Clinical trials: Central Nervous Injury
SCI - Spinal Cord Injury
Improving Balance After Spinal Cord Injury Using a Robotic Upright Stand Trainer and Spinal Cord Epidural Stimulation
The purpose of this study is to understand how standing and sitting balance control is altered after spinal cord injury and how a new type of robotic assistive device may be used with spinal stimulation to improve muscle…
- Trial name
- NCT06650202
- Testing
- The Tethered Pelvic Assist Device (TPAD)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kessler Foundation
Injury, Brain, Traumatic, Traumatic Brain Injury
Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury
The investigators will conduct an observational crossover study. The investigators aim to recruit 50 participants with severe Traumatic Brain Injury (TBI) requiring intracranial pressure (ICP) monitoring during their stay at the…
- Trial name
- NCT02507973
- Testing
- Airway Pressure Release Ventilation, Low Tidal Volume Ventilation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Maryland, Baltimore
Spinal Cord Injuries, Bone Resorption
Bone-biomarkers of Spinal Cord Injury Patients
Patients with spinal cord injury have a high prevalence of osteoporosis due to chronic skeletal unloading. Recently, various treatment drugs for osteoporosis have been developed.
- Conditions
- Spinal Cord Injuries, Bone Resorption, Osteoporosis
- Trial name
- NCT04403256
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Yeungnam University Hospital
Stroke, TBI
Assessment of Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments
This study will evaluate the safety and performance of the Spatial StimeMD (SSMD) medical device in people with multiple sclerosis (MS). The SSMD device is intended to support patients through a non-invasive stimulation program.
- Conditions
- Stroke, TBI, Spinal Cord Injury, Peripheral Nerve Damage
- Trial name
- NCT07396922
- Testing
- SSMD, Functional Electrical Stimulation (FES)
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Motion Informatics LTD
Carpal Tunnel Syndrome
IMpact of Perineural Hydrodissection Over Alternative Therapies in Patients With Carpal Tunnel Syndrome
This is a multidisciplinary, single-blinded, three-arm randomized controlled trial, comparing perineural hydrodissection and steroid injection for the treatment of CTS.
- Trial name
- IMPACTS (NCT03616353)
- Testing
- Perineural Hydrodissection, Corticosteroid Injection
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Leslie Witton
Acquired Brain Injury
Experimentation of an Ankle Mobilization Device for the Rehabilitation of Patients With Acquired Brain Injuries.
The proposed clinical investigation plan is a randomized controlled pivotal study with 2 parallel groups, has a total duration of two years.
- Trial name
- NCT03879070
- Testing
- Ankle active and passive mobilization using an Ankle mobilization device
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Concussion, Mild
Sex and Age Ultrasound Response to Differential Jugular Vein Pressure
Clinical trials have suggested that this device is effective in mitigating changes in brain structure and function in athlete populations.
- Trial name
- NCT03017937
- Testing
- Q-collar
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Spinal Cord Injuries, Pressure Ulcer
Interactive Telehealth for Pressure Ulcer Prevention After SCI
The goal of this module project is to establish the efficacy of a portable sensor and app-based biofeedback technology system for promoting effective pressure relief behaviors and reducing risk of pressure ulcer development among…
- Trial name
- NCT03469141
- Testing
- Pressure Relief Monitoring System
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Rancho Research Institute, Inc.
Traumatic Brain Injury
Defining Axonal Injury in Children With Mild Traumatic Brain Injury
To measure Axonal Injury in children with mild traumatic brain injury enrolled in an Emergency Department using Diffusion Tensor Imaging, a type of MRI and biomarkers.
- Trial name
- NCT01922531
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Spinal Cord Injury
Preventing Pneumonia and Other Respiratory Problems in Persons With Spinal Cord Injury
It is known that individuals with spinal cord injury are at increased risk for respiratory tract infections like pneumonia. Part of this risk is due to weakened chest and abdominal muscles that are vital to deep breathing and the…
- Trial name
- NCT00448045
- Testing
- Manual and mechanical assisted cough, Incentive spirometry
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Kessler Foundation
Spinal Cord Injury
VALSE: Integration of Neuromodulation and Exoskeleton Systems for Mobility in Individuals With Chronic Spinal Cord Injury
The purpose of this clinical study is to evaluate the preliminary safety and feasibility of using the VALSE system, which combines spinal cord stimulation with the TWIICE robotic exoskeleton, to support motor recovery and reduce…
- Trial name
- VALSE (NCT07745686)
- Testing
- TWIICE Rise 1.0 robotic exoskeleton combined with epidural electrical stimulation (EES)
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Critical Illness, Sepsis
Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis
Sepsis related cerebral dysfunction was underestimated in critical illness setting, and inflammatory response of brain could not be monitored directly and cerebral oximetry offered information of cerebral dysfunction.
- Conditions
- Critical Illness, Sepsis, Cerebral Injury
- Trial name
- NCT03523169
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Brain Damage
Cognitive Abilities in Brain Damaged Patients
The presence of damage to the central and / or peripheral nervous system resulting from pathologies of a different nature (such as multiple sclerosis, Parkinson's disease, dementia, cranial trauma, stroke, epilepsy or other…
- Trial name
- Cog (NCT03344731)
- Testing
- Cognitive evaluation, Non-invasive brain stimulation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Mild Traumatic Brain Injury (mTBI)
Symptom-Targeted Approach to Rehabilitation for Concussion (STAR-C)
Purpose: Investigators propose a three-arm RCT across two military treatment facilities:1) in-person STAR-C, 2) telehealth STAR-C, and 3) no treatment control.
- Trial name
- STAR-C (NCT06855186)
- Testing
- Symptom-Targeted Approach to Rehabilitation for Concussion
- Where
- 2 sites in United States
- Volunteers
- 222 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Traumatic Brain Injury, Closed Traumatic Brain Injury
The Effects of Transcranial Direct Current Stimulation (tDCS) and Cognitive Training in Patients With TBI
Long-term sequelae in TBI is a well-recognized burn. We designed a proof of concept study, randomized, double-blind, placebo-controlled to evaluate 36 adult TBI patients.
- Conditions
- Traumatic Brain Injury, Closed Traumatic Brain Injury, Severe Brain Injury
- Trial name
- NCT04540783
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo General Hospital
Spinal Cord Injury, Spasticity
Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury
Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands.
- Conditions
- Spinal Cord Injury, Spasticity, Shockwave Therapy
- Trial name
- NCT07501429
- Testing
- Focused extracorporeal shockwave therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries
Acute Mechanisms of Cervical Transcutaneous Electrical Stimulation of the Spinal Cord
The purpose of this study is to examine how delivery of subthreshold electrical stimulation of the spinal cord alters the excitability of neural pathways and consequently movement performance in healthy and spinal cord injured…
- Trial name
- NCT04843137
- Testing
- Cervical Transcutaneous Electrical Spinal Cord Stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Cerebral Palsy, Spinal Muscular Atrophy
Pediatric Powered Wheelchair Standing Devices: An Exploratory Study
For children who use a power wheelchair, a powered wheelchair standing device (PWSD) may be considered for daily use. A PWSD allows a child to electronically move between sitting and standing and can be driven in either position.
- Conditions
- Cerebral Palsy, Spinal Muscular Atrophy, Spinal Cord Injuries, Spina Bifida
- Trial name
- NCT05117827
- Testing
- Power Wheelchair Standing Device
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Brain Injuries, Acquired Brain Injury
Human-Animal Interaction to Promote Recovery Following Pediatric Brain Injury
This study evaluates the addition of therapy dogs in inpatient physical and occupational therapy. Data will be collected across 10 PT and 10 OT sessions, half of which will incorporate a therapy dog.
- Conditions
- Brain Injuries, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- AAT (NCT04016961)
- Testing
- AAT - Dog, TAU - No Dog
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Brain Injury, Head Injury
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial.
- Conditions
- Traumatic Brain Injury, Head Injury, Head Injuries, Closed, Brain Hemorrhage, Traumatic
- Trial name
- NCT05622461
- Testing
- Road-to-recovery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
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