial name
- NCT07193654
- Testing
- Intrathecal injection of thiotepa, Stupp regimen (oral temozolomide), Radical radiotherapy
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Urinary Bladder Tumour, MRI
Tumor Staging T of Bladder Tumours: Correlation of MRI and Anatomopathologic Analysis
Urinary bladder tumors with a frequency of 13000 new cases a year, have a heterogeneity in terms of survival according to the stage of local flooding. This is an aggressive tumor because of the potential muscular infiltration.
- Conditions
- Urinary Bladder Tumour, MRI, Invasion, Diagnosis
- Trial name
- IRMAA (NCT05464576)
- Testing
- MRI
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Colorectal Neoplasms
Observation of Microvessels and Invasion in Early Colorectal Lesions by NBI
Combined with magnifying endoscopy,narrow-band imaging (NBI) contrasts microvascular architecture on lesion surface.The histology of early colorectal lesions could be predicted under NBI view.However,its capability for estimating…
- Trial name
- NCT02047188
- Volunteers
- 418 people
- Sponsor
- Xiaobo Li
Hepatocellular Carcinoma
Adjuvant Radiotherapy for Resected Hepatocellular Carcinoma With MVI
Positive micro vascular invasion in early stage hepatocellular carcinoma(HCC) leads to early recurrence after surgery. Adjuvant external radiotherapy will be applied in those patients to see if disease free survival and overall…
- Trial name
- NCT04891874
- Testing
- Stereotactic radiotherapy
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma
Study of Axitinib for Reducing Extent of Venous Tumour Thrombus in Renal Cancer With Venous Invasion
NAXIVA is a study of axitinib in patients with metastatic and non-metastatic renal cell carcinoma with venous invasion. Patients will be given axitinib (twice daily) for 8 weeks (at an escalated dose) and the response of the…
- Conditions
- Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Non-metastatic Renal Cell Carcinoma
- Trial name
- NAXIVA (NCT03494816)
- Testing
- Axitinib Oral Tablet
- Where
- 7 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Scottish Clinical Trials Research Unit
Colorectal Cancer
Comparison of Diagnostic Accuracies of Various Endoscopic Examination Techniques
Endoscopic diagnosis of lateral spreading tumours (LST) with submucosal invasion is important in guiding the treatment strategy. The use of advanced imaging is not standard clinical practice in China.
- Trial name
- NCT03109938
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Colorectal Cancer
Identification the Expression of Sox2 in Colorectal Cancer Tissues
Sox2 has been studied in several types of human solid tumors. The investigators found that Sox2 had higher expression level in colorectal cancer and metastatic tissues than normal tissues.
- Trial name
- NCT01589900
- Volunteers
- 136 people
- Sponsor
- Sun Yat-sen University
Hepatocellular Carcinoma, Hepatic Portal Vein Tumor Invasion
Combination Treatment for Advanced Liver Cancer
The purpose of this study is to determine whether TACE combined endovascular stent implantation confers a survival benefit over TACE alone.
- Trial name
- NCT02149771
- Testing
- chemoembolization, endovascular stents implantation, iodine-125 seed strand implantation
- Where
- China
- Sponsor
- Shanghai Zhongshan Hospital
Carcinoma, Renal Cell, Inferior Vena Cava Tumor Thrombus
Habitat Analysis of Tumor Thrombus for Vena Cava Wall Invasion in Renal Cell Carcinoma
Tumor thrombus in the inferior vena cava can invade the vessel wall. Doctors must know the invasion status before surgery. The status changes the surgical plan. Preoperative imaging has limited accuracy for wall invasion.
- Trial name
- HABITAT (NCT07901569)
- Where
- China
- Volunteers
- 273 people
- Sponsor
- Liu Zhuo
Hepatocellular Carcinoma
Camrelizumab, Apatinib Plus HAIC Versus Camrelizumab and Apatinib for HCC With Portal Vein Invasion: a Randomized Trial
Compare the efficacy and safety of camrelizumab, apatinib plus FOLFOX-HAIC and camrelizumab plus apatinib in hepatocellular carcinoma with portal vein invasion.
- Trial name
- NCT05198609
- Testing
- FOLFOX-HAIC, Camrelizumab, Apatinib
- Where
- China
- Volunteers
- 214 people
- Sponsor
- Sun Yat-sen University
Hepatocellular Carcinoma
Perfusion and Dual Energy Computer Tomography in Hepatocellular Carcinoma
The aim of this study is to evaluate the hepatic perfusion computer tomography and dual energy computer tomography in the assessment of tumor characterization of Hepatocellular carcinoma in patients with resectable Hepatocellular…
- Trial name
- PERCAHEC (NCT03754192)
- Testing
- perfusion Computed Tomography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia
the Implications of Pathogenesis of Pre-Eclampsia
Preeclampsia is a severe complication of human pregnancy. It occurs in 4-5% of all pregnancies and remains a leading cause of maternal and neonatal mortality and morbidity.
- Trial name
- NCT00154934
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Lung Cancer
Molecular Mechanism of Trophinin in Cancer Invasion and Metastasis
Our study established a model combine the in silico biology and empirical methods to identify clinically useful biomarker from information of microarray gene expression profiles in public domain.
- Trial name
- NCT00166972
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Hepatocellular Carcinoma, Recurrence
Effect of Intraoperative Controlled Release 5-Fluorouracil Therapy on Recurrence in Hepatocellular Carcinoma Patients
The aim of this study is to confirmed the role of intraoperative controlled release 5-Fluorouracil therapy in the prevention of recurrence after surgery for HCC patients with high risk of preoperative prediction of microvascular…
- Trial name
- NCT02523053
- Testing
- Hepatectomy, 5-Fluorouracil
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Hepatocellular Carcinoma (HCC), Macrovascular Invasion
Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant
The goal of this clinical trial is to learn if locoregional therapy and immunotherapy can be used together to help patients with hepatocellular carcinoma (HCC) and macrovascular invasion achieve liver transplantation.
- Conditions
- Hepatocellular Carcinoma (HCC), Macrovascular Invasion, Liver Transplant Surgery, Downstaging
- Trial name
- MacroTrans (NCT06725121)
- Testing
- Atezolizumab & Bevacizumab, Yttrium-90 (Y-90), Stereotactic body radiotherapy (SBRT)
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University Health Network, Toronto
Tongue SCC, Oral Cancer
Use of Ultrasound for Measuring Size of Oral Tongue Cancers
The purpose of this study is to investigate the use intraoral ultrasound for measuring depth of invasion (DOI) in oral tongue squamous cell carcinoma.
- Trial name
- NCT04614896
- Testing
- Transoral ultrasound of tongue tumors
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Endometrial Cancer, Cervical Stromal Invasion
Radiomics Based Multimodal Transvaginal Ultrasound Imaging in Endometrial Cancer
Retrospectively collect preoperative transvaginal B-mode ultrasound (BMUS), color Doppler flow imaging (CDFI) and three-dimensional ultrasound (3D-US) images and clinical data in patients with non-endometrial cancer diseases and…
- Conditions
- Endometrial Cancer, Cervical Stromal Invasion, Transvaginal Ultrasound
- Trial name
- NCT05387460
- Testing
- radiomics
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Tongji Hospital
Ovarian Cancer
PTEN and IGFBP-3 Correlation in Ovarian Carcinoma Invasion
We have identified insulin-like growth factor binding protein (IGFBP)-3 as an invasion suppressor gene in ovarian endometrioid carcinoma, and showed association with lower cancer migration, invasion and metastasis.
- Trial name
- NCT00173407
- Testing
- immunohistochemical, methylation, gene transfection
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Hepatocellular Carcinoma (HCC), Microvascular Invasion (MVI)
Computer-Aided Diagnosis for Hepatocellular Carcinoma Microvascular Invasion
Hepatocellular carcinoma (HCC) is a common malignancy in China with a high mortality rate. Its early recurrence and long-term prognosis are closely associated with tumor aggressiveness.
- Trial name
- HCC-MVI-CAD (NCT07170345)
- Testing
- Computer-Aided Diagnosis System for Preoperative Prediction of MVI in HCC
- Where
- 19 sites in China
- Volunteers
- 400 people
- Sponsor
- Chinese Academy of Sciences
Liver Carcinoma, Liver Transplant Disorder
AFP Model and Liver Transplantation.
Background \& Aim: Presence of microvascular invasion (mvi) in the explanted liver defines a higher risk of recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT).
- Trial name
- NCT03775863
- Testing
- Liver transplantation
- Where
- 2 sites in Argentina, France
- Volunteers
- 1,200 people
- Sponsor
- Austral University, Argentina