Clinical trials: Central Nervous Injury
Brain Injuries, Sleep Disturbance
Music Listening and Sleep in Rehabilitation of People With Acquired Brain Injury
An Injury to the brain may lead to sleep-wake disturbances which may negatively influence functional recovery, quality of life and general rehabilitation.
- Trial name
- NCT05620069
- Testing
- Music listening
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- Vejlefjord Rehabilitation
Spinal Cord Injury
Pilot Study Exploring the Effects of Rhythmic Auditory Stimulation on Gait in People With Motor Incomplete Spinal Cord Injury
This pilot study aims to evaluate the feasibility and preliminary efficacy of a wearable rhythmic auditory stimulation system, MedRhythms, for improving gait parameters in patients with motor incomplete SCI.
- Trial name
- NCT07674927
- Testing
- rhythmic auditory stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Mild Traumatic Brain Injury
BRAINI-2 Elderly Mild TBI European Study
Mild traumatic brain injury (mTBI) is one of the most frequent emergencies in the elderly population. Despite most mTBI are managed with cranial computed tomography (CT), only 10% of CTs show lesions, determining CT overuse.
- Trial name
- BRAINI2ELDER (NCT05425251)
- Testing
- GFAP and UCH-L1
- Where
- 7 sites in France, Germany and 1 more
- Volunteers
- 2,297 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario 12 de Octubre
Spinal Cord Injury, Urinary Tract Infection
Effect of Cranberry Capsules on Urinary Infection Rates in Spinal Cord Injured Patients During Post Acute Rehabilitation
The purpose of this study is to establish whether cranberry capsules reduce rates of urinary tract infections during initial rehabilitation immediately after spinal cord injury.
- Conditions
- Spinal Cord Injury, Urinary Tract Infection, Rehabilitation
- Trial name
- NCT01079169
- Testing
- Cranberry capsules
- Where
- Sweden
- Volunteers
- 3 people
- Sponsor
- Uppsala University
Muscle Spasticity, Spinal Cord Injury
Effect of Joint Mobilization on Alpha Motoneuron Reflex Excitability
Objective: To determine the effect of ankle joint mobilization on the alpha motoneuron reflex excitability of the soleus muscle in people with spasticity.
- Conditions
- Muscle Spasticity, Spinal Cord Injury, Stroke, Craniocerebral Trauma
- Trial name
- JM-HRreflex (NCT01153022)
- Testing
- joint mobilization techniques
- Where
- Colombia
- Volunteers
- 24 people
- Sponsor
- Universidad Autónoma de Manizales, Colombia
Spinal Cord Injury
Effect of Electrostimulation on Denervated Muscles in Individuals With Spinal Cord Injury
The aim of the study is to investigate whether there is an effect of electrical stimulation on the denervated gluteus muscle (buttocks) in individuals with chronic spinal cord injury.
- Trial name
- NCT02265042
- Testing
- Stimulette
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Traumatic Brain Injury With Brief Loss of Consciousness
The Clinical Research on the Relationship Between Depression and Gut Microbiota in TBI Patients
Microbiome studies may be highlighted as crucial in the development of depression for TBI patients. The microbiota-gut-brain connection may further provide an opportunity for microbiota manipulation to treat the TBI patients with…
- Trial name
- NCT02874027
- Testing
- The TBI patients with depression
- Where
- China
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Traumatic Brain Injury
Testing Devices That Involve the Sense of Touch in Subjects With Traumatic Brain Injury
Background: Previous studies have shown that computer-based devices that simulate everyday tasks can be helpful for evaluation and rehabilitation in people who have had strokes.
- Trial name
- NCT01404494
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Neuropathic Pain
Treatment of Neuropathic Pain Following Spinal Cord Injury - a RTMS Approach
This study aims to determine if repetitive transcranial magnetic stimulation (rTMS) can improve pain symptomology in adults with neuropathic pain (NP) following a spinal cord injury (SCI).
- Trial name
- NCT06284694
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Severe Traumatic Brain Injury, Pancreatic Diseases
The Effect of Closed Suction System on the Incidence of Ventilator-associated Pneumonia.
The investigators are suggesting that closed suction systems may reduce the risk of the ventilator - associated pneumoniae (VAP) and the contamination of the closest unanimated surfaces. In 2011 David et al.
- Conditions
- Severe Traumatic Brain Injury, Pancreatic Diseases, Trauma Injury, Seizures
- Trial name
- CSS-VAP (NCT04323150)
- Testing
- Closed suction systems, Conventional suction system
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Northern State Medical University
Dysarthria, Acquired Brain Injury
ACURES: Acoustic and Respiratory Parameters for Dysarthria Assessment
The goal of this observational study is to describe speech and breathing patterns in adults after acquired brain injury (ABI) and understand how these patterns relate to the presence, severity, and type of dysarthria.
- Trial name
- ACURES (NCT07435155)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- University of Salamanca
Motor-incomplete Spinal Cord Injury
Enhancing Walking in People With Incomplete Spinal Cord Injury: a Pilot Study
The research proposed here will determine the effect of a novel treadmill gait training strategy using a robotic gait trainer (the Lokomat) on functional ambulation in people with SCI.
- Trial name
- NCT00610974
- Testing
- Body-weight supported treadmill training
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Traumatic Brain Injury
Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide
The purpose of this study is to assess the incidence of early post-traumatic seizures. The study will also assess the benefit of lacosamide compared to levetiracetam in regards to agitation and behavioral adverse effects in…
- Trial name
- SEIZE-TBI (NCT06866691)
- Testing
- levetiracetam, lacosamide
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Wake Forest University Health Sciences
Cerebral Hypoxia, Severe Traumatic Brain Injury
Prioritization of Cerebral Deoxygenation in Severe Traumatic Brain Injury and Mortality Benefit.
Severe traumatic brain injury with a decrease in cerebral oximetry is associated with multiple impaired systemic microcirculations, more morbidities, and a higher mortality rate.
- Trial name
- NCT06306950
- Testing
- Near infrared spectroscopy neuromonitor to prevent cerebral desaturation
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Probable Alzheimer Disease, Parkinson Disease
In Vivo Alzheimer Proteomics
In France, an estimated 860 000 patients are affected by Alzheimer Disease (AD) which represents, as in other developed countries, a major public health issue.
- Conditions
- Probable Alzheimer Disease, Parkinson Disease, Neurological Disease Without Cognitive Degradation, Brain Trauma
- Trial name
- PROMARA (NCT02263235)
- Testing
- administration of stable isotope-labelled leucine-, collection of CSF, blood, urine, saliva
- Where
- France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Montpellier
Traumatic Brain INjury
Biomarkers in Prehospital Prediction of Need for Neurosurgical Observation or Intervention in TBI Patients
The PreTBI II study aims to investigate the diagnostic potential of prehospital S100B and GFAP measurements in prediction of need for neurosurgical observation and/or intervention in moderate TBI patients, to rule-in high-risk…
- Trial name
- PreTBI II (NCT03028376)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Brain Injuries
Risk Factors Predicting Prognosis and Outcome of Elderly Patients With Isolated Traumatic Brain Injury
Although several prognostic models have been developed to predict outcome for patients with severe traumatic brain injury (TBI), currently no study describes the impact of respiratory failure during Emergency Department treatment…
- Trial name
- NCT02386865
- Volunteers
- 292 people
- Sponsor
- Medical University of Vienna
Acquired Brain Injury, Development, Child
COgnitive REhabilitation in Pediatric Patients with ABI, from Vegetative State to Functional Recovery
Acquired brain injuries (ABI) represent one of the most important cause of disability and mortality during the pediatric age, also in the western Countries.
- Trial name
- COREABI (NCT04499092)
- Testing
- Personalized Neuropsychological treatment (CORE-ABI), Sequential Neuropsychological treatment (SET-ABI)
- Where
- Italy
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Traumatic Brain Injury (TBI) Patients
Efficacy of Propranolol in Traumatic Brain Injury Patients Admitted to the ICU: A Prospective, Randomized, Triple-Blind Study
Beta-blockers have shown promise as a treatment to improve patient prognosis following traumatic brain injury (TBI), although the exact mechanism by which they might confer this benefit remains unknown.
- Trial name
- ProP-TBI ICU (NCT07899164)
- Where
- 6 sites in Spain
- Volunteers
- 536 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Mild Traumatic Brain Injury
Passive Neurosensory Reintegration Training as a Tool to Augment Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) poses a substantial clinical and public health burden, often leading to persistent neurosensory and cognitive symptoms for which diagnostic and therapeutic solutions remain limited.
- Trial name
- PNRT for mTBI (NCT07356167)
- Testing
- Passive neurosensory reintegration training (PNRT)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Miami
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