Clinical trials: Central Nervous Injury
Cardiac Surgery, Brain Injury
The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS)
Context: Neurocognitive dysfunction complicates coronary artery bypass graft surgery. Neurocognitive dysfunction is a measurable problem with thinking. Erythropoietin may be a neuroprotectant.
- Trial name
- NCT00336466
- Testing
- Human recombinant erythropoietin
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Calgary
Spinal Cord Injury
Biomechanical Validation of the Transfer Assessment Instrument (TAI)
The purpose of this research study is to further develop and refine the Transfer Assessment Instrument (TAI). The TAI is a clinical tool to be used by therapists to evaluate transfer techniques and performance.
- Trial name
- NCT01183546
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Male Fertility Program
Following spinal cord injury, most men are infertile and require medical assistance to father children. The conditions that contribute to their infertility are erectile dysfunction, ejaculatory dysfunction, and semen…
- Trial name
- MFP (NCT01467869)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction
Radio-frequency (RF) Bladder Monitor
The goal of this pilot feasibility study is to evaluate a wearable microwave (MW)-based bladder monitoring system in adult volunteers and those with spinal cord injury (SCI) who use self-catheterization for bladder management.
- Conditions
- Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction, Neurogenic Bladder (NB)
- Trial name
- NCT07639541
- Testing
- Wearable microwave Bladder Monitoring System
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Spinal Cord Injury
Clinical Study Evaluating Safety of a New Catheter for Urinary Intermittent Catheter in Healthy Volunteers
To evaluate discomfort of a new coating and catheter material compared to SpeediCath (SC)
- Trial name
- NCT01292941
- Testing
- Intermittent catheterisation, NonCE marked intermittent catheter/red, NonCE marked intermittent catheter/green
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Coloplast A/S
Chronic Subdural Hematoma
Tranexamic Acid in Chronic Subdural Hematomas
BACKGROUND Chronic subdural hematoma (CSDH) is one of the most frequent reasons for cranial neurosurgical consult. There is no widely accepted medical treatment for CSDH.
- Trial name
- TRACS (NCT02568124)
- Testing
- Tranexamic Acid
- Where
- 3 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Spinal Cord Injuries
Regain of Arm and Hand Movements in Cervical Spinal Stimulation
We will develop a "bottom to top" approach employing animal models and human testing to determine whether or not non-invasive neuro-modulation of the cervical spinal cord concomitant with upper limb rehabilitation driven by…
- Trial name
- tcSCS (NCT07140354)
- Testing
- cervical transcutaneous spinal cord stimulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Institut Guttmann
Traumatic Brain Injury
Transforming Research and Clinical Knowledge in Geriatric Traumatic Brain Injury (TRACK-GERI)
The purpose of this study is to improve the diagnosis and prediction of recovery after traumatic brain injury (TBI) in adults age 65 years and older.
- Trial name
- TRACK-GERI (NCT07296783)
- Where
- 3 sites in United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Mild Traumatic Brain Injury, Alexithymia
Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury
The purpose of the study is to test two different training programs to find out which is better at helping people with a concussion or mild TBI (mTBI) improve their emotional health and well-being.
- Trial name
- NCT07436754
- Testing
- Program 1, Program 2
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Hackensack Meridian Health
Traumatic Brain Injury, Acute Brain Injuries
Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury
The purpose of this single-center, prospective, randomized (1:1), double-blind, sham-controlled parallel-arm pilot study is to provide initial evidence of use of the noninvasive vagus nerve stimulator for treatment in patients…
- Trial name
- NCT02974959
- Testing
- gammaCore active device
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- CentraCare
Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level
Neuromodulation With Spinal Stimulation Methods
This is a pilot research study to test the protocols needed for transcutaneous spinal electrical stimulation in persons living with spinal cord injury (SCI). Up to 24 participants will be enrolled.
- Conditions
- Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level, Paraplegia, Spinal, Paraplegia, Incomplete
- Trial name
- NCT06272279
- Testing
- spinal stimulation-DCS, spinal stimulation-EPS
- Where
- 2 sites in Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Traumatic Brain Injury
Study on the Effect of Prostacyclin Compared to Placebo in Traumatic Brain Injury
This study is a prospective consecutive double-blinded randomized study on the effect of PGI2, prostacyclin (epoprostenol, Flolan®) versus placebo (saline)in patients with severe traumatic brain injury.
- Trial name
- NCT01363583
- Testing
- epoprostenol versus normal saline, normal saline
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Umeå University
Infant, Extremely Premature, Brain Injuries
Safeguarding the Brain of Our Smallest Infants Phase III
the SafeBoosC-III trial investigates the benefit and harms of treatment based on near-infrared spectroscopy monitoring compared with treatment as usual.
- Conditions
- Infant, Extremely Premature, Brain Injuries, Death, Brain, Death; Neonatal
- Trial name
- SafeBoosC (NCT03770741)
- Testing
- Modify cardio-respiratory support to avoid cerebral hypoxia, Treatment as usual
- Where
- Denmark
- Volunteers
- 1,601 people
- Sponsor
- Gorm Greisen
Spinal Cord Injuries, Spasticity, Muscle
Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury
Spasticity develops months after spinal cord injury (SCI) and persists over time. It presents as a mixture of tonic features, namely increased muscle tone (hypertonia) and phasic features, such as hyperactive reflexes…
- Trial name
- NCT05457205
- Testing
- Electrical neuromodulation
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Mississippi Medical Center
Neurobehavioral Disinhibition
Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Participants With Traumatic Brain Injury
This is a multicenter, randomized, placebo-controlled study to evaluate AVP-786 for the treatment of neurobehavioral disinhibition including aggression, agitation, and irritability in participants with traumatic brain injury…
- Trial name
- NCT03095066
- Testing
- AVP-786-28, AVP-786-42.63
- Where
- 54 sites in United States
- Volunteers
- 168 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Acquired Brain Injury (Including Stroke), Caregivers
Nature in Harmony: Music and Nature-based Self-care for Individuals With Acquired Brain Injuries and Their Care Partners
The goal of this pilot study is to determine the initial impact on wellbeing for clients with acquired brain injury and their care partner after engaging in a nature \& music-based program facilitated by occupational therapy and…
- Trial name
- NCT07568301
- Testing
- Nature in Harmony
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Monitored Anesthesia Care
Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery
MgSO4 was found to reduce the perioperative anesthetic and analgesic requirements when used as an adjuvant to general anesthesia. Fentanyl is a potent opioid and used as adjuvant to other sedatives in awake craniotomy procedure.
- Trial name
- NCT03854812
- Testing
- Magnesium Sulphate, Fentanyl, Propofol
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Kasr El Aini Hospital
Hypoxic-Ischemic Encephalopathy, Cardiac Arrest
Propofol-induced EEG Changes in Hypoxic Brain Injury
PROPEA3 is a prospective observational study investigating the recovery of propofol-induced EEG slow-wave activity and its association with neurological outcome after cardiac arrest.
- Trial name
- PROPEA3 (NCT03485781)
- Where
- 2 sites in Finland
- Volunteers
- 102 people
- Sponsor
- University of Oulu
Disorders of Consciousness
Intensive Neurowave Emotional Stimulation (INES)
This is a randomized and controlled pilot study investigating the effects of intensive emotional stimulation with neurological waves (INES) on cognitive-motor functions in patients diagnosed with Vegetative State (VS) and…
- Trial name
- INES_ABI (NCT06204172)
- Testing
- Intensive Neurowave Emotional Stimulation (INES), Intensive Sensorial Emotional Stimulation (ISES)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Cervicogenic Headache, Whiplash Injuries
Manipulation and Dry Needling in Patients With Cervicogenic Headache and WAD II
The purpose of this research is to compare two different approaches for treating patients with cervicogenic headaches associated with type II whiplash associated disorder: non-thrust mobilization and exercise versus thrust…
- Trial name
- NCT06502951
- Testing
- Dry Needling,Thrust Manipulation, Exercise,Non-thrust Mobilization
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Alabama Physical Therapy & Acupuncture
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