Clinical trials: Central Nervous System Tumors
Pineal Tumor, Brainstem Tumor
The Evolution of Neuroendoscopy Guided by Head-mounted Mixed Reality Technique Navigation System in Neurosurgery
The pineal region and brainstem tumors are located at the central position of the cranial cavity, surrounded by important neural structures and venous systems, leading to challenges in preoperative diagnosis, adding uncertainty…
- Conditions
- Pineal Tumor, Brainstem Tumor, Surgery
- Trial name
- NCT06516471
- Testing
- Conventinal Navigation System Group
- Volunteers
- 40 people
- Sponsor
- Shanghai Zhongshan Hospital
Glioma, Brain Tumor
Non-invasive Glioma Characterization Through Molecular Imaging
MRI-based sequences can provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and help guide the development of novel glioma therapies.
- Conditions
- Glioma, Brain Tumor, Primary Brain Tumor, Malignant Glioma
- Trial name
- NCT03684109
- Testing
- 3T MRI Scanner
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Brain Cancer
TPI 287 in Patients With Recurrent Glioblastoma Multiforme
The goal of this clinical research study is to learn if TPI 287 can help to control glioblastoma. The safety of this drug will also be studied.
- Trial name
- NCT01113463
- Testing
- TPI 287
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- M.D. Anderson Cancer Center
Cerebral Palsy (CP), Encephalitis
Effects of Combined Music Therapy and Occupational Therapy on Motor and Physiological Parameters in Children With Neurological Impairments: A Non-Randomized Controlled Trial
This study aims to explore the effects of an occupational therapy program combined with music therapy elements on children 5-12 years old with neurological disorders including those with neurogenic scoliosis.
- Conditions
- Cerebral Palsy (CP), Encephalitis, Brain Tumor (After Recovery)
- Trial name
- NCT07200687
- Testing
- Music therapy, occupational therapy
- Where
- Greece
- Volunteers
- 18 people
- Sponsor
- Armakola Filomeni
Primary Brain Tumor, PBT
CBT for Insomnia in Primary Brain Tumor Patients
The purpose of this study is to pilot test an empirically supported psychotherapeutic intervention, Cognitive Behavior Therapy for Insomnia (CBT-I) in primary brain tumor patients.
- Trial name
- NCT04919993
- Testing
- Cognitive Behavioral Therapy-Insomnia
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Virginia Commonwealth University
BRAF V600 Wild Type, Clinical Stage IV Cutaneous Melanoma AJCC v8
Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases
This phase II trial studies how well bevacizumab and atezolizumab with or without cobimetinib work in treating patients with untreated melanoma that has spread to the brain (brain metastases).
- Conditions
- BRAF V600 Wild Type, Clinical Stage IV Cutaneous Melanoma AJCC v8, Intracranial Melanoma, Metastatic Malignant Neoplasm in the Brain
- Trial name
- NCT03175432
- Testing
- Atezolizumab, Bevacizumab, Cobimetinib
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- M.D. Anderson Cancer Center
Cerebral Tumor
Brain Areas of Cognitive Functions: a Study in Awake Surgery
This research project focuses on low-level cognitive functions such as perception (auditory, visual, etc.) and high-level cognitive functions (memory, language, temporal estimation, etc.).
- Trial name
- BRAIN-MAP (NCT07170436)
- Testing
- Short version of cognitive testing during surgery
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Toulouse
Glioma (Any Grade) in the Brain, Glioma
Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation
This study plans to learn more about using contrast enhanced ultrasound (CEUS) in brain tumor surgery. The goal of glioma brain tumor surgery is to remove as much of the glioma as possible.
- Trial name
- NCT07050836
- Testing
- Definity contrast during ultrasound
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Colorado, Denver
Developmental and Epileptic Encephalopathy, Dravet Syndrome
Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies
The objective of this study is to assess the safety, tolerability, efficacy, and pharmacokinetics of adjunctive therapy of LP352 in adults and adolescents with developmental and epileptic encephalopathies.
- Conditions
- Developmental and Epileptic Encephalopathy, Dravet Syndrome, Lennox Gastaut Syndrome
- Trial name
- PACIFIC (NCT05364021)
- Testing
- LP352
- Where
- 34 sites in United States, Australia
- Volunteers
- 52 people
- Sponsor
- Longboard Pharmaceuticals
Amblyopia, Myopia
Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population
Screening of haitian children between the ages of 3 and 6 years old for amblyogenic risk factors with the use of the Spot photoscreener. The photoscreener results will be compared to the complete ophthalmologic evaluation.
- Conditions
- Amblyopia, Myopia, Hyperopia, Astigmatism
- Trial name
- POPH (NCT02655432)
- Testing
- Spot photoscreener, Ophthalmologic evaluation, Cyclopleged refraction
- Where
- 3 sites in Haiti
- Volunteers
- healthy volunteers welcome
- Sponsor
- Université de Montréal
Brain and Central Nervous System Tumors
Standard Radiation Therapy, Higher-Dose Radiation Therapy, or Chemotherapy in Treating Older Patients With Glioblastoma Multiforme
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy in higher doses over a shorter period of time may kill more tumor cells and have fewer side effects.
- Trial name
- NCT00820963
- Testing
- temozolomide, hypofractionated radiation therapy, radiation therapy
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Leon Berard
Lymphoma, B Cell
Phase II Trial of Combined Modality Treatment in Primary Central Nervous System Lymphoma
Aim of the study is to establish in a prospective, randomized clinical trial the activity of primary chemotherapy containing high dose-methotrexate, alone or combined with high dose cytarabine, in patients with primary central…
- Trial name
- NCT00210314
- Testing
- high dose methotrexate, high dose cytarabine, radiotherapy
- Where
- Switzerland
- Volunteers
- 79 people
- Sponsor
- International Extranodal Lymphoma Study Group (IELSG)
Non-small Cell Lung Cancer, Leptomeningeal Metastasis
A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis
Leptomeningeal metastasis (LM) is one of the disastrous events when managing advanced Non-small cell lung cancer (NSCLC) due to a grave prognosis.
- Trial name
- NCT02803619
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Leptomeningeal Metastasis
Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.
Pemetrexed is one of the first-line chemotherapeutic agents for non-squamous non-small cell lung cancer (NSCLC). Since 2017, intrathecal pemetrexed has shown good efficacy for patients with leptomeningeal metastases from NSCLC.
- Trial name
- NCT06296745
- Testing
- Pemetrexed
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Guangzhou Medical University
Cancer, Head and Neck Cancer
Phase IB Study Using Sunitinib Plus Radiation Therapy for Cancer Patients
This study is using the combination of radiation and antiangiogenic agents (agents that destroy existing blood vessels) seems to be an approach to tumor cure.
- Conditions
- Cancer, Head and Neck Cancer, Pelvic Cancer, Nervous System Neoplasms
- Trial name
- NCT00437372
- Testing
- Sunitinib, External Beam Radiation Therapy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Glioma, Brain Metastases
Use of CEST (Chemical Exchange Saturation Transfer) Imaging in PET/MRI
Standard Magnetic Resonance Imaging (MRI) is based on the excitation of hydrogen nuclei that are presents in water molecules, which abundance in human body allows for obtention of superior contrast.
- Trial name
- GlioCEST (NCT05464992)
- Testing
- Additional CEST sequences during PET/MRI exam
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Centre Paul Strauss
Pituitary Adenoma, Neuroendocrine Tumors
Predictive Value of Serum and Tissue Molecular Markers and Imaging Features in the Invasiveness and Prognosis of Pituitary Neuroendocrine Tumors
As the clinical manifestations of pituitary neuroendocrine tumors vary greatly, 2.7-15% of them are resistant to conventional treatments such as surgery, drug therapy and radiotherapy, and often relapse or regrow in the early…
- Trial name
- NCT06015802
- Testing
- diagnosed and treated reasonably according to the clinical guidelines and clinical pathways
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Headache, Tumor
Dexmedetomidine and Propofol for Pediatric MRI Sedation
The purpose of this study is to compare the results of combining two anesthetic medications (dexmedetomidine and propofol) in low doses with a standard dose of a single drug that is commonly used to provide sedation/anesthesia…
- Conditions
- Headache, Tumor, Seizure Disorder, Neurofibromatoses
- Trial name
- NCT03513757
- Testing
- propofol, Dexmedetomidine, Glycopyrrolate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
CNS Tumor, Childhood
Patient Reported Outcome Measurement Within the Secured Access to Innovative Medicines for Children With cAncer (SACHA) Study
Patient-Reported Outcomes (PROs) are patient-centered measures used to assess health status, track changes over time, and evaluate the impact of treatment on the patient's perceived health.
- Trial name
- PRO-SACHA (NCT07738601)
- Testing
- SSPedi - Symptom Screening in Pediatrics Questionnaire
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Brain and Central Nervous System Tumors
Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving a chemotherapy drug before surgery or radiation therapy may shrink the tumor so that it can be removed…
- Trial name
- NCT00025077
- Testing
- filgrastim, carboplatin, cyclophosphamide
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 50 people
- Sponsor
- Children's Cancer and Leukaemia Group
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