Clinical trials: Central Nervous Injury
Traumatic Brain Injury, TBI
Novel Intervention for Chronic Complex TBI in OEF/OIF/OND Veterans
The goal of this clinical trial is to compare pregnenolone and placebo (a placebo is a look-alike substance that contains no active drug) in Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND)-Era…
- Trial name
- NCT05671692
- Testing
- Pregnenolone
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- Christine Marx, MD
Traumatic Brain Injury, Cerebral Anoxia
Intrathecal Baclofen Therapy and Paroxysmal Dysautonomia in Severe Brain-Injured Patients
Within the framework of a prospective double-blind and randomized study evaluating the efficacy of continuous intrathecal baclofen therapy (CIBT) on paroxysmal dysautonomia (main objective) and hypertonia, recovery and tolerance…
- Conditions
- Traumatic Brain Injury, Cerebral Anoxia, Coma, Hypertonia
- Trial name
- NCT00221689
- Testing
- baclofen (drug)
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Bordeaux
Stroke, Spinal Cord Injuries
A Feasible Smart Upper Limb Rehabilitation Model for Patients With Stroke and Spinal Cord Injuries
The goal of this clinical trial is to investigate the effectiveness of the developed application and exoskeleton robot devices for home-based training in stroke patients and patients with spinal cord injuries.
- Trial name
- NCT06215625
- Testing
- Robot-assisted therapy, Task-oriented training
- Where
- 2 sites in Taiwan
- Volunteers
- 90 people
- Sponsor
- National Cheng-Kung University Hospital
Traumatic Brain INjury
Biomarkers in Prehospital Prediction of Need for Neurosurgical Observation or Intervention in TBI Patients
The PreTBI II study aims to investigate the diagnostic potential of prehospital S100B and GFAP measurements in prediction of need for neurosurgical observation and/or intervention in moderate TBI patients, to rule-in high-risk…
- Trial name
- PreTBI II (NCT03028376)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Spinal Cord Injuries
Effects of FES-Rowing in Neurological Disorders (FES-ROW)
The main objective of this project is to measure the increase in aerobic physical and metabolic capacities with a 6-month training on a rower assisted by electrostimulation of lower limbs in a population of adults with traumatic…
- Trial name
- FES-ROW (NCT04821635)
- Testing
- Rower assisted by electrostimulation (FES-ROW)
- Where
- 2 sites in France
- Sponsor
- UGECAM Rhône-Alpes
Traumatic Brain Injury, Dementia Alzheimers
Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury
Patients with a history of traumatic brain injury (TBI) are at elevated risk for Alzheimer's disease and related dementias (ADRD). Improvements in TBI treatment may mitigate this risk.
- Conditions
- Traumatic Brain Injury, Dementia Alzheimers, Military Activity
- Trial name
- OCEANS-TBI (NCT04073225)
- Testing
- MindPod Dolphin, 10 Keys to Healthy Aging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Johns Hopkins University
Stroke, Engagement, Patient
Gamification of Neurorehabilitation-centric Hand Exercises Post Stroke or Brain Injury
Stroke is the leading cause of adult disability worldwide. Often, severe neurological deficits occur after a stroke and roughly 70% of all stroke survivors have some form of hand function disability.
- Trial name
- NCT05547217
- Testing
- Hand Therapy using the MyHand System
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- IRegained Inc.
Chronic Wound, Diabetes
Exciflex Electroceutical Banadage for Chronic Wound Therapy
Objectives: The study objective is to carry a pilot clinical assessment comparing the exciflex bandage to standard of care (SoC) for ischemic wounds and will involve participants who are Veterans with lower extremity ischemic…
- Conditions
- Chronic Wound, Diabetes, Spinal Cord Injury, Ischemic Wound
- Trial name
- NCT04887688
- Testing
- exciflex
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Head Injury, Face
Craneofacial Injuries in Rink Hockey Athletes
To collect the number of injuries that affect the face and head in rink hockey athletes prospectively during a regular season.
- Conditions
- Head Injury, Face, Concussion, Brain
- Trial name
- NCT05400551
- Where
- 2 sites in Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Spinal Cord Injuries, Neurogenic Bowel
Abdominal Functional Electrical Stimulation to Improve Bowel Function in Spinal Cord Injury
The primary objective of this study is to gather information about the effectiveness of abdominal FES to improve bowel management time (BMT) for people with chronic SCI.
- Trial name
- NCT06345781
- Testing
- Abdominal Functional Electrical Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Craig Hospital
Spinal Cord Injury
Longitudinal Morphometric Changes Following SCI
In patients with chronic spinal cord injury, imaging of the spinal cord and brain above the level of the lesion provides evidence of neural degeneration; however, the spatial and temporal patterns of progression and their…
- Trial name
- NCT02149511
- Where
- Switzerland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Disorder of Consciousness, Electroacupuncture
Electro-acupuncture to Treat Disorder of Consciousness
With the rapid development of life support technology, more and more people can survive severe brain injury. Some survivors regain consciousness after a period of coma, however, many patients develop prolonged disorders of…
- Trial name
- NCT06268236
- Testing
- Electroacupuncture
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Acute Brain Injury, Hypoxia, Brain
Portable MRI for Pediatric Hypoxic Ischemic Brain Injury
This study will evaluate the sensitivity and specificity of low field portable MRI (pMRI) for detection of hypoxic ischemic brain injuries in pediatric patients compared to clinically obtained neuroimaging to define pediatric…
- Conditions
- Acute Brain Injury, Hypoxia, Brain, Ischemia, Brain, Brain Injuries
- Trial name
- pMRI for HIBI (NCT07577336)
- Testing
- Portable MRI, Scavenged Sample Collection
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Mercy Hospital Kansas City
Cerebral Amyloid Angiopathy, Siderosis
Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy
Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging…
- Trial name
- CSS (NCT05394636)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 111 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Mild Traumatic Brain Injury, Concussion, Mild
Facilitating Access to Specialty Treatment
The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention…
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- NCT05741411
- Testing
- RPM-assisted specialist access
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Children's Hospital of Philadelphia
Anosognosia, Brain Damage
Cognitive-functional Evaluation of Anosognosia
Acquired brain damage patients usually show severe cognitive deficit that alter their performance on every day life activities. Some of them suffer anosognosia and they are not aware of their own limitations.
- Trial name
- NCT03712839
- Testing
- Cognitive-functional evaluation
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- María Rodríguez Bailón
Spinal Cord Injuries
Turkish Version of the Neurogenic Bladder Symptom Score Questionnaire: a Cross-cultural Adaptation, Reliability and Validity Study
Turkish version of the Neurogenic Bladder Symptom Score questionnaire: a cross-cultural adaptation, reliability and validity study
- Trial name
- NCT03964077
- Testing
- Neurogenic Bladder Symptom Score Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Traumatic Brain Injury
Study on Cerebral Protection of Dexmedetomidine for Patients With Traumatic Brain Injury
The aim of the study is to investigate whether dexmedetomidine could suppress catecholamine release into peripheral blood to prevent PSH attacks and to achieve neuroprotection.
- Trial name
- NCT04006054
- Testing
- Dexmedetomidine, Midazolam
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Xiangya Hospital of Central South University
Bone Loss, Spinal Cord Injuries
Intervention on Bone Health in Wheelchair Users
The low mechanical loading of bones among wheelchair users leads to an increased risk of bone fractures and associated complications due to low bone mineral density (BMD).
- Conditions
- Bone Loss, Spinal Cord Injuries, Cerebral Palsy, Spina Bifida
- Trial name
- BoneWheel (NCT05615402)
- Testing
- Bone-specific strength training, Nutrition optimalisation
- Where
- Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Neurological Disorders, Wheelchair Mobility
Evaluation of the Wheelchair School (Drivkraft) a Clinical Study
This project will evaluate the Wheelchair School with the Drivkraft Methodology in a clinical setting. Participants are adults with chronic neurological diagnoses.
- Conditions
- Neurological Disorders, Wheelchair Mobility, Rehabilitation
- Trial name
- NCT07131553
- Testing
- Wheelchair school, Comparison group, conventional rehabilitation
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
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