Clinical trials: Central Nervous Injury
Spinal Cord Injury
Safety and Feasibility of Intranasal Insulin in Patients With Spinal Cord Injury
The purpose of this study is to find out whether insulin, a drug approved by the FDA for the treatment of diabetes mellitus, is safe when administered as a nasal spray (intranasally) to people who have experienced a spinal cord…
- Trial name
- INI-SCI (NCT07384052)
- Testing
- Regular Insulin, 0.9 % Normal Saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- HealthPartners Institute
Spinal Cord Injuries, Fatigue
Effects of In-Wheel Suspension
Manual wheelchairs allow individuals with spinal cord injuries (SCI) to safely and effectively access their environment. However, continual exposure to whole body vibration (WBV) is one of many contributing factors to neck pain…
- Conditions
- Spinal Cord Injuries, Fatigue, Back Pain, Neck Pain
- Trial name
- NCT04467749
- Testing
- Suspension Wheel
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Pittsburgh
Spinal Cord Injury
Longitudinal Morphometric Changes Following SCI
In patients with chronic spinal cord injury, imaging of the spinal cord and brain above the level of the lesion provides evidence of neural degeneration; however, the spatial and temporal patterns of progression and their…
- Trial name
- NCT02149511
- Where
- Switzerland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Mild Traumatic Brain Injury, Post-Concussion Syndrome
Treatment of Insomnia for Adolescents With Mild Traumatic Brain Injury
A substantial number of children and adolescents sustain a mild traumatic brain injury (mTBI) each year. Although research supports that the vast majority of youth will recover quickly and return to normal functioning, some…
- Conditions
- Mild Traumatic Brain Injury, Post-Concussion Syndrome, Insomnia
- Trial name
- NCT03688984
- Testing
- Cognitive Behavioural Therapy for Insomnia
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Acute Brain Injury, Ventilator-Induced Lung Injury
Ventilator Settings on Patients With Acute Brain Injury
The present study is an explorative analysis of the relationship between cerebral blood perfusion and oxygenation and lung mechanical variables at different ventilator settings.
- Conditions
- Acute Brain Injury, Ventilator-Induced Lung Injury, Cerebrovascular Circulation
- Trial name
- NCT03278769
- Testing
- Lung protective ventilator settings
- Where
- Norway
- Volunteers
- 27 people
- Sponsor
- University Hospital of North Norway
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Consciousness Disorders, Brain Injuries
Thalamic Low Intensity Focused Ultrasound in Brain Injury
Few neurological conditions are as scientifically mysterious and clinically, legally, and ethically challenging as disorders of consciousness.
- Trial name
- LIFUP (NCT02522429)
- Testing
- Low Intensity Focused Ultrasound Device
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, Los Angeles
Stroke, Peripheral Neuropathy
Arm Motor Control on Bi and Uni ADLs
This study is being performed to assess how certain chronic disabilities - stroke, upper extremity (UE) amputation, spinal cord injuries (SCI), cerebral palsy (CP) - differ from healthy subjects in their ability to perform ADLs.
- Conditions
- Stroke, Peripheral Neuropathy, Spinal Cord Injuries, Cerebral Palsy
- Trial name
- BiAs (NCT02778529)
- Testing
- Bilateral assessment robots (BiAS)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Spinal Cord Injuries, Upper Extremity Paresis
Targeted Plasticity Therapy for Upper Limb Rehabilitation in Spinal Cord Injuries
Texas Biomedical Device Center at UT Dallas has developed an innovative strategy to enhance recovery of motor and sensory function after neurological injury termed targeted plasticity therapy (TPT).
- Trial name
- NCT04288245
- Testing
- Active Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute
Brain Injuries
Invasive and Non-Invasive Assessment of Cerebral Oxygenation in Patients With Severe Traumatic Brain Injury (TBI)
The purpose of this study is to investigate the relationship among regional transcranial oxygen saturation (rSO2), brain tissue oxygen pressure (PbtO2) and cerebral perfusion pressure (CPP) in patients with severe traumatic brain…
- Trial name
- NCT00703495
- Testing
- transcranial oxygen saturation measurement (INVOS Somanetics 5100C)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Spinal Cord Injuries
Effects of Robotic Versus Manually-Assisted Locomotor Training for Individuals With Incomplete Spinal Cord Injury
The purpose of this study is to collect data comparing two means of providing locomotor training: manual and robotic and the possible differential effects it may have on walking ability for persons with spinal cord injury (SCI).
- Trial name
- DE (NCT00127439)
- Testing
- Manually Assisted Locomotor Training, Robotic Assisted Locomotor Training
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Prediction of Secondary Neurological Deterioration in Patients With Moderate Traumatic Brain Injury
Patients with moderate traumatic brain injury (mTBI) are 1,5 times more frequent than those with severe TBI and some of them will develop secondary neurologic deterioration (SND) within the first 7 days.
- Trial name
- PREDICT-TCM (NCT04854954)
- Where
- France
- Volunteers
- 142 people
- Sponsor
- University Hospital, Brest
Incomplete Spinal Cord Injury, Muscular Dystrophy
Evaluating a New Knee-Ankle-Foot Brace to Improve Gait in Children With Movement Disorders
Background: Cerebral palsy (CP) is the most common motor disorder in children. CP often causes crouch gait, an abnormal way of walking. Knee crouch has many causes, so no single device or approach works best for everybody.
- Conditions
- Incomplete Spinal Cord Injury, Muscular Dystrophy, Spina Bifida, Cerebral Palsy
- Trial name
- NCT01961557
- Testing
- EA-KAFO
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Traumatic Brain Injury
Managing Severe Traumatic Brain Injury (TBI) Without Intracranial Pressure Monitoring (ICP) Monitoring Guidelines
Management of intracranial hypertension (ICH) in patients with severe traumatic brain injury (sTBI) is crucial to their survival and optimal recovery.
- Trial name
- NCT02059941
- Where
- 13 sites in Bolivia, Colombia and 2 more
- Volunteers
- 780 people
- Sponsor
- University of Washington
Subdural Hematoma, Atrial Fibrillation
Anticoagulation Therapy Timing in Atrial Fibrillation After Acute and Chronic Subdural Hematoma
Subdural hematoma (SDH) is a common disorder that typically results from head trauma and has increased in prevalence in recent decades.
- Trial name
- ATTAACH (NCT05472766)
- Testing
- Direct Acting Oral Anticoagulant starting at Day 30, Direct Acting Oral Anticoagulant starting at Day 90
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Sunnybrook Health Sciences Centre
Spinal Cord Injury
Identify Training Strategies for Progressing Exoskeleton Users Towards Everyday Functional Ambulation
Many people with spinal cord injury are no longer able to walk and must use wheelchairs for mobility. These individuals experience greater rates of depression and lower quality of life.
- Trial name
- NCT02104622
- Testing
- ReWalk Rehabilitation 2.0
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Improving Ventilatory Capacity in Those With Chronic High Level SCI
The purpose of this study is to find out if taking the drug Buspar will increase breathing capacity in individuals with spinal cord injuries.
- Trial name
- NCT05041322
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury
Physical Activity Guidelines for People With Spinal Cord Injury (SCI)
The first evidence-based physical activity guidelines for people with spinal cord injury were released in March, 2011. This project will evaluate the implementation of the new physical activity guidelines in a community exercise…
- Trial name
- NCT01368172
- Testing
- Physical Activity Guidelines
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cervicogenic Headache, Neck Pain
Multi Cervical Unit Measures of Cervical Isometric Strength and Range of Motion: A Pilot Study
This study is designed to collect normative data on cervical isometric strength and range of motion to supplement an existing normative data base.
- Conditions
- Cervicogenic Headache, Neck Pain, Whiplash, Kyphotic and Reversed Cervical Curves
- Trial name
- NCT00510757
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Logan College of Chiropractic
Out-Of-Hospital Cardiac Arrest, Post Cardiac Arrest Syndrome
Pre-hospital Post ROSC Care: Are we Achieving Our Targets?
Rational: Out of hospital cardiac arrest is a devastating event with a high mortality. Survival rates have increased over the last years, with the availability of AED's and public BLS.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Post Cardiac Arrest Syndrome, Emergency Medical Services
- Trial name
- POP-ROC (NCT04339257)
- Volunteers
- 175 people
- Sponsor
- University Medical Center Groningen
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