Clinical trials: Central Nervous System Sensitization
Neck Pain
Chronic Neck Pain and Central Sensizitation
Chronic neck pain is one of the musculoskeletal pain problems that can cause chronic disability. It is emphasised that individuals with chronic neck pain have difficulty during different activities in their daily lives, and that…
- Trial name
- NCT06976398
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Fibromyalgia
Suprathreshold Pressure Pain Stimulation in Fibromyalgia
The purpose of this study is to investigate the induced-pain characteristics after suprathreshold pressure stimulation at different intensities in fibromyalgia subjects, compared with healthy volunteers.
- Trial name
- NCT04047407
- Testing
- Suprathreshold pain stimulation
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Subacromial Impingement Syndrome, Central Nervous System Sensitization
Muscle Function, Central Nervous System Sensitization, and Pain Profiling in Patients With Subacromial Pain (SAP-CNSS).
In this case-control study, the investigators compare shoulder muscle function, pain, and central nervous system sensitization in patients with Subacromial Pain (SAP) to that in healthy controls.
- Trial name
- NCT03326466
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Chronic Plantar Fasciitis, Control Group
Frequency of Neuropathic Pain in Patients With Plantar Fasciitis
Study Design This prospective cross-sectional study was undertaken between November 2023 and March 2024. Written and verbal informed consent was obtained from all patients.
- Trial name
- NCT06348017
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Yozgat City Hospital
Central Sensitisation
Differences in Pain Processing Between Men and Women
Many chronic pain conditions show clear differences between between men and women, such as reported pain intensities or treatment effects, with chronic pain conditions being generally more frequent in women.
- Trial name
- NCT05031286
- Testing
- Cutaneous thermal stimuli
- Where
- Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Chronic Low-back Pain
The METRIC Study Protocol
The goal of this clinical trial is to test the effects of spinal manipulative therapy in individuals with chronic primary low back pain and determine the neurophysiological mechanisms underlying pain relief.
- Trial name
- METRIC (NCT05986370)
- Testing
- lumbar spinal manipulative therapy, full spine spinal manipulative therapy
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Université du Québec à Trois-Rivières
Central Sensitisation, Elbow Pain
Relation Between Temporal Summation and Fatigue
Central sensitization (CS) is a common feature in chronic musculoskeletal pain conditions including rheumatoid arthritis, chronic whiplash syndrome, fibromyalgia, temporomandibular joint disorders, low back pain and lateral elbow…
- Conditions
- Central Sensitisation, Elbow Pain, Fatigue
- Trial name
- NCT05146960
- Testing
- Temporal summation
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Ghent
Healthy Participants
Association Between Central Sensitization and the Root Mean Square of Successive Differences
The aim of this study was to examine the relationship between central sensitization and resting RMSSD (Root Mean Square of Successive Differences) in individuals exhibiting prolonged sitting behavior, controlling for potential…
- Trial name
- NCT07755332
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istanbul Demiroglu Bilim University
Arthritis
Sensitization in Osteoarthritic Knees
Musculoskeletal pains represent a major part of pain complaints in patients. Moreover, the treatment of musculoskeletal pain conditions by currently available drugs is not optimal (Curatolo and Bogduk 2001).
- Trial name
- NCT00379184
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Northern Orthopaedic Division, Denmark
Central Sensitisation, Cervical Spine Stenosis
Comparison of Pain, Sensitisation, Function and Quality of Life According to Stenosis Degree in Chronic Neck Pain
The cervical spine is a structure that bears the weight of the head and has important functions, but is susceptible to mechanical stress and degenerative processes.
- Trial name
- NCT06967415
- Testing
- Pain, central sensitization,functional status and quality of life.
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Non-specific Chronic Low Back Pain
The Effect of Body Awareness on Pain, Disability, Sensorimotor Acuity, Psychosocial and Central Sensitization Levels in Individuals With Non-Specific Chronic Low Back Pain
This study will be conducted to examine the levels of pain, pressure pain threshold, joint position sense, sensation, functionality, pain catastrophizing, central sensitization, and body awareness in individuals with non-specific…
- Trial name
- NCT07296185
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Medipol University
Axial Spondyloarthritis, Central Sensitisation
Investigation of Central Sensitization Frequency and Related Factors in Axial Spondyloarthritis Patients
The term axial spondyloarthritis (axSpA) describes a group of chronic inflammatory diseases that characterized with spinal involvement.
- Trial name
- NCT04485078
- Testing
- Pressure pain threshold, Temporal summation, Conditioned pain modulation
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Marmara University
Sensitization, Central, Peripheral Sensitization
Pain, Sleep and Gut Microbiota
The objective of this study in healthy volunteers is to evaluate whether the composition of the gut microbiota and sleep quality influence the susceptibility to develop peripheral and central sensitization of pain pathways.
- Conditions
- Sensitization, Central, Peripheral Sensitization, Gut Microbiota, Sleep Quality
- Trial name
- NCT05494983
- Testing
- Screening visit, Peripheral sensitization session, Central sensitization session
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Autonomic Nervous System Modulation, Pain Perception
Pain Perception and the Autonomic Nervous System
In this study, we want to investigate how pain processing and sensation are related to a certain part of the nervous system, the so-called autonomic nervous system.
- Conditions
- Autonomic Nervous System Modulation, Pain Perception, Pain Sensitivity, Central Sensitization
- Trial name
- NCT06667895
- Testing
- respiratory gated taVNS, random burst stimulation, continuous stimulation
- Where
- Switzerland
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Fibromyalgia
The Relationship Between Serum S100B and Brain-Derived Neurotrophic Factor
Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive symptoms.
- Trial name
- S100B-BDNF (NCT07358754)
- Testing
- No Intervention (Observational Study)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Chronic Cough
Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity
A cough lasting more than 2 months is known as a chronic cough, affecting 12-23% of the adult non-smoking population. Chronic cough has many associated complications including incontinence, muscular chest pains, blackouts and…
- Trial name
- NCT00858624
- Testing
- ketamine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jacky Smith