Clinical trials: Central Pain Syndrome
Interstitial Cystitis
Evaluation of Intravesical LP08 in Patients With Interstitial Cystitis/Painful Bladder Syndrome
The purpose of this study is to assess the safety and tolerability of two doses of LP08 compared to placebo. Hypothesis: Safety of the LP-08 therapy will not be significantly different from the placebo group.
- Trial name
- NCT01393223
- Testing
- LP-08 80mg, Normal saline, LP-08 20mg
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Lipella Pharmaceuticals, Inc.
Rotator Cuff Lesion, Subacromial Impingement Syndrome
Investigation of the Effect of Central Sensitization Symptom Severity on Steroid Injection Results in Shoulder Pain
The aim of this study was to investigate the effect of the presence and severity of pre-treatment central sensitization on the results of subacromial/ intra-articular shoulder injection in patients with rotator cuff…
- Conditions
- Rotator Cuff Lesion, Subacromial Impingement Syndrome, Shoulder Pain, Chronic Pain
- Trial name
- NCT06404125
- Testing
- Range of Motion of Shoulde Joint, Hand Grip Test, Numeric Rating Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Irritable Bowel Syndrome
Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome
The purpose of this study is to provide new information and to determine which kinds of brief, tolerable, experimental pain are affected by the drugs being studied in patients with irritable bowel syndrome, a disease that causes…
- Trial name
- NCT00100425
- Testing
- Viceral Perception Testing
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Chronic, Intractable Back Pain and/or Leg Pain
Clinical Trial of MED HF10™ Spinal Cord Stimulation for the Treatment of Chronic Pain
This is a single-center, prospective, non-randomized exploratory study in subjects with chronic, intractable back pain and/or leg pain per the center's routine practice.
- Trial name
- MED (NCT06897280)
- Testing
- SCS Device Program Setting
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Nevro Corp
Post Concussive Headache, Post Concussive Syndrome
Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial
Concussion is defined as any temporary disturbance in brain function following a blow to the head. It may not involve a loss of consciousness and usually results in a post concussive headache (PCH) immediately after the injury.
- Trial name
- NCT00237705
- Testing
- metoclopramide
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Vancouver General Hospital
Chronic Pain, Complex Regional Pain Syndromes
Dance-therapy and Chronic Pain
Pain, when it becomes chronic, can be a threat to patients and it is very common to observe a fear of pain and a fear of movement (kinesiophobia).
- Conditions
- Chronic Pain, Complex Regional Pain Syndromes, Tension-Type Headache
- Trial name
- ALGODANCE (NCT05689944)
- Testing
- Dance-therapy, Art-therapy, Yoga
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Lower Back Pain Chronic
The Potential of Transcutaneous Electrical Nerve Stimulation to Improve Pain Experienced During Posterior Branch Blocks in Patients With Lumbar Posterior Joint Syndrome
Procedural pain is inadequately managed in two-thirds of patients undergoing invasive medical procedures. Several techniques exist for managing procedural pain, but they all present implementation challenges and are not without…
- Trial name
- TENS-INFIDOL (NCT07627490)
- Testing
- Stimulation with TENS, which allows the release of endorphins, Stimulation with TENS does not allow the release of endorphins, Questionnaires
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Toulouse
Fibrous Dysplasia of Bone, McCune Albright Syndrome
PAINDYS_Characterizing Pain in Fibrous Dysplasia of Bone/McCune-Albright Syndrome: an Exploratory Pilot Study
Fibrous dysplasia of bone (FD) / McCune-Albright syndrome (MAS) is a rare congenital bone disorder affecting one or multiple bones, caused by a mosaic somatic mutation of the GNAS gene.
- Trial name
- PAINDYS (NCT07476768)
- Testing
- Visit 1 at the center
- Where
- France
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Borderline Personality Disorder
Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder
Selegiline is superior to placebo in improving psychological and physical functioning in patients with Borderline Personality Disorder.
- Trial name
- NCT01912391
- Testing
- Selegiline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mood and Anxiety Research, Inc
Neck Pain, Posterior, Trapezius Muscle Strain
Central Pain Modulatory Effects of Dry-Needling in Patients With Non-Specific Neck Pain
An experimental study will be conducted to evaluate the effect of a single dry needling session, compared to a sham needling session, on pain intensity, local and peripheral hyperalgesia, and conditioned pain modulation in…
- Trial name
- NCT04725825
- Testing
- Dry needling
- Where
- Belgium
- Volunteers
- 54 people
- Sponsor
- University Ghent
Cancer
Multiple Symptoms in Cancer Patients a Cross Sectional Multi Center Study
This study will assess the occurrence of multiple symptoms in cancer patients of 5 German university hospitals. Primary goal of the study is to assess the prevalence of multiple symptoms and related symptom clusters (e.g.
- Trial name
- ProKID (NCT01317355)
- Where
- Germany
- Volunteers
- 697 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Posttraumatic Stress Symptom, Central Sensitization
Central Sensitization Syndromes and Post-Traumatic Stress in Women: Psychological Profile and Intervention
Central Sensitivity Syndromes (CSSs) are a group of conditions that are highly prevalent, particularly among women, and often occur alongside post-traumatic stress disorder (PTSD).
- Conditions
- Posttraumatic Stress Symptom, Central Sensitization, Chronic Pain Syndrome
- Trial name
- SINSENTRA (NCT07313280)
- Testing
- CSS-PTSD psychological interventions
- Where
- 3 sites in Spain
- Volunteers
- 12 people
- Sponsor
- University of Malaga
Chronic Pain
Central Nervous System Amplification in Lumbar Failed Back Surgery Syndrome
The purpose of this study is to learn whether or not certain risk factors and patient characteristics are linked with and possibly can predict the development of chronic pain after lumbar spine surgery.
- Trial name
- NCT03444168
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Spinal Cord Injuries, Central Pain Syndrome
Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI
Central neuropathic pain (CNP) is defined as chronic pain due to injury or disease in the central nervous system. This pain is most common among people with a spinal cord injuries (SCI), with a prevalence of about 50%.
- Trial name
- NCT03748290
- Testing
- Pregabalin
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Post-Concussion Symptoms, Insomnia
Neurotechnology Following Traumatic Brain Injury
This two-part study seeks to improve symptoms such as pain and sleep problems after concussion, or mild traumatic brain injury (mTBI).
- Conditions
- Post-Concussion Symptoms, Insomnia, Pain, Chronic, Depressive Symptoms
- Trial name
- Cereset (NCT03649958)
- Testing
- HIRREM-SOP or Cereset, Cereset 2x
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Brain State Technologies, LLC
Traumatic Encephalopathies, Chronic, Concussion, Mild
Use of Adipose-Derived Stem/Stromal Cells in Concussion and Traumatic Brain Injuries
Concussion is the most common type of brain injury throughout life. Study is seeking improvement of long-term residua following adolescent and adult post-traumatic injuries often associated with contact sports and accidental…
- Conditions
- Traumatic Encephalopathies, Chronic, Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- C-TBI (NCT02959294)
- Testing
- Microcannula Harvest Adipose, Centricyte 1000, Sterile Normal Saline IV deployment AD-cSVF
- Where
- United States
- Sponsor
- Robert W. Alexander, MD, FICS
Neuropathy
Pregabalin Versus Placebo In The Treatment Of Neuropathic Pain Associated With HIV Neuropathy
The purpose of this study is to evaluate the efficacy of pregabalin compared to placebo in reducing neuropathic pain associated with HIV neuropathy.
- Trial name
- NCT01049217
- Testing
- pregabalin
- Where
- 63 sites in United States, Colombia and 7 more
- Volunteers
- 377 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Acute Coronary Syndrome, Angina Pectoris
Comparison of BIOdegradable Polymer and DuRablE Polymer Drug-eluting Stents in an All COmeRs PopulaTion (BIO-RESORT)
The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- BIO-RESORT (NCT01674803)
- Testing
- Orsiro, Synergy, Resolute Integrity
- Where
- Netherlands
- Volunteers
- 3,514 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Malignant Pain, Non-malignant Pain
To Demonstrate Equivalence in Analgesic Efficacy & Bowel Function Between OXN PR Higher Dose & Lower Dose Tablet Strengths in Subjects With Non-cancer or Cancer Pain
This study is aimed to demonstrate equivalence between combinations of lower strength OXN PR tablets (OXN PR LST) and single higher strength OXN PR tablets (OXN PR HST) taken at the same overall daily dose.
- Trial name
- NCT02321397
- Testing
- Oxycodone, Naloxone
- Where
- Germany
- Volunteers
- 155 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc