Clinical trials: Central Nervous System Inflammation
Biomarker, Lipid
Shotgun Mass Spectrometry-based Lipid Profiling in Chronic Inflammatory Diseases
Collect blood from patients admitted for coronary angiography to tubes with heparin, centrifuge and collect plasma. This will be frozen at -80C.
- Conditions
- Biomarker, Lipid, Inflammation, Cardiovascular Diseases
- Trial name
- NCT04786431
- Testing
- Blood collection for lipid profiling by LC-MS
- Volunteers
- 427 people
- Sponsor
- Universidade Nova de Lisboa
Amyotrophic Lateral Sclerosis
MIROCALS: Modifying Immune Response and OutComes in ALS
MIROCALS is a phase II study of ld-IL-2 as a therapeutic agent for ALS. A randomized (1:1), placebo-controlled, double-blind, parallel group trial will be carried out to assess ld-IL-2 safety and clinical efficacy on survival and…
- Trial name
- MIROCALS (NCT03039673)
- Testing
- Riluzole, IL-2, 5% glucose water solution
- Where
- 17 sites in France, United Kingdom
- Volunteers
- 304 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Fabry Disease
FASHION Fabry Disease Hypertrophic Cardiomyopathy and Infammation
In Fabry disease (FD) and hypertrophic cardiomyopathy (HCM) systemic inflammation recently gained attention as a possible key pathophysiologic process involved in the development of cardiac hypertrophy and progression of the…
- Trial name
- FASHION (NCT05761834)
- Testing
- Sample blood and 2D-echocardiography with Doppler
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Amyotrophic Lateral Sclerosis (ALS)
Safety, Tolerability, and Pharmacodynamic Exploration of Orelabrutinib in Patients With Amyotrophic Lateral Sclerosis (ALS)
This is a single-center, open-label, dose-escalation, investigator-initiated pilot study to evaluate the safety, tolerability, dose-limiting toxicity (DLT), and pharmacodynamic signals of orelabrutinib in patients with…
- Trial name
- NCT07875972
- Testing
- Orelabrutinib
- Volunteers
- 12 people
- Sponsor
- Liu Qing
Alzheimer Disease
Pioglitazone in Alzheimer Disease
This study was designed to assess the safety and tolerability of pioglitazone, an approved drug for type 2 diabetes, in non diabetic patients with Alzheimer's disease.
- Trial name
- NCT00982202
- Testing
- pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Institute on Aging (NIA)
Sclerosis, Multiple, Neurocognitive Impairment, Mild
The DANCEREX Proof-of-Concept Study for Chronic Neurological Disorders
The goal of this clinical trial is to test a new digital therapeutic solution which combines a holistic, multidimensional rehabilitation program based on dance and music with an innovative motivational system (DANCEREX-DTx) in…
- Conditions
- Sclerosis, Multiple, Neurocognitive Impairment, Mild, Neurocognitive Dysfunction
- Trial name
- DANCEREX-DTx (NCT06112639)
- Testing
- DANCEREX-DTx, Multidimensional dance-based program, Educational Program
- Where
- 3 sites in Italy
- Volunteers
- 192 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Detecting Sepsis in Patients With Severe Subarachnoideal Hemorrhage
The study aims to evaluate the suitability of the SOFA score implemented by the Sepsis 3 guideline to detect sepsis in patients suffering from subrarachnoid hemorrhage.
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Sepsis Syndrome, Sepsis
- Trial name
- NCT05246969
- Testing
- Sepsis detection
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Goethe University
Amyotrophic Lateral Sclerosis
sCD163 in ALS Patients
Amyotrophic lateral sclerosis (ALS) is a fatal disease with progressive muscle weakness leading to severe disability and eventually death.Since the diagnosis relies on clinical features and electromyographic abnormalities, which…
- Trial name
- NCT02325375
- Testing
- lumbar puncture for spinal fluid and blood sample
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Alzheimer Disease
Therapeutic Evaluation of Low-dose IL-2-based Immunomodulatory Approach in Patients With Early AD
Study aims at evaluating the therapeutic efficacy and safety of low-dose IL-2 immunomodulatory treatment in patients with early AD, in a phase II, randomized, double blind, placebo-controlled phase II clinical trial.
- Trial name
- IL-2-AD (NCT05468073)
- Testing
- Proleukin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier St Anne
Brain Death
The Use of Liraglutide in Brain Death
There is evidence of the association of brain death and inflammation, affecting outcomes of transplanted organs, but in a way not fully understood.
- Trial name
- NCT03672812
- Testing
- Liraglutide
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Encephalopathy, Organ Dysfunction Syndrome
Prospective Analysis of Septic Associated Encephalopathy Using the Non-invasive Acoustocerebrography-ACG
The patients of the group "sepsis" are measured several times with the non-invasive multi-spectral sonography (Sonovum "ACG-Diagnosesystem") (days 1, 3, 7 and 14).
- Trial name
- SAEACG (NCT03173196)
- Testing
- Non-invasive Multispectral Sonography
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Rostock
Spinal Cord Injury, Depression
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Inflammation and Depression Following SCI
Spinal cord injury (SCI) has been shown to be associated with impairment to the autonomic nervous system in the form of reduced activity of a key nerve known as the vagus nerve.
- Trial name
- NCT06493071
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Carotid Stenosis, Caloric Restriction
Short-Term Endogenous Hydrogen Sulfide Upregulation
This research study will compare the impact of dietary restriction pre-operatively before carotid endarterectomy compared to the standard nutrition that a patient typically eats.
- Trial name
- NCT03303534
- Testing
- ScandiShake
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Brigham and Women's Hospital
Pneumonia, Bacterial
Study Evaluating Streptococcus Pneumoniae Serotype Carriage Rate for Nasopharyngeal Carriage in Filipino Children
Evaluation of the carriage rate of Streptococcus pneumoniae in the nasopharynx of healthy children and the carriage rate and distribution of Streptococcus pneumoniae serotypes
- Trial name
- NCT00724828
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Subarachnoid Hemorrhage, Aneurysmal
Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.
- Trial name
- NCT04938414
- Testing
- Lumbar puncture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Systemic Juvenile Idiopathic Arthritis, Hereditary Periodic Fevers
A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 Studies
The objective of this extension protocol is to collect safety data (serious and non-serious adverse events) and to provide continuous canakinumab to patients in France who completed study CACZ885G2301E1(NCT00891046), CACZ885G2306…
- Trial name
- NCT02334748
- Testing
- canakinumab
- Where
- 3 sites in France
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Central Nervous System Cancer, Brain Metastases
Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1
Adult patients with primary or secondary central nervous system malignancies will be invited to undergo a baseline [C-11]-CS1P1 PET scan and a follow-up scan within 24 months of the baseline scan (preferably within 6-months…
- Trial name
- NCT07462507
- Testing
- [C-11]-CS1P1, Brain MRI
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Washington University School of Medicine
Subarachnoid Hemorrhage, Muscle Atrophy
Impact of NMES and HPRO on Recovery After SAH- Pilot Study
The study purpose is to investigate the hypothesis that in adults with SAH, early neuromuscular electrical stimulation (NMES) and high protein supplementation (HPRO) will improve muscle mass, metabolic and inflammatory biomarker…
- Conditions
- Subarachnoid Hemorrhage, Muscle Atrophy, Inflammation, Nutritional and Metabolic Disease
- Trial name
- NCT03201094
- Testing
- Neuromuscular Electrical Stimulation (NMES), High Protein Supplementation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
HIV Infections, Central Nervous System Diseases
Central Nervous System Disease in HIV-infected Children on HAART
This study will examine how HIV affects the brain and nervous system, learning, and behavior in children on highly active antiretroviral therapy (HAART).
- Trial name
- NCT00110331
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Cardiovascular Diseases, Coronary Disease
Inflammation, Infection, and Future Cardiovascular Risk
To examine markers of underlying chronic inflammation and infection as potential risk factors for future myocardial infarction (MI), stroke (CVA), and venous thromboembolism (VTE) in plasma samples collected at baseline from…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Myocardial Infarction
- Trial name
- NCT00005496
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)