Clinical trials: Central Airway Stenosis
Airway Disease
Treatment of Central Airway Stenoses Using Computer-Assisted Customized 3d Stents TATUM
Airway stenting is usually efficient to treat central airway obstruction but can lead to severe and potentially lethal complications (stent migration, obstructive granuloma, perforation, and hemoptysis).
- Trial name
- TATUM (NCT04848025)
- Testing
- Custom-designed tracheobronchial prostheses
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Airway Stenosis
The Efficacy and Safety of Robotic Bronchoscopy System-Assisted Stent Placement in Patients with Malignant Central Airway Stenosis
The primary aim of this research is to assess the efficacy and safety of the bronchial navigation positioning equipment in assisting stent implantation for malignant central airway stenosis while guaranteeing the safety of the…
- Trial name
- NCT06832943
- Testing
- Unicorn system
- Volunteers
- 30 people
- Sponsor
- Guangzhou Medical University
Adult Subjects With Symptomatic Benign Airway Obstruction, Adult Benign Central Airway Stenosis
Paclitaxel-Coated Pulmonary Balloon for the Treatment of Benign Central Airway Stenosis
The OXYGEN-RCT trial is a randomized, controlled, double blinded, prospective, multi-center trial to demonstrate the safety and efficacy in adult benign central airway stenosis.
- Conditions
- Adult Subjects With Symptomatic Benign Airway Obstruction, Adult Benign Central Airway Stenosis, Adult Tracheobronchial Stenosis, Tracheal Stenosis
- Trial name
- OXYGEN-RCT (NCT07191860)
- Testing
- The Airiver Pulmonary drug-coated balloon (DCB) dilation, Commercial airway balloon dilation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Airiver Medical, Inc.
Emphysema, Pulmonary Disease, Chronic Obstructive
Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a lung disease that is primarily caused by cigarette smoking. The breakdown of elastin, a protein found in the lungs, can cause lung damage and may contribute to the development of…
- Trial name
- NCT00725309
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- Washington University School of Medicine
Barrett Esophagus, Esophageal Dysplasia
trūFreeze® Spray Cryotherapy Patient Registry
To collect efficacy and outcomes data related to the use of trūFreeze® spray cryotherapy for the treatment of unwanted tissue in the pulmonary and gastrointestinal settings.
- Conditions
- Barrett Esophagus, Esophageal Dysplasia, Esophageal Neoplasm, Esophageal Stenosis
- Trial name
- NCT01802203
- Testing
- truFreeze Spray Cryotherapy
- Where
- 16 sites in United States
- Volunteers
- 275 people
- Sponsor
- US Endoscopy Group Inc.
Pulmonary Valve Insufficiency, Pulmonary Regurgitation
COMPASSION - COngenital Multicenter Trial of Pulmonic VAlve Regurgitation Studying the SAPIEN InterventIONal THV
To assess the safety and effectiveness of pulmonic THV implantation in subjects with dysfunctional RVOT conduit requiring treatment for moderate or severe pulmonary regurgitation (≥3+ pulmonary regurgitation) and/or RVOT conduit…
- Conditions
- Pulmonary Valve Insufficiency, Pulmonary Regurgitation, Dysfunctional RVOT Conduit, Pulmonary Obstruction
- Trial name
- NCT00676689
- Testing
- SAPIEN Transcatheter Valve Implantation
- Where
- 7 sites in United States
- Volunteers
- 81 people
- Sponsor
- Edwards Lifesciences
Central Airway Stenosis
Vibration Response Imaging (VRI) in Patients That Are Undergoing Pulmonary Interventional Procedure
Vibration response imaging (VRI) technology, provides a radiation-free dynamic image of the lung, by visualizing vibration energy emitted during the respiration cycle (lung sounds).
- Trial name
- NCT00672893
- Testing
- Vibration Response Imaging
- Where
- 5 sites in United States, France and 2 more
- Volunteers
- 200 people
- Sponsor
- Deep Breeze
Disorder Related to Lung Transplantation, Central Airway Stenosis
Hyperbaric Oxygen Therapy for Lung Transplantation
The objective of this study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) on airway complications in post-lung transplant recipients with evidence of restricted levels of blood and oxygen in the airway tissue.
- Conditions
- Disorder Related to Lung Transplantation, Central Airway Stenosis, Airway Exudative Plaques, Airway Complications Post-Lung Transplantation
- Trial name
- NCT02363959
- Testing
- Hyperbaric Oxygen Therapy, Endobronchial Biopsy of Airway Epithelium
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Central Airway Obstruction
Paclitaxel-Coated Pulmonary Balloon for the Treatment of Benign Airway Stenosis
The goal of this Prospective Trial of Paclitaxel-Coated Pulmonary Balloon for the Treatment of Benign Airway Obstruction (OXYGEN-1) is to evaluate clinical safety and potential efficacy of the Airiver Pulmonary DCB in the…
- Trial name
- NCT05895305
- Testing
- Paclitaxel-Coated Pulmonary Balloon Catheter
- Where
- Georgia
- Volunteers
- 45 people
- Sponsor
- Airiver Medical, Inc.
Obstructive Airway Disease
Study of Interventional Pulmonologic Treatment of Benign Central Airway Fibrotic Stricture
The purpose of this study is to evaluate the efficacy and safety of four interventional pulmonology techniques for the treatment of fibrotic central airway stricture.
- Trial name
- NCT02287389
- Testing
- balloon dilation, cryotherapy, spiculiform electrosurgery
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tang-Du Hospital
Noninvasive Positive Pressure Ventilation;, Sedation;
Interventional Bronchoscopy Under Noninvasive Ventilation
To evaluate the effect and safety of noninvasive ventilation assisted interventional bronchoscopy for hypoxemia patients with central airway stenosis.
- Conditions
- Noninvasive Positive Pressure Ventilation;, Sedation;, Bronchoscopy；, Interventional；
- Trial name
- NCT02289586
- Testing
- invasive ventilation, interventional bronchoscopy, noninvasive ventilation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Futian People's Hospital
Stenosis of Trachea
Spray Cryotherapy for the Management of Benign Central Airway Stenosis (Cryo-BAS)
The goal of this clinical trial is to compare spray cryotherapy plus balloon dilatation versus current standard of Care (SoC - steroid injection, radial cuts and balloon dilatation) in patients with benign airway stenosis with…
- Trial name
- Cryo-BAS (NCT06761170)
- Testing
- Spray cryo therapy, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Airway Obstruction
Study of Interventional Pulmonologic Treatment of Malignant Central Airway Stricture
The purpose of this study is to evaluate the efficacy and safety of four interventional pulmonology techniques for the treatment of malignant central airway stricture.
- Trial name
- NCT02299830
- Testing
- cryotherapy, argon plasma coagulation, stent placement
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital
Malignant Airway Obstruction
A Metal Bare Stent With 125 Iodine （125I）Seeds for the Treatment of Malignant Central Airway Stenosis
Malignant central airway stenosis caused by primary or metastatic malignant tumor may lead to dyspnea even death of patients.With the rapid development of interventional pulmonology, bronchoscopic therapy has become the main…
- Trial name
- NCT03944408
- Testing
- stent implantation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Stricture; Trachea, Malignant Neoplasm
Airway Segmented Stent Modified With 3D Printing for Malignant Stricture Involving Carina and Distal Bronchi
In this study, we used the covered metallic segmented airway stent to treat malignant strictures involving carina and bronchi distal to carina and aimed to determine the feasibility, efficacy and safety of this technique.
- Trial name
- NCT03890575
- Testing
- Airway stent implantation
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Ruijin Hospital