Clinical trials: Central Nervous System Lesion
Brain Tumor
18F-DOPA-PET in Non-tumoral and Tumoral Brain Lesions
Background: 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine (FDOPA) positron emission tomography (PET) can identify well low and high grade brain tumors.
- Trial name
- FDOPA (NCT04306484)
- Testing
- FDOPA-TEP
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cerebral Amyloid Angiopathy
High Frequency Imaging in Cerebral Amyloid Angiopathy
Cerebral amyloid angiopathy (CAA), caused by amyloid beta depositions in the walls of small cerebral vessels, is remarkably common in the elderly.
- Trial name
- HIFI-CAA (NCT06128824)
- Testing
- MR Imaging
- Where
- 3 sites in Germany
- Volunteers
- 75 people
- Sponsor
- Martin Dichgans
Stroke
Effect of Rehabilitation of Patients With a Central Nervous System Lesion
The purpose of the study is to analyse the prehensions deficits and the effect of prehension rehabilitation in central nervous system lesioned people
- Trial name
- NCT00837460
- Testing
- rehabilitation
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Ischemic Stroke, Transient Ischemic Attack
Multiomics Targeting Microbiome Associated Changes in Stroke Patients (StrokeMicroBiomics)
Preclinical research has established a convincing connection between changes in the gut microbiota composition and stroke outcome. However clinical data on the gut-brain axis, and its chronic characteristics, is sparse.
- Trial name
- SMB (NCT04315922)
- Testing
- Microbiome and Plasma Characterisation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Spinal Cord Injury at C5-Th10 Level With Complete Lesion, Spinal Cord Transection
Autologous Bulbar Olfactory Ensheathing Cells and Nerve Grafts for Treatment of Patients With Spinal Cord Transection
The purpose of this experimental therapy is to evaluate the safety and efficacy of transplantation of autologous olfactory ensheathing cells (OECs) and olfactory nerve fibroblasts (ONFs) obtained from the olfactory bulb with…
- Trial name
- NCT03933072
- Testing
- obtaining of autologous human olfactory bulb, autologous sural nerve preparation, production of Glial Neuropatch, microsurgical reconstruction of the transected spinal cord with autologous Glial Neuropatch-nerve bridges
- Where
- Poland
- Volunteers
- 2 people
- Sponsor
- Nicholls Spinal Injury Foundation
Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Multimodal Approach to the Intrathecal Catheter for Obstetric Accidental Dural Puncture
Accidental dural puncture is an uncommon complication of epidural analgesia and can cause postdural puncture headache.
- Trial name
- NCT05910086
- Testing
- collection of data from the medical record
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Brain Lesion, Brain Tumor Adult
Handheld Dynamometer During Awake Craniotomy Pilot
The primary purpose of this study is to assess the feasibility, safety and reliability of the use of handheld dynamometry in evaluating intraoperative motor function for patients undergoing awake craniotomy for the resection of…
- Conditions
- Brain Lesion, Brain Tumor Adult, Brain Tumor
- Trial name
- NCT04742231
- Testing
- Hand-held dynamometer
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Traumatic Brain Injury
Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries
The goal of this observational study is to evaluate the performance of UCH-L1 and GFAP combined in patients with a mild traumatic brain injury.
- Trial name
- GUEST (NCT05885529)
- Testing
- UCH-L1 GFAP
- Where
- 15 sites in France, Monaco
- Volunteers
- 1,500 people
- Sponsor
- Centre Hospitalier Princesse Grace
IDIOPATHIC PARKINSON'S DISEASE
A Trial to Evaluate the Effects of Rotigotine Transdermal Patch on Early Morning Motor Impairment and Sleep Disorders Idiopathic Parkinson's Disease
The objective of this trial is to assess the effect of rotigotine (SPM 962) on the control of early morning motor impairment and sleep disorders in subjects with idiopathic PD.
- Trial name
- NCT00243945
- Testing
- Rotigotine
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- UCB Pharma
HIV Infections, Lymphoma, AIDS-Related
Evaluation of Brain Lesions in HIV-infected Patients for Diagnosis of Primary Central Nervous System Lymphoma
This study will evaluate the usefulness of two tests in quickly distinguishing whether a patient with HIV infection and focal brain lesions (an injury in a specific area of the brain) has a rare type of cancer called primary…
- Trial name
- NCT00226304
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Dural Tear, Cerebrospinal Fluid Leak
A Prospective, Randomized, Controlled Multi-center Study of ArtiFascia® Dural Repair Patch Compared With Commercially Available Dural Substitutes. To Evaluate the Safety and Effectiveness of ArtiFascia® in Subjects Requiring Dural Repair.
The objective of this study was to evaluate the safety and effectiveness of ArtiFascia® in comparison with commercially available dural substitutes in subjects requiring Dural repair following neurosurgery.
- Trial name
- NEOART (NCT04145544)
- Testing
- Implantation of the ArtiFascia®, Implantation of other commercial suturable dural substitute
- Where
- 9 sites in Belgium, Czechia and 3 more
- Volunteers
- 92 people
- Sponsor
- Nurami Medical Ltd
Brain Neoplasms
Magnevist (SH L 451A) Intra-individual Dose Comparison Study in Patients With Brain Metastasis
To verify the number of metastatic brain tumors detected in contrast-enhanced MRI, which is the primary variable, increases after an additional dose of Magnevist (SH L 451A) comparing images after an initial dose (0.1 mmol/kg)…
- Trial name
- NCT00681551
- Testing
- Magnevist (SH L 451A)
- Where
- 9 sites in Japan
- Volunteers
- 45 people
- Sponsor
- Bayer
Malignant Central Nervous System Neoplasm
Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research
This study explores how microorganisms in the gut can affect the growth and progression of brain tumors.
- Trial name
- NCT06117930
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Ischemic Stroke
MRI-based Artificial Intelligence Software (NNS-SOT) for Onset Time Estimation in Lesion With Acute Ischemic Stroke
This study evaluates the efficacy of investigational device named Stroke Onset Time Artificial Intelligence(AI) (Model name:NNS-SOT).
- Trial name
- NCT06160726
- Where
- South Korea
- Volunteers
- 474 people
- Sponsor
- Nunaps Inc
Brain Injury, Neuropsychological Deficits
Cognitive Functions in Severe Acquired Brain Injury After Cranioplasty
Cranioplasty is the main reconstructive neurosurgical procedure, performed in approximately 80% of patients who have previously undergone demolitive surgeries in an emergency setting, particularly in the case of decompressive…
- Conditions
- Brain Injury, Neuropsychological Deficits, Cranioplasty, Cognitive Deficit Following Brain Lesions
- Trial name
- NeC (NCT06895109)
- Testing
- improvement of cognitive functions and psychological aspects
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Brain Tumor
Comparing Cosmetic Outcomes: Endoscopic vs. Conventional Craniotomy for Frontal Skull Base Lesions
This research study will compare the cosmetic outcomes, specifically scar assessment and complications, between two surgical approaches for treating frontal skull base lesions: the endoscopic supraorbital eyebrow craniotomy and…
- Trial name
- NCT06417658
- Testing
- Endoscopic Supraorbital Eyebrow Craniotomy, Conventional Frontal Craniotomy
- Volunteers
- 42 people
- Sponsor
- University of Health Sciences Lahore
Traumatic Brain Injury
Quantitative Automated Lesion Detection of Traumatic Brain Injury
The investigators propose to develop quantitative automated lesion detection (QALD) procedures to identify brain damage following traumatic brain injury more accurately than is possible with a normal magnetic resonance imaging…
- Trial name
- QALD (NCT01022307)
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Peripheral Nerve Injury, Postherpetic Neuralgia
Study of Capsaicin Patch for the Management of Peripheral Neuropathic Pain
The efficacy and safety of the low concentration [0.65% (50 µg/cm2) and 1.25% (100 µg/cm2)] capsaicin patches and compared them to conventional 0.075% capsaicin cream and placebo patch in patients suffering from peripheral…
- Trial name
- NCT02228928
- Testing
- CAPNP, 50 ug/cm2 capsaicin patch, CAPNP, 100 ug/cm2 capsaicin patch, 0.075% capsaicin cream
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samyang Biopharmaceuticals Corporation
Posterior Fossa Lesion
Comparison of Surgical Outcomes of Craniotomy and Craniectomy in Posterior Fossa Lesions
The purpose of this randomized controlled trial is to compare the surgical outcomes of craniotomy and craniectomy among patients with posterior fossa lesions.
- Trial name
- NCT06831695
- Testing
- Craniotomy, Craniectomy
- Volunteers
- 80 people
- Sponsor
- University of Health Sciences Lahore
Traumatic Brain Injury, Cognitive Impairment
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
Difficulties with intellectual functioning, particularly memory functions, are common and source of long-term disability after Traumatic Brain Injury (TBI).
- Trial name
- RIVET (NCT01670526)
- Testing
- Rivastigmine Transdermal Patch
- Where
- 8 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development