Clinical trials: Central Nervous System Disease
Cerebral Infarction, Brain Ischemia
Japan Alteplase Clinical Trial (J-ACT): Efficacy and Safety Study of Tissue Plasminogen Activator (Alteplase) for Ischemic Stroke
Based on previous studies comparing Duteplase[a recombinant tissue plasminogen activator (rt-PA) very similar to alteplase] doses, we performed a clinical trial with 0.6mg/kg, which is lower than the internationally approved…
- Trial name
- NCT00147316
- Testing
- Alteplase
- Where
- Japan
- Volunteers
- 103 people
- Sponsor
- Tanabe Pharma Corporation
Spinal Muscular Atrophy
A Registered Cohort Study on SMA
Spinal muscular atrophy (SMA) is an autosomal recessive disease that causes progressive muscle wasting and weakness due to loss of motor neurons in the spinal cord.
- Trial name
- NCT04010604
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Wan-Jin Chen
Brain Injuries, Hyperglycemia
Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury
An increase in blood glucose is a common clinical symptom in patients following traumatic brain injury. Studies confirm that death after traumatic brain injury was not only associated with nerve injury, but also correlated with…
- Trial name
- NCT02161055
- Testing
- Insulin
- Where
- 2 sites in China
- Volunteers
- 144 people
- Sponsor
- Lianyungang Oriental Hospital
Anderson-Fabry Disease
Functional Capacity in Anderson-Fabry Disease Patients
The goal of this observational study is to observe the relation between excercise parameters - assessed by CPET - and rest/stress hemodynamic parameters - assessed by echocardiogram and CMR - in patients with a genetic diagnosis…
- Trial name
- OPTIMA-FD (NCT06884358)
- Where
- 5 sites in Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Epilepsy, Epilepsies, Partial
Treating Postictal Symptoms Using Ibuprofen and Nifedipine
This study will evaluate the effect of ibuprofen or nifedipine on post-seizure hypoperfusion and neurological deficits in patients with epilepsy.
- Trial name
- NCT03949478
- Testing
- Ibuprofen, Nifedipine
- Where
- 2 sites in Canada
- Volunteers
- 90 people
- Sponsor
- University of Calgary
Vascular Dementia, Subcortical Vascular Dementia
Effect of Zydena (Udenafil) on Cerebral Blood Flow and Peripheral Blood Viscosity
The purpose of this study is to determine whether Zydena (Udenafil) has effect on cerebral blood flow and peripheral blood viscosity in normal and subcortical vascular cognitive impairment subjects.
- Trial name
- SMCZN01 (NCT01466543)
- Testing
- Zydena (Udenafil)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Upper Extremity Paresis, Stroke, Chronic
Non-invasive Trigeminal and Vagus Nerve Stimulation for Stroke Subjects With Chronic Upper Extremity Deficits
This is a single-center, multiphase pilot study of 16 subjects with residual upper extremity deficits at least six months after a supratentorial ischemic or hemorrhagic stroke.
- Trial name
- NCT06288217
- Testing
- NeuraStasis Stimulator System (Non-Invasive Trigeminal and Vagus Nerve Stimulation), Upper Limb Rehabilitation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NeuraStasis, Inc
Brain and Central Nervous System Tumors
Irinotecan Followed by Radiation Therapy and Temozolomide in Treating Children With Newly Diagnosed Brain Tumor
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00004068
- Testing
- irinotecan hydrochloride, temozolomide, conventional surgery
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- St. Jude Children's Research Hospital
Back Pain Lower Back Chronic
Effectiveness of a Psychoeducative Intervention on Patients With Cronic Low Back Pain
One of the treatment modalities currently available in this hospital to treat this type of patients with low back pain who present with chronic pain are the group sessions that are carried out to provide information to the…
- Trial name
- PNE (NCT03964389)
- Testing
- Pain Neuroscience Education" (PNE)
- Where
- Spain
- Volunteers
- 179 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Stroke
Real-time Neuromuscular Control of Exoskeletons
The purpose of this study is to develop a real-time controller for exoskeletons using neural information embedded in human musculature.
- Trial name
- NCT04661891
- Testing
- Isometric contractions, Isokinetic contractions, Dynamic contractions
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Cancer, Breast, Alzheimer Disease
Decisions About Cancer Screening in Alzheimer's Disease
The Decisions about Cancer screening in Alzheimer's Disease (DECAD) study tests if an evidence-based decision aid for dementia caregivers can support decision-making about mammography and improve the quality of medical…
- Trial name
- DECAD (NCT03282097)
- Testing
- DECAD decision aid, Home safety guide
- Where
- 5 sites in United States
- Volunteers
- 442 people
- Sponsor
- Indiana University
Spinal Cord Injury
Improving Hand and Arm Function After Spinal Cord Injury (SCI)
The long-term goal of this project is to develop rehabilitation strategies that facilitate optimal restoration of skilled hand use in individuals with spinal cord injury (SCI).
- Trial name
- NCT01143597
- Testing
- Arm and hand training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Miami
Stroke
Cranial Nerve Neuromodulation to Improve Arm Function and Brain Plasticity in Stroke
Following a stroke, persistent residual muscle weakness in the upper limb (UL) drastically impacts the individuals' quality of life and level of independence.
- Trial name
- CN-NINM (NCT06386510)
- Testing
- Strength training, Cranial nerve non-invasive neuromodulation
- Where
- 3 sites in Canada
- Volunteers
- 74 people
- Sponsor
- Université de Sherbrooke
Stroke, Spastic Paraplegia
Turkish Lower-Extremity Motor Activity Log (LE-MAL)
The Motor Activity Log was developed to measure paretic upper extremity use in daily activities in the real-life context (real world) of people with different health conditions, including stroke.
- Trial name
- NCT06156813
- Testing
- Diagnostic test
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gaziantep Islam Science and Technology University
Posterior Reversible Encephalopathy Syndrome, Intensive Care Units
The Predictors of ICU Admission of oPRES
The purpose of this study is to explore the predictors of ICU admission of obstetric posterior reversible encephalopathy syndrome.
- Trial name
- NCT05310513
- Testing
- Whether the patient needs to be admitted to the ICU
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Dunjin Chen
Liver Cirrhosis, Hepatic Encephalopathy
Quality of Life and Nutritional Improvements in Cirrhotic Patients
The purpose of this study is to determine whether taking Rifaximin (Xifaxan) in conjunction with the use of nutritional concepts is effective in improving morbidity and quality of life in cirrhotic patients suffering from hepatic…
- Conditions
- Liver Cirrhosis, Hepatic Encephalopathy, Portal Hypertension
- Trial name
- NCT01842113
- Testing
- Rifaximin, Lactulose
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Tampa General Hospital
Ependymomas, Gliomas
A Pilot Study of Inpatient Hospice With Procurement of Brain Tumor Tissue on Expiration for Research Purposes
Background: An important new area of brain tumor research is the development of tumor and brain stem cell lines. Successful growth of these cell lines requires obtaining large volumes of fresh tumor and brain tissue, which is…
- Conditions
- Ependymomas, Gliomas, PNET, Pineal Tumors
- Trial name
- NCT01251913
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Cancer Institute (NCI)
Dementia, Alzheimer Type
Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of Alzheimer's Type
The primary objective of the study is to compare the efficacy of aripiprazole with placebo in patients with psychosis associated with Alzheimer's dementia.
- Trial name
- NCT01438060
- Testing
- Aripiprazole (BMS-337039)
- Volunteers
- 232 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Stroke
Anodal Transcranial Direct Current Stimulation on Mobility and Balance in Post Stroke Patients.
To determine the effects of anodal transcranial direct current stimulation on mobility and balance in post stroke patients.
- Trial name
- NCT04611360
- Testing
- Anodal Transcranial Direct Current Stimulation Group, Conventional Training Exercises Group
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Epilepsy, Complex Partial
A Treatment Use Protocol for Subjects Continuing on From the Open-label Extension 0601
This study is designed to provide ganaxolone to those patients deriving significant benefit from current treatment in protocol 1042-0601.
- Trial name
- 0602 (NCT01002820)
- Testing
- ganaxolone
- Where
- 7 sites in United States
- Volunteers
- 11 people
- Sponsor
- Marinus Pharmaceuticals
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