Clinical trials: Central Nervous System Disease
Ischemic Stroke, MCA Infarction
Osmotic Agent Use in Middle Cerebral Artery Stroke
This is a retrospective chart review of patients that were admitted with large MCA stroke to the Fairview system hospitals between December 2017-December 2018.
- Trial name
- OMCAS (NCT04156490)
- Testing
- No intervention is planned, this will be a purely retrospective trial.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Epilepsy, Bipolar Disorder
Lamotrigine Pregnancy Registry (LAM05)
Antiepileptic drugs (AEDs) are not indicated for use in pregnancy. However, women with epilepsy, and other approved indications including bipolar disorder, may require or be unintentionally exposed to AEDs during pregnancy.
- Trial name
- NCT01064297
- Testing
- Lamotrigine monotherapy, Lamotrigine polytherapy including valproate, Lamotrigine polytherapy without valproate
- Volunteers
- 3,416 people
- Sponsor
- GlaxoSmithKline
Epilepsy, Epilepsy, Generalized
Clobazam in Patients With Lennox-Gastaut Syndrome
The purpose of this study is to evaluate the safety and efficacy of clobazam as adjunctive therapy in the treatment of seizures which lead to drop attacks (drop seizures) in patients 2 to 60 years of age with Lennox-Gastaut…
- Conditions
- Epilepsy, Epilepsy, Generalized, Seizures
- Trial name
- NCT00518713
- Testing
- Clobazam Low Dose, Clobazam Medium Dose, Clobazam High Dose
- Where
- 53 sites in United States, Australia and 3 more
- Volunteers
- 238 people
- Sponsor
- Lundbeck LLC
Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.
- Conditions
- Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome, Duane Radial Ray Syndrome, Mobius Syndrome
- Trial name
- NCT03059420
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Brain Injuries, Traumatic, Coagulopathy
The Influence of Noradrenaline on Coagulation and Fibrinolysis in Severe Isolated Brain Injury
Aim of the study The investigators aim to establish: Whether noradrenaline (NA) infusion has a significant effect on coagulation and fibrinolysis in patients with severe traumatic brain injury (TBI).
- Conditions
- Brain Injuries, Traumatic, Coagulopathy, Coagulation Defect; Acquired, Coagulation Defect; Bleeding
- Trial name
- NCT04515420
- Testing
- noradrenaline
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Epilepsy, Focal Cortical Dysplasia
First-in-human Experience Using Novel Ultraflexible Low-impedance Electrode Arrays: an IDEAL Stage 1 Study
The goal of this first-in-human study is to evaluate a novel ultraflexible microelectrode in children undergoing neurosurgery to remove tissue that causes epilepsy (seizures) in focal cortical dysplasia (FCD) or long-term…
- Trial name
- NCT06116279
- Testing
- Insertion of electrode during planned neurosurgery for epilepsy
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Seizures
Retigabine (Adjunctive Therapy) Efficacy and Safety Study for Partial Onset Refractory Seizures in Epilepsy
This Phase 3 study is being conducted to evaluate the efficacy and safety of retigabine dosed at 1200 mg/day, in three equally divided doses, compared with placebo in patients with epilepsy who are receiving up to three…
- Trial name
- RESTORE1 (NCT00232596)
- Testing
- Retigabine
- Where
- 54 sites in United States, Argentina and 3 more
- Volunteers
- 306 people
- Sponsor
- GlaxoSmithKline
Susac Syndrome
Physiotherapy Approach for Susac Syndrome
Susac's syndrome is a rare autoimmune disorder characterised by a triad of encephalopathy (brain dysfunction), branch retinal artery occlusion (loss of vision) and sensorineural hearing loss.
- Trial name
- NCT06349603
- Where
- Bosnia and Herzegovina
- Volunteers
- 1 people
- Sponsor
- Rehabilitation Centre Zivot
Cerebrovascular Accident
Measuring the Concurrent Validity of the Upper Limb Use Ratio With Accelerometers in an Ecological Situation After Stroke.
The purpose of this stufy is to measure the concurrent validity of the upper limb use ratio with accelerometers in an ecological situation after stroke.
- Trial name
- ValidFUR (NCT06509542)
- Testing
- Objective assessment of upper limb use during activities in ecological situation
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
Cervicogenic Headache
Prevalence of Cervicogenic Headache in Lab Technicians
The purpose of the study is to determine the prevalence of cervicogenic headache among lab technicians
- Trial name
- NCT07067242
- Where
- Pakistan
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Elite College of Management Sciences, Gujranwala, Pakistan
Phenylketonurias, Non Alcoholic Fatty Liver
Walking Program in Fatty Liver Children With Phenylketonuria
phenylketonuria (commonly known as PKU) is an inherited disorder that increases the levels of a substance called phenylalanine in the blood.
- Trial name
- NCT06718842
- Testing
- walking free online supervised program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Brain Injuries
Cognitive Rehabilitation in Pediatric Acquired Brain Injury
Acquired brain injury (e.g., traumatic brain injury, brain tumour, brain infections) is one of the leading causes of death and disability for children and adolescents.
- Trial name
- CORE-pABI (NCT03215342)
- Testing
- Pediatric Goal Management Training, Pediatric Brain Health Workshop
- Where
- 2 sites in Norway
- Volunteers
- 76 people
- Sponsor
- St. Olavs Hospital
Brain Abscess
MICROBIOLOGY OF CEREBRAL ABSCESSES
Establish the repertoire of bacteria and Archaea responsible for brain abscesses. Correlate the microbial repertoire to epidemiological, clinical and radiological data; to define the different nosological entities falling within…
- Trial name
- NCT04018742
- Testing
- Surgical puncture
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Intracerebral Hemorrhage, Cerebral Hemorrhage
High Risk of Death or Disability in Brain Hemorrhage: Role of Spot Sign and Secondary Markers
This study looks at patients with brain hemorrhage to see if a special sign on brain scans, called the "Spot Sign," combined with other scan features, can predict a higher risk of death or disability.
- Conditions
- Intracerebral Hemorrhage, Cerebral Hemorrhage, Stroke, Brain Injuries
- Trial name
- NCT07172542
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier de Gonesse
Brain Metastasis
Vorinostat and Concurrent Whole Brain Radiotherapy for Brain Metastasis
Vorinostat is a potent and well tolerated HDAC inhibitor. It has been reported to enhance radiosensitivity of cancer cells. We hypothesize that the addition of vorinostat to WBRT may increase therapeutic efficacy for patients…
- Trial name
- NCT01600742
- Testing
- Vorinostat
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- National Taiwan University Hospital
Alzheimer's Disease
Cytokines and Cognitive Decline in Alzheimer's Disease
Amyloid plaques and neurofibrillary tangles are the 2 well-known etiopathological hallmarks of Alzheimer's disease (AD). Beside these 2 lesions, inflammation response is described in the brain of patients with AD.
- Trial name
- NCT01351142
- Testing
- blood test and cognitive tests
- Where
- 10 sites in France
- Volunteers
- 133 people
- Sponsor
- Poitiers University Hospital
Meningioma
A Study of JZP3507 (ONC206) in Recurrent Grade 2 or 3 Meningioma
This study will recruit participants with Grade 2 and 3 meningiomas who have failed prior therapy. Participants will receive oral doses of JZP3507. The antitumor activity and safety of JZP3507 will be evaluated.
- Trial name
- NCT07533942
- Testing
- JZP3507
- Where
- 8 sites in United States
- Volunteers
- 30 people
- Sponsor
- Jazz Pharmaceuticals
Chronic Migraine
Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine
Migraine imposes a substantial burden on patients in terms of diminished daily functioning, quality of life, and financial loss.
- Trial name
- Tx360 (NCT01709708)
- Testing
- Marcaine, Saline
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Tian Medical Inc.
Stroke
ArmeoSenso - Reward
This study investigates the use of motivating/rewarding features in a computer based arm rehabilitation program. Half of the subjects will take part, besides receiving standard therapy, in a computer based program delivering a…
- Trial name
- NCT02257125
- Testing
- high incentive, low incentive
- Where
- 3 sites in Switzerland
- Volunteers
- 38 people
- Sponsor
- Cereneo AG
Glioblastoma
A Study of Abemaciclib in Recurrent Glioblastoma
This research study is studying a targeted therapy as a possible treatment for recurrent glioblastoma (GBM). The following intervention will be used in this study: -Abemaciclib
- Trial name
- NCT02981940
- Testing
- Abemaciclib, Surgery
- Where
- 7 sites in United States
- Volunteers
- 45 people
- Sponsor
- Dana-Farber Cancer Institute
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