Clinical trials: Central Nervous Injury
Cardiac Arrest (CA), Post Cardiac Arrest Syndrome
Breakthrough Platform Trial for PCAS
The goal of this platform clinical trial is to evaluate whether specific post-cardiac arrest care strategies can improve neurological recovery and survival in adult patients who remain comatose after return of spontaneous…
- Trial name
- BPT-PCAS (NCT07769086)
- Testing
- Head Positioning, Temperature Control
- Where
- 12 sites in Japan
- Volunteers
- 630 people
- Sponsor
- Kagawa University
Traumatic Brain Injury
Biomarkers in Prehospital Rule-out of Intracranial Lesions in TBI Patients
The PreTBI I study will investigate whether prehospital blood samples drawn already in the ambulance can rule-out intracranial lesions in patients suffering head trauma.
- Trial name
- PreTBI I (NCT02867137)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 595 people
- Sponsor
- University of Aarhus
Traumatic Brain Injury
Pilot Study of NeuroTriage Device in Patients with Potential Brain Injury And/or Impairment
This protocol is aimed at collecting oculomotor response data from a variety of brain injuries and impairments, and to secondarily evaluate the functionality and ease of use of the NeuroTriage device in the ED in patients with…
- Trial name
- NCT03761641
- Testing
- Neurotriage
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Texas Southwestern Medical Center
Spinal Cord Injury
6 Minute Propulsion Test Sensitivity to Increased Aerobic Capacity
The goals of this project are to 1)determine the responsiveness of the 6 Minute Push Test (6MPT) and 2) explore the relationship between 6MPT distance and measures of handicap, wheelchair satisfaction, depression, and…
- Trial name
- NCT01184729
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Miami
Spinal Cord Injuries
Feasibility of Mindfulness Meditation Training and Home Practice in Persons With Spinal Cord Injury
The purpose of this study is to evaluate the feasibility and acceptability of a 6-week app-guided Mindfulness meditation training (MM) intervention and health education (active control) condition in people with spinal cord injury…
- Trial name
- NCT05556057
- Testing
- mindfulness meditation(MM), Health Education (active control)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injury
Pilot Study: The Role of Macrophage Migration Inhibitory Factor (MIF) in Spinal Cord Injury
The purpose of the study is to investigate inflammatory and other substances that may be elevated in the blood and blood cells following spinal cord injury (SCI).
- Trial name
- NCT00919581
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Posttraumatic Headache, Posttraumatic Stress Disorder
Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD
Post-Traumatic Stress Disorder (PTSD) and traumatic brain injury (TBI) with associated headache are amongst the most common injuries sustained by our deployed forces in Iraq and Afghanistan, as well as in more recent conflicts in…
- Trial name
- NCT06608277
- Testing
- Group A active comparator, Group B active comparator, Group C Experimental
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- Northwestern University
Spinal Cord Injuries, Spinal Cord Diseases
Transcutaneous Auricular Vagus Nerve Stimulation in Spinal Cord Injury
This study is a single blinded prospective randomized monocentric study examining the effectiveness of transcutaneous auricular vagus nerve stimulation paired with rehabilitation and low frequency/antidromic stimulation of the…
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Nervous System Diseases, Trauma, Nervous System
- Trial name
- taVNS (NCT05852379)
- Testing
- active taVNS
- Volunteers
- 10 people
- Sponsor
- Possover International Medical Center AG
Lung Disease, Brain Injury
Genomics, Single Nucleotide Polymorphisms (SNPs), and Clinical Neonatology
This research seeks to establish a neonatal DNA Tissue Bank to find out if differences in small segments of DNA predispose babies to Chronic Lung Disease (CLD), Periventricular Brain Injury (PVI), Necrotizing Enterocolitis (NEC)…
- Conditions
- Lung Disease, Brain Injury, Necrotizing Enterocolitis, Respiratory Failure
- Trial name
- NCT00315263
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Children's Mercy Hospital Kansas City
Hydrocephalus
UVC in Prevention of Surgical Wound Infection
The LF-PODD study investigates the use of UVC (270nm) light in the prevention of surgical wound infections. Three devices are used in the study, two of which are actively producing UVC light (265 and 275 nm) and one device does…
- Trial name
- UVCJAS (NCT07600463)
- Testing
- UVC Irradiation
- Where
- Finland
- Volunteers
- 75 people
- Sponsor
- Ville Leinonen
Adult-Onset Growth Hormone Deficiency
Metabolic and QOL Effects of GH Treatment in Patients With TBI and AGHD
This PILOT, NON-INTERVENTIONAL STUDY will follow patients about to start rhGH for a period of six months and collect valuable pilot data to evaluate feasibility of a larger study and treatment tolerability and compliance.
- Trial name
- NCT02988687
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Garcia, Jose M., MD, PhD
Spinal Cord Injuries
Effects of Intensive Chiropractic Care to Usual Care for Adults With Spinal Cord Injuries.
To determine the effects of chiropractic care on spasticity, functional outcomes and quality of life in Spinal Cord Injuries in adults.
- Trial name
- NCT05315115
- Testing
- Chiropractic Care, Physical therapy intervention
- Where
- Pakistan
- Volunteers
- 29 people
- Sponsor
- Riphah International University
Traumatic Brain Injury
A Health and Wellness Lifestyle Program to Support Community-Dwelling Persons With Traumatic Brain Injury
To evaluate the efficacy of an adapted telehealth-based, health and wellness lifestyle program on promoting healthy lifestyle behaviors and improving health outcomes.
- Trial name
- POWERS-TBI (NCT04288258)
- Testing
- Telehealth-Based Health and Wellness Program (POWERS-TBI)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Alabama at Birmingham
Mild Traumatic Brain Injury
Long Term Results of Psychoeducation and Cognitive Rehabilitation After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) accounts for 70-90% of brain injuries, with 600 cases of mTBI per 100 000 people in the united states, but only 100-300 mTBI patients per 100 000 people receive hospital-based care.
- Trial name
- ReLoT-TCCL (NCT04746716)
- Testing
- Phone call
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypoxia, Brain, Hypoxia-Ischemia, Brain
Home Stimulation for Brain-Asphyxiated Infants
This study examines the potential benefits of a home stimulation program to treat infants who have suffered from brain asphyxiation (lack of oxygen). The program involves one year of stimulatory activities.
- Trial name
- NCT00006516
- Testing
- Infant stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Spinal Cord Injuries
Hemodynamic Management Following Acute Traumatic Spinal Cord Injury
The purpose of this study is to assess the effect of various hemodynamic management strategies on functional neurologic outcomes and non-neurologic adverse events in the first 5 days following acute spinal cord injury (SCI).
- Trial name
- NCT06451133
- Testing
- Mean arterial blood pressure (MAP) goal of ≥65 mmHg, Mean arterial blood pressure (MAP) goal of 85-90 mmHg, Spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg
- Where
- United States
- Volunteers
- 228 people
- Sponsor
- The University of Texas Health Science Center, Houston
Brachial Plexus Neuropathies, Traumatic Brachial Plexus Lesion
Central Programming in Patients With a Bionic Hand After Traumatic Brachial Plexus Injury
Traumatic brachial plexus lesions may lead to permanent impairment of hand function despite brachial plexus surgery. In selected cases the affected forearm can be amputated and replaced by a bionic hand.
- Conditions
- Brachial Plexus Neuropathies, Traumatic Brachial Plexus Lesion, Bionic Hand Reconstruction
- Trial name
- NCT04649749
- Testing
- MRI
- Where
- Austria
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Spinal Cord Injuries, Traumatic Brain Injury
Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study
The purpose of this study is to test the effects of an innovative exercise program referred to as movement-2-music (M2M) on health and fitness outcomes in adults with physical/mobility disabilities.
- Conditions
- Spinal Cord Injuries, Traumatic Brain Injury, Spina Bifida, Cerebral Palsy
- Trial name
- M2M LEADERS (NCT03797378)
- Testing
- eM2M
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injury, Hypotension
A Dose Titration of Droxidopa in Patients With Spinal Cord Injury
The investigators seek to determine the efficacy, duration of action and safety of escalating dose of droxidopa on systemic blood pressure, cerebral blood flow and vasoactive hormones and catecholamines during upright seated…
- Trial name
- NCT01354158
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Bronx VA Medical Center
Concussion; Syndrome
Correlation Between Changes in Measures of the Visual System and Changes in Concussion-associated Symptoms
Sports-related concussion affect 1.6 to 3.8 million people each year in the United States. Despite increased media attention and awareness campaigns, the exact number is difficult to determine due to underreporting by athletes.
- Trial name
- NCT03259178
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- McGill University
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