Clinical trials: Central Spinal Cord Syndrome
Spinal Cord Injury
Use of an Oral Beta-2 Agonist in Persons With Spinal Cord Injury
The primary purpose of this study is to determine the effect of administration of the oral beta-2 adrenergic agonist, albuterol, on respiratory muscle strength in individuals with cervical (neck) and high thoracic (upper back)…
- Trial name
- NCT00755079
- Testing
- extended release beta-2 adrenergic agonist
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury
Biomarkers of Spontaneous Recovery From Traumatic Spinal Cord Injury
The purpose of the study is to profile biochemical responses and measure functional recovery in parallel, throughout the 1st year after spinal cord injury (SCI), within the same participants.
- Trial name
- SCIMARK (NCT02731027)
- Where
- 6 sites in United States, Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Spinal Cord Injuries
Ischaemic Preconditioning and Upper Body Exercise Performance in Persons With Spinal Cord Injury
Regular physical activity improves physical fitness, fatigue, quality of life, gait and reduces progression of the disability in persons with SCI. However, persons with SCI are less physically active than the general population.
- Trial name
- NCT05954715
- Testing
- Ischaemic Preconditioning
- Volunteers
- 40 people
- Sponsor
- Loughborough University
Spinal Cord Injury
Intervention Study to Assess the Effects of Moderate and High Intensity Aerobic Training on Physical Capacity and Activity Level in Persons With Incomplete Spinal Cord Injury
The aims of this study are to assess the effects of medium versus high intensity 12-week adjusted training programs on physical capacity in persons with incomplete SCI, early after discharge from primary rehabilitation, and to…
- Trial name
- NCT01903226
- Testing
- High intensity training, Moderate intensity training
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Stroke, Spinal Cord Injuries
The Roll of Balance Confidence in Gait Rehabilitation in Persons With a Lesion of the Central Nervous System
Persons with an injury of the central nervous system clearly experience motor impairments. Among the most commonly described consequences are gait abnormalities and impaired balance.
- Conditions
- Stroke, Spinal Cord Injuries, Traumatic Brain Injury
- Trial name
- NCT05503316
- Testing
- Dynamic balance training, Traditional gait rehabilitation
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- University Hospital, Ghent
Stiff Person Syndrome
Rituximab to Treat Stiff Person Syndrome
This study will test whether rituximab (RITUXAN (Trademark)) can relieve symptoms of stiff person syndrome (SPS), a progressive disease that causes stiffness of the muscles and muscle spasms induced by unexpected noises, touches…
- Trial name
- NCT00091897
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injury
The Effects of Anti-oxidants on Clinical Outcomes and Radiological Features of Chronic Spinal Cord Injury: A Pilot Study
This study will enroll 10 adults with a chronic spinal cord injury. The investigators will image their damaged motor tracts using MRI tractography scanning, and the investigators will formally assess their ASIA motor level at the…
- Trial name
- NCT01904591
- Testing
- Selenium, Vitamin E
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- McMaster University
SCI - Spinal Cord Injury
Effect of tSCS on Ankle Movement Training in Individuals With SCI
This clinical trial explores the effectiveness of transcutaneous spinal cord stimulation (tSCS), a non-invasive technique, in facilitating spinal circuitry adaptation in individuals with spinal cord injury (SCI).
- Trial name
- NCT06596174
- Testing
- Transcutaneous spinal cord stimulation (tSCS), Short-term Machine-Assisted Ankle Movement Training with tSCS, Long-term Effects of Machine-Assisted Ankle Movement Training with tSCS
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Acute Spinal Cord Injury, Acute Spinal Paralysis
"SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation
Prospective, single center study designed to assess blood biomarkers for classifying injury severity and predict neurologic recovery in traumatic spinal cord injured (SCI) patients.
- Conditions
- Acute Spinal Cord Injury, Acute Spinal Paralysis, Spinal Cord Injuries, Trauma, Spinal Cord
- Trial name
- SCRIBBLE (NCT05244408)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
Stroke, Spinal Cord Injuries
Human-like Robotic Controllers for Enhanced Motor Learning
The purpose of this study is to develop a new paradigm to understand how humans physically interact with each other at a single and at multiple joints, with multiple contact points, so as to synthesize robot controllers that can…
- Trial name
- HRCEML (NCT04578665)
- Testing
- Behavioral Interaction Conditions, Haptic Impedance Level, Skill Level of Partner
- Where
- United States
- Volunteers
- 764 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Electric Stimulation Therapy, Bowel Dysfunction
The Effect of NMES on Bowel Management in People With Chronic SCI
It has been reported that 62% of all people with Spinal Cord Injury (SCI) have experienced faecal incontinence and that neurogenic bowel dysfunction (NBD) is a major sequela.
- Conditions
- Electric Stimulation Therapy, Bowel Dysfunction, Spinal Cord Injuries, Defecation Disorder
- Trial name
- FES_Bowel (NCT04914975)
- Testing
- Neuromuscular electrical stimulation
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spinal Cord Injuries, Paraplegia, Spinal
Transspinal-Transcortical Paired Stimulation for Neuroplasticity and Recovery After SCI
People with spinal cord injury (SCI) have motor dysfunction that results in substantial social, personal, and economic costs. Uncontrolled muscle spasticity and motor dysfunction result in disabilities that significantly reduce…
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis
- Trial name
- NCT04624607
- Testing
- Transspinal-transcortical paired-associative stimiulation combined with robotic gait training, Transcortical-transspinal paired-associative stimiulation combined with robotic gait training
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- College of Staten Island, the City University of New York
Spinal Cord Injury, Neuropathic Pain
Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury
This pilot randomized, double-blind, sham-controlled clinical investigation will evaluate the feasibility and safety of a 30-day home-based transcutaneous auricular vagus nerve stimulation (taVNS) intervention in adults with…
- Trial name
- NCT07588711
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Spinal Cord Injury, Psychosocial Problem
Effects of a Coping-oriented Supportive Programme (COSP) for People With Spinal Cord Injury During Inpatient Rehabilitation
The aim of this proposed PhD study is to test the effectiveness of a newly developed coping-oriented supportive programme (COSP) for Chinese people with SCI during their early period of inpatient rehabilitation in Xi'an, China.
- Trial name
- NCT02672670
- Testing
- Experimental: Intervention group---coping-oriented supportive programme, Active Comparator: Comparison group---a didactic talk (usual care)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Spinal Cord Injury (SCI), Initial Encounter
Assessment of Neural Signals for the Control of Assistive Devices
The study will investigate the use of motor intention-based cortical signals to trigger epidural spinal cord stimulation (ESCS) with individuals with SCI.
- Trial name
- NCT06533969
- Testing
- Epidural Spinal Cord Stimulation, Electrocorticographic, Electroencephalographic
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Miami
Acute Cervical Spinal Cord Injury
Safety and Efficacy of Cethrin® in Adult Subjects With Acute Cervical Spinal Cord Injury
This is a multicenter, randomized, double-blind, placebo-controlled, Phase IIb study to be conducted in North America and Europe and will include male and female subjects with acute cervical SCI, 18 to 62 years of age, who…
- Trial name
- NCT00610337
- Testing
- Cethrin® (BA-210)
- Sponsor
- BioAxone BioSciences, Inc.
Spinal Cord Injuries
Circuit Training Program for Persons With Spinal Cord Injury
This initiative represents development and pilot testing of a circuit training exercise program for persons with spinal cord injury (SCI) to be implemented within a rehabilitation centre.
- Trial name
- NCT04263272
- Testing
- Upper Body Circuit Training Program
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Stroke, Incomplete Spinal Cord Injury
Comparison of Gait Training Methods in Sub-acute Stroke and Spinal Cord Injury
The purpose of the project is to compare intensity (minutes in target heart rate zone) and steps per session across three gait training modalities, including body-weight supported treadmill training (BWSTT), overground gait…
- Trial name
- NCT06169657
- Testing
- Body-weight-supported treadmill training (BWSTT), EksoNR exoskeleton gait training, Overground gait training
- Where
- United States
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Spinal Cord and Artificial Intelligence
The aim of this study was to analyze using an artificial intelligence engine (IA) the influence of the pathophysiological environment (set parametric monitoring data, imaging, biology etc.) of acute spinal cord trauma on spinal…
- Trial name
- SKY (NCT02833428)
- Testing
- Biomedical equipment (Eclipse Nim, Medtronic®)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Neuropathic Pain
Virtual Walking and Neuromulation to Reduce Neuropathic Pain After a Spinal Cord Injury
The goal of this single-subject design is to evaluate an intervention combining neuromodulation, virtual reality, and muscle vibration to reduce neuropathic pain in individuals following a spinal cord injury.
- Trial name
- NCT07254767
- Testing
- Transcranial Direct Current Stimulation (tDCS) combined with virtual reality and muscle vibration
- Volunteers
- 10 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.