Clinical trials: Central Nervous System Inflammation
HIV Dementia
Modulation of Monocyte Activation by Atorvastatin in HIV Infection
Activated monocytes play a key role in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Individuals with HAND have expanded populations of activated monocytes.
- Trial name
- NCT01263938
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Diabetes Mellitus, Type 2, Heart Failure
Prediction of Heart Failure and Cognitive Decline in Type 2 Diabetes
Type 2 diabetes is a risk factor of heart failure and cognitive decline. Heart failure at its early stage is often silent. At present, primary prevention for heart failure is not available.
- Conditions
- Diabetes Mellitus, Type 2, Heart Failure, Cognitive Decline
- Trial name
- PreciDIAB-H&B (NCT04583800)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Lille
Parkinson Disease (PD)
Changes in Movement, Fitness, and Quality of Life in People With Parkinson's Disease After Different Exercise Programs
Parkinson's disease (PD) is a progressive neurological condition that can affect movement, balance, endurance, and overall quality of life.
- Trial name
- NCT07221266
- Testing
- Guided Cycling, Non-Contact Boxing, Traditional Physical Therapy Program (Standard of Care)
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Texas, El Paso
Traumatic Brain Injury, Brain Inflammation
"The Effect of Stellate Ganglion Block in Severe Brain Injury"
Blood flow through the brain is reduced after brain damage. Secondary brain ischemia caused by hypoxia and hypotension, further increase the susceptibility of the ischemically compromised brain to secondary impairment during this…
- Conditions
- Traumatic Brain Injury, Brain Inflammation, Cerebral Vasospasm
- Trial name
- NCT04208477
- Testing
- one site blockade of the stellate ganglion
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Alzheimer Disease
Pioglitazone in Alzheimer Disease
This study was designed to assess the safety and tolerability of pioglitazone, an approved drug for type 2 diabetes, in non diabetic patients with Alzheimer's disease.
- Trial name
- NCT00982202
- Testing
- pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Institute on Aging (NIA)
Meningiomas
Effects of Scalp Nerve Blocks on Systemic Inflammation
Patients undergoing meningeoma resection surgery will be randomly assigned to two groups. One group will receive scalp nerve blocks with 0.5% ropivacaine, whereas the other group will receive scalp nerve blocks with 0.9% saline…
- Trial name
- NCT02939833
- Testing
- Scalp Nerve Blocks With Ropivacaine, Scalp Nerve Blocks With Saline
- Where
- China
- Volunteers
- 160 people
- Sponsor
- RenJi Hospital
Alzheimer Disease
Investigation of Inflammation in Alzheimer's Disease and Related Dementias (ADRD) Using [11C]-CS1P1
This study involves a brain positron emission tomography (PET) scan with a new, investigational radioactive tracer called [11C]-CS1P1 to identify inflammation in the brain by testing with healthy older adults and with cognitively…
- Trial name
- NCT06129838
- Testing
- [11C]-CS1P1
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Mild Cognitive Impairment (MCI), Alzheimer Disease
Study to Assess the Efficacy of XPro1595 in Patients With Mild Cognitive Impairment With Biomarkers of Inflammation
The goal of this Phase 2 MCI study is to determine whether 1.0 mg/kg XPro1595 is superior to placebo at improving measures of cognition, functioning and brain quality in individuals with MCI and biomarkers associated with…
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer Disease, Dementia, Brain Diseases
- Trial name
- NCT05321498
- Testing
- XPro1595
- Sponsor
- Inmune Bio, Inc.
Periodontal Disease, Periodontitis
Investigation of the Relationship Between Periodontitis and Alzheimer's Disease in Terms of Blood Parameters
The aim of this study was to analyse the possible relationship between periodontal inflammation and Alzheimer's disease and to investigate the role of blood parameters in this relationship.
- Conditions
- Periodontal Disease, Periodontitis, Periodontal Inflammation, Biomarkers / Blood
- Trial name
- NCT07069244
- Testing
- Complete Blood Count Test, Periodontal examinations, Clinical Dementia Rating scale
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Uskudar University
Intracerebral Hemorrhage, Nontraumatic Intracerebral Hemorrhage
CIRP and Cathepsin B in Neuroinflammation After Intracerebral Hemorrhage
This is a single-center, investigator-initiated, prospective observational case-control study. Patients with intracerebral hemorrhage and healthy controls will be enrolled at Xuanwu Hospital, Capital Medical University.
- Trial name
- CIRP-ICH (NCT07665255)
- Testing
- Blood Sample Collection
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Lewy Body Dementia (LBD), Alzheimer Dementia (AD)
Targeting Neuroinflammation as a Contributing Pathology in Alzheimer's Disease Dementia and Related Dementias
This study is being done to research the usefulness of PET/CT imaging for measuring brain inflammation and its relation to Alzheimer's Disease Dementia and related dementias.
- Trial name
- NCT04786223
- Testing
- C-11 ER-176, Blood Test
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Val Lowe
Encephalitis
Investigating the Role of Early Intravenous Immunoglobulin Treatment for Children With Encephalitis
This is a phase III multi-centre randomised, double blind, placebo controlled trial to assess the role of intravenous immunoglobulin in the treatment of children with encephalitis.
- Trial name
- IgNiTE (NCT02308982)
- Testing
- Immunoglobulins, Intravenous (Privigen)
- Where
- 25 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Oxford
Cerebral Palsy, Spastic
Muscle-tendon Pathology and Metabolic Dysregulation in CP
The main aim of this project is to gain knowledge about the muscle-tendon pathology of moderately to severely affected young people with cerebral palsy and their risk for cardiometabolic diseases and chronic inflammation.
- Trial name
- NCT06330922
- Testing
- Cardiorespiratory fitness training
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Graz
Inflammation, Coagulation and Hemorrhagic Disorders
Inflammation and Coagulation Factors for Predicting Cerebral Edema After SAH
Explore the role of Inflammation and coagulation factors in cerebrospinal fluid for predicting persistent cerebral edema after subarachnoid hemorrhage
- Conditions
- Inflammation, Coagulation and Hemorrhagic Disorders, Cerebral Edema
- Trial name
- NCT06009016
- Testing
- Inflammatory factors and coagulation factors level in cerebrospinal fluid after subarachnoid hemorrhage
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Systemic Infection
Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion
Strokes management, secondary to proximal arterial occlusion, by endovascular thrombectomy (TM) is now well established. The immuno-inflammatory events of reperfusion after TM are discussed.
- Trial name
- CONVASC-I (NCT04731584)
- Testing
- Blood sample
- Where
- 4 sites in France
- Volunteers
- 15 people
- Sponsor
- Hospices Civils de Lyon
Spinocerebellar Ataxia
Effects of Oral Administration of Antrodia Cinnamomea Products for Clinical Symptoms in Spinocerebellar Ataxia Patients
This study aims to assess the effect of Antrodia cinnamomea on clinical symptoms in spinocerebellar ataxia patients. To investigate the advancements in neurodegenerative diseases.
- Trial name
- NCT06633003
- Testing
- Antrodia cinnamomea Products
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- ALPS Biotech CO. LTD
Stroke, Inflammation
Inflammatory Abnormalities in Muscle After Stroke: Effects of Exercise
The purpose of this study is to first define whether abnormalities of skeletal muscle are related to the presence of inflammation and to poor motor performance and whether this can be modified by exercise interventions.
- Trial name
- NCT00387712
- Testing
- Velocity based treadmill training, Duration based treadmill training
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- VA Office of Research and Development
Necrotizing Enterocolitis, Intraventricular Hemorrhage
PUFAs in Preterm Infants
The research endeavors to examine the critical composition of Polyunsaturated Fatty Acids (PUFAs) in premature infants across different gestational stages and under varying disease conditions, and delineate the metabolic…
- Conditions
- Necrotizing Enterocolitis, Intraventricular Hemorrhage, BPD - Bronchopulmonary Dysplasia, Sepsis
- Trial name
- PIPI (NCT06045130)
- Volunteers
- 600 people
- Sponsor
- The First Hospital of Jilin University
Atherosclerosis, Stroke
Metabolic Imaging in Carotid Atherosclerosis
Hardening of the arteries (atherosclerosis) is a common disorder that causes heart attacks and strokes. PET CT and contrast-enhanced MRI scans are two new ways of assessing atherosclerosis.
- Trial name
- MICA (NCT01674257)
- Testing
- USPIO (ferumoxytol)-enhanced MRI scan, 18f-Fluoride PET/CT scan, 18F-Flurodeoxyglucose PET/CT scan
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Edinburgh