Clinical trials: Central Nervous Injury
Acute Subdural Hematoma
Comparison of Total Intravenous Anesthesia vs. Inhalational Anesthesia in Acute Subdural Hematoma Patients
Consent will be taken from the relatives and the patient will be taken to the operating room. Inside the operation theatre patient will be shifted to operating table and standard monitors will be attached.
- Trial name
- NCT03146104
- Testing
- Propofol, Isoflurane
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Spinal Cord Injuries
tSCS + UL Robotics Training in SCI Patients
This study is aimed to evaluate whether transcutaneous spinal cord stimulation (tSCS) can augment upper limb robotic training (ULRT) to improve functional mobility in participants with chronic spinal cord injuries.
- Trial name
- NCT07432321
- Testing
- ULRT + tSCS + conventional occupational therapy, ULRT + conventional occupational therapy
- Where
- Singapore
- Volunteers
- 6 people
- Sponsor
- National University Hospital, Singapore
Spinal Cord Injuries
Needs of Persons with Spinal Cord Injury (SCI)
Persons with spinal cord injury (PwSCI) are at a greater risk for major health conditions and poorer health outcomes than persons without spinal cord injury (SCI).
- Trial name
- NCT04422769
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Washington University School of Medicine
Urinary Tract Infection
Role of Residual Urine and Asymptomatic Prostatitis in the Development of Urinary Tract Infections in Spinal Cord Injury
The purpose of this prospective study is to investigate the association between the amount of residual urine and asymptomatic bacterial prostate infection with the occurrence of recurrent (>2 /year) symptomatic urinary tract…
- Trial name
- NCT01601041
- Testing
- sonographic assessment of residual urine, urine culture
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
TBI (Traumatic Brain Injury)
Evaluation of Well-being Interventions in Adults With TBI
The purpose of this research is to evaluate the potential benefits of two Intervention programs in adults with TBI to improve well-being and other outcomes that are maintained over time.
- Trial name
- NCT05943756
- Testing
- Signature Strengths, TBI Education Course
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Kessler Foundation
Premature Birth
Effect of Erythropoietin on Preterm Brain Injury
EPO has been safely used for prevent preterm anemia and recent studies have shown the neuroprotective effect. Our hypothesis is that EPO could prevent preterm brain injury.
- Trial name
- EPO (NCT02036073)
- Testing
- recombinant human erythropoietin
- Where
- China
- Volunteers
- 490 people
- Sponsor
- Zhengzhou Children's Hospital, China
Repetitive Head Impacts
Monitoring Patients With Repetitive Head Impact With Gamma-glutamylcysteine Supplementation
The goal of this clinical trial is to test whether the gamma - glutamylcystiene (GGC) oral supplement can reach the brain and subsequently increase antioxidant glutathione (GSH) level in people with repetitive head impact (RHI).
- Trial name
- RHIGSH (NCT07050173)
- Testing
- Gamma-glutamylcysteine (GGC)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Pravat Mandal
Spinal Cord Injuries, Spinal Cord Stimulation
Spinal Cord Stimulation and Respiration After Injury
Respiratory motor control deficit is the leading cause of morbidity and mortality in patients with spinal cord injury. The long-term goal of this NIH-funded study is to develop a rehabilitation strategy for respiration in…
- Conditions
- Spinal Cord Injuries, Spinal Cord Stimulation, Breathing Exercises, Rehabilitation
- Trial name
- NCT05178056
- Testing
- Spinal Cord Epidural Stimulation, Respiratory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Louisville
Spinal Cord Injuries
Efficacy and Safety of hUC-MSCs and hUCB-MSCs in the Treatment of Chronic Spinal Cord Injury
There is evidence that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) can differentiate into oligodendrocytes and neurons, and improve the recovery of nerve function, which strongly suggests the feasibility…
- Trial name
- NCT04213131
- Testing
- Stem cell transplantation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Ischemic Stroke, Brain Tumor
Confounding Factors in the Detection of Intracranial Hemorrhage With the Infrascanner
The investigators prospectively want to use the Infrascanner in patients with ischemic stroke, patients with brain surgery, patients with brain tumors, patients with intracranial hemorrhage and patients with a normal CT scan of…
- Conditions
- Ischemic Stroke, Brain Tumor, Brain Surgery, Intracranial Hemorrhage
- Trial name
- NCT02809651
- Testing
- Infrascanner
- Where
- Belgium
- Volunteers
- 89 people
- Sponsor
- Ziekenhuis Oost-Limburg
TBI (Traumatic Brain Injury)
Validation of an Ecological Organization and Problem Solving Test (TEM-PRO) in Vocational Rehabilitation
Standard neuropsychological evaluations after severe TBI (traumatic brain injury) often minimizes the executive deficits, these latter are known to seriously impair return to work.
- Trial name
- TEM-PRO (NCT04087486)
- Testing
- Implementation of a behavioural test for patients with TBI
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Clinique Romande de Readaptation
Spinal Cord Injuries
Hyperbaric Oxygen and Orthopedic Comprehensive Treatment for Traumatic Incomplete Spinal Cord Injury in the Plateau
To observe modified Barthel index, American Spinal Injury Association (ASIA) impairment scale grading, sensory score and motor score in patients with incomplete SCI in the plateau using 0.2 MPa HBO combined with pedicle screw…
- Trial name
- NCT03112941
- Testing
- control group, hyperbaric oxygen group
- Volunteers
- 164 people
- Sponsor
- Qinghai University
Sport Related Concussion
Pilot Study on the Correlation Between Accelerations Experienced
Concussion, or mild traumatic brain injury, accounts for 85% of brain injuries and is common in both professional and amateur sports.
- Trial name
- BIOIMPACT (NCT07507253)
- Testing
- Analyze correlations between the measurements of the variations in biomarkers with those obtained by an instrumented mouthguard measuring accelerations.
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Sys2Diag
Brain Injuries, Traumatic
Assignment of the Verbal Component Score and Addition of Pupil Reaction to the Glasgow Coma Scale
In this study, it is aimed to determine the prognostic value of GCS-P and the GCS-P score, which is formed by assigning a verbal score, in patients with traumatic brain injury, where all parameters can be evaluated.
- Trial name
- NCT05767502
- Testing
- GCS-Pupil score
- Where
- Turkey (Türkiye)
- Volunteers
- 199 people
- Sponsor
- Uludag University
Neurogenic Detrusor Overactivity
A Two-week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Years) With Neurogenic Detrusor Overactivity
This study will evaluate the pharmacodynamics and pharmacokinetics of darifenacin liquid oral suspension in children, ages 2-15 years, with neurogenic detrusor overactivity.
- Trial name
- NCT00712322
- Testing
- Darifenacin
- Where
- 12 sites in United States, Colombia
- Volunteers
- 35 people
- Sponsor
- Warner Chilcott
Spinal Cord Injuries (SCI), Urinary Retention
Clinical Trial of Abdominal Breathing for Urinary Retention After Spinal Cord Injury
Randomized controlled trials were conducted in patients with urinary retention after spinal cord injury. The effects of abdominal breathing training on pelvic floor muscle tone, muscle strength and residual urine volume in…
- Trial name
- NCT06964256
- Testing
- Abdominal breathing exercises, Control group: intermittent catheterization, Experimental group: intermittent catheterization
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Qilu Hospital of Shandong University
Traumatic Brain Injury
A Pilot Study to Identify Biomarkers Associated With Chronic Traumatic Brain Injury
The aim of this research is to determine if the biological fluids (blood/saliva) from chronic brain-injured patients (both blast and non-penetrating TBI) contain reproducible protein markers.
- Trial name
- Chronic TBI (NCT01171131)
- Testing
- Blood/saliva sampling
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Traumatic Brain Injury
A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury.
A Randomized, Double Blind, Placebo Controlled, Phase 2 Dose Escalation Study to Investigate the Safety and Pharmacokinetics after Single and Multiple I.V.
- Trial name
- NCT00735085
- Testing
- SLV334
- Where
- 14 sites in United States, Israel and 2 more
- Volunteers
- 57 people
- Sponsor
- Abbott Products
Stroke, Intracerebral Haemorrhage
Comparison of Blended Care Outpatient Neurorehabilitation With Traditional Outpatient Neurorehabilitation
What is this study about? Outpatient neurorehabilitation (therapy after leaving the hospital) is an important follow-up treatment for people who have had a stroke, brain bleeding, or serious head injury.
- Conditions
- Stroke, Intracerebral Haemorrhage, Brain Trauma
- Trial name
- NCT07458308
- Testing
- Blended care outpatient neurorehabilitation
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Luzerner Kantonsspital
Healthy, Neurodegenerative Disease
Brain Health Registry: An Online Registry to Identify and Assess Subjects for Brain Research
The overall goal of this project is to identify, assess and longitudinally monitor subjects who are interested in participating in brain research.
- Trial name
- BHR (NCT02402426)
- Where
- United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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