Clinical trials: Central Nervous System Depression
Traumatic Brain Injury, Depression
Feasibility Study of Duloxetine in the Treatment of Depression in Patients With Traumatic Brain Injury
The primary objective of the study is to compare the efficacy of duloxetine 60 mg by mouth daily with placebo in the prevention of depression associated with mild/moderate traumatic brain injury and to enhance cognitive function.
- Trial name
- Duloxetine (NCT01223001)
- Testing
- Duloxetine, Sugar pill
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rehabilitation Hospital of Indiana
Depression, HIV Infections
PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects
Background: Human immunodeficiency virus (HIV) infection is a serious disease with no cure. Some people with HIV have depression and other mood problems. They can have problems with thinking and memory.
- Conditions
- Depression, HIV Infections, HIV-Associated Cognitive Motor Complex
- Trial name
- NCT03581305
- Testing
- 18F-FDOPA, 11C-DASB
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Depression
Managing Cancer and Living Meaningfully (CALM) Therapy in Individuals Diagnosed With a Primary Brain Tumor
Background: Psychological distress affects many people diagnosed with a primary central nervous system tumor (CNST). Distress can include negative feelings such as anger, fear, or sadness.
- Trial name
- NCT04852302
- Testing
- Cancer and Living Meaningfully (CALM) Therapy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Cancer Institute (NCI)
Major Depressive Disorder, Idiopathic Parkinson Disease
Study on the Tolerability of Duloxetine in Depressed Patients With Parkinson's Disease
This study aims to assess the tolerability of duloxetine, 60mg once daily, in open label fashion, in depressed patients with Parkinson's disease during 12 weeks treatment.
- Trial name
- NCT00437125
- Testing
- Duloxetine hydrochloride
- Where
- 13 sites in Italy
- Volunteers
- 151 people
- Sponsor
- Eli Lilly and Company
Depression, Parkinson's Disease
The Effects of Sertraline on Depression in Parkinson's Disease
The aim of this open-label, self-control study is to evaluate the efficacy of sertraline in treating depression in Patients with Parkinson's disease.
- Trial name
- PD (NCT01437189)
- Testing
- Sertraline
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Zhejiang University
Parkinson Disease, Depression
Study of Antidepressants in Parkinson's Disease
The purpose of this study is to find out if two antidepressant medications, paroxetine and venlafaxine, can help control depression in Parkinson's disease, and if these medications affect the motor symptoms of Parkinson's disease…
- Trial name
- SAD-PD (NCT00086190)
- Testing
- paroxetine, venlafaxine
- Where
- 18 sites in United States, Canada and 1 more
- Volunteers
- 115 people
- Sponsor
- University of Rochester
Parkinson's Disease, Depression
SAM-e for the Treatment of Depression in Patients With Parkinson's Disease
This study will test a chemical called s-adenosyl-methionine (SAM-e) for the treatment of depression in patients with Parkinson's disease (PD).
- Trial name
- NCT00070941
- Testing
- SAM-e, oral escitalopram
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- NYU Langone Health
Depression
Spanish Intervention for Caregivers of Veterans With Stroke
This research study will test a problem-solving intervention for Spanish-speaking stroke caregivers that will be delivered over the telephone and online via the previously developed and nationally available Spanish version of the…
- Trial name
- RESCUE (NCT03142841)
- Testing
- RESCUE Problem Solving Intervention
- Where
- 4 sites in United States, Puerto Rico
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Quality of Life, Brain Diseases
Long Term Survivors of High-grade Glioma and Their Caregivers
This study builds on the limited body of existing literature combined with the results from the investigators' previous research conducted with 30 newly diagnosed patients with high-grade glioma (HGG) and 33 of their caregivers.
- Conditions
- Quality of Life, Brain Diseases, Depression, Physical Impairment
- Trial name
- NCT02965144
- Testing
- no treatment
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Depression
Reducing Depression in Dementia Caregivers
The purpose of this study was to develop and examine the initial impact of a distance-based intervention for female family dementia caregivers.
- Trial name
- NCT00056316
- Testing
- Basic Education, Behavioral Skills Training: Experimental
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Missouri, St. Louis
Parkinson Disease, Depression
Treatment of Depression in Parkinson's Disease Trial
The goal of this study is to evaluate the effectiveness and safety of two antidepressants--nortriptyline and paroxetine, compared to placebo in patients with Parkinson's disease and depression.
- Trial name
- NCT00062738
- Testing
- paroxetine, Nortriptyline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Rutgers, The State University of New Jersey
Stroke, Stroke Sequelae
Mindfulness Based Stress Reduction and Post-Stroke Cognition
The investigators don't fully understand how, regardless of the size or location in the brain, minor strokes can result in significant problems with focus, attention, and multi-tasking that prevent individuals from returning to…
- Conditions
- Stroke, Stroke Sequelae, Depression, Cognitive Impairment
- Trial name
- NCT04302493
- Testing
- Mindfulness Based Stress Reduction (MBSR), Stroke Support Group (SSG)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Depression, Acute Pain
A Depression and Opioid Pragmatic Trial in Pharmacogenetics (DCRI Coordinating Center)
This is a Master Protocol Screening record. This study is comprised of three separate pharmacogenetic trials grouped into a single protocol due to similarities in the intervention, the hypotheses, and the trial design.
- Conditions
- Depression, Acute Pain, Chronic Pain
- Trial name
- ADOPT PGx (NCT04445792)
- Testing
- Pharmacogenetic testing, Clinical decisions support
- Where
- 14 sites in United States
- Volunteers
- 4,284 people
- Sponsor
- Duke University
Quality of Life, Anxiety
EMR Outcomes: Anxiety and Depression in Epilepsy
The purpose of this research is to find out how people with epilepsy and possible symptoms of anxiety or depression are doing for 6 months after a regular epilepsy clinic visit.
- Conditions
- Quality of Life, Anxiety, Depression, Epilepsy
- Trial name
- NCT03879525
- Testing
- EMR-based-interventional method, Telephone-based-standard method
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Depression, Anxiety
IntelliCare in College Students - Implementation (ICCS-I)
This study is a hybrid effectiveness-implementation trial of the smartphone student stress-management app IntelliCare for college students.
- Trial name
- NCT04108429
- Testing
- IntelliCare for College Students
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Anxiety, Depression
Anxiety and Depression in Epilepsy: A Treatment Study
As a potential solution to address high rates of depression and anxiety seen in epilepsy patients and poor mental health care access, this randomized trial aims to study treatment for anxiety and depression in epilepsy taking…
- Conditions
- Anxiety, Depression, Epilepsy
- Trial name
- NCT03464383
- Testing
- Escitalopram 10mg, Referral to Psychiatry, Survey only
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Wake Forest University Health Sciences
Depression, Parkinson's Disease
Telehealth Cognitive Behavioral Therapy for Depression in Parkinson's Disease (PD)
When Veterans with Parkinson's disease (PD) suffer from depression, they are more likely to experience disease complications, interpersonal difficulties with caregivers, and poorer quality of life.
- Trial name
- TH-CBT (NCT02475954)
- Testing
- TH-CBT, Standard Care
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development
Stroke, Acute Stroke
Inflammation and Post-Stroke Depression
This study is being done to see if there is a relationship between stroke, post-stroke depression, and measures of inflammatory and/or stress compounds in the blood.
- Trial name
- NCT02368145
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Alexander Kusnecov, Ph.D.
Parkinson's Disease, Depression
Coping With Depression in Parkinson's Disease
The purpose of this study is to evaluate the efficacy of a cognitive-behavioral treatment, that includes a caregiver-focused social support intervention, for depression in persons with Parkinson's disease.
- Trial name
- NCT00464464
- Testing
- cognitive-behavioral therapy
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Bipolar Disorder
A Study to Evaluate the Effectiveness and Safety of Extended-Release (ER) Paliperidone Compared With Placebo in Delaying the Recurrence of Symptoms in Bipolar I Disorder
The purpose of this study is to evaluate the effectiveness and safety of oral extended-release (ER) paliperidone compared with placebo in the prevention of the recurrence of mood symptoms in patients with Bipolar I Disorder who…
- Trial name
- NCT00490971
- Testing
- Olanzapine, Paliperidone ER
- Where
- 78 sites in United States, Bulgaria and 14 more
- Volunteers
- 768 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.