Clinical trials: Central Nervous Injury
Peripheral Nerve Injuries
Mid-term Effect Observation of Biodegradable Conduit Small Gap Tublization Repairing Peripheral Nerve Injury
To observe the Mid-term clinical effect of biodegradable conduit small gap tublization to repair peripheral nerve injury in multi-center．
- Trial name
- NCT03359330
- Testing
- Degradable Conduit Small Gap Tublization
- Volunteers
- 150 people
- Sponsor
- Peking University People's Hospital
SCI - Spinal Cord Injury, Upper Extremity Dysfunction
The Utilization Effects of Powered Wearable Orthotics in Improving Upper Extremity Function and ADL in Persons With SCI
To evaluate the usefulness of an upper extremity assistive device, called (MyoPro) in improving upper extremity activities in people with incomplete spinal cord injury. The Department of Defense is supporting this study.
- Conditions
- SCI - Spinal Cord Injury, Upper Extremity Dysfunction, Upper Extremity Problem
- Trial name
- NCT06349434
- Testing
- MyoMo, conventional therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kessler Foundation
Minor Head Injury
Outcome of Patients With Mild Head Injury and Presence of an Acute Traumatic Abnormality on CT Scan of Head
Background: Patients with mild blunt traumatic brain injury (TBI) are frequently transferred to Level 1 trauma centers (L1TC) if they have any positive finding of any acute intracranial injury identified on a CT scan of the head.
- Trial name
- NCT04143347
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Massachusetts General Hospital
Concussion Post Syndrome, Headaches Posttraumatic
Pediatric Concussion Outcomes
This is a randomized, placebo-controlled, double-blinded trial in which subjects with a post concussive headache meeting inclusion criterion will be assigned to one of two treatment groups: placebo or nortriptyline.
- Conditions
- Concussion Post Syndrome, Headaches Posttraumatic, Mild Traumatic Brain Injury
- Trial name
- PeCon (NCT04226365)
- Testing
- Nortriptyline
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Spinal Cord Injuries
Feasibility of Early Gabapentin as an Intervention for Neurorecovery
The objective of the proposed study is to conduct the first ever prospective, dose-exploration trial to test the feasibility of early administration of gabapentin as an intervention for neurorecovery.
- Trial name
- NCT05302999
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- MetroHealth Medical Center
Spinal Cord Injuries
Trunk Task-oriented Training Combined With Functional Electrical Stimulation in Spinal Cord Injured Individuals
The objectives of the study are to evaluate trunk task-oriented training combined with function electrical stimulation (FES/T-TOT) efficacy on sitting balance and functional independence, and to understand the mechanisms of…
- Trial name
- NCT05196204
- Testing
- Trunk-oriented task training combined with functional electrical stimulation, Trunk-oriented task training alone
- Where
- 2 sites in Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Bladder Cancer, Spinal Cord Injury
Novel mRNA-based Urine Test for Bladder Cancer in Spinal Cord Injury Individuals
Bladder cancer is a well-recognized complication in spinal cord injury (SCI) individuals. The observed incidence rates in SCI individuals are considerably higher compared to the general population.
- Trial name
- NCT02538809
- Testing
- measurement of tumor mRNA concentration in urine
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Brain Injuries, Disorders of Consciousness
Erigo®Pro Coma Outcome Study - Study on the Effectiveness of a Robotic Tilt Table Device for Recovery of Consciousness
Patients with acquired brain injury (ABI) often suffer from severe disorders of consciousness (DOC), such as coma, unresponsive wakefulness syndrome (UWS), or minimally conscious state (MCS).
- Trial name
- EriCOS (NCT02639481)
- Testing
- Standard physiotherapy, Erigo®Pro group without FES, Erigo®Pro group with FES
- Where
- 2 sites in Germany
- Volunteers
- 47 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Perioperative Complications, Perioperative/Postoperative Complications
Perioperative Database of Chinese Elderly Patients
The investigators aim to establish a prospective database of perioperative elderly patients from multiple regions and centers. Collected data involves postoperative complications of the central nervous system, cardiovascular…
- Conditions
- Perioperative Complications, Perioperative/Postoperative Complications, Perioperative Adverse Events
- Trial name
- PDCEP (NCT04911530)
- Testing
- no intervention
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Chinese PLA General Hospital
Consciousness Disorders
Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU
Disorders of consciousness (DoC) caused by severe brain injury affect millions of people worldwide each year. A patient's level of consciousness in the intensive care unit (ICU) significantly impacts the recovery from disability…
- Trial name
- COMPASS (NCT06568536)
- Testing
- Repeated behavioral assessments, functional electroencephalography and brain imagery, TMS-EEG
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Brain Injuries, Hypothermia
Hypothermia to Treat Severe Brain Injury
The purpose of this trial is to determine if hypothermia (body cooling), administered very soon after a severe brain injury improves functional outcome. This pilot trial ended in July 2005.
- Trial name
- NCT00040339
- Testing
- hypothermia (body temperature lowered to 33°C or 91.4°F)
- Where
- 5 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Depression, Traumatic Brain Injury
Depression and Traumatic Brain Injury
Problem: Depressive symptoms are a common mental health problem following traumatic brain injury (TBI), occurring in up to 87% of patients.
- Trial name
- NCT00254007
- Testing
- citalopram (celexa)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cerebral Palsy, Spina Bifida
A Peer E-mentoring Intervention to Improve Employment
Despite the strong business case of hiring people with disabilities, a significant proportion of youth with disabilities leave high school and neither work nor continue their education and are unprepared to meet the demands of a…
- Conditions
- Cerebral Palsy, Spina Bifida, Juvenile Arthritis, Spinal Cord Injury
- Trial name
- NCT02522507
- Testing
- Empowering youth towards employment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
MTBI - Mild Traumatic Brain Injury
Imaging of Injury Mechanism and Interaction of Intestinal Bacteria in Children With Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is the leading cause of disability in children and young adults. Children with moderate to severe TBI are typically at risk of poor functional outcome in terms of neurocognitive impairment and…
- Trial name
- NCT05090007
- Testing
- magnetic resonance image, gut microbiota
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Spinal Cord Injuries
Effects of Paired Associative Nerve Stimulation on Spinal Cord Injury Subjects
This study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) combined with trans-spinal electrical stimulation (tsES) intervention on cortical excitability, brain structure, motor ability of…
- Trial name
- NCT04194099
- Testing
- 20 Hz rTMS (Brain), iTBS rTMS (Brain), Anode tsDCS (Spinal)
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- Taipei Medical University Hospital
Acute Respiratory Distress Syndrome (ARDS), Acute Brain Injury
Contribution of Transthoracic and Transcranial Ultrasonography to the Titration of PEEP in Patients With ARDS and ABI
The present study will investigate whether the combined use of lung and brain ultrasonography is useful in selecting the optimal positive end-expiratory pressure in mechanically ventilated critically ill patients with acute…
- Trial name
- NCT07248995
- Testing
- Stepwise Positive End-Expiratory Pressure (PEEP) Increase Protocol
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Theodoros Schizodimos
Traumatic Brain Injury
Improving Time-Based Prospective Memory in TBI
This research aims to test aspects of a computer-based cognitive rehabilitation program designed to improve thinking skills in individuals with traumatic brain injury (TBI).
- Trial name
- TBPM (NCT04065477)
- Testing
- computer-based cognitive rehabilitation (CBCR)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Kessler Foundation
Brain Injuries, Concussion, Brain
The Monaco Initiative for Concussion in Motorsport Pilots
The study aims: to observe a population particularly exposed by the past to brain trauma and concussion: Motorsport Pilots who are retired from a professional practice of motor sport; to report results of their neuro-cognitive…
- Conditions
- Brain Injuries, Concussion, Brain, Sport Injury
- Trial name
- NCT04730167
- Testing
- Neurological and neuropsychological assessments / MRI / PET scan / Video-oculography.
- Where
- Monaco
- Volunteers
- 12 people
- Sponsor
- Association de Recherche Bibliographique pour les Neurosciences
Intracranial Hypertension
Clinical Value of Noninvasive Intracranial Pressure Measurement
The aim of the study is to evaluate accuracy and precision of non-invasive intracranial pressure measurement device (Vittamed 205) for selected patients compared with cerebrospinal fluid pressure measured during lumbar puncture
- Trial name
- Braincare (NCT02130219)
- Testing
- Non-invasive intracranial pressure measurement, Brain MRI/CT, Lumbar puncture and cerebrospinal fluid pressure measurement
- Where
- Lithuania
- Volunteers
- 45 people
- Sponsor
- Lithuanian University of Health Sciences
Traumatic Brain Injury
Insulin-sensitizing NE3107 in Improving Sleep and Fatigue in Subjects With Traumatic Brain Injury
This study seeks to measure changes in cognition through verbal and visual test procedures and changes in biomarkers of Traumatic Brain Injury and inflammatory and metabolic parameters.
- Trial name
- NCT05970575
- Testing
- NE3107
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Neurological Associates of West Los Angeles
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