Clinical trials: Central Nervous Injury
Cerebral Hemorrhage
Retrospective Study on the Direction of Artificial Intelligence in Identifying Cranial Trauma CT Imaging
The goal of this observational retrospective study is to evaluate artificial intelligences (AI)'s proficiency in identifying and annotating brain bleeds in computed tomography (CT) images.
- Trial name
- NCT06230419
- Where
- China
- Volunteers
- 208 people
- Sponsor
- RenJi Hospital
Spinal Cord Injury
Precision Versus Endurance Training to Improve Walking After Chronic Incomplete SCI
The objective of the study was to determine the efficacy of two forms of physical therapy training, one emphasizing precise, visually guided walking over obstacles and on targets (Precision Training), the other emphasizing mass…
- Trial name
- NCT01765153
- Testing
- Endurance, Precision
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Alberta
Metastatic Cancer, Radiation Toxicity
Melatonin and Radiation Therapy in Treating Patients With Brain Metastases
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as melatonin may make tumor cells more sensitive to radiation therapy and may protect normal cells from the side effects of radiation therapy.
- Conditions
- Metastatic Cancer, Radiation Toxicity, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00031967
- Testing
- therapeutic melatonin, radiation therapy
- Where
- 234 sites in United States, Canada
- Sponsor
- Radiation Therapy Oncology Group
Traumatic Brain Injury
Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate
This project is to evaluate sensitivity and specificity of hyperpolarized 13C-pyruvate as imaging agents of altered cerebral glycolysis and mitochondrial dysfunction and assess pyruvate utilization in mitochondria in Traumatic…
- Trial name
- HPTBI (NCT03502967)
- Testing
- Hyperpolarized [1-13C] Pyruvate, Hyperpolarized [2-13C] Pyruvate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Tetraplegia, Tetraplegia/Tetraparesis
[BrainConnexion] - Neurodevice Phase I Trial
This study aims to evaluate the safety of a wireless implantable neurodevice microsystem in tetraplegic patients, as well as the efficacy of the electrodes for long-term recording of neural activities and the successful control…
- Conditions
- Tetraplegia, Tetraplegia/Tetraparesis, Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
- Trial name
- NCT03811301
- Testing
- BrainConnexion
- Where
- Singapore
- Volunteers
- 5 people
- Sponsor
- National Neuroscience Institute
Spinal Cord Injuries, Obesity
Telenutrition for Individuals With SCI
This study will provide nutrition counseling via FaceTime on an iPad to persons with traumatic spinal cord injury (SCI) who are overweight or obese and are at least one-year post-injury.
- Conditions
- Spinal Cord Injuries, Obesity, Cardiometabolic Syndrome
- Trial name
- NCT05468437
- Testing
- Telenutrition
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Santa Clara Valley Health & Hospital System
Cardiovascular Disease, Spinal Cord Injury
Effect of Exercise on Blood Coagulation in Persons With Chronic Spinal Cord Injury
The purpose of this study is to determine if exercise affects the clotting of blood (hemostasis). The effect of exercise on hemostasis will be determined in persons with spinal cord injury, a population reported to have an…
- Trial name
- FES (NCT00223912)
- Testing
- ERGYS BikeFunctional Electrical Stimulation Ergometry
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- US Department of Veterans Affairs
Neuropathic Pain, Radiotherapy Side Effect
Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Radiotherapy-Related Neuropathic Pain
This multi-center, randomized, double-blind, sham-controlled trial aims to investigate the effect and safety of TaVNS in treating radiotherapy-related neuropathic pain.
- Trial name
- RELAX (NCT05543239)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation(TaVNS)
- Where
- 4 sites in China
- Volunteers
- 116 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Concussion; Syndrome
Feasibility of a Purpose in Life Renewal Intervention for Adults With Persistent Symptoms After Concussion
A group of clinicians and researchers developed an 8-session group intervention that integrates education, support, self-reflection, and action-expectation to help people reaffirm or reconstruct self-grounded purpose after…
- Trial name
- PSC (NCT05780658)
- Testing
- Compass Course
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mary Radomski
Spinal Cord Injuries
Ischaemic Preconditioning and Upper Body Exercise Performance in Persons With Spinal Cord Injury
Regular physical activity improves physical fitness, fatigue, quality of life, gait and reduces progression of the disability in persons with SCI. However, persons with SCI are less physically active than the general population.
- Trial name
- NCT05954715
- Testing
- Ischaemic Preconditioning
- Volunteers
- 40 people
- Sponsor
- Loughborough University
Brain Injuries
Lariboisière Cognitive Assessment: Evaluation of the 1-year Outcomes
Cognitive sequelae are common following acquired brain injuries. However, their detection can be challenging, particularly in acute care units such as neurosurgery.
- Trial name
- ECOG (NCT06171568)
- Testing
- Tests and questionnaires
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cognitive/Functional Effects, Metastatic Cancer
Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery
RATIONALE: Stereotactic radiosurgery may be able to send x-rays directly to the tumor and cause less damage to normal tissue. Radiation therapy uses high-energy x rays to kill tumor cells.
- Conditions
- Cognitive/Functional Effects, Metastatic Cancer, Neurotoxicity, Radiation Toxicity
- Trial name
- NCT01372774
- Testing
- stereotactic radiosurgery, whole-brain radiation therapy
- Where
- 37 sites in United States
- Volunteers
- 194 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Post Traumatic Stress Disorder, Traumatic Brain Injury
Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation
This study will test the clinical efficacy of an accelerated TMS (accel-TMS) protocol that rapidly addresses PTSD symptoms with 1 week (25 sessions over 5 days) of condensed treatment.
- Trial name
- NCT06544408
- Testing
- Cool B70 AP Coil - Active (dl-PFC), Cool D-B80 AP Coil - Active (dm-PFC), Cool B70 Treatment Coil - Active Only
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Florida State University
Chronic Subdural Hematomas
Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma.
Chronic subdural hematoma (cSDH) is a very common disease, primarily affecting older people, and is associated with significant morbidity and mortality.
- Trial name
- iSDH (NCT07556991)
- Testing
- Amoxicillin + clavulanic acid
- Where
- Germany
- Volunteers
- 164 people
- Sponsor
- University of Rostock
Mild Traumatic Brain Injury
Efficacy of Multidimensional Management of Mild Traumatic Brain Injury
Unfavorable outcomes (UO) are seen in 15 to 20% of patients with mild traumatic brain injury (mTBI). Early identification of patients at risk for UO is crucial for suitable management to be initiated, increasing their chances for…
- Trial name
- NCT03811626
- Testing
- cognitive-behavioral rehabilitation
- Where
- 6 sites in France
- Volunteers
- 221 people
- Sponsor
- Institut de Recherche sur la Moelle épinière et l'Encéphale
Child, Cerebral Palsy
Prevention of Hip Displacement in Children With Cerebral Palsy in Denmark
Children with cerebral palsy have an increased risk of hip dislocation, which is a painful and severe complication of cerebral palsy.
- Conditions
- Child, Cerebral Palsy, Radiography, Hip Dislocation
- Trial name
- NCT04403178
- Testing
- Radiographic examination with a Migration of > 40 %
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Mette Røn Kristensen
Spinal Cord Injuries, Spinal Cord Diseases
Non-invasive Spinal Cord Stimulation After Spinal Cord Injury
Spinal cord injury (SCI) is a central nervous system injury that often leads to motor dysfunction. Non-invasive electrical stimulation of the spinal cord has been recognized as a potential method of reactivating lost spinal…
- Trial name
- SCI-ES-WALK (NCT06260735)
- Testing
- Trans-spinal electrical stimulation, Electrical muscle activation, Treadmill walking
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Traumatic Shock, Hemorrhagic Shock
Prehospital Norepinephrine and Early Mortality in Traumatic Shock
The effect of early, prehospital norepinephrine use in patients with traumatic shock on mortality is unknown. Recent existing observational evidence from single system data (US, France, Japan) are conflicting.
- Conditions
- Traumatic Shock, Hemorrhagic Shock, Traumatic Brain Injury, Hypotension and Shock
- Trial name
- NCT04497155
- Testing
- Norepinephrine
- Volunteers
- 2,164 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Stroke, Spinal Cord Injuries
A Feasible Smart Upper Limb Rehabilitation Model for Patients With Stroke and Spinal Cord Injuries
The goal of this clinical trial is to investigate the effectiveness of the developed application and exoskeleton robot devices for home-based training in stroke patients and patients with spinal cord injuries.
- Trial name
- NCT06215625
- Testing
- Robot-assisted therapy, Task-oriented training
- Where
- 2 sites in Taiwan
- Volunteers
- 90 people
- Sponsor
- National Cheng-Kung University Hospital
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury
Objective: This prospective interventional study introduces "SeeMe," an automated, high-resolution computer vision platform designed to objectively quantify microscopic, auditory command-evoked movements in patients with…
- Trial name
- NCT07560631
- Testing
- SeeMe Multimodal Auditory Command Protocol
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
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