Clinical trials: Central Line Catheters
Procedural Complication, Competence
Ergonomics in Ultrasound Procedures
The study will compare two different positions of the ultrasound machine during simulated CVC positioning. The position of the ultrasound machine will be randomized.
- Trial name
- NCT06417021
- Testing
- Frontal Ultrasound Machine, Lateral Ultrasound Machine
- Where
- Italy
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- University of Padova
Septic Thrombophlebitis
Description of Septic Thrombophlebitis on Central Venous Catheter and Midline
Central venous catheters improve the tolerability and feasibility of patient care in the hospital setting by allowing the administration of hyper-osmotic, vesicant and venotoxic fluids.
- Trial name
- THROMBOSEP (NCT05743738)
- Testing
- Doppler ultrasound
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier le Mans
Cancer Patients, Central Venous Catheter Thrombosis
Central Venous Catheter (CVC) Associated Deep Vein Thrombosis (DVT) in Cancer Patients
Cancer patients with Central Venous Catheter (CVC) Associated Deep Vein Thrombosis (DVT) will be treated with Low Molecular Weight Heparin (LMWH) and apixaban. Study duration is 12 weeks.
- Conditions
- Cancer Patients, Central Venous Catheter Thrombosis, Upper Extremity Thrombosis
- Trial name
- NCT03100071
- Testing
- Apixaban
- Where
- 2 sites in Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Michael Kovacs
Pneumothorax Iatrogenic Postprocedural, Malposition, Central Venous Catheter
Comparison of Bedside Ultrasound With Chest X-ray for Confirmation of Central Venous Catheter Position
Background: Insertion of a central venous catheter (CVC) could lead to a variety of complications. To detect those complications, Chest X-ray (CXR) is still the reference standard.
- Trial name
- COMBUX (NCT02959203)
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Amsterdam UMC, location VUmc
Acute Anterior Myocardial Infarction
Rapid Intravascular Cooling in Myocardial Infarction as Adjunctive to Percutaneous Coronary Intervention
Rapid MI-ICE-Pilot is designed to demonstrate the safety and efficacy of the Celsius Control™ System (CCS) endovascular catheter to reduce the infarct size resulting from acute anterior myocardial infarction when used in…
- Trial name
- NCT00417638
- Testing
- Endovascular cooling by the Celsius Control System, Standard of care
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- ZOLL Circulation, Inc., USA
Catheter-related Infections
Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI
This is a Phase 3, multi-center, randomized, open-label, assess-blind study to determine the efficacy and safety of MLT, a novel antibiotic lock therapy that combines minocycline with edetate disodium in 25% ethanol solution as…
- Trial name
- NCT02901717
- Testing
- Mino-Lok, Antibiotic lock
- Where
- 22 sites in United States, Puerto Rico
- Volunteers
- 144 people
- Sponsor
- Leonard-Meron Biosciences, Inc.
Childhood Cancer, Aplastic Anemia
Trial of Two Central Venous Catheter (CVC) Flushing Schemes in Pediatric Hematology and Oncology Patients
The purpose of this study is to determine whether flushing Central Venous Catheters (CVCs) with Normal saline once per week is not inferior to flushing with 10U/ml heparin 3 times per week, in preventing CVC occlusions.
- Conditions
- Childhood Cancer, Aplastic Anemia, Metabolic Disorders
- Trial name
- NCT01343680
- Testing
- Heparin, Normal saline
- Where
- 2 sites in Canada
- Volunteers
- 2 people
- Sponsor
- Alberta Children's Hospital
Central Venous Catheter Thrombosis
Thrombotic Complications After Central Venous Catheterization
Rationale: Complications related to central venous catheterization are mechanical, infectious or thrombotic in origin. Potential complications of catheter-related thrombosis are not insubstantial and include pulmonary embolism…
- Trial name
- TARZAN (NCT04302376)
- Testing
- Cather-related thrombosis ultrasonography
- Where
- Netherlands
- Volunteers
- 173 people
- Sponsor
- Amsterdam UMC, location VUmc
Child
Femoral Central Venous Access Comparison of 2 Methods
The purpose of this study is to compare the effectiveness and safety of the installation of femoral central venous catheter (CVC) ultrasound-guided real-time 2D versus the landmark method
- Trial name
- NCT02318940
- Testing
- central venous catheter
- Where
- 2 sites in Chile
- Volunteers
- 99 people
- Sponsor
- University of Chile
Patients With PICC-Line
SHERLOCK 3CG vs. Fluoroscopy in Implantation of PICC-Line
Peripherally inserted central catheters, or PICC lines, has now been successfully in use for many years, especially in the chemotherapeutic treatment of oncologic patients or in parenertal nutrition.
- Trial name
- 3CG (NCT02929368)
- Testing
- PICC implantation under fluoroscopy, PICC Implantation under Sherlock System
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- Jena University Hospital
Central Line
Exploration of Central Venous Catheter Protective Devices in the Pediatric Population: A Mixed Methods Study
1. to determine the feasibility of utilizing a wearable device 2. to prospectively measure and evaluate parent and nurse satisfaction with the protective wearable device.
- Trial name
- NCT05415449
- Testing
- Gus gear protective wearable device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Newborn Complication, Catheter Complications
Intravenous Neonatal Central Access Safety Trial
Particulate contamination due to infusion therapy (administration of parenteral nutrition and medications) carries a potential health risk for infants in neonatal intensive care units (NICU).
- Trial name
- INCAS (NCT05537389)
- Testing
- In-line filter
- Where
- Italy
- Volunteers
- 768 people
- Sponsor
- University of Turin, Italy
Cancer
Heparin Versus Normal Saline in Peripherally Inserted Central Catheter Lines
The study team will be performing a study comparing the use of Heparin Flushes vs. Normal Saline Flushes in making sure central lines stay open.
- Trial name
- NCT05029596
- Testing
- Normal Saline Group, Heparin Group
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Central Venous Catheter, Point of Care Ultrasound (POCUS)
Central Venous Catheter Placement With Thoracic Ultrasound and Intracavity ECG Positioning
The goal of this interventional study is to assess the feasibility of two bedside techniques for confirming central venous catheter (CVC) placement and detecting complications: Intracavity ECG monitoring to confirm internal…
- Conditions
- Central Venous Catheter, Point of Care Ultrasound (POCUS), Intracavitary Electrocardiogram Guiding, Feasibility Studies
- Trial name
- CVC-TIP (NCT07291869)
- Testing
- Intracavity ECG, Thoracic point of care ultrasound
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- York Teaching Hospitals NHS Foundation Trust
Venous Thromboembolism, Cancer
Primary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters
The purpose of the full trial is to determine the efficacy and safety of prophylactic dose rivaroxaban to prevent VTE among cancer patients with CVC.
- Trial name
- TRIM-Line (NCT05029063)
- Testing
- Rivaroxaban 10 MG
- Where
- 11 sites in Canada
- Volunteers
- 1,828 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiac Surgery, Shock
Hemoglobin Saturation in Superior Vena Cava and Right Atrium
The aim of the study is to compare oxygen saturation of blood samples collected from the superior vena cava, the right atrium, and the pulmonary artery.
- Trial name
- NCT01398436
- Testing
- central venous catheter positioning in right atrium
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Catholic University of the Sacred Heart
Infection
Developing and Maintaining a Central Venous Catheter Registry
It has been estimated that 90% of bloodstream infections associated with catheters, are due to CVCs, and that 500 to 4,000 patients in the United States die annually due to these bloodstream infections.
- Trial name
- NCT01165411
- Where
- United States
- Volunteers
- 4,530 people
- Sponsor
- Lehigh Valley Hospital
Catheter Related Infection
Catheter Early Withdrawal or Maintenance in Sepsis or Septic Shock
Central venous catheter(CVC)-related infection is an inherent complication of this device that should be treated promptly. However, there are doubts about the need for the immediate withdrawal of CVC while there is still no…
- Trial name
- NCT01947751
- Testing
- CVC exchange, CVC maintenance
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Healthy
Central Venous Catheter Insertion Train the Trainer
The investigators previously successfully implemented a central venous catheter (CVC) simulation-based mastery learning (SBML) curriculum at Northwestern University.
- Trial name
- NCT02402257
- Testing
- CVC Train the Trainer
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Northwestern University
Behavior, Process, Acceptance
Implementation of Ultrasound Guided Central Venous Catheter Confirmation Protocol
The bedside use of ultrasound after central venous catheter (CVCs) insertion has lagged behind other applications in medicine, thus presenting an opportunity for innovative, evidence-based research that will influence clinician…
- Conditions
- Behavior, Process, Acceptance, Inertia of Accommodation
- Trial name
- DRAUP (NCT04324762)
- Testing
- targetted implementation strategies
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine