Clinical trials: Central Post Stroke Pain
Chronic Pain, Post Stroke Pain
Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but current technology is unable to reliably achieve long-term pain symptom relief.
- Conditions
- Chronic Pain, Post Stroke Pain, Phantom Limb Pain, Spinal Cord Injuries
- Trial name
- NCT03029884
- Testing
- Open-Loop DBS, Closed-Loop DBS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Prasad Shirvalkar, MD, PhD
Stroke
The Role of Peripheral Afferents in Modulating Post-stroke Central Pain
Central post-stroke pain (CPP) is extremely difficult to relieve and responds very poorly to analgesics targeting neuropathic pain, probably because the mechanisms underlying this pain remain poorly understood.
- Trial name
- APEDOC (NCT06446960)
- Testing
- Lidocaine 20mg/ml, Levobupivacaine Hydrochloride 1.25 MG/ML, Sodium Chloride 0.9% Inj
- Where
- 2 sites in France
- Volunteers
- 33 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Central Post-Stroke Pain
Treatment of Post-Stroke Central Pain
To evaluate the short-term analgesic efficacy of stSCS combined with pharmacotherapy compared with pharmacotherapy alone in patients with CPSP, measured by Numerical Rating Scale (NRS) score immediately after treatment.
- Trial name
- NCT07593313
- Testing
- stSCS+Gabapentin or Pregabalin (with optional Duloxetine or Amitriptyline), Gabapentin or Pregabalin (with optional Duloxetine or Amitriptyline)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanchong Central Hospital
Stroke ( 3 Months After Onset), Stroke in Patients: New Tool to Evaluate the Impact in Their Life
Radiofrequency vs. Ultrasound Therapy for Shoulder Joint in Stroke Patients: A Comparative Clinical Trial
The purpose of the current study is to: Compare between radiofrequency (TECAR) therapy and ultrasound on Shoulder Pain, Range of Motion and Functional Outcome in Patients with stroke.
- Trial name
- TECAR (NCT07131943)
- Testing
- Radiofrequency, Ultrasound, The designed physical therapy program
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Complex Regional Pain Syndromes
Investigation of the Efficacy of Transcranial Magnetic Stimulation in Patients Developing Complex Regional Pain Syndrome Type 1 in the Upper Extremity During the Subacute-Chronic Period After Ischemic Stroke
The aim of our study is to investigate transcranial magnetic stimulation (TMS) as a treatment option in Complex Regional Pain Syndrome, disseminate it to a broader patient population, and simultaneously demonstrate its…
- Trial name
- NCT06215079
- Testing
- The Magstim Rapid2 Plus Magnetic Stimulator (Magstim, Whitland, Dyfed, UK), conventional rehabilitation program
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Post-stroke Spasticity
Pain During Injection With Botulinum Toxin in Post-stroke Spasticity Treatment
The aim of the study was to analyze which step of the procedure of toxin botulinum injection is the most painful between skin break-in, electric stimulation, injection and needle withdrawal.
- Trial name
- DOLOTOX (NCT03251521)
- Testing
- pain rating during injection with botulinum toxin
- Volunteers
- 46 people
- Sponsor
- University Hospital, Grenoble
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Stroke
ROBOtic Care of Post-stroke Pain.
In agreement to the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) recommendations that support the importance of physical functioning as core outcome for pain this randomized, double-blind…
- Trial name
- Robocop (NCT05288270)
- Testing
- Aramis, Conventional therapy
- Volunteers
- 118 people
- Sponsor
- S.Anna Rehabilitation Institute
Central Post-stroke Pain, Stroke
Motor Cortex Stimulation for Post-Stroke Thalamic Pain
The goal of this clinical trial is to investigate the mechanisms and predictive factors of motor cortex stimulation (MCS) for treating post-stroke thalamic pain, a challenging central neuropathic pain condition.
- Conditions
- Central Post-stroke Pain, Stroke, Electric Stimulation Therapy, Multimodal Imaging
- Trial name
- NCT07758829
- Testing
- Motor Cortex Stimulation (MCS) System
- Volunteers
- 200 people
- Sponsor
- Aerospace Center Hospital
Shoulder Pain, Hemiplegia
Observational Study of Hemiplegic Shoulder Pain After Recent Stroke
This is an observational study to address the following questions. 1. How many people develop stroke-shoulder pain within 3 days of stroke? 2. How many people have stroke shoulder pain at 8-10 weeks after stroke? 3.
- Conditions
- Shoulder Pain, Hemiplegia, Stroke
- Trial name
- SPARS (NCT02574000)
- Testing
- ShoulderQ which is a shoulder pain questionnaire, Clinical shoulder examination
- Where
- United Kingdom
- Volunteers
- 163 people
- Sponsor
- St George's, University of London
Pain
Central Post-Stroke Pain - a Prospective Study
Part 1: The purpose of the first part of the study is to investigate the prevalence of pain at stroke onset and 3 and 6 months after stroke in a consecutive cohort of stroke patients admitted to a stroke unit.
- Trial name
- NCT00957645
- Volunteers
- 275 people
- Sponsor
- Danish Pain Research Center
Stroke, Complex Regional Pain Syndrome I (CRPS I)
Mirror Therapy for Complex Regional Pain Syndrome in Stroke Patients
The goal of this clinical study is to evaluate the effectiveness of mirror therapy in treating complex regional pain syndrome (CRPS) in patients after stroke using clinical assessments, electrophysiological evaluations, and…
- Conditions
- Stroke, Complex Regional Pain Syndrome I (CRPS I), Mirror Therapy
- Trial name
- MT-CRPS-ST (NCT07537465)
- Testing
- Mirror Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Stroke
Dry Needling for Shoulder Pain in Stroke Patients
Spasticity and pain, particularly int he shoulder region, are the most common impairments experienced by subjects who had experienced a stroke.
- Trial name
- NCT03703193
- Testing
- Dry Needling, Physical Therapy
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Universidad Rey Juan Carlos
Hemiplegia
Effectiveness of NeuroMuscular Taping on Painful Hemiplegic Shoulder
Painful Shoulder Syndrome is a frequent complication after stroke occurring in between 5% and 84% of patients, often having a strong impact on their well-being and resulting in delays achieving rehabilitative objectives.
- Trial name
- NCT02254876
- Testing
- Standard physical therapy program, NeuroMuscular Taping (NMT)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Bologna
Post-stroke Shoulder Pain
Repetitive Transcranial Magnetic Stimulation in Hemiplegic Shoulder Pain
Shoulder pain after stroke is one of the most common complications of stroke. Underlying mechanisms of shoulder pain after stroke still completely is not clarified.
- Trial name
- NCT05601921
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Izmir Katip Celebi University
Complex Regional Pain Syndrome I of Upper Limb, Pain
THE EFFECTS OF FUNCTIONAL ELECTRICAL STIMULATION-ASSISTED BICYCLE ERGOMETRY IN PATIENTS DIAGNOSED WITH COMPLEX REGIONAL PAIN SYNDROME.(CRPS)
The goal of this clinical study is to evaluate the effectiveness of functional electrical stimulation (FES)-assisted cycling in patients with post-stroke Complex Regional Pain Syndrome (CRPS) Type 1.
- Trial name
- CRPS (NCT07570199)
- Testing
- Functional Electrical Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Zeynep Nur Köseoğlu
Shoulder Pain, Stroke
Exergames on Shoulder Pain and Motor Function
This study is to investigate the effects of exergame on shoulder pain and motor function of upper extremity in individuals with stroke.
- Trial name
- NCT03716206
- Testing
- Exergame, Physical therapy
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Yang Ming Chiao Tung University
Central Post-stroke Pain
Structural and Functional Grey and White Matter Changes in Patients With Pain Disorders
The goal of this observational study is to examine the association between exact lesion location and presence of thalamic CPSP (Central post-stroke pain) in a larger number of patients after thalamic stroke.
- Trial name
- NCT05679297
- Testing
- Quantitative sensory testing (QST), Magnetic resonance imaging (MRI), Clinical interview/exam
- Where
- Switzerland
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Shoulder Pain
Electrical Stimulation for the Treatment of Post-Stroke Shoulder Pain
Post-stroke shoulder pain is defined as pain in the shoulder area that starts after a person has had a stroke. The SPR System is an investigational device that is being studied for the relief of post-stroke shoulder pain.
- Trial name
- NCT01094301
- Testing
- The SPR System
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- SPR Therapeutics, Inc.
Stroke
Early Electrical Stimulation to Prevent Complications in the Arm Post-stroke - a Feasibility Study
Stroke is the largest cause of adult disability in the United Kingdom. Loss of hand function, muscle weakness, pain, and joint deformities are persistent and disabling problems for nearly half of all stroke survivors.
- Trial name
- ESCAPS (NCT02324634)
- Testing
- NeuroTrac Rehab dual channel device
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Nottingham