Clinical trials: Central Corneal Thickness
Cataracts, Corneal Edema
Study of Difluprednate vs. Prednisolone Acetate on Visual Acuity, and Corneal Edema Following Cataract Surgery.
The purpose of this clinical research study is to investigate the efficacy of predosing patients undergoing cataract surgery with the potent corticosteroid difluprednate ophthalmic emulsion 0.05% compared to prednisolone acetate…
- Conditions
- Cataracts, Corneal Edema, Retinal Structural Change, Deposit and Degeneration, Visual Acuity Reduced Transiently
- Trial name
- NCT01244334
- Testing
- Difluprednate ophthalmic emulsion 0.05%, Prednisolone acetate 1%
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- Edward J. Holland
Hard Nuclear Cataract, Phacoemulsification Cataract Surgery
Study on the Surgical Strategy of Corneal Endothelial Protection for Hard Nuclear Cataract Patients
In this study, we compared two types of phacoemulsification commonly used in cataract surgery to evaluate their effect on the prognosis of patients with hard nuclei.
- Conditions
- Hard Nuclear Cataract, Phacoemulsification Cataract Surgery, Endothelial Cell Density Loss, Central Corneal Thickness
- Trial name
- NCT06991374
- Testing
- combined burst mode, torsional mode
- Where
- China
- Volunteers
- 207 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Laser Corneal Surgery
Corneal Biomechanics With Hydration in Normal and LASIK Eyes
The research will utilize LASIK and non-LASIK populations to analyze the biomechanical differences between these corneas.
- Trial name
- NCT01183702
- Testing
- LASIK surgery, No Intervention
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Deb Grzybowski
Corneal Endothelial Cell Loss
Second Comparative Study of Specular Microscopes for Endothelial and Corneal Cell Measurements
The primary objective of this clinical study is to collect additional clinical data to support an FDA 510(k) submission for the Topcon Specular Microscope SP-1P.
- Trial name
- NCT02427256
- Testing
- Topcon Specular Microscope SP-1P, Konan Specular Microscope CELLCHEK XL
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Topcon Medical Systems, Inc.
Corneal Dystrophy
Corneal Endothelium Morphology and Central Thickness in Type II Diabetes Mellitus and Normal Subjects
The purpose of this study is to compare corneal endothelium morphology and central thickness in type II Diabetes Mellitus and normal subjects with special reference to glycemic status.
- Trial name
- NCT01084850
- Where
- Denmark
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Frederiksberg University Hospital
Corneal Edema, Corneal Endothelial Dysfunction
AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction
The purpose of this study is to assess the efficacy and safety of single injection dose of AURN001 compared with placebo in adult participants with corneal edema secondary to corneal endothelial dysfunction.
- Conditions
- Corneal Edema, Corneal Endothelial Dysfunction, Fuchs Endothelial Corneal Dysfunction, Pseudophakic Bullous Keratopathy (PBK)
- Trial name
- NCT07368959
- Testing
- Combination Product: AURN001 + Y-27632
- Where
- 12 sites in United States
- Volunteers
- 130 people
- Sponsor
- Aurion Biotech
Corneal Thickness
Comparison of Three Different No-contact Pachymetries
Study wants to compare central corneal thickness (CCT) obtained through 3 different no-contact instruments and to compare them with contact ultrasound pachymetry, actually the gold standard technique.
- Trial name
- NCT01541501
- Testing
- Pachymetry
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Keratoconus, Healthy Controls
Corneal Thickness Changes With Scleral Contact Lenses
The purpose of this study is to investigate changes in the corneal thickness of scleral contact lens wearers in a keratoconic (KC) population and compare to age-matched controls.
- Trial name
- NCT03249233
- Testing
- ZenLens™, Zen™ RC
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Exfoliation Syndrome
Central Corneal Thickness in Glaucoma
The purpose of this study is to compare the central corneal thickness measurement in patients with exfoliation syndrome, exfoliative glaucoma, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate…
- Trial name
- NCT01023997
- Where
- Greece
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Cornea
Multi-center Clinical Trial on Corneal Morphology Analysis in Chinese Population
Based on the corneal morphometry instrumentation Oculus Pentacam, which is commonly used before and after clinical refractive surgery, we will collect the corneal morphological and biologic parameters of the population under…
- Trial name
- NCT03010748
- Testing
- Scheimpflug tomography system (Pentacam) measurement
- Where
- China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Cataract Surgery, Cataract and Fuchs Endothelial Corneal Dystrophy
Trial Comparing Cataract Surgery With Triple-DMEK in Patients With Cataract and Fuchs Endothelial Corneal Dystrophy
The purpose of the study is to investigate whether there is a difference in BCVA in patients who receive one of the following two surgeries: intervention group (arm 1) cataract surgery alone and control group (arm 2) cataract…
- Trial name
- ETCF (NCT06425666)
- Testing
- Intervention group /arm 1 (Cataract surgery alone), Control group /arm 2: Corneal transplantation as Descemet Membrane Endothelial Keratoplasty (DMEK) in combination with cataract surgery (triple-DMEK)
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- University of Cologne
Glaucoma Eye
Assessment of the Occuity PM1 Pachymeter
To determine whether the Occuity PM1 device is non-inferior in measuring central corneal thickness when compared to ultrasound pachymetry, the Lenstar and the Pentacam.
- Trial name
- NCT05895617
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Occuity Limited
Intraocular Pressure
Effect of Central Corneal Thickness On IOP Using Various Tonometers
The primary purpose of this study is to evaluate the effects of ocular physical properties on intraocular pressure (IOP) measurements in eyes with healthy corneas using the following instruments to measure IOP: Goldmann…
- Trial name
- CCT (NCT00570791)
- Testing
- Tonometer
- Where
- 2 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Central Corneal Thickness
The Effect of Refractive Errors on Central Corneal Thickness by Using Pentacam and IOL Master
To evaluate the impact of refractive errors on the central corneal thickness obtained by Pentacam and intraocular lenses (IOL) master in eyes with different refractive errors.
- Trial name
- NCT06484894
- Testing
- Pentacam and IOL master
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cataract
Impact of Ophthalmic Surgeon Experience on Early Postoperative Central Corneal Thickness
To assess the impact of surgeon experience on early postoperative central corneal thickness (CCT) in eyes that have undergone phacoemulsification-based cataract surgery.
- Trial name
- CHICA (NCT03685825)
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Cataract, Cataract Surgery
Outcomes of High vs Physiological Intraocular Pressure During Cataract Surgery Using ACTIVE SENTRY
Cataract surgery is a widely performed procedure across the world that helps restore vision in many patients suffering from cataracts. Irrigation is an essential component of the surgery.
- Conditions
- Cataract, Cataract Surgery, Cataract Bilateral
- Trial name
- ACTIVESENTRY (NCT06611670)
- Testing
- Cataract surgery with Active Sentry, Traditional cataract surgery
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Corneal and Endothelial Cell Measurements
Comparative Study of the TOMEY Specular Microscope EM-4000 and the Konan CellChek XL
The Tomey EM-4000 Specular Microscope is designed to observe and analyze corneal endothelium.
- Trial name
- NCT02977793
- Testing
- Tomey EM-4000 Specular Microscope, Konan CellChek XL Specular Microscope
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Tomey Corporation
Glaucoma, Glaucoma, Open Angle
Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments.
The purpose of this study is to evaluate the relationship between intraocular pressure and central corneal thickness using various instruments in ocular hypertension, normal-tension glaucoma, primary open angle glaucoma…
- Conditions
- Glaucoma, Glaucoma, Open Angle, Ocular Hypertension, Keratoconus
- Trial name
- NCT00347191
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Aston University
Myopia Progression, Axial Length, Eye
Low Dose Atropine Eye Drops in Myopic Egyptian Children
Previous Studies reported that low concentration atropine eye drops may be effective in increasing the choroidal blood flow and thickness and this slows myopia progression.
- Conditions
- Myopia Progression, Axial Length, Eye, Sclera Thickness
- Trial name
- LAMP (NCT06265454)
- Testing
- low dose atropine eye drops
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Glaucoma, Ocular Hypertension
Central Corneal Thickness With SENSIMED Triggerfish
Investigation of the occurrence of possible corneal swelling after continuous Intraocular pressure (IOP) monitoring with a contact lens-based Sensor during the sleeping period.
- Trial name
- 09/08 (NCT01210963)
- Testing
- SENSIMED Triggerfish
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Sensimed AG