Clinical trials: Central Sensitization
Ehlers-Danlos Syndrome, Craniocervical Syndrome
Opioid-Free Anesthesia for Patients With Joint Hypermobility Syndrome Undergoing Craneo-Cervical Fixation: A Case-series
Cranio-cervical instability (CCI) has been well identified in diseases regarding connective tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT).
- Trial name
- NCT04437589
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Servei Central d'Anestesiologia
Central Sensitisation
Investigation of the Relationship Between Central Sensitization and Neuropathic Pain in Lumbar Disc Herniation
Central sensitization (CS) is as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with in many musculoskeletal diseases with chronic pain has been demonstrated in several…
- Trial name
- NCT06269068
- Testing
- Central sensitization inventory, Short form-36, Oswestry Low Back Pain Disability Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Marmara University
Central Sensitisation, Carpal Tunnel Syndrome
Investigation of the Relationship Between Pain Sensitization and Diagnostic Parameters in Carpal Tunnel Syndrome
The aim of this observational, cross-sectional study is to investigate the relationship between pain sensitization and ultrasonographic and nerve conduction studies in patients diagnosed with carpal tunnel syndrome (CTS).
- Trial name
- NCT06043141
- Testing
- Nerve ultrasound, Nerve conduction studies, Pressure pain threshold
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
TMD, Masticatory Muscle Pain
Pain, Central Sensitization and Psychoemotional State in Patients With Chronic Masticatory Muscle Pain
The aim of this study is to investigate the relationship of psychological aspects, selected blood parameters, pain, central sensitization, and muscle electromyography activity in patients with chronic masticatory muscle pain.
- Trial name
- NCT05676827
- Testing
- Diagnostic Criteria for Temporomandibular Disorders Clinical Examination, Blood test
- Where
- Poland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Chronotype, Fibromyalgia Syndrome
Evaluation of Chronotype and Central Sensitization in Patients With Fibromyalgia Syndrome
The aim of study is to examine the chronotype preferences of patients with fibromyalgia syndrome and the relationship between central sensitization and chronotype, and to examine its relationship with pain intensity, disability…
- Trial name
- NCT06197087
- Testing
- cross-sectional observational survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Oğuzhan Kandemir
Knee Osteoarthritis
Neurofeedback for Pain Sensitization in Knee Osteoarthritis
The goal of this clinical trial is to learn whether a training method called neurofeedback is safe and practical to use in people with knee osteoarthritis (knee OA).
- Trial name
- NCT07832682
- Testing
- FWR Down-Conditioning Neurofeedback
- Volunteers
- 50 people
- Sponsor
- Northeastern University
Endometriosis, Postoperative Pain
Postoperative Pain Trajectories After Endometriosis Surgery
The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors.
- Conditions
- Endometriosis, Postoperative Pain, Pain Trajectories, Chronic Postsurgical Pain
- Trial name
- TRACK-ENDO (NCT07882498)
- Testing
- Perioperative quantitative sensory testing, questionnaire
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Low Back Pain
Active Music-Based Intervention in Patients With Chronic Low Back Pain
The goal of this clinical trial is to learn if active music-based intervention works to treat patients with chronic low back pain. The main questions it aims to answer are: 1.
- Trial name
- NCT06940063
- Testing
- Active music-based intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Sharon Wang-Price
Thoracic Outlet Syndrome
Motivational Interviewing in Thoracic Outlet Syndrome
The goal of this clinical trial is to learn if motivational interviewing (MI) works to improve symptoms in people with thoracic outlet syndrome (TOS).
- Trial name
- NCT07668206
- Testing
- Motivational Interviewing, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hacettepe University
Neuropathic Pain
The Effect of Central Sensitization and Neuropathic Pain After Total Knee Arthroplasty
It has been well known that central sensitization (CS) is a risk factor for inferior outcomes following total knee arthroplasty (TKA).
- Trial name
- NCT05581836
- Where
- South Korea
- Volunteers
- 312 people
- Sponsor
- The Catholic University of Korea
Dysmenorrhea, Menstrual Pain
Non-Steroidal Anti-Inflammatory Drug (NSAID) Response and Central Sensitization of Pain in Women With Dysmenorrhea
Menstrual pain is the most common gynecological complaint and the leading cause of school and work absences in reproductive-age girls and women.
- Conditions
- Dysmenorrhea, Menstrual Pain, Non-steroidal Anti-inflammatory Drug
- Trial name
- NCT05900336
- Testing
- Sodium Naproxen
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Fibromyalgia
Effects of Milnacipran on Widespread Mechanical and Thermal Hyperalgesia of Fibromyalgia Patients
Fibromyalgia syndrome (FM) shares many symptoms common to chronic neuropathic pain, including the characteristic hyperalgesia of the skin (thermal, mechanical) and muscles (mechanical) found in almost all FM patients.
- Trial name
- NCT01294059
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Florida
Dysmenorrhea, Endometriosis
Effects of Physiotherapy on Ultrasound and Clinical Parameters in Women With Dysmenorrhea
Dysmenorrhea affects up to 90% of women of reproductive age and represents a significant public health concern. Beyond prostaglandin-mediated uterine contractions, dysmenorrhea involves central sensitization mechanisms and…
- Trial name
- NCT07645196
- Testing
- Abdominal manual mobilization
- Where
- 2 sites in Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Chronic Low-back Pain
Mechanisms of Chiropractic Spinal Manipulation for Chronic Low Back Pain
This is a mechanistic randomized controlled trial on the effects of chiropractic spinal manipulative therapy on patients with chronic low back pain.
- Trial name
- NCT05162924
- Testing
- Spinal Manipulation
- Where
- Spain
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Real Centro Universitario Maria Cristina
Endometriosis
Central Awareness in Women With Endometriosis
Gathering some information obtained during the gynaecological examination and transvaginal ultrasound check-up to be able to assess the prevalence of Central Sensitisation Syndrome (CSS) in women with endometriosis and also to be…
- Trial name
- NCT06773065
- Where
- Italy
- Volunteers
- 310 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Chronic Pain
The Effect of Pain Education Group Therapy and Its Impact on Chronic Pain, Kinesiophobia, and Physical Activity
The goal of this clinical trial is to learn if pain knowledge group intervention among chronic pain patients would influence their level of physical activity, pain intensity, depression, kinesiophobia and central sensitization.
- Trial name
- NCT07491549
- Testing
- pain education
- Where
- Estonia
- Volunteers
- 50 people
- Sponsor
- University of Tartu
Osteoarthritis, Knee
Effects of Duloxetine on Postoperative Wound Complication of Total Knee Arthroplasty (TKA) in Central Sensitization Patients
Postoperative wound complications such as wound dehiscence, skin necrosis, persistent wound drainage, delayed healing, and superficial skin infection could have devastating consequences, leading to arthroplasty failure and…
- Trial name
- NCT03880916
- Testing
- Duloxetine
- Volunteers
- 80 people
- Sponsor
- The Catholic University of Korea
Lipedema
The Relationship Between Central Sensitization, Pain, and Psychosocial Factors in Individuals With Lipedema
This cross-sectional study will include women aged 18-75 with clinically diagnosed lipedema and healthy controls. Sociodemographic and clinical data will be collected, and participants will complete the Central Sensitization…
- Trial name
- NCT07240285
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Neuropathic Pain
Exploring the Role of the GABAergic Modulation in Pain Transmission in Human
Neuropathic pain affects about 7% of the general population in European countries. Meta-analyses indicate that only a minority of neuropathic pain patients has adequate response to drug therapy and management of neuropathic pain…
- Trial name
- NDMC-101 (NCT03375034)
- Testing
- NDMC 20mg, NDMC60mg, Clonazepam 1.5mg
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jules Desmeules
Pain Management, Autism Spectrum Disorder (ASD)
Prospective Study to Determine the Prevalence of Signs of Central Sensitization in Adults With ASD Without Intellectual Developmental Disorders
Autism is a neurodevelopmental disorder (NDD) characterized by two key features: persistent deficits in communication and social interaction, and restricted, repetitive patterns of behavior, interests, and activities.
- Trial name
- Presca (NCT07495761)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Groupe Hospitalier Mutualiste de Grenoble